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The map label for this gene is uvrC [H]

Identifier: 170751775

GI number: 170751775

Start: 5709056

End: 5711122

Strand: Reverse

Name: uvrC [H]

Synonym: Mrad2831_5405

Alternate gene names: 170751775

Gene position: 5711122-5709056 (Counterclockwise)

Preceding gene: 170751776

Following gene: 170751774

Centisome position: 93.97

GC content: 70.05

Gene sequence:

>2067_bases
ATGAGCCGCAGAGCCCTCTCAGACCTGCCCCCCGACACCTTCGACGACGGCCGCGACGCCGAGCGGGACGAGACCGTCGA
CGAGCCGGAAGCCGAACTCCCCGACACGGAGACGCCGGAGATCGACTTCGATTTCGAGCCGGGCGCCGTCCAGGCTGGCA
CGGAGGTGATCCGCCGGTTCTGGTCGACCCTGCCGTCGTCGCCCGGCGTCTACCGGATGTTCGACCATCGCGGCGACGTC
CTCTACGTCGGCAAGGCCAAGAACCTGAAAGCGCGGGTCGGCTCGTACGCGCGGGGCCAGGCGCACTCGAACCGCATCGC
CCGGATGATCTCGCAGACGGCGGCGATGGAGTTCGTCACCACCGCGACCGAGACCGAGGCGCTCCTCCTCGAGGCCAACC
TCATCAAGCAGCTGAAGCCCCGCTTCAACGTGCTGATGCGGGACGACAAGTCGTTCCCCTACATCCTGGTCACCGACGAC
GGCCCCGCCCCGCAGATCGTCAAGCACCGGGGGGCCCGGCGCCGGAAGGGCAACTATTACGGCCCCTTCGCCAGCGTCTG
GGCGGTGAACCGGACGGTGAACGCGCTGCAGCGCGCCTTCCTGCTGCGCACCTGCACCGACAGCTACTACGAGAACCGCA
CCCGGCCCTGCCTGCTCTACCAGATCAAGCGCTGCTCCGGCCCTTGCACGAACGAGATCGGGCCCGAGGACTACGCCGCG
ATGGCGGATTCCGCGCGGGCGTTCCTCGCGGGCAAGTCGAACGCCGTGAAGGACCGCATGCGCGCCGAGATGCAGGCGGC
GTCCGAGGCGATGGAGTTCGAGCGTGCCGCCCGGTTCCGCGACCGCATCGCAGCCCTGTCGGCGATCCAGGGGGTGCAGG
GGGTCAACACCCAGGGTGTGGAAGAGGCGGATGTGTTCGCCCTCGACGAGCAGGCCGGCCAGTTCTGCATCGAGGTGTTC
TTCTTCCGGAACTTCCAGAACTGGGGCAACCGCGCCTATTTCCCGAAGGCCGACCGGACCATGACGCCCGACGAGGTGCT
GGGCTCGTTCATCGGCCAGTTCTACGACGACAAGCCCGCGCCCCGGACGGTGCTGACGAGCCACGCGATCGAGGACGCGG
AGCTGGTGGCGGCGGCCCTGTCGAGCCGGGTGGAGTACCGCGTCGAGATCCACCGGCCGAGCCGCGGCGAGCGGAAGAAC
CTCGTCGACTACGCCCAGCGCAACGCCAAGGAGGCGCTGGCCCGGCGCCTCGCCGACACGGCCTCGCAGGGCAAGCTGCT
CGCGGCGCTCGGCCAGGCCTTCGGGCTCGACGGCGCACCCCGCCGGATCGAGGTCTACGACAACTCGCACATCATGGGCA
CGAACGCGGTCGGCGGCATGATCGTCGCCGGCCCGACGGGCTTCATGAAGGCGCATTACCGCACGTTCAACATCAAGTCC
GAGGATCTCACGCCCGGCGACGATTACGGCATGATGCGCGAGGTGCTGCAGCGGCGCTTCAAGCGGCTCGTGAAAGAGGC
GCCGCGCACCGAGCGCGAGGCGGCCGCGTCCGCGGGCGAGGGCGACGTGCCGGAGCCGGTGCCCGCGCCGGCGGAGGAGA
GCGATGCGTTCCCGGCCTGGCCGGATCTCGTGCTGATCGACGGCGGCAAGGGCCAGCTCGAGGCCGCGCGGGCGGCGCTG
GAGGAGGTCGGCGTGGCGGGCGTTCCCCTGGTCGGCGTCGCCAAGGGCCGCGACCGCGATGCCGGCCGCGAGACGTTTTT
CGTGCCCGGCCGCCCCCCCTTCAAGCTTCCGCCGCGCGACCCGACGCTCTACTTCGTGCAGCGGCTCCGCGACGAGGCGC
ACCGCTTCGCCATCGGCAGCCATCGGGCCAAGCGGAAGCGAGAGATGGTGAAGAATCCCTTGGACGAGATCGCCGGCATC
GGCCCGAGCCGCAAGCGCGCGCTCCTGCACCATTTCGGGACCGTGAAGGCGATCCAGCGCGCCGCCTTCGAGGATCTGGC
CAGGACCCCGGGCGTGAACGCCGCCACAGCGCGGGCGGTCTACGACTTCTTCCATGCCGGCGCCTGA

