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The map label for this gene is zraS [C]

Identifier: 170751602

GI number: 170751602

Start: 5540340

End: 5542508

Strand: Reverse

Name: zraS [C]

Synonym: Mrad2831_5223

Alternate gene names: 170751602

Gene position: 5542508-5540340 (Counterclockwise)

Preceding gene: 170751615

Following gene: 170751601

Centisome position: 91.19

GC content: 67.31

Gene sequence:

>2169_bases
ATGATCGACCGAAGCGCCCCCGAGAGCCTCGACGGCGGCGCTCCCGATACAGTCGATCCGATCAGCGGCACGGCCGTTCG
CTGGTTCACTGGCTTCGTTCGAGCGTCGAGCGCCGTGGTCCTGCTCGTCGGCGTCGCGGTCATCGGCGGCTACGCCCTCC
ATCTGCCGATCCTGACCACGCTGCATCCCACGCTCCAGGCGATGTCGGTGATCACCGCGACGGGCCTCATCCTGGCAGCC
GTCGCTCTGAGCGCGGACAGCTTGGGATGGCGATGGCTCATCGGCCCCTCGTCCGCGCTCGTTCTCGCGCTAGCGGTCGT
GATCCTCGCGAGCCACACGCTCACGGGTGCGGACCGCATCAGCGCGCCGCTGGCCGAGCATCTGTTCGGCTACGATCCCA
GGCTAGCCGGGCGTGTGTCCATCGCCACGGCAACGGGCCTGATGCTCATCGCGATCAGCGTATCGCTCGGCGGTTGGAGG
CGCCCTCGGACCGCTGCCTTCGGCGACGCCTGCGCCGGGTCAGCCGGCTTGATCAGCGGCTTGGCACTCATCGGCTACGC
CTACGGGGTACGCGACCTCTACGCGTTCAATCCGTTCAACACGATGGCCCTTCACACGGCCACGGCCTTGTTCCTGCTCG
CCCTCTCCGCCCTCGTCGTCCGATCGGACCGCGGCGCGGCGGCGGTCATCGCCTCCAGCTTGGCAGGCGGCTCACCCACG
CGGAGGCAGCTCACGGTCACGCTGCTCATCCCGCTCCTCGGAGCCCTCCTGCTGCGCGCCACCGACACGCAGAAGGTCGG
TCCAGGCATGGCCATGGCCTTGCTGGTTTCTCTCACCGTGTCCGTGCTGATCCTGCTCATCCTGCGTGACGGACAGGTCC
AGAACGCGCTGGACCGAGAGCGACGCAGCCGAACTGCGGTCCTCGCTCAGGCCCGGACAGTCCTGGAACAGGATCTGGCC
GGCCGTGTCGAAGCGCTCGACGCGGCAACGCGCGAGCGCTTCAAGGCTGAGGATGCGCTACGTCAATCGCAGAAAATGGA
GGCGATCGGTCAGTTGACCGGAGGCGTCGCCCACGATTTCAACAACCTGCTCACCGTGATCCGCTCGTCGAGCGAGCTGC
TGCGCCGCCCGAACCTGCCGGAACAGCGCCGACTCCGTTACGTCGAGGCCATCGCCACCACCGCTGACCGGGCCGCCAAG
CTGACCGGACAGCTGCTGGCGTTCTCGCGTCGGCAATCCCTCAAGCCGGAGGTGTTCGACGTCGGTCAGAGCGTGGCCGC
CATCACCGAGATGGTCGGCACGCTGACCGGTGCGCGCATCCGGATCACGGTCAGCGTGCCCAACGAGCCGTGCTTCGTCG
ACGCCGATCCGAGCCAGTTCGACACCTCACTGGTCAACATGGCGGTGAATGCGCGCGATGCCATGTCCGGGGAAGGGGCG
TTGACCGTCACCGTAAGACTGAGTTCCGACATCCCGGGAACCGCCCCGTCGCCCGCTCCCGGCGATGGGTTCGTGGCGGT
GGATGTCGCCGATACCGGCACTGGGATCCCTCCGACGGACCTGGAACGGATCTTCGAGCCGTTCTTCACGACGAAGGGCG
TCGGCCATGGCACCGGGCTCGGCCTGTCCCAGGTGTTCGGCTTCGCCAAACAGTCGGGCGGCGAGGTCCGGGTCGTCAGT
ACGCCGGGGCTCGGCTCGACGTTCACGCTGTACCTGCCGCGGTCCGCCGGCATGAGCCGCGCCGCGATCGTTGCCAACGA
GATGGAGCCGATGGTCGACGGCCATGGCACCTGCGTGCTGCTGGTCGAGGACAACACCGATGTCGGGGCGTTCGCCGCGC
AGGCGTTGGAGGAACTCGGGTATCGCACGGTCTGGGCAACCGACGGGGCTCAAGCCCTGGCGCAGCTAGCCGAGGATGCC
AGCCAGTTCGACGTGGTGTTCTCGGACGTGGTGATGCCGGGCATGACGGGGATCGAGCTCGGACAGGAGATCCGTAAGCG
CCACCACGACCTGCCGGTGGTGCTGACCTCGGGCTACAGTCACGTGCTCGCGCAAAACGGCACCTATGGGTTCGAGCTGC
TGCATAAGCCGTATTCGGTCGAGCAGCTTTCACGTGTCCTGCGCAAGGCAGCGACGTGGCAGCGACGTCGGCGCGTCCTG
AACGGGTAA

