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The map label for this gene is vanR [H]

Identifier: 170755164

GI number: 170755164

Start: 320515

End: 321201

Strand: Direct

Name: vanR [H]

Synonym: CLD_0506

Alternate gene names: 170755164

Gene position: 320515-321201 (Clockwise)

Preceding gene: 170755669

Following gene: 170756435

Centisome position: 8.1

GC content: 30.28

Gene sequence:

>687_bases
ATGGAAAAAATTTTAATAATTGAAGATGATGAGGACATAAGAGATATATTAAAGCTTTACTTGGAAGGTCAATCCTATGA
GATATTGGAGGCTGAAAATGGGGCTAAAGCCATGAAGCAATTAGTTAAACAACCAGATCTTGTTATTTTAGATTTGATGC
TTCCAGATATTGATGGGCTAAGCATTTGTAAAAGTATTCGTAAAAAATATTATTACCCTATTATCATGATTACAGCTAAA
AATGCAGATCAGGACAAAATATTAGGTTTAAGCTATGGTGCTGATGATTATATTACCAAGCCCTTTAATCCATTAGAAGT
AGTTGCTAGAGTAAAGGCACAATTAAGACGTTATAAACAATATGATGAAAACATAACTGATACGGAAAGTATTTATTATA
AAGCGCTTACTTTAAATCAAAAGAGTAAACAAGTAAGTATTAATGAAAAAGAGATTAAGCTTACACCTACGGAGTTTAAA
ATCTTAGAAGCTTTGTTAAAGAGAAAAGGGGAAGTTTTAAGTGGAGAGGAATTGTTTAATTTGATTTGGGAAGACGAATA
TTATTCTAAATCAACTAATACTATTACTGTTCATGTTAGAAATTTGAGAGAAAAAATGGATGATTCTTTTGAGAAACCAG
AGTATATTAAAACAGTGTGGGGGGTAGGTTATATTATTGAAGCGTAA

Upstream 100 bases:

>100_bases
TGTTCATAGAAAAAGAAATGATGAAGTGAGAAACTTGTTGATTTTATCTTTTACCAATAGGTAAGCCGCAAAAAGTGTAT
AATAAAATAGGGGGGATAGT

Downstream 100 bases:

>100_bases
AAAATGGAAATGGAATCATTATATTATAGCATTTATAGCATTTATCGTCATATTAATTTTTATTGATGTGTATTTAGAAG
GAAGTGTTGGTGAATACTTT

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MEKILIIEDDEDIRDILKLYLEGQSYEILEAENGAKAMKQLVKQPDLVILDLMLPDIDGLSICKSIRKKYYYPIIMITAK
NADQDKILGLSYGADDYITKPFNPLEVVARVKAQLRRYKQYDENITDTESIYYKALTLNQKSKQVSINEKEIKLTPTEFK
ILEALLKRKGEVLSGEELFNLIWEDEYYSKSTNTITVHVRNLREKMDDSFEKPEYIKTVWGVGYIIEA

Sequences:

>Translated_228_residues
MEKILIIEDDEDIRDILKLYLEGQSYEILEAENGAKAMKQLVKQPDLVILDLMLPDIDGLSICKSIRKKYYYPIIMITAK
NADQDKILGLSYGADDYITKPFNPLEVVARVKAQLRRYKQYDENITDTESIYYKALTLNQKSKQVSINEKEIKLTPTEFK
ILEALLKRKGEVLSGEELFNLIWEDEYYSKSTNTITVHVRNLREKMDDSFEKPEYIKTVWGVGYIIEA
>Mature_228_residues
MEKILIIEDDEDIRDILKLYLEGQSYEILEAENGAKAMKQLVKQPDLVILDLMLPDIDGLSICKSIRKKYYYPIIMITAK
NADQDKILGLSYGADDYITKPFNPLEVVARVKAQLRRYKQYDENITDTESIYYKALTLNQKSKQVSINEKEIKLTPTEFK
ILEALLKRKGEVLSGEELFNLIWEDEYYSKSTNTITVHVRNLREKMDDSFEKPEYIKTVWGVGYIIEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=41.9213973799127, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=38.5964912280702, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=35.8407079646018, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.8888888888889, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.9344978165939, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=34.1991341991342, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=38.695652173913, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=36.4035087719298, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=35.2678571428571, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=35.2422907488987, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=33.9130434782609, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.5991189427313, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=29.7872340425532, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790299, Length=122, Percent_Identity=31.1475409836066, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=183, Percent_Identity=25.6830601092896, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26549; Mature: 26549

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKILIIEDDEDIRDILKLYLEGQSYEILEAENGAKAMKQLVKQPDLVILDLMLPDIDGL
CCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCHH
SICKSIRKKYYYPIIMITAKNADQDKILGLSYGADDYITKPFNPLEVVARVKAQLRRYKQ
HHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YDENITDTESIYYKALTLNQKSKQVSINEKEIKLTPTEFKILEALLKRKGEVLSGEELFN
HCCCCCCCHHHEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHH
LIWEDEYYSKSTNTITVHVRNLREKMDDSFEKPEYIKTVWGVGYIIEA
HHHCCHHHCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHCCEEEEEC
>Mature Secondary Structure
MEKILIIEDDEDIRDILKLYLEGQSYEILEAENGAKAMKQLVKQPDLVILDLMLPDIDGL
CCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCHH
SICKSIRKKYYYPIIMITAKNADQDKILGLSYGADDYITKPFNPLEVVARVKAQLRRYKQ
HHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YDENITDTESIYYKALTLNQKSKQVSINEKEIKLTPTEFKILEALLKRKGEVLSGEELFN
HCCCCCCCHHHEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHH
LIWEDEYYSKSTNTITVHVRNLREKMDDSFEKPEYIKTVWGVGYIIEA
HHHCCHHHCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]