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The map label for this gene is ldc [H]

Identifier: 170751044

GI number: 170751044

Start: 4955813

End: 4956979

Strand: Direct

Name: ldc [H]

Synonym: Mrad2831_4655

Alternate gene names: 170751044

Gene position: 4955813-4956979 (Clockwise)

Preceding gene: 170751036

Following gene: 170751045

Centisome position: 81.54

GC content: 69.58

Gene sequence:

>1167_bases
ATGACCGACCGCATCCGTGACTACCTGCGCGTGCGCCGCGACCTCGGTCAGGACGAGGGCCCCGTGATGGTCCTCGACCT
CGACGTCGTGCGCGACAACTACACCGCCTTCGCGCGCTCCCTGCCGGACACCCGGGTGTTCTACGCCGTGAAGGCGAACC
CGGCTCCCGAGGTGCTGCGCCTTCTGGCCGAGATGGGCTCGTGCTTCGACACGGCCTCCGTCGCCGAGATGGAGATGGTG
CTGGCCGCCGGCGCCACCGCCGACCGGATCTCCTTCGGCAACACCATCAAGAAGGAGCGCTGCATCGGCCGTGCCCTGAA
GCTCGGCATCCGCCTGTTCGCGGTCGACTGCCAGGCCGAGGTCGAGAAGATCGCCCGGGCCGCCGAGGCCGTGGACGTGC
CGGCCGGCGAGATCCGGGTGTTCTGCCGCATCCTCTGCGACGGCGTGGGCGCCGATTGGCCGCTCTCCCGCAAGTTCGGC
TGCGTGCCCGAGATGGCCGCGGACGTGCTGGAGCACGCCCACCGCCAGGGGCTGGAGGCCTACGGGATCTCGTTCCATGT
CGGCTCGCAGCAAGGCAACACCGAGGCCTGGGACGGGGCCCTCGGCTCCGCGGCGGCGGTCTTCCGCGAGTGCGCGGAGC
GCGGCATCGGCCTGTCGATGGTCAATCTCGGCGGCGGCTTCCCGACCAAGTACCTCAAGGCGGTGCCGGGTGTGGAGAGC
TACGGCGAGGCGATCTTCCGGGGCCTGACCAAGCATTTCGGCAACCAGATCCCCGAGACGATCATCGAGCCGGGCCGCGG
CATGGTCGGCAATGCCGGCCTGATCGAGGCGGAAGTTGTTCTCGTGTCGCGCAAGTCCGCGGATGCCGACGAGGTCCGAT
GGGTCTACCTCGACATCGGCAAGTTCGGCGGGCTGGCCGAGACCATGGACGAGGCGATCCGCTACCCGATCCGCACCGCG
CGGGACGGGGACGCGACCGAGCCCTGCGTCATCGCCGGCCCGACCTGCGACTCGGTGGACGTGCTCTACGAGCGGCAGCT
CTACCCGCTGCCGGTCTCGCTCTCGATCGGCGACAAGGTGCTGATCGAGGGCGCGGGCGCCTACACCACGACCTACGCGG
CGGTGGCCTTCAACGGCTTCCCGCCCCTTCAGCAGATCGTGATCTGA

Upstream 100 bases:

>100_bases
GCGCGACGCATCGCCCCCTGACGCCGGCGGCCTGTCAGGCCGTCATCTTCGACAGCGCGCCCCGCGTAGGGCGCCCGCGA
ACCCGTGCCGGGAGACGACC

Downstream 100 bases:

>100_bases
TCGCGCGCGCCGCCCGGGACACTCCGGGCGGCATCCTTCCGAGACTGCTCCCGGCGGGTGACAGGCGGCAGGAGGCGGAC
GCACGGATCCCGTGCGTCTG

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTDRIRDYLRVRRDLGQDEGPVMVLDLDVVRDNYTAFARSLPDTRVFYAVKANPAPEVLRLLAEMGSCFDTASVAEMEMV
LAAGATADRISFGNTIKKERCIGRALKLGIRLFAVDCQAEVEKIARAAEAVDVPAGEIRVFCRILCDGVGADWPLSRKFG
