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The map label for this gene is pth

Identifier: 170755332

GI number: 170755332

Start: 3857181

End: 3857750

Strand: Reverse

Name: pth

Synonym: CLD_0943

Alternate gene names: 170755332

Gene position: 3857750-3857181 (Counterclockwise)

Preceding gene: 170754796

Following gene: 170756439

Centisome position: 97.46

GC content: 27.54

Gene sequence:

>570_bases
ATGTATTTAGTAGTTGGATTAGGAAATATAGGAAAAGAATATAAAAAGACTAGACATAATATAGGTTTTGATGTAGTTGA
CATTATAGCTGAGAAGTATAATATTGAAATAAATAGGCAAAAATTTAAAGGAAGTTATGGTGAAGGAAGAATAGGAAATG
AAAAGATAATATTATTAAAACCTAGTACATATATGAATTTAAGTGGAGAAAGTGTTATAGAAGCAGCTAATTTTTATAAA
ATAGATAAAGAAAATATAATAGTGATATATGATGATATGAGTATAGACATAGGAAAATTAAGAGTTAGAGGCAAGGGAAG
TGCAGGTGGACATAATGGTATAAAAAATATTATACAACATTTAAATTCAGATATTTTTCCTAGAGTTAGAGTAGGCATTG
GACAGCCTGATGAAAATGTAGTAAACTATGTTTTGGGAAAATTTTCAAAAGATCAAAGGGAAATTATAGATAAAGTACTA
GCTATGTCAGCTAAAGCATGTATAAGTATAGTAGAAGATGGAGTGACAGAGGCTATGAATAAGTACAATGGAGTAAAAAT
AGAAGTATAA

Upstream 100 bases:

>100_bases
TATAATAAATAGTAAAGGGACCTAATAAGTCTCTTTATTATTTATTTATTATAGTATAATATTCTTTAGTGATATTAATA
TTATAATTAGGAGTGAAGGT

Downstream 100 bases:

>100_bases
ACAGAGTTCTTGGCTTTAGAGGGAGTTTTTACTCCCACTAAAGCTTAGAAATCGTTATCCAGAGACGTAGCCGCTCTTTA
CTCCCACTTTGAAGAAGATG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLKPSTYMNLSGESVIEAANFYK
IDKENIIVIYDDMSIDIGKLRVRGKGSAGGHNGIKNIIQHLNSDIFPRVRVGIGQPDENVVNYVLGKFSKDQREIIDKVL
AMSAKACISIVEDGVTEAMNKYNGVKIEV

Sequences:

>Translated_189_residues
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLKPSTYMNLSGESVIEAANFYK
IDKENIIVIYDDMSIDIGKLRVRGKGSAGGHNGIKNIIQHLNSDIFPRVRVGIGQPDENVVNYVLGKFSKDQREIIDKVL
AMSAKACISIVEDGVTEAMNKYNGVKIEV
>Mature_189_residues
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLKPSTYMNLSGESVIEAANFYK
IDKENIIVIYDDMSIDIGKLRVRGKGSAGGHNGIKNIIQHLNSDIFPRVRVGIGQPDENVVNYVLGKFSKDQREIIDKVL
AMSAKACISIVEDGVTEAMNKYNGVKIEV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=164, Percent_Identity=33.5365853658537, Blast_Score=113, Evalue=1e-25,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=38.9473684210526, Blast_Score=121, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321983, Length=167, Percent_Identity=25.748502994012, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21068; Mature: 21068

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEHHHHCCCCCCCCCCCCEEEEEC
PSTYMNLSGESVIEAANFYKIDKENIIVIYDDMSIDIGKLRVRGKGSAGGHNGIKNIIQH
CCCEECCCCHHHHHHHHHEEECCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHH
LNSDIFPRVRVGIGQPDENVVNYVLGKFSKDQREIIDKVLAMSAKACISIVEDGVTEAMN
CCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNGVKIEV
HCCCEEEEC
>Mature Secondary Structure
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCEEEHHHHCCCCCCCCCCCCEEEEEC
PSTYMNLSGESVIEAANFYKIDKENIIVIYDDMSIDIGKLRVRGKGSAGGHNGIKNIIQH
CCCEECCCCHHHHHHHHHEEECCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHH
LNSDIFPRVRVGIGQPDENVVNYVLGKFSKDQREIIDKVLAMSAKACISIVEDGVTEAMN
CCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNGVKIEV
HCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA