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The map label for this gene is coxS [H]

Identifier: 170751109

GI number: 170751109

Start: 5030702

End: 5031235

Strand: Direct

Name: coxS [H]

Synonym: Mrad2831_4725

Alternate gene names: 170751109

Gene position: 5030702-5031235 (Clockwise)

Preceding gene: 170751108

Following gene: 170751110

Centisome position: 82.77

GC content: 73.03

Gene sequence:

>534_bases
ATGCCACAGCTAGACGCGAAGGGCCGTCACACGGTGGCCTTTACCCTCAACGGGCGCGAGACCACGGTCGAGGTCGAGAC
CCGCACCCTGCTGACCGACGCCCTGCGCCACGGGCTCGGGGCCACGGGCACGCATGTCGGCTGCGAGCACGGCGTCTGCG
GCGCCTGCACGGTGTCCATCGACGGGGTTCCCGCCCGGGCCTGCCTGACGCTCGCCGTGGGGGTCGAGGGCTGCGCCGTG
CGGACCGTCGAGGGTCTGGCTCCGGAGCCCGGCCGCCTCGGGGTGCTGCAGGCGGCGTTCCGGCGGCGGCACGCCCTGCA
ATGCGGCTTCTGCACCGCCGGCATCCTGATGTCGCTCGACGCCTATCTCGCCTTCCGGCCGAACCCCTCGCGCCGGGAGA
TCACGGAAGTGATCGGCGGCCATCTCTGCCGCTGCACCGGCTACGCGCCGATCATCGAGGCCGCCCTGGAGGCGGCTGCG
GAACTCAGGGGCGACATCCCGGCCCCGTCATCCCCGGAGGCCGCCCATGCTTGA

Upstream 100 bases:

>100_bases
CCGCCCGCTACCGCCGCGAGCTCGTGCGCAGCCTCGGCCGCCGGGTGCTGGAACAGGCCGTCAAGGTCGCCCGCGGCGAC
ACCCATCAGGAGGCCGTGCC

Downstream 100 bases:

>100_bases
TCTCGGCACCAGCTTCCTTGCGAGCGTCTCCCGCGATCCCCGCGCCCTGGCCCTCGTCGACGGGGAGACCCGGCTGAGCT
ACGCGGAGTGGTTCGGGGTC

Product: 2Fe-2S iron-sulfur cluster binding domain-containing protein

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MPQLDAKGRHTVAFTLNGRETTVEVETRTLLTDALRHGLGATGTHVGCEHGVCGACTVSIDGVPARACLTLAVGVEGCAV
RTVEGLAPEPGRLGVLQAAFRRRHALQCGFCTAGILMSLDAYLAFRPNPSRREITEVIGGHLCRCTGYAPIIEAALEAAA
ELRGDIPAPSSPEAAHA

Sequences:

>Translated_177_residues
MPQLDAKGRHTVAFTLNGRETTVEVETRTLLTDALRHGLGATGTHVGCEHGVCGACTVSIDGVPARACLTLAVGVEGCAV
RTVEGLAPEPGRLGVLQAAFRRRHALQCGFCTAGILMSLDAYLAFRPNPSRREITEVIGGHLCRCTGYAPIIEAALEAAA
ELRGDIPAPSSPEAAHA
>Mature_176_residues
PQLDAKGRHTVAFTLNGRETTVEVETRTLLTDALRHGLGATGTHVGCEHGVCGACTVSIDGVPARACLTLAVGVEGCAVR
TVEGLAPEPGRLGVLQAAFRRRHALQCGFCTAGILMSLDAYLAFRPNPSRREITEVIGGHLCRCTGYAPIIEAALEAAAE
LRGDIPAPSSPEAAHA

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=91, Percent_Identity=45.0549450549451, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI91823271, Length=153, Percent_Identity=39.2156862745098, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786480, Length=167, Percent_Identity=39.5209580838323, Blast_Score=116, Evalue=8e-28,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=40.6666666666667, Blast_Score=97, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=165, Percent_Identity=39.3939393939394, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32566215, Length=164, Percent_Identity=38.4146341463415, Blast_Score=109, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=40.2597402597403, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17737937, Length=153, Percent_Identity=41.1764705882353, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647193, Length=170, Percent_Identity=31.1764705882353, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647197, Length=174, Percent_Identity=29.8850574712644, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647195, Length=174, Percent_Identity=29.8850574712644, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647199, Length=168, Percent_Identity=31.547619047619, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=30.5194805194805, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 18451; Mature: 18320

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLDAKGRHTVAFTLNGRETTVEVETRTLLTDALRHGLGATGTHVGCEHGVCGACTVSI
CCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEE
DGVPARACLTLAVGVEGCAVRTVEGLAPEPGRLGVLQAAFRRRHALQCGFCTAGILMSLD
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AYLAFRPNPSRREITEVIGGHLCRCTGYAPIIEAALEAAAELRGDIPAPSSPEAAHA
HHEEECCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQLDAKGRHTVAFTLNGRETTVEVETRTLLTDALRHGLGATGTHVGCEHGVCGACTVSI
CCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEE
DGVPARACLTLAVGVEGCAVRTVEGLAPEPGRLGVLQAAFRRRHALQCGFCTAGILMSLD
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AYLAFRPNPSRREITEVIGGHLCRCTGYAPIIEAALEAAAELRGDIPAPSSPEAAHA
HHEEECCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 10430865; 12475995 [H]