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The map label for this gene is emrA [H]

Identifier: 170751621

GI number: 170751621

Start: 5567586

End: 5568587

Strand: Reverse

Name: emrA [H]

Synonym: Mrad2831_5245

Alternate gene names: 170751621

Gene position: 5568587-5567586 (Counterclockwise)

Preceding gene: 170751624

Following gene: 170751620

Centisome position: 91.62

GC content: 64.57

Gene sequence:

>1002_bases
GTGGTCCTACTGCTGCTCGCCGGCGGCGGCCTGTACTACTGGCTCTCGACGCGCGGGAAGATTAGCACCGACGATGCCTA
CACCGACGGGAATATCGTCAACGTCGCCCCGCAGGTCGCCGGACAGGTCATCGCCCTGGATGTCACGGACAACCAGTTCG
TCCGCAAGGGCGATCCGCTCTTCCGCATTGACCCGCGGCAGTTCAGGTTCAGCCGCGAGCAGGCCCAGGGCCAACTCGAC
GCCAGCAACGCGCAGGTCGCCAACCAGAAGCTCGGCGTCGAGATCGCCAGGAAGAACTTTCCCGCCGCGCTCCAGCTCGC
ACAGGCCAACCTCGACTCGGCCAAGGCCAACCTCGCCCTGCAGCAGGCGAACTACGACCGTCAGAGGAGCCTGCCGAAGC
TCGCCACGACTCAGCAGGACGTCGACACTACCGCGGCGAACTACCAGCAGGCTAAGGCACAGGTCGAGCAGGCGCAGGCG
CGCCTCGTCCAGGCCATGCCGGTTCAGCAGAACATCGGTCAGTCCGAGCAGCAGGTCGACCAGCTTAAGGGCCAGGCCGA
ACAGGCCAAGGCGCAAGTCGAGCAGGCTGACCTGAACATTGAGTGGAGCGTGGTGCGCGCGTCTCAGGACGGCTGGGTCA
CGAAGCGCAACGTCAACGCCGGCGACTACCTGTCAGCCGGCCAGCAAGTGATGTCGCTCGTCACCACCGACGTCTGGGTG
ACGGCCAACTACAAGGAGACTGAACTCGACGGCATGCGCCCCGGGCAACGGGTCAAGATTGCCATCGACGCCTACCCCGA
CCTCGATCTGGAGGGCCACGTGGATTCGATCCAGCGCGGCTCCGGCTCTAAGTTTTCCGCCTTCCCGGCCGAGAACGCCA
CCGGCAACTTCATCAAGATCGTTCAGCGCGTGCCGGTGAAGATCGTCATCGACGGCGGTCTGAAGAAGGACGAGCCGCTG
CCGCTCGGCATCAGCGTCGTACCGACGGTGATGCTCAAATGA

Upstream 100 bases:

>100_bases
TGAAGACGACCGCAAAGGCTCCGGGGCGGGCAAAGACGAAGCCGAAGGCGACAAGCGAGCTCGGAGGAAACGACGGCCGC
TCGTCATCGGCATCGCGGCG

Downstream 100 bases:

>100_bases
GCGACGCCTCGAACGGTCGAAAATCCGCCCACAACCCTTGGCTCGTCGCCATCGCGGTCACGCTGGCGGCGTTCATGGAG
GTGCTCGACACCACCATCGT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVLLLLAGGGLYYWLSTRGKISTDDAYTDGNIVNVAPQVAGQVIALDVTDNQFVRKGDPLFRIDPRQFRFSREQAQGQLD
ASNAQVANQKLGVEIARKNFPAALQLAQANLDSAKANLALQQANYDRQRSLPKLATTQQDVDTTAANYQQAKAQVEQAQA
RLVQAMPVQQNIGQSEQQVDQLKGQAEQAKAQVEQADLNIEWSVVRASQDGWVTKRNVNAGDYLSAGQQVMSLVTTDVWV
TANYKETELDGMRPGQRVKIAIDAYPDLDLEGHVDSIQRGSGSKFSAFPAENATGNFIKIVQRVPVKIVIDGGLKKDEPL
PLGISVVPTVMLK

Sequences:

>Translated_333_residues
MVLLLLAGGGLYYWLSTRGKISTDDAYTDGNIVNVAPQVAGQVIALDVTDNQFVRKGDPLFRIDPRQFRFSREQAQGQLD
ASNAQVANQKLGVEIARKNFPAALQLAQANLDSAKANLALQQANYDRQRSLPKLATTQQDVDTTAANYQQAKAQVEQAQA
RLVQAMPVQQNIGQSEQQVDQLKGQAEQAKAQVEQADLNIEWSVVRASQDGWVTKRNVNAGDYLSAGQQVMSLVTTDVWV
TANYKETELDGMRPGQRVKIAIDAYPDLDLEGHVDSIQRGSGSKFSAFPAENATGNFIKIVQRVPVKIVIDGGLKKDEPL
PLGISVVPTVMLK
>Mature_333_residues
MVLLLLAGGGLYYWLSTRGKISTDDAYTDGNIVNVAPQVAGQVIALDVTDNQFVRKGDPLFRIDPRQFRFSREQAQGQLD
ASNAQVANQKLGVEIARKNFPAALQLAQANLDSAKANLALQQANYDRQRSLPKLATTQQDVDTTAANYQQAKAQVEQAQA
RLVQAMPVQQNIGQSEQQVDQLKGQAEQAKAQVEQADLNIEWSVVRASQDGWVTKRNVNAGDYLSAGQQVMSLVTTDVWV
TANYKETELDGMRPGQRVKIAIDAYPDLDLEGHVDSIQRGSGSKFSAFPAENATGNFIKIVQRVPVKIVIDGGLKKDEPL
PLGISVVPTVMLK

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=332, Percent_Identity=33.7349397590361, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1788711, Length=342, Percent_Identity=30.9941520467836, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790519, Length=299, Percent_Identity=32.1070234113712, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87081951, Length=318, Percent_Identity=28.6163522012579, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789637, Length=208, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790012, Length=254, Percent_Identity=27.1653543307087, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789900, Length=324, Percent_Identity=25.3086419753086, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790024, Length=251, Percent_Identity=24.7011952191235, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787013, Length=270, Percent_Identity=30, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36373; Mature: 36373

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLLLAGGGLYYWLSTRGKISTDDAYTDGNIVNVAPQVAGQVIALDVTDNQFVRKGDPL
CEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEECHHHCCEEEEEEECCCCHHHCCCCE
FRIDPRQFRFSREQAQGQLDASNAQVANQKLGVEIARKNFPAALQLAQANLDSAKANLAL
EEECHHHHHHHHHHHCCCCCCCCHHHHHHHHCEEEECCCCCHHHHHHHCCCCCHHHHEEE
QQANYDRQRSLPKLATTQQDVDTTAANYQQAKAQVEQAQARLVQAMPVQQNIGQSEQQVD
ECCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHH
QLKGQAEQAKAQVEQADLNIEWSVVRASQDGWVTKRNVNAGDYLSAGQQVMSLVTTDVWV
HHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHEEEE
TANYKETELDGMRPGQRVKIAIDAYPDLDLEGHVDSIQRGSGSKFSAFPAENATGNFIKI
EECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCHHHHH
VQRVPVKIVIDGGLKKDEPLPLGISVVPTVMLK
HHHCCEEEEEECCCCCCCCCCCCCEECCCEECC
>Mature Secondary Structure
MVLLLLAGGGLYYWLSTRGKISTDDAYTDGNIVNVAPQVAGQVIALDVTDNQFVRKGDPL
CEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEECHHHCCEEEEEEECCCCHHHCCCCE
FRIDPRQFRFSREQAQGQLDASNAQVANQKLGVEIARKNFPAALQLAQANLDSAKANLAL
EEECHHHHHHHHHHHCCCCCCCCHHHHHHHHCEEEECCCCCHHHHHHHCCCCCHHHHEEE
QQANYDRQRSLPKLATTQQDVDTTAANYQQAKAQVEQAQARLVQAMPVQQNIGQSEQQVD
ECCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHH
QLKGQAEQAKAQVEQADLNIEWSVVRASQDGWVTKRNVNAGDYLSAGQQVMSLVTTDVWV
HHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHEEEE
TANYKETELDGMRPGQRVKIAIDAYPDLDLEGHVDSIQRGSGSKFSAFPAENATGNFIKI
EECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCHHHHH
VQRVPVKIVIDGGLKKDEPLPLGISVVPTVMLK
HHHCCEEEEEECCCCCCCCCCCCCEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]