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The map label for this gene is yhcA [H]

Identifier: 170751097

GI number: 170751097

Start: 5014688

End: 5016220

Strand: Reverse

Name: yhcA [H]

Synonym: Mrad2831_4713

Alternate gene names: 170751097

Gene position: 5016220-5014688 (Counterclockwise)

Preceding gene: 170751100

Following gene: 170751096

Centisome position: 82.53

GC content: 69.99

Gene sequence:

>1533_bases
GTGCCGACCGCCGGGCCCCGAACATGGGCCGGCTTCGCCATCCTGTGCGTCGGCATGTTCATCGCCATCCTGGACATCCA
GATCGTCGCGACATCCCTTCCGCGGATCCAGGCGGGTCTCGGGATCCCGCCGGACCGGGTCAGCTGGGTCCAGACGGCGT
ATCTCACCGCAGAGGTGCTCGTCATTCCGCTCACGGGTCCCCTCACGCGCCTAGCGAGCATGCGCCGGCTCTTCGTGACA
TCGGTGACCCTGTTCACGCTCGCGTCGTGCGGTTGTGCCGCAAGCGGCGGCTTTGCCTCGCTCATCGTCTGGCGCGCGCT
CCAGGGCGCGTCCGGGGGCGCGTTGATCCCGACCGTGTTTTCAGCCGTCTTTCTGCTGTTCCCGCCGAACCGCCAGGGCA
TCGCCACGGCCGTTGCGGGAACGCTCGCCGTTCTCGCCCCGACCGCCGGCCCCGTCGTCGGCGGCTGGATCACTGAGACG
GCGACCTGGCATTGGCTGTTCCTGATCAACGTGCCCCCCGGTCTCGTCTCGGCCACCGGCGGGTATTGGCTGCTGCCGCG
TGACCGGCGGCGCGGACGGCTCGGCGAACTCGATGTGACAGCCCTAGGGCTCCTGGCCGTCGCCCTGTGCAATCTGGAGC
TCGGCCTCAAGGCGGCCCCGGAATCCGGCTGGGCGGCGCCTGCAGCCGTCGCACATCTCGGCGCGAGCACGGTGGCCGCG
CTCGTGTTCGTCCGCCGTACCCTGGCGGCGGCCCATCCGCTCGTCGAGCTCCGGATGTTCGCGGATCGCCGCTTCGCCGT
GGGCTCGGCACTCAGCTTCGCGTGCGGGGTGGGCCTTTACGGTTGCGTCTACCTCATGCCGGTCTTCCTCGGCTACGTGC
AGGGACGCGGGCCGCTGGCGACCGGCGAGATCATGCTCGTCACCGGCCTGGCGCAACTCGCCGCGTCTCCGCTTGCCGTC
GCCCTGGACGAGCGCGTCGACGCGACCGTGCTCGCCGTCCTCGGATTCGGTCTGTTCGCGCTCGGCTCGTTCCTGAGCAC
GACCCAGTCGGCCGCGACGGATCCGGGCGCGCTGGTCGTCCCGCAGATCGTACGCGGGCTCTCCGTCATGGTCTGCCTGC
TGGCGCCGACACGGTTGGCGCTGGGGCATGTGGCGGCCGAGAGCGTTCCGGATGCCAGCGGGTTGTTCAACCTGATGCGG
AATCTTGGCGGCGCCGTCGGCCTCTCGCTGATCGACACCGTGATCTACGGGCGGATCCCCGGCCACGTATCTGATCTCGT
CGCGCGACTCGCGTCCGGCGATCTCGACGCCGCGCGATGGGTCGGCATCCCGCCGGCCGTTCTCGCTGCCCAGGCGGGCA
AGCCGATCAGCGAAGCGACGCGTGCCCTCGTCGCGCCGCTGGTCGAGAAAGCCGCCCTGACCGCCTCGATCAACGACGCC
TGGATTCTTGTCGGGACCCTCAACGTGGTGGCGATCGCCGTCCTGGCGCTCGTTCACCGACGCGCCGATCCGAGCCTGGA
GTCGAAGCCATGA

Upstream 100 bases:

>100_bases
TATCCGTCACGCGGCCCGGGCTGCCGTCCCGATCGTCCGCGACGTCGCGGACGCCGCCGATCGACCGGCTCCAACGGACC
TGGGTGGGGCCAGTGCGCCT

Downstream 100 bases:

>100_bases
CGGAAGCCTACCTCAACCGCATCGAGACGGCCGTCCCGCCCCACGACGTCCACGCGGCCTTCGCGGCCTTCGCGCGATCC
CAGCTCGCCGACGACCAACG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MPTAGPRTWAGFAILCVGMFIAILDIQIVATSLPRIQAGLGIPPDRVSWVQTAYLTAEVLVIPLTGPLTRLASMRRLFVT
SVTLFTLASCGCAASGGFASLIVWRALQGASGGALIPTVFSAVFLLFPPNRQGIATAVAGTLAVLAPTAGPVVGGWITET
ATWHWLFLINVPPGLVSATGGYWLLPRDRRRGRLGELDVTALGLLAVALCNLELGLKAAPESGWAAPAAVAHLGASTVAA
LVFVRRTLAAAHPLVELRMFADRRFAVGSALSFACGVGLYGCVYLMPVFLGYVQGRGPLATGEIMLVTGLAQLAASPLAV
ALDERVDATVLAVLGFGLFALGSFLSTTQSAATDPGALVVPQIVRGLSVMVCLLAPTRLALGHVAAESVPDASGLFNLMR
NLGGAVGLSLIDTVIYGRIPGHVSDLVARLASGDLDAARWVGIPPAVLAAQAGKPISEATRALVAPLVEKAALTASINDA
WILVGTLNVVAIAVLALVHRRADPSLESKP

Sequences:

>Translated_510_residues
MPTAGPRTWAGFAILCVGMFIAILDIQIVATSLPRIQAGLGIPPDRVSWVQTAYLTAEVLVIPLTGPLTRLASMRRLFVT
SVTLFTLASCGCAASGGFASLIVWRALQGASGGALIPTVFSAVFLLFPPNRQGIATAVAGTLAVLAPTAGPVVGGWITET
ATWHWLFLINVPPGLVSATGGYWLLPRDRRRGRLGELDVTALGLLAVALCNLELGLKAAPESGWAAPAAVAHLGASTVAA
LVFVRRTLAAAHPLVELRMFADRRFAVGSALSFACGVGLYGCVYLMPVFLGYVQGRGPLATGEIMLVTGLAQLAASPLAV
ALDERVDATVLAVLGFGLFALGSFLSTTQSAATDPGALVVPQIVRGLSVMVCLLAPTRLALGHVAAESVPDASGLFNLMR
NLGGAVGLSLIDTVIYGRIPGHVSDLVARLASGDLDAARWVGIPPAVLAAQAGKPISEATRALVAPLVEKAALTASINDA
WILVGTLNVVAIAVLALVHRRADPSLESKP
>Mature_509_residues
PTAGPRTWAGFAILCVGMFIAILDIQIVATSLPRIQAGLGIPPDRVSWVQTAYLTAEVLVIPLTGPLTRLASMRRLFVTS
VTLFTLASCGCAASGGFASLIVWRALQGASGGALIPTVFSAVFLLFPPNRQGIATAVAGTLAVLAPTAGPVVGGWITETA
TWHWLFLINVPPGLVSATGGYWLLPRDRRRGRLGELDVTALGLLAVALCNLELGLKAAPESGWAAPAAVAHLGASTVAAL
VFVRRTLAAAHPLVELRMFADRRFAVGSALSFACGVGLYGCVYLMPVFLGYVQGRGPLATGEIMLVTGLAQLAASPLAVA
LDERVDATVLAVLGFGLFALGSFLSTTQSAATDPGALVVPQIVRGLSVMVCLLAPTRLALGHVAAESVPDASGLFNLMRN
LGGAVGLSLIDTVIYGRIPGHVSDLVARLASGDLDAARWVGIPPAVLAAQAGKPISEATRALVAPLVEKAALTASINDAW
ILVGTLNVVAIAVLALVHRRADPSLESKP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=432, Percent_Identity=29.1666666666667, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789042, Length=415, Percent_Identity=28.9156626506024, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1790195, Length=422, Percent_Identity=26.5402843601896, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788392, Length=317, Percent_Identity=31.2302839116719, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081983, Length=426, Percent_Identity=26.7605633802817, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52577; Mature: 52445

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAGPRTWAGFAILCVGMFIAILDIQIVATSLPRIQAGLGIPPDRVSWVQTAYLTAEVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHEEEEEE
VIPLTGPLTRLASMRRLFVTSVTLFTLASCGCAASGGFASLIVWRALQGASGGALIPTVF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
SAVFLLFPPNRQGIATAVAGTLAVLAPTAGPVVGGWITETATWHWLFLINVPPGLVSATG
HHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEECCC
GYWLLPRDRRRGRLGELDVTALGLLAVALCNLELGLKAAPESGWAAPAAVAHLGASTVAA
CEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHH
LVFVRRTLAAAHPLVELRMFADRRFAVGSALSFACGVGLYGCVYLMPVFLGYVQGRGPLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TGEIMLVTGLAQLAASPLAVALDERVDATVLAVLGFGLFALGSFLSTTQSAATDPGALVV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
PQIVRGLSVMVCLLAPTRLALGHVAAESVPDASGLFNLMRNLGGAVGLSLIDTVIYGRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCC
GHVSDLVARLASGDLDAARWVGIPPAVLAAQAGKPISEATRALVAPLVEKAALTASINDA
CHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCC
WILVGTLNVVAIAVLALVHRRADPSLESKP
EEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PTAGPRTWAGFAILCVGMFIAILDIQIVATSLPRIQAGLGIPPDRVSWVQTAYLTAEVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHEEEEEE
VIPLTGPLTRLASMRRLFVTSVTLFTLASCGCAASGGFASLIVWRALQGASGGALIPTVF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
SAVFLLFPPNRQGIATAVAGTLAVLAPTAGPVVGGWITETATWHWLFLINVPPGLVSATG
HHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEECCC
GYWLLPRDRRRGRLGELDVTALGLLAVALCNLELGLKAAPESGWAAPAAVAHLGASTVAA
CEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHH
LVFVRRTLAAAHPLVELRMFADRRFAVGSALSFACGVGLYGCVYLMPVFLGYVQGRGPLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TGEIMLVTGLAQLAASPLAVALDERVDATVLAVLGFGLFALGSFLSTTQSAATDPGALVV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
PQIVRGLSVMVCLLAPTRLALGHVAAESVPDASGLFNLMRNLGGAVGLSLIDTVIYGRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCC
GHVSDLVARLASGDLDAARWVGIPPAVLAAQAGKPISEATRALVAPLVEKAALTASINDA
CHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCC
WILVGTLNVVAIAVLALVHRRADPSLESKP
EEEEHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]