Upstream 100 bases:

>100_bases
GCGACATCGACTCGCTGTTCGACTGATTGATCGGACCGGGCGCGCGATTTTTGTCGCCGCCCCCGTCCCCCTGGCGGTCC
GGAGCGCTTAGATCTGCGGT

Downstream 100 bases:

>100_bases
GAACCCGGCCGCGATGGCCGAGGCAGACTCAGAGGCGTTGACGCCCGGGCCCCGCTCTGATTTCACCCCTGCGATGAACG
CCGTCCTTCCCCGACGACGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSRRALSDLPPDTFDDGRDAERDETVDEPEAELPDTETPEIDFDFEPGAVQAGTEVIRRFWSTLPSSPGVYRMFDHRGDV
LYVGKAKNLKARVGSYARGQAHSNRIARMISQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILVTDD
GPAPQIVKHRGARRRKGNYYGPFASVWAVNRTVNALQRAFLLRTCTDSYYENRTRPCLLYQIKRCSGPCTNEIGPEDYAA
MADSARAFLAGKSNAVKDRMRAEMQAASEAMEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFALDEQAGQFCIEVF
FFRNFQNWGNRAYFPKADRTMTPDEVLGSFIGQFYDDKPAPRTVLTSHAIEDAELVAAALSSRVEYRVEIHRPSRGERKN
LVDYAQRNAKEALARRLADTASQGKLLAALGQAFGLDGAPRRIEVYDNSHIMGTNAVGGMIVAGPTGFMKAHYRTFNIKS
EDLTPGDDYGMMREVLQRRFKRLVKEAPRTEREAAASAGEGDVPEPVPAPAEESDAFPAWPDLVLIDGGKGQLEAARAAL
EEVGVAGVPLVGVAKGRDRDAGRETFFVPGRPPFKLPPRDPTLYFVQRLRDEAHRFAIGSHRAKRKREMVKNPLDEIAGI
GPSRKRALLHHFGTVKAIQRAAFEDLARTPGVNAATARAVYDFFHAGA

Sequences:

>Translated_688_residues
MSRRALSDLPPDTFDDGRDAERDETVDEPEAELPDTETPEIDFDFEPGAVQAGTEVIRRFWSTLPSSPGVYRMFDHRGDV
LYVGKAKNLKARVGSYARGQAHSNRIARMISQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILVTDD
GPAPQIVKHRGARRRKGNYYGPFASVWAVNRTVNALQRAFLLRTCTDSYYENRTRPCLLYQIKRCSGPCTNEIGPEDYAA
MADSARAFLAGKSNAVKDRMRAEMQAASEAMEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFALDEQAGQFCIEVF
FFRNFQNWGNRAYFPKADRTMTPDEVLGSFIGQFYDDKPAPRTVLTSHAIEDAELVAAALSSRVEYRVEIHRPSRGERKN
LVDYAQRNAKEALARRLADTASQGKLLAALGQAFGLDGAPRRIEVYDNSHIMGTNAVGGMIVAGPTGFMKAHYRTFNIKS
EDLTPGDDYGMMREVLQRRFKRLVKEAPRTEREAAASAGEGDVPEPVPAPAEESDAFPAWPDLVLIDGGKGQLEAARAAL
EEVGVAGVPLVGVAKGRDRDAGRETFFVPGRPPFKLPPRDPTLYFVQRLRDEAHRFAIGSHRAKRKREMVKNPLDEIAGI
GPSRKRALLHHFGTVKAIQRAAFEDLARTPGVNAATARAVYDFFHAGA
>Mature_687_residues
SRRALSDLPPDTFDDGRDAERDETVDEPEAELPDTETPEIDFDFEPGAVQAGTEVIRRFWSTLPSSPGVYRMFDHRGDVL
YVGKAKNLKARVGSYARGQAHSNRIARMISQTAAMEFVTTATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILVTDDG
PAPQIVKHRGARRRKGNYYGPFASVWAVNRTVNALQRAFLLRTCTDSYYENRTRPCLLYQIKRCSGPCTNEIGPEDYAAM
ADSARAFLAGKSNAVKDRMRAEMQAASEAMEFERAARFRDRIAALSAIQGVQGVNTQGVEEADVFALDEQAGQFCIEVFF
FRNFQNWGNRAYFPKADRTMTPDEVLGSFIGQFYDDKPAPRTVLTSHAIEDAELVAAALSSRVEYRVEIHRPSRGERKNL
VDYAQRNAKEALARRLADTASQGKLLAALGQAFGLDGAPRRIEVYDNSHIMGTNAVGGMIVAGPTGFMKAHYRTFNIKSE
DLTPGDDYGMMREVLQRRFKRLVKEAPRTEREAAASAGEGDVPEPVPAPAEESDAFPAWPDLVLIDGGKGQLEAARAALE
EVGVAGVPLVGVAKGRDRDAGRETFFVPGRPPFKLPPRDPTLYFVQRLRDEAHRFAIGSHRAKRKREMVKNPLDEIAGIG
PSRKRALLHHFGTVKAIQRAAFEDLARTPGVNAATARAVYDFFHAGA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=632, Percent_Identity=38.2911392405063, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788037, Length=209, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 76325; Mature: 76194

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRALSDLPPDTFDDGRDAERDETVDEPEAELPDTETPEIDFDFEPGAVQAGTEVIRRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
WSTLPSSPGVYRMFDHRGDVLYVGKAKNLKARVGSYARGQAHSNRIARMISQTAAMEFVT
HHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
TATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILVTDDGPAPQIVKHRGARRRKGNYY
HCCCHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCHHHHHHCCCHHCCCCCC
GPFASVWAVNRTVNALQRAFLLRTCTDSYYENRTRPCLLYQIKRCSGPCTNEIGPEDYAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHH
MADSARAFLAGKSNAVKDRMRAEMQAASEAMEFERAARFRDRIAALSAIQGVQGVNTQGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EEADVFALDEQAGQFCIEVFFFRNFQNWGNRAYFPKADRTMTPDEVLGSFIGQFYDDKPA
CHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PRTVLTSHAIEDAELVAAALSSRVEYRVEIHRPSRGERKNLVDYAQRNAKEALARRLADT
CHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASQGKLLAALGQAFGLDGAPRRIEVYDNSHIMGTNAVGGMIVAGPTGFMKAHYRTFNIKS
HHCCHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCHHHHHHEEEEECCC
EDLTPGDDYGMMREVLQRRFKRLVKEAPRTEREAAASAGEGDVPEPVPAPAEESDAFPAW
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PDLVLIDGGKGQLEAARAALEEVGVAGVPLVGVAKGRDRDAGRETFFVPGRPPFKLPPRD
CCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
PTLYFVQRLRDEAHRFAIGSHRAKRKREMVKNPLDEIAGIGPSRKRALLHHFGTVKAIQR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AAFEDLARTPGVNAATARAVYDFFHAGA
HHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRRALSDLPPDTFDDGRDAERDETVDEPEAELPDTETPEIDFDFEPGAVQAGTEVIRRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
WSTLPSSPGVYRMFDHRGDVLYVGKAKNLKARVGSYARGQAHSNRIARMISQTAAMEFVT
HHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
TATETEALLLEANLIKQLKPRFNVLMRDDKSFPYILVTDDGPAPQIVKHRGARRRKGNYY
HCCCHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCHHHHHHCCCHHCCCCCC
GPFASVWAVNRTVNALQRAFLLRTCTDSYYENRTRPCLLYQIKRCSGPCTNEIGPEDYAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHH
MADSARAFLAGKSNAVKDRMRAEMQAASEAMEFERAARFRDRIAALSAIQGVQGVNTQGV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EEADVFALDEQAGQFCIEVFFFRNFQNWGNRAYFPKADRTMTPDEVLGSFIGQFYDDKPA
CHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PRTVLTSHAIEDAELVAAALSSRVEYRVEIHRPSRGERKNLVDYAQRNAKEALARRLADT
CHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASQGKLLAALGQAFGLDGAPRRIEVYDNSHIMGTNAVGGMIVAGPTGFMKAHYRTFNIKS
HHCCHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCHHHHHHEEEEECCC
EDLTPGDDYGMMREVLQRRFKRLVKEAPRTEREAAASAGEGDVPEPVPAPAEESDAFPAW
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PDLVLIDGGKGQLEAARAALEEVGVAGVPLVGVAKGRDRDAGRETFFVPGRPPFKLPPRD
CCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
PTLYFVQRLRDEAHRFAIGSHRAKRKREMVKNPLDEIAGIGPSRKRALLHHFGTVKAIQR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AAFEDLARTPGVNAATARAVYDFFHAGA
HHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA