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The map label for this gene is hpt

Identifier: 170754732

GI number: 170754732

Start: 3840437

End: 3840982

Strand: Reverse

Name: hpt

Synonym: CLD_0965

Alternate gene names: 170754732

Gene position: 3840982-3840437 (Counterclockwise)

Preceding gene: 170757599

Following gene: 170755847

Centisome position: 97.04

GC content: 30.04

Gene sequence:

>546_bases
ATGGATTTGATAAGTAGGGACATAGAAAAAATACTTATATCTGAAGAACAAATACAAAGCAAAATAAATGAATTAGGAGA
TCAAATCAGTAAGGATTATGATGGTAAAAATTTAATGCTGGTAGGTATATTAAAGGGGTCTGTACCTTTTATGGCGGATC
TACTAAAAAGAATAACTATACCTTGTACTATGGATTTTATGGCAGTGTCTAGCTATGGAAATTCTACCACATCCTCGGGA
GTAGTTAGAATATTAAAGGATCTAGATTTTGAAATAGAAGGGAAAGATATTCTTATAGTAGAAGATATAATAGATTCTGG
TATAACATTAAAATATTTATTAGAAAATTTGCGTGCGAGAAAACCTGCTAGCATAAATATAGCTTGCTTGCTTAATAAGG
AAGAAAGAAGAAAGGCAGAAATTGATGTTCATTATTTAGGTTTTAATGTTCCTGATTATTTCCTTGTAGGATATGGATTA
GATTTTGCTGAAAAGTATAGAAACCTACCATACATTGGAATACTAAAGGAGGAAGTTTATAAATAA

Upstream 100 bases:

>100_bases
GAAATAGCTTGGATTATAGGTTGTAGAACAGGCAATAATTTTAAAATAGATAAAAATACAAAGAATGTATTAGAAATAAC
TGTTGAAAGAGGGGAAGCAA

Downstream 100 bases:

>100_bases
TTAATATTCAATTTATTGTAAACAAATTTTTGTTATGATACAATTTTACAGTATAAAACTAGAAAGTGAGGGTGGCCAAA
TATGAAAAAATTTTCAAGTG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MDLISRDIEKILISEEQIQSKINELGDQISKDYDGKNLMLVGILKGSVPFMADLLKRITIPCTMDFMAVSSYGNSTTSSG
VVRILKDLDFEIEGKDILIVEDIIDSGITLKYLLENLRARKPASINIACLLNKEERRKAEIDVHYLGFNVPDYFLVGYGL
DFAEKYRNLPYIGILKEEVYK

Sequences:

>Translated_181_residues
MDLISRDIEKILISEEQIQSKINELGDQISKDYDGKNLMLVGILKGSVPFMADLLKRITIPCTMDFMAVSSYGNSTTSSG
VVRILKDLDFEIEGKDILIVEDIIDSGITLKYLLENLRARKPASINIACLLNKEERRKAEIDVHYLGFNVPDYFLVGYGL
DFAEKYRNLPYIGILKEEVYK
>Mature_181_residues
MDLISRDIEKILISEEQIQSKINELGDQISKDYDGKNLMLVGILKGSVPFMADLLKRITIPCTMDFMAVSSYGNSTTSSG
VVRILKDLDFEIEGKDILIVEDIIDSGITLKYLLENLRARKPASINIACLLNKEERRKAEIDVHYLGFNVPDYFLVGYGL
DFAEKYRNLPYIGILKEEVYK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=183, Percent_Identity=33.879781420765, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI9910262, Length=182, Percent_Identity=34.6153846153846, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=49.3975903614458, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=33.7078651685393, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20561; Mature: 20561

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLISRDIEKILISEEQIQSKINELGDQISKDYDGKNLMLVGILKGSVPFMADLLKRITI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCC
PCTMDFMAVSSYGNSTTSSGVVRILKDLDFEIEGKDILIVEDIIDSGITLKYLLENLRAR
CCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCEEEEEHHHHCCCCCHHHHHHHHHCC
KPASINIACLLNKEERRKAEIDVHYLGFNVPDYFLVGYGLDFAEKYRNLPYIGILKEEVY
CCCCEEEEEEECCHHHHHHEEEEEEECCCCCCCEEEECCCCHHHHHCCCCEEEEHHHHHC
K
C
>Mature Secondary Structure
MDLISRDIEKILISEEQIQSKINELGDQISKDYDGKNLMLVGILKGSVPFMADLLKRITI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCC
PCTMDFMAVSSYGNSTTSSGVVRILKDLDFEIEGKDILIVEDIIDSGITLKYLLENLRAR
CCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCEEEEEHHHHCCCCCHHHHHHHHHCC
KPASINIACLLNKEERRKAEIDVHYLGFNVPDYFLVGYGLDFAEKYRNLPYIGILKEEVY
CCCCEEEEEEECCHHHHHHEEEEEEECCCCCCCEEEECCCCHHHHHCCCCEEEEHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]