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The map label for this gene is serS

Identifier: 170754615

GI number: 170754615

Start: 22386

End: 23666

Strand: Direct

Name: serS

Synonym: CLD_0805

Alternate gene names: 170754615

Gene position: 22386-23666 (Clockwise)

Preceding gene: 170755420

Following gene: 170756254

Centisome position: 0.57

GC content: 29.43

Gene sequence:

>1281_bases
ATGTTAGATTTAAAAAGAATAAGAAATAATTCAAATGAAATAAAAGAAGCATTAAACAATAGAGGAGAAAAGTTTGATGT
AACTGTAATTGATGAAGTTTTAAAATTAGATGAAGAAAGAAGAAATATTTTAGTTAAAGTTGAGGTTTTAAAAAGTAAGA
GAAATCAAGTTTCTTCTGAAGTTCCTAAATTAAAAAAAGAAGGAAAAGATGTATCTAATATAGTAGCTGAAATGAAGAAT
TTATCAGAAGAGATAAAAGGATTTGATGCTACTTTAGCTAAAATAGATGAAAAAATACAATATATAATGCTCAGAATACC
TAATATACCAAACCCACAAGTTCCAGATGGAGAAACAGATGAGGATAATATAGAAATAAGAAATTGGTTAGAACCAACAA
AATTTGATTTTGAACCTAAAGCACATTGGGATATAGGAACAAATTTAAATATTCTTGATTTTGAAAGAGCTGGAAAAGTA
ACAGGATCAAGATTTACTTTTTATAAAGGATTAGGGGCTAGATTAGAAAGAGCAGTAATATCTTATTTTTTAGATACTCA
TACAGAAAAACATGGTTATACTGAAATATTACCACCTTATATGGTAAATAGAACAAGTATGATAGGAACAGGACAATTAC
CTAAATTTGAAGAAGACGCTTTTAAAATTTCAGAGGATGATTACTTCTTAATACCAACTGCAGAGGTTCCTGTAACTAAT
TTATATAGAGATGAAATCTTAAAAGGTGATGAATTACCATTAAAACATGTAGCTTATAGTGCTTGTTTTAGATCAGAAGC
AGGTTCAGCAGGTAGAGATACAAGAGGTCTTGTTAGACAACATCAATTTAATAAAGTAGAGCTTGTTAAATTTACAAAAC
CAGAACAATCCTATGAAGAATTGGAAAAATTAACCAACGATGCTGAAACAGTATTAAAAGAGTTGGGTATTCCATATAGA
GTTGTAAGAATATGCAAAGGTGATTTAGGATTTACAGCTGCATTAAAATATGATTTAGAAGTTTGGATGCCAAGTTACAA
TAGATATGTTGAAATATCAAGCTGTAGTAACTTTGAAGACTTCCAAGCAAGACGTGCTAATATAAGATACAAAGAAGATG
CAAAAGCAAAACCACAATATGTTCATACATTAAATGGATCAGGAGTTGCTATTGGAAGAACTGTTGCAGCTATACTTGAA
AACTATCAAAGTGAAGATGGATCAGTTACAATACCAGAAGTGTTAAGACCTTATATGGGAGGAAGAGAAGTAATAAAATA
A

Upstream 100 bases:

>100_bases
GTCCCTTTTATAGGGACGAGGGGCTTTTTTTATTATATTATAAAGCTATAAAATCTGAAGGGAGGAAGTATTTATTGGAT
AATCCAATAAATAAAATATT

Downstream 100 bases:

>100_bases
CTGAATATTATTTGTTATAAAGAATTTATATATATTTAATTTAAAATAAACACTATTAAATTAATTAATTGTGATAAAAT
TTAATAGTGTTTTTATTATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK

Sequences:

>Translated_426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK
>Mature_426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=470, Percent_Identity=34.468085106383, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI8923421, Length=397, Percent_Identity=30.7304785894207, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI225579074, Length=438, Percent_Identity=28.9954337899543, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=48.6111111111111, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539260, Length=439, Percent_Identity=33.4851936218679, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=31.7460317460317, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321799, Length=432, Percent_Identity=34.0277777777778, Blast_Score=242, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6320226, Length=411, Percent_Identity=34.7931873479319, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=32.3467230443975, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=33.8028169014084, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48759; Mature: 48759

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETD
HHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKVTGSRFTFYKGLGARLERAVI
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQSEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GREVIK
CHHHCC
>Mature Secondary Structure
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDATLAKIDEKIQYIMLRIPNIPNPQVPDGETD
HHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKVTGSRFTFYKGLGARLERAVI
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQSEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GREVIK
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA