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The map label for this gene is xdhA [H]

Identifier: 170754460

GI number: 170754460

Start: 327022

End: 329352

Strand: Direct

Name: xdhA [H]

Synonym: CLD_0500

Alternate gene names: 170754460

Gene position: 327022-329352 (Clockwise)

Preceding gene: 170754616

Following gene: 170756032

Centisome position: 8.26

GC content: 37.79

Gene sequence:

>2331_bases
ATGTATGATTTAAATATTATAGGTAAAAATGTACCAAGAAAAGAGTCCATAGACAAAGTAACAGGTGCAGCAAAGTATAC
AAATGATTATGAAGCCAATGGACTTTTATATGCCAGAATGGTAACAAGTCCCTATGCTCATGCAAAAATAAAGGCTATCG
AATATGAAAATTCACTAAAGACTTCCGGAGTTAGGGCCGTGATAACAGGAGAATACTTTCCCCAGCTTGTTGGATCTACT
ATTGTTGATAGACCTCCCATTGCTATAGATAAAGTAAGATACAATGGTGAACCGGTGGCAGTGGTAGTAGCTGATAGCGA
GATTGAAGCTAAAAAAGCTGCTCAGATGATAAAAGTAGAATATGAACCTCTACCGGTAGTGAATTCTCCAAGTGAAGCAA
TAAAAAAAGATTCACCGTTGGTTCATGAAAAACTTGGTGATTATGAGATTATTGATGAAGTTTTTCCGGAACCTAACACA
AATATCGCTAACAGAACTAAGATTAGAAAAGGTGATATAAAGAAAGGATGGCATGAAAGTGAGGTAACTGTGGAGGCAAG
TTTTTCATTTCCACCTTCTGATCATGCTGCTATGGAGACAAGGTCCGTAACAGCAAGGATATTACCAGATGGAAGAGTTA
TTATATACTCTTGCTCTCAGGCTCCATTTGCCATAAAAAAACTTATAAGTCATTTCTTTAATATCGATCCTGGCAAGGTT
ATTGTCCATGTACCTCTTGTAGGTGGAGCCTATGGAGGGAAAACAGCCGTGCAGCTAGAATTTATTGCCTATTTATGCTC
AAGAGCTGTTGGGGGGAGACAGGTTAAACTCACCAATACAAGAGAAGAAGATTTTATTACATCTCCGGTTCATATAGGTC
TTGATGCGAAAATCAAACTTGGATGTACAAAAGCTGGAAGGCTTACTGTTGGGGAAATAACCTATTTATTTGATGGTGGC
TCATATTCTGATAGAGCTGTAATTATAAGCAGAGCGGCGGGAGTAGATTGTACAGGACCTTACAATATTGAAAATGTATG
GTGTGATTCACTATGCATGTATACTAATCATCCTTATGCTGCAGCTTTTAGAGGATTCGGTCATCCTGAACTTACCTTTG
CAATAGAAAGATCAATGGACATTTTAGCGGATAAGCTAGGAATGGATCCCTTAGAATTAAGGTTAAGAAATGCAATTTTA
CCAGGGGATACTAGTGCTACTCAGATCTTGCTTAATAAAAGCAATTTAGGCAATTTACCACAGTGCATACAAAAGCTAAT
TGAATTAATACATTGGGGAGAAGTAGATGAAGCTGAAACTGAGGACGGTAAAGTTAGGGCTAAAGGTGTAAGCTGCTTCT
GGAAAAATTCAAATACATCTTTAAATGCAGGGGGAGGAGCGGTTCTTACATTTAATTTAGATGGAAGTATTAATCTTATT
TGTGCTGCAGTTGAAATAGGTCAGGGAATTAAAACAGCTTTAGCACAAATATTAGCAGAAAAAATGAAAATGGATGTAGA
TCAAATTCATGTAACAATGGAGGTTAATACTAAGACCAATCCTGAACACTGGAAAACGGCTGCGAGTAGAACTACTTTAC
TAGTTGGAAGAGCAGTTTTAAGGGCAGCAGAGGATGTCATTAATCAACTATGCGATATTGCCGCTGTTGTTCTGGGACGT
TCACCAGTTGAACTGGAGGTTGGTAGAGGAAGAGTATTTTTAAAAGATAACCCCCGAATAGGGGTAGAAATTAGTAAAAT
TGCATTCGGGTATATCTTGCCTAATGGGAATTCAATTGGTGCACAAGTTATTGGAAGAGGGAGTTATGCTTTTAATAATC
TAACAACATTAGATCCTAAAACCGGCAAAGGCAATCCAGGGCCTGAATGGACTGTTGGAGCAGCAGCTGTAGAGGTAGAG
CTTGATAAAAAAGAATATACCTACAAAATTATAAAGGCTGCTTGTGTTGTAGATGCAGGTAAAGTTATTAATGCTGGAGC
GGCAAGAGGTCAAATATCCGGTGGCATGAACTTGGGTTTAAGCTTTGCTAGTCGTGAAGCATTTTTGTTTACAAATAAAG
GCATTATTCAAAATAAGCAACTAAGAACATATAATATTATGAGATTAGGAGAAAATCCAGAATATCTTGTAGATTTTGTA
GAAACTCCAAATTTGGATGGTCCATATGGTGCAAGAGGAATTGGAGAATATGGCGTAATTGGAATGCCTGCAGCACTTGG
AAATAGCTTATCCTGTGCAGTAGAAGTACCTCTTAATCAATTGCCGTTGATTCCTGAATTTATATGGAAAGTAAAAGAGG
GAGGACATTAA

Upstream 100 bases:

>100_bases
TGATGTAGTTATCTTTATGCAAAGGTAGAATTACATTCATAATAATTAAATATGATAAATATATTATAAAAGAAAATGAT
ATTATTCCAGGGAGTAATCA

Downstream 100 bases:

>100_bases
TGATTGCATTTAATTTTGAATACTATAAACCTGATTCATTGGATGAGGCGGTAAAGCTGTATAAAGAGCTTAGTAAGAGT
GGAAAAGAACCTTTATATTA

Product: xanthine dehydrogenase family protein, molybdopterin-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEANGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKVEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSRAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGCTKAGRLTVGEITYLFDGG
SYSDRAVIISRAAGVDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFAIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELIHWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDVINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPRIGVEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEVE
LDKKEYTYKIIKAACVVDAGKVINAGAARGQISGGMNLGLSFASREAFLFTNKGIIQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAVEVPLNQLPLIPEFIWKVKEGGH

Sequences:

>Translated_776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEANGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKVEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSRAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGCTKAGRLTVGEITYLFDGG
SYSDRAVIISRAAGVDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFAIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELIHWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDVINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPRIGVEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEVE
LDKKEYTYKIIKAACVVDAGKVINAGAARGQISGGMNLGLSFASREAFLFTNKGIIQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAVEVPLNQLPLIPEFIWKVKEGGH
>Mature_776_residues
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEANGLLYARMVTSPYAHAKIKAIEYENSLKTSGVRAVITGEYFPQLVGST
IVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKVEYEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNT
NIANRTKIRKGDIKKGWHESEVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
IVHVPLVGGAYGGKTAVQLEFIAYLCSRAVGGRQVKLTNTREEDFITSPVHIGLDAKIKLGCTKAGRLTVGEITYLFDGG
SYSDRAVIISRAAGVDCTGPYNIENVWCDSLCMYTNHPYAAAFRGFGHPELTFAIERSMDILADKLGMDPLELRLRNAIL
PGDTSATQILLNKSNLGNLPQCIQKLIELIHWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVLRAAEDVINQLCDIAAVVLGR
SPVELEVGRGRVFLKDNPRIGVEISKIAFGYILPNGNSIGAQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEVE
LDKKEYTYKIIKAACVVDAGKVINAGAARGQISGGMNLGLSFASREAFLFTNKGIIQNKQLRTYNIMRLGENPEYLVDFV
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAVEVPLNQLPLIPEFIWKVKEGGH

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=759, Percent_Identity=26.7457180500659, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI71773480, Length=759, Percent_Identity=25.5599472990777, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1789230, Length=781, Percent_Identity=29.0653008962868, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1789246, Length=827, Percent_Identity=25.1511487303507, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786478, Length=775, Percent_Identity=20.258064516129, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=751, Percent_Identity=23.0359520639148, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17539860, Length=734, Percent_Identity=23.1607629427793, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32566215, Length=745, Percent_Identity=22.8187919463087, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737937, Length=759, Percent_Identity=24.2424242424242, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24647193, Length=699, Percent_Identity=19.5994277539342, Blast_Score=87, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84198; Mature: 84198

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEANGLLYARMVTSPYAHAKIKAIEYENSLK
CEEEEEECCCCCCHHHHHHHCCCHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCC
TSGVRAVITGEYFPQLVGSTIVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKVE
CCCEEEEEECHHHHHHHCCHHCCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHEEEEE
YEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNTNIANRTKIRKGDIKKGWHES
CCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
EVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
EEEEEEEECCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCE
IVHVPLVGGAYGGKTAVQLEFIAYLCSRAVGGRQVKLTNTREEDFITSPVHIGLDAKIKL
EEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEEE
GCTKAGRLTVGEITYLFDGGSYSDRAVIISRAAGVDCTGPYNIENVWCDSLCMYTNHPYA
ECCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEECCCCHH
AAFRGFGHPELTFAIERSMDILADKLGMDPLELRLRNAILPGDTSATQILLNKSNLGNLP
HHHCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
QCIQKLIELIHWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCEEEEEECCCCCEEE
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVL
EEEEHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAAEDVINQLCDIAAVVLGRSPVELEVGRGRVFLKDNPRIGVEISKIAFGYILPNGNSIG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEEEEEEECCCCCCC
AQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEVELDKKEYTYKIIKAACVVDAG
EEEEECCCEEECCEEECCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCC
KVINAGAARGQISGGMNLGLSFASREAFLFTNKGIIQNKQLRTYNIMRLGENPEYLVDFV
CEEECCCCCCCCCCCCEECEEECCCEEEEEECCCCEECCCEEEEEEEEECCCHHEEEEEE
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAVEVPLNQLPLIPEFIWKVKEGGH
CCCCCCCCCCCCCCCCCCCEECCHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MYDLNIIGKNVPRKESIDKVTGAAKYTNDYEANGLLYARMVTSPYAHAKIKAIEYENSLK
CEEEEEECCCCCCHHHHHHHCCCHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCC
TSGVRAVITGEYFPQLVGSTIVDRPPIAIDKVRYNGEPVAVVVADSEIEAKKAAQMIKVE
CCCEEEEEECHHHHHHHCCHHCCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHEEEEE
YEPLPVVNSPSEAIKKDSPLVHEKLGDYEIIDEVFPEPNTNIANRTKIRKGDIKKGWHES
CCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
EVTVEASFSFPPSDHAAMETRSVTARILPDGRVIIYSCSQAPFAIKKLISHFFNIDPGKV
EEEEEEEECCCCCCCHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCE
IVHVPLVGGAYGGKTAVQLEFIAYLCSRAVGGRQVKLTNTREEDFITSPVHIGLDAKIKL
EEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEEE
GCTKAGRLTVGEITYLFDGGSYSDRAVIISRAAGVDCTGPYNIENVWCDSLCMYTNHPYA
ECCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEECCCCHH
AAFRGFGHPELTFAIERSMDILADKLGMDPLELRLRNAILPGDTSATQILLNKSNLGNLP
HHHCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHH
QCIQKLIELIHWGEVDEAETEDGKVRAKGVSCFWKNSNTSLNAGGGAVLTFNLDGSINLI
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCEEEEEECCCCCEEE
CAAVEIGQGIKTALAQILAEKMKMDVDQIHVTMEVNTKTNPEHWKTAASRTTLLVGRAVL
EEEEHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RAAEDVINQLCDIAAVVLGRSPVELEVGRGRVFLKDNPRIGVEISKIAFGYILPNGNSIG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEEEEEEECCCCCCC
AQVIGRGSYAFNNLTTLDPKTGKGNPGPEWTVGAAAVEVELDKKEYTYKIIKAACVVDAG
EEEEECCCEEECCEEECCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCC
KVINAGAARGQISGGMNLGLSFASREAFLFTNKGIIQNKQLRTYNIMRLGENPEYLVDFV
CEEECCCCCCCCCCCCEECEEECCCEEEEEECCCCEECCCEEEEEEEEECCCHHEEEEEE
ETPNLDGPYGARGIGEYGVIGMPAALGNSLSCAVEVPLNQLPLIPEFIWKVKEGGH
CCCCCCCCCCCCCCCCCCCEECCHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]