Upstream 100 bases:

>100_bases
TGATGAACGGTGCGCGTTGGATTTTTAGGCCGGGAGCTTGCGCCCGTTGAGCCTACGACAAAACCAAGTGCGAACAGCGC
ATCGGTGCTACAAACGGTTC

Downstream 100 bases:

>100_bases
CCTGCCGAGGCCGAAGGTCCGGTTTCGGGCGTCGTGCCAATTTCCGTTTGCCGCCCTGAGCCGTTGGTTCCGGAGGGCTG
TGTAGGCTGCTTTCGGGGAG

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MIDRSAPESLDGGAPDTVDPISGTAVRWFTGFVRASSAVVLLVGVAVIGGYALHLPILTTLHPTLQAMSVITATGLILAA
VALSADSLGWRWLIGPSSALVLALAVVILASHTLTGADRISAPLAEHLFGYDPRLAGRVSIATATGLMLIAISVSLGGWR
RPRTAAFGDACAGSAGLISGLALIGYAYGVRDLYAFNPFNTMALHTATALFLLALSALVVRSDRGAAAVIASSLAGGSPT
RRQLTVTLLIPLLGALLLRATDTQKVGPGMAMALLVSLTVSVLILLILRDGQVQNALDRERRSRTAVLAQARTVLEQDLA
GRVEALDAATRERFKAEDALRQSQKMEAIGQLTGGVAHDFNNLLTVIRSSSELLRRPNLPEQRRLRYVEAIATTADRAAK
LTGQLLAFSRRQSLKPEVFDVGQSVAAITEMVGTLTGARIRITVSVPNEPCFVDADPSQFDTSLVNMAVNARDAMSGEGA
LTVTVRLSSDIPGTAPSPAPGDGFVAVDVADTGTGIPPTDLERIFEPFFTTKGVGHGTGLGLSQVFGFAKQSGGEVRVVS
TPGLGSTFTLYLPRSAGMSRAAIVANEMEPMVDGHGTCVLLVEDNTDVGAFAAQALEELGYRTVWATDGAQALAQLAEDA
SQFDVVFSDVVMPGMTGIELGQEIRKRHHDLPVVLTSGYSHVLAQNGTYGFELLHKPYSVEQLSRVLRKAATWQRRRRVL
NG

Sequences:

>Translated_722_residues
MIDRSAPESLDGGAPDTVDPISGTAVRWFTGFVRASSAVVLLVGVAVIGGYALHLPILTTLHPTLQAMSVITATGLILAA
VALSADSLGWRWLIGPSSALVLALAVVILASHTLTGADRISAPLAEHLFGYDPRLAGRVSIATATGLMLIAISVSLGGWR
RPRTAAFGDACAGSAGLISGLALIGYAYGVRDLYAFNPFNTMALHTATALFLLALSALVVRSDRGAAAVIASSLAGGSPT
RRQLTVTLLIPLLGALLLRATDTQKVGPGMAMALLVSLTVSVLILLILRDGQVQNALDRERRSRTAVLAQARTVLEQDLA
GRVEALDAATRERFKAEDALRQSQKMEAIGQLTGGVAHDFNNLLTVIRSSSELLRRPNLPEQRRLRYVEAIATTADRAAK
LTGQLLAFSRRQSLKPEVFDVGQSVAAITEMVGTLTGARIRITVSVPNEPCFVDADPSQFDTSLVNMAVNARDAMSGEGA
LTVTVRLSSDIPGTAPSPAPGDGFVAVDVADTGTGIPPTDLERIFEPFFTTKGVGHGTGLGLSQVFGFAKQSGGEVRVVS
TPGLGSTFTLYLPRSAGMSRAAIVANEMEPMVDGHGTCVLLVEDNTDVGAFAAQALEELGYRTVWATDGAQALAQLAEDA
SQFDVVFSDVVMPGMTGIELGQEIRKRHHDLPVVLTSGYSHVLAQNGTYGFELLHKPYSVEQLSRVLRKAATWQRRRRVL
NG
>Mature_722_residues
MIDRSAPESLDGGAPDTVDPISGTAVRWFTGFVRASSAVVLLVGVAVIGGYALHLPILTTLHPTLQAMSVITATGLILAA
VALSADSLGWRWLIGPSSALVLALAVVILASHTLTGADRISAPLAEHLFGYDPRLAGRVSIATATGLMLIAISVSLGGWR
RPRTAAFGDACAGSAGLISGLALIGYAYGVRDLYAFNPFNTMALHTATALFLLALSALVVRSDRGAAAVIASSLAGGSPT
RRQLTVTLLIPLLGALLLRATDTQKVGPGMAMALLVSLTVSVLILLILRDGQVQNALDRERRSRTAVLAQARTVLEQDLA
GRVEALDAATRERFKAEDALRQSQKMEAIGQLTGGVAHDFNNLLTVIRSSSELLRRPNLPEQRRLRYVEAIATTADRAAK
LTGQLLAFSRRQSLKPEVFDVGQSVAAITEMVGTLTGARIRITVSVPNEPCFVDADPSQFDTSLVNMAVNARDAMSGEGA
LTVTVRLSSDIPGTAPSPAPGDGFVAVDVADTGTGIPPTDLERIFEPFFTTKGVGHGTGLGLSQVFGFAKQSGGEVRVVS
TPGLGSTFTLYLPRSAGMSRAAIVANEMEPMVDGHGTCVLLVEDNTDVGAFAAQALEELGYRTVWATDGAQALAQLAEDA
SQFDVVFSDVVMPGMTGIELGQEIRKRHHDLPVVLTSGYSHVLAQNGTYGFELLHKPYSVEQLSRVLRKAATWQRRRRVL
NG

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=31.7073170731707, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=31.8181818181818, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=366, Percent_Identity=24.5901639344262, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081816, Length=255, Percent_Identity=29.8039215686275, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=292, Percent_Identity=31.8493150684932, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790300, Length=252, Percent_Identity=29.3650793650794, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=26.5917602996255, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=29.1304347826087, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76197; Mature: 76197

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRSAPESLDGGAPDTVDPISGTAVRWFTGFVRASSAVVLLVGVAVIGGYALHLPILTT
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHH
LHPTLQAMSVITATGLILAAVALSADSLGWRWLIGPSSALVLALAVVILASHTLTGADRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHH
SAPLAEHLFGYDPRLAGRVSIATATGLMLIAISVSLGGWRRPRTAAFGDACAGSAGLISG
HHHHHHHHCCCCCCCCCEEEEHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
LALIGYAYGVRDLYAFNPFNTMALHTATALFLLALSALVVRSDRGAAAVIASSLAGGSPT
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
RRQLTVTLLIPLLGALLLRATDTQKVGPGMAMALLVSLTVSVLILLILRDGQVQNALDRE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRSRTAVLAQARTVLEQDLAGRVEALDAATRERFKAEDALRQSQKMEAIGQLTGGVAHDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
NNLLTVIRSSSELLRRPNLPEQRRLRYVEAIATTADRAAKLTGQLLAFSRRQSLKPEVFD
HHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VGQSVAAITEMVGTLTGARIRITVSVPNEPCFVDADPSQFDTSLVNMAVNARDAMSGEGA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCHHCCCCCCE
LTVTVRLSSDIPGTAPSPAPGDGFVAVDVADTGTGIPPTDLERIFEPFFTTKGVGHGTGL
EEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GLSQVFGFAKQSGGEVRVVSTPGLGSTFTLYLPRSAGMSRAAIVANEMEPMVDGHGTCVL
CHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHCCCCEEEE
LVEDNTDVGAFAAQALEELGYRTVWATDGAQALAQLAEDASQFDVVFSDVVMPGMTGIEL
EEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GQEIRKRHHDLPVVLTSGYSHVLAQNGTYGFELLHKPYSVEQLSRVLRKAATWQRRRRVL
HHHHHHHHCCCCEEEECCCHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
NG
CC
>Mature Secondary Structure
MIDRSAPESLDGGAPDTVDPISGTAVRWFTGFVRASSAVVLLVGVAVIGGYALHLPILTT
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHH
LHPTLQAMSVITATGLILAAVALSADSLGWRWLIGPSSALVLALAVVILASHTLTGADRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHH
SAPLAEHLFGYDPRLAGRVSIATATGLMLIAISVSLGGWRRPRTAAFGDACAGSAGLISG
HHHHHHHHCCCCCCCCCEEEEHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
LALIGYAYGVRDLYAFNPFNTMALHTATALFLLALSALVVRSDRGAAAVIASSLAGGSPT
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
RRQLTVTLLIPLLGALLLRATDTQKVGPGMAMALLVSLTVSVLILLILRDGQVQNALDRE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRSRTAVLAQARTVLEQDLAGRVEALDAATRERFKAEDALRQSQKMEAIGQLTGGVAHDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
NNLLTVIRSSSELLRRPNLPEQRRLRYVEAIATTADRAAKLTGQLLAFSRRQSLKPEVFD
HHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VGQSVAAITEMVGTLTGARIRITVSVPNEPCFVDADPSQFDTSLVNMAVNARDAMSGEGA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCHHCCCCCCE
LTVTVRLSSDIPGTAPSPAPGDGFVAVDVADTGTGIPPTDLERIFEPFFTTKGVGHGTGL
EEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GLSQVFGFAKQSGGEVRVVSTPGLGSTFTLYLPRSAGMSRAAIVANEMEPMVDGHGTCVL
CHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHCCCHHHCCCCEEEE
LVEDNTDVGAFAAQALEELGYRTVWATDGAQALAQLAEDASQFDVVFSDVVMPGMTGIEL
EEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GQEIRKRHHDLPVVLTSGYSHVLAQNGTYGFELLHKPYSVEQLSRVLRKAATWQRRRRVL
HHHHHHHHCCCCEEEECCCHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
NG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA