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The map label for this gene is pgsA [H]

Identifier: 170751774

GI number: 170751774

Start: 5708383

End: 5708982

Strand: Reverse

Name: pgsA [H]

Synonym: Mrad2831_5404

Alternate gene names: 170751774

Gene position: 5708982-5708383 (Counterclockwise)

Preceding gene: 170751775

Following gene: 170751773

Centisome position: 93.93

GC content: 69.67

Gene sequence:

>600_bases
ATGAACGCCGTCCTTCCCCGACGACGGTCGCCGGCCTGGACGCTCGCGAATTGCCTGACCTACGGGCGCCTCGTTGCCGT
GCCGGTGATGGTCGCGCTGCTGTTCTGGCCCGAATCCCACACGGCGCGGTGGACGGCGCTGGGGGTGTTCGTCGCGGCCG
CGATCACCGACTATCTCGACGGCTACGTCGCCCGCACCTACCACCAGAGCTCGGCGCTCGGCCGGATGCTCGATCCGATC
GCCGACAAGCTCCTCGTCTCGGCCTGCCTGCTGATGCTGGCGGCGGACCACACCATCGTCGGCTCGAACATCTGGGCGGC
GATCGTGATCCTGTGCCGCGAGGTGCTGGTCTCCGGCCTGCGCGAGTATCTGGCGGAGCTGAAGGTCGGCGTGCCGGTCA
GTCGGATCGCCAAGTGGAAGACCACCGTGCAGCTCCTGGCGCTCGGCTTCCTGGTGGCCGGCCCGGCGGGCGAGACGGTG
CTCCCGGGAACCGAGGCGATCGGCCTGACGCTCCTGTGGCTCGCCGCCGCGCTCACGCTGTGGACCGGCTGGGACTACAT
GCGGGCCGGGATCAAGCACGTCATCGACGATCCGCGCTGA

Upstream 100 bases:

>100_bases
TACGACTTCTTCCATGCCGGCGCCTGAGAACCCGGCCGCGATGGCCGAGGCAGACTCAGAGGCGTTGACGCCCGGGCCCC
GCTCTGATTTCACCCCTGCG

Downstream 100 bases:

>100_bases
CGGATCCGCCTCCGGGACGCGCGGTCCCTGCCCTGTCTCCGGTACGGTGATGCGATGAAGCTCGTCTATTTCGCCTGGGT
CCGCGAGCGGATCGGCCGCT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MNAVLPRRRSPAWTLANCLTYGRLVAVPVMVALLFWPESHTARWTALGVFVAAAITDYLDGYVARTYHQSSALGRMLDPI
ADKLLVSACLLMLAADHTIVGSNIWAAIVILCREVLVSGLREYLAELKVGVPVSRIAKWKTTVQLLALGFLVAGPAGETV
LPGTEAIGLTLLWLAAALTLWTGWDYMRAGIKHVIDDPR

Sequences:

>Translated_199_residues
MNAVLPRRRSPAWTLANCLTYGRLVAVPVMVALLFWPESHTARWTALGVFVAAAITDYLDGYVARTYHQSSALGRMLDPI
ADKLLVSACLLMLAADHTIVGSNIWAAIVILCREVLVSGLREYLAELKVGVPVSRIAKWKTTVQLLALGFLVAGPAGETV
LPGTEAIGLTLLWLAAALTLWTGWDYMRAGIKHVIDDPR
>Mature_199_residues
MNAVLPRRRSPAWTLANCLTYGRLVAVPVMVALLFWPESHTARWTALGVFVAAAITDYLDGYVARTYHQSSALGRMLDPI
ADKLLVSACLLMLAADHTIVGSNIWAAIVILCREVLVSGLREYLAELKVGVPVSRIAKWKTTVQLLALGFLVAGPAGETV
LPGTEAIGLTLLWLAAALTLWTGWDYMRAGIKHVIDDPR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=214, Percent_Identity=30.3738317757009, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI10092647, Length=203, Percent_Identity=31.5270935960591, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1788220, Length=186, Percent_Identity=35.4838709677419, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320059, Length=166, Percent_Identity=30.7228915662651, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21649; Mature: 21649

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVLPRRRSPAWTLANCLTYGRLVAVPVMVALLFWPESHTARWTALGVFVAAAITDYLD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GYVARTYHQSSALGRMLDPIADKLLVSACLLMLAADHTIVGSNIWAAIVILCREVLVSGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHH
REYLAELKVGVPVSRIAKWKTTVQLLALGFLVAGPAGETVLPGTEAIGLTLLWLAAALTL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
WTGWDYMRAGIKHVIDDPR
HCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNAVLPRRRSPAWTLANCLTYGRLVAVPVMVALLFWPESHTARWTALGVFVAAAITDYLD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GYVARTYHQSSALGRMLDPIADKLLVSACLLMLAADHTIVGSNIWAAIVILCREVLVSGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHH
REYLAELKVGVPVSRIAKWKTTVQLLALGFLVAGPAGETVLPGTEAIGLTLLWLAAALTL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
WTGWDYMRAGIKHVIDDPR
HCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA