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The map label for this gene is guaD [H]

Identifier: 170751176

GI number: 170751176

Start: 5113732

End: 5114214

Strand: Reverse

Name: guaD [H]

Synonym: Mrad2831_4793

Alternate gene names: 170751176

Gene position: 5114214-5113732 (Counterclockwise)

Preceding gene: 170751177

Following gene: 170751175

Centisome position: 84.15

GC content: 65.63

Gene sequence:

>483_bases
ATGTCTGACAACCACGAGAAGTTCATGGCCCGGGCGATCGCCCTGTCGGAGAAGACGTCACTGGTCGACAGCGCCGGCGG
CGTGTTCGGCTGCGTGATCGTCCAGGACGGCGAGATCATCGCCGAGGGCGCCAACCGCGTCGTCGCCGAGAACGACCCGA
CCTGGCACGGCGAGATCGAGGCCATCCGGAAGGCCTGCAAGGCGCAGGGCAGCTTCAAGCTCCGGAACGCGACGCTCTAC
ACCAGCGCCGAACCCTGCCCGATGTGCATGGCGGCCGCCTACTGGGCCGGCGTCAAGAACGTCTACTACGCGGCGCAGGT
CGAAGACGCGCTGGAGTACGGCGGCTTCGACGACAGCATGATCTACGCCGAACTCAAGAAGGATGTCGGCGAGCGCTCCA
TCCCGACCCAGCAGATCATGCGCGAGGAGGCCGTCGAGGTCTGGAAGAAGTACGCGCAGAAAGCGGACCGCGTCCCCTAC
TGA

Upstream 100 bases:

>100_bases
GCGCGGTTCGACACAACAAACGGGATCGCCCCTCGATAAGCAAGTCTCCGCGGTTCACAGTCTCGATCAGCCGACCCGTT
TCGCGACGACAGAGGTTCCA

Downstream 100 bases:

>100_bases
GGGCCGGATCGCGAGATCGGCCGTCCTGTTCCGCCCGCTCAGGCCCCCTCGCCCGAGCGGGTCTCCCCGCCCGCGCAGTG
CCTGGACATGAATGCTGAGA

Product: zinc-binding CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSDNHEKFMARAIALSEKTSLVDSAGGVFGCVIVQDGEIIAEGANRVVAENDPTWHGEIEAIRKACKAQGSFKLRNATLY
TSAEPCPMCMAAAYWAGVKNVYYAAQVEDALEYGGFDDSMIYAELKKDVGERSIPTQQIMREEAVEVWKKYAQKADRVPY

Sequences:

>Translated_160_residues
MSDNHEKFMARAIALSEKTSLVDSAGGVFGCVIVQDGEIIAEGANRVVAENDPTWHGEIEAIRKACKAQGSFKLRNATLY
TSAEPCPMCMAAAYWAGVKNVYYAAQVEDALEYGGFDDSMIYAELKKDVGERSIPTQQIMREEAVEVWKKYAQKADRVPY
>Mature_159_residues
SDNHEKFMARAIALSEKTSLVDSAGGVFGCVIVQDGEIIAEGANRVVAENDPTWHGEIEAIRKACKAQGSFKLRNATLYT
SAEPCPMCMAAAYWAGVKNVYYAAQVEDALEYGGFDDSMIYAELKKDVGERSIPTQQIMREEAVEVWKKYAQKADRVPY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554608, Length=154, Percent_Identity=37.012987012987, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555996, Length=162, Percent_Identity=35.8024691358025, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541138, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17696; Mature: 17565

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNHEKFMARAIALSEKTSLVDSAGGVFGCVIVQDGEIIAEGANRVVAENDPTWHGEIE
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCEEEECCCCEEEECCCCCCCCHHH
AIRKACKAQGSFKLRNATLYTSAEPCPMCMAAAYWAGVKNVYYAAQVEDALEYGGFDDSM
HHHHHHHCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IYAELKKDVGERSIPTQQIMREEAVEVWKKYAQKADRVPY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDNHEKFMARAIALSEKTSLVDSAGGVFGCVIVQDGEIIAEGANRVVAENDPTWHGEIE
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCEEEECCCCEEEECCCCCCCCHHH
AIRKACKAQGSFKLRNATLYTSAEPCPMCMAAAYWAGVKNVYYAAQVEDALEYGGFDDSM
HHHHHHHCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IYAELKKDVGERSIPTQQIMREEAVEVWKKYAQKADRVPY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]