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The map label for this gene is dxs

Identifier: 170755138

GI number: 170755138

Start: 2009035

End: 2010903

Strand: Reverse

Name: dxs

Synonym: CLD_2756

Alternate gene names: 170755138

Gene position: 2010903-2009035 (Counterclockwise)

Preceding gene: 170754789

Following gene: 170754365

Centisome position: 50.8

GC content: 30.23

Gene sequence:

>1869_bases
ATGAAAATGAAAAACATATTAGATAAATACCAAGATTTTGATAGTATAAAATCCATGTCTATAAATGAGTTAAACCAATT
CTCTTACGAGATAAGAGAATTTTTAATAGATAATGTATCTAAAACAGGGGGGCATTTGGCCTCTAATTTAGGAGTGGTAG
AACTTACTTTAAGTATTTTTAATGTATTCGATTTAAATAAAGATAAAGTTATTTGGGATGTAGGACATCAAGCCTATGTA
CATAAAATATTAACGGGAAGAAAGGATAAATTTAATACATTAAGACAATATGGAGGATTAAGTGGTTTCCCTAAAATATG
TGAGAGTCCTTACGATGTATTTGAAACAGGACATAGCAGTACCTCTATATCTGCCGCTCTAGGAATGGCAAGAGCAAGGG
ACATAAAAGGAGAAAATAATAAAGTTATAGCTGTAATAGGAGATGGAGCTCTAACTGGCGGAATGGCTTTAGAAGCATTA
AATGATTTAGGCTTTAATAAAACAGATTTAATCATTATATTAAATGACAATCAAATGTCTATAGCTGAAAATGTAGGAGG
AATGTCTAGCTATTTAAGTAAAGTGAGATTAGACCCTACCTATAATAAATTAAAAAAAGAAGTTAATAATACTTTAAATA
AAATACCTAATGTTGGAAAAGGAATGGCCCGTTCTTTGGAAAAAGTAAAAAACGGTATAAAGCAAATGATTGTACCAGGT
ATGCTTTTTGAAAATTTAGGAATAAAATATTTGGGGCCAATAGATGGTCATGATATAAAAGAGTTAAGTAAAGTTATGAA
AATGGCTAAAAATATAAATGGACCAGTTCTAATACATACTATAACTAAAAAAGGAAAAGGCTATGCTTATGCAGAAAAAA
AACCTGATAAATTTCATGGTATAGGTCCTTTTGATTGTGATAGTGGTGAAGTTAATTCAAAAACCTGTTTAACTTATTCA
AAAGTTTTTGGAGAAGAGCTAACTAAAATAGCAAAAGAAGATAAAAAAGTGGTAGCTATAACTGCAGCTATGAAAGATGG
TACTGGTCTTAGAAAATTCGGAGAAACTTTCCCTAAAAGATTTTTTGACGTTGGCATAGCAGAACAGCATGCAGTAACCT
TAGCAGCGGGTATAGCAACAGAAGGATTAAAACCTGTTTTTGCTGTTTATTCAACATTTCTTCAAAGAGCATATGATCAA
ATATTACATGACATATGTATACAAAATTTACCTGTAGTATTAGGTATAGATAGAGCAGGTATAGTAGGAAGTGATGGAGA
AACACACCAAGGAATTTTTGACTTGTCATATTTATCTTCTTTACCTAATATGACAATAATAGCACCTAAATGTTTAGAAG
AAATGGGGATAATGCTAAGGTGGGCATTAAATCAAAATTCACCAGTAGCCATAAGATATCCTAGAGGTGGGGATATAAAA
TCCTTAGAAATGACTCCTATAAAAAATATGAAAAAAGGTAAGTGGGAAGTAATTTGCGAGGAAGGAGATATAGCCATAAT
AGCTACGGGAAAAATGGTGCAGCATGCTATAATAGCACGAGAAAAATTAAAAGAATATGGAATAAAATCTACAATTGTAA
ATGCAAACTTTATAAAACCTATAGATAAGGAATTAATAAAAAACTTTGTAAAAAAAGGATATAAGATAGTAACTGTAGAA
GATAATGTAATAAAAGGTGGATTTGGTTCTCTAGTTCTTCAATACATAAGTGAGCTAAAAGCTAACAATACTGTTTTAAA
TTTAGGTTTTAAAGATAAGTTTGTACCCCATGGTAGTACAGATATATTATATAAAATAGAAGGATTAGATCCAGAGGGTA
TTGTTAAAAATATAATAAAGATTATATAA

Upstream 100 bases:

>100_bases
TATAGGGGGAAAAGCTTTAGGTAAAGGATTTGCTATAACAAATAGTAATGATATATTAGAAAAGGTTACGAGAATAATAT
ATTTTTTTAAAAGAGGATAG

Downstream 100 bases:

>100_bases
TATTATATGAAGGAGTTAGTTATGGCAGAAAAAAAAGAAAGATTAGACTTGCTTTTGGTGGAAAAGGGCATTTTTCAGTC
TAGAGAAAGAGCAAAAGCTA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLEKVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKRFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII

Sequences:

>Translated_622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLEKVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKRFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII
>Mature_622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLEKVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKRFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=414, Percent_Identity=24.8792270531401, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4507521, Length=414, Percent_Identity=24.8792270531401, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI225637463, Length=261, Percent_Identity=26.8199233716475, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI225637461, Length=261, Percent_Identity=26.8199233716475, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=26.8199233716475, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI133778974, Length=370, Percent_Identity=23.5135135135135, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI156564403, Length=270, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=44.8051948051948, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539652, Length=407, Percent_Identity=23.5872235872236, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319698, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666278, Length=593, Percent_Identity=24.7892074198988, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551847, Length=673, Percent_Identity=22.4368499257058, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45550715, Length=673, Percent_Identity=22.4368499257058, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24645119, Length=626, Percent_Identity=23.0031948881789, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21358145, Length=277, Percent_Identity=24.9097472924188, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650940, Length=277, Percent_Identity=24.9097472924188, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68642; Mature: 68642

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
NVFDLNKDKVIWDVGHQAYVHKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSS
HHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCC
TSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEALNDLGFNKTDLIIILNDNQMS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
IAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLEKVKNGIKQMIVPG
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHG
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCC
IGPFDCDSGEVNSKTCLTYSKVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
FFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQILHDICIQNLPVVLGIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
CCCCCCCCCCCEEEHHHHHHCCCCEEECHHHHHHCCCEEEEEECCCCCEEEECCCCCCCC
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKP
EEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHEEECCHHCCH
IDKELIKNFVKKGYKIVTVEDNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGST
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
DILYKIEGLDPEGIVKNIIKII
EEEEEEECCCHHHHHHHHHHHC
>Mature Secondary Structure
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
NVFDLNKDKVIWDVGHQAYVHKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSS
HHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCC
TSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEALNDLGFNKTDLIIILNDNQMS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
IAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLEKVKNGIKQMIVPG
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHG
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCC
IGPFDCDSGEVNSKTCLTYSKVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
FFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQILHDICIQNLPVVLGIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
CCCCCCCCCCCEEEHHHHHHCCCCEEECHHHHHHCCCEEEEEECCCCCEEEECCCCCCCC
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKP
EEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHEEECCHHCCH
IDKELIKNFVKKGYKIVTVEDNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGST
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
DILYKIEGLDPEGIVKNIIKII
EEEEEEECCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA