Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 229597238

GI number: 229597238

Start: 4241416

End: 4243410

Strand: Direct

Name: dxs [H]

Synonym: Mrad2831_3992

Alternate gene names: 229597238

Gene position: 4241416-4243410 (Clockwise)

Preceding gene: 170750388

Following gene: 170750392

Centisome position: 69.79

GC content: 72.13

Gene sequence:

>1995_bases
GTGGCGATTACCCCCGAGCAGAGTGCACTTCTCGACCGCGTTCCGTCTCCATCGGCGCTTCGGCGTCTTCCGGAGTCGGA
GCTTCAGGCGGTGGCGGACGCGGTGCGCGCCGAGATGATCGACGCGGTCTCGATCACCGGCGGCCATCTCGGCTCGGGGC
TGGGCGTGGTCGAGCTGACGGTGGCGCTGCACCACGTGTTCGACACCCCCGACGACCGCATCGTCTGGGACGTCGGCCAC
CAGTGCTACCCCCACAAGATCCTCACCGAGCGCCGCGACCGGATCCGCACGCTGCGCCAGGGCGGCGGCCTGTCGGGCTT
CACCAAGCGGAGCGAGAGCGTCTACGATCCCTTCGGCGCCGCCCACTCCTCGACCTCGATCTCGGCCGCGCTGGGCATGG
CGGTCGCCCGCGACCTCGACAACGCCACCGCCAAGCAGAAGGGCGGCGCGCAGAAGCGCCGCAACGCCATCGCGGTGATC
GGCGACGGCTCGATGTCGGCCGGCATGGCCTACGAGGCCCTCAACAACGCCGGCGCCCTGCACTCGCGCCTGATCGTCAT
CCTCAACGACAACGACATGTCGATCGCGCCCCCCGTCGGCGCCATGTCGGCCTACCTCGCAAGGCTGGCGTCGGGCGGCG
CCTACCAGTCCCTGCGCGAGACCGCCAAGCAGCTCGGCAAGCTCCTGCCCAAGGCGCTCTACCAGCGCGCCGCCGCGGCC
GAGGAGTACGCCCGCTCGCTGGTGGTCGGCGGCGGCACCATGTTCGAGGAGATGGGCTTCCACTACGTCGGCCCGGTCGA
CGGGCACAACCTCGACCACCTGCTGCCGGTGCTCAAGAACGTCCGCGACGCCGAGCACGGCCCGATCCTGCTCCACGTCG
TCACCCAGAAGGGCAAGGGCTACGCGCCGGCCGAGGCCTCGGCCGACCGCTACCACGGCGTGGTCAAGTTCGACGTGGTC
TCAGGGATCCAGGCCAAGGCCAAGCCGAACGCGCCGGCCTACACGCGGGTGTTCGGCGAGAGCCTGATCAAGGCGGCCGA
CGCCGACGACAAGGTCGTGGCGATCACCGCCGCCATGCCGGGCGGGACCGGCATCGACCTGTTCGGCAAGGCGCACCCGG
ACAAGACCTTCGACGTGGGCATCGCCGAGCAGCACGCGGTGACGTTCGCGGGCGGTCTGGCGACCGAGGGCTACCGGCCG
TTCGTGGCGATCTACTCGACCTTCCTGCAGCGGGCCTACGACCAGGTGGTGCACGACGTGGCGCTGCAGAACCTGCCCGT
GCGGTTCTGCCTGGACCGGGCGGGCCTGGTCGGCGCGGACGGGGCGACGCACGCGGGCGCGTTCGACCTGGCGTACCTGT
GCTGCCTGCCGAACATGACCGTGATGGCGGCGGCCGACGAGGCCGAGCTGGTGCACATGGTGGCGACCGCCCACGCCCAC
GACACGGGCCCGATCGCGCTGCGCTACCCGCGCGGCGAGGGGGTGGGCGTCGAGCTTCCGGAGCGGGGCGAGGTCCTGGC
GATCGGCAAGGGCCGGGTGGTGCGCCGGGACGCGGAGGCGCGGGTGGCGCTCCTGTCGCTCGGCACGCGGCTGGCGGAGG
CCTTGAAGGCGGCGGACGCGCTGGCCGAGCAGGGCGTGGCGGTGACGGTGGCGGACGCGCGGTTCGCCAAGCCGCTGGAC
GAGGCGCTGATCCTGGATCTGGCGCGCGACCACGAGGTGCTGATCACGGTGGAGGAGGGCTCGCGGGGCGGGTTCGGCGC
GATGGTGCTGCACCTGCTGGCCGAGCGCGGCGCGCTGGACGCGGGCGGCGTGCGGGTGCGGACCATGACGCTGCCGGACG
CCTACCAGGACCACGACAGCCCGGAGAAGATGTACGCCGAGGCAGGCCTCGACGCCAAAACCATCGTCCGGACCGCCCTC
GCCACACTGCCGGCAGAGACCGCCAAGGCCGAGCCGGCGAGCAACGTCGTGAGCGTGCGCCGCCGCCCGCGCTGA

Upstream 100 bases:

>100_bases
ATCACGCTGGGCTCCGACGGGCGGCCCGAGGGCGTCGCCCCACTCGACATGTCCTGAGGCTCGGCGGTCGAACCGATCCC
ATCCGTTAGAGGTTGATGCC

Downstream 100 bases:

>100_bases
CGCCACGGTCCGCTACGGGTCTCCCGACCACGCACCGCAACCTGAGGCGGCGGAGCGCAGCGTAGCCCTCGAAGGAGCCG
TCCAGAGGTCTCGCGATCCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MAITPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGH
QCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVI
GDGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVV
SGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRP
FVAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLD
EALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTAL
ATLPAETAKAEPASNVVSVRRRPR

Sequences:

>Translated_664_residues
MAITPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGH
QCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVI
GDGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVV
SGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRP
FVAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLD
EALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTAL
ATLPAETAKAEPASNVVSVRRRPR
>Mature_663_residues
AITPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGHQ
CYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIG
DGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAAE
EYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVVS
GIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPF
VAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAHD
TGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLDE
ALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALA
TLPAETAKAEPASNVVSVRRRPR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=375, Percent_Identity=28.5333333333333, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI4507521, Length=375, Percent_Identity=28.5333333333333, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI225637459, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI133778974, Length=366, Percent_Identity=27.3224043715847, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI225637461, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI225637463, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=7e-22,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=51.3643659711075, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=427, Percent_Identity=27.8688524590164, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45551847, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550715, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645119, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666278, Length=571, Percent_Identity=26.7950963222417, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 70264; Mature: 70133

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELT
CCCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHH
VALHHVFDTPDDRIVWDVGHQCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGA
HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC
AHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIGDGSMSAGMAYEALNNAGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHCCCCC
HSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
CEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKG
HHHHHHEEECCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
YAPAEASADRYHGVVKFDVVSGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMP
CCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPFVAIYSTFLQRAYDQVVHDV
CCCCEECCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
HHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCC
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADA
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAEQGVAVTVADARFAKPLDEALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALD
HHHCCCEEEEECCHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
AGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALATLPAETAKAEPASNVVSVR
CCCEEEEEEECCCHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
RRPR
CCCC
>Mature Secondary Structure 
AITPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELT
CCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHH
VALHHVFDTPDDRIVWDVGHQCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGA
HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC
AHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIGDGSMSAGMAYEALNNAGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHCCCCC
HSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
CEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKG
HHHHHHEEECCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
YAPAEASADRYHGVVKFDVVSGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMP
CCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPFVAIYSTFLQRAYDQVVHDV
CCCCEECCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
HHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCC
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADA
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAEQGVAVTVADARFAKPLDEALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALD
HHHCCCEEEEECCHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
AGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALATLPAETAKAEPASNVVSVR
CCCEEEEEEECCCHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
RRPR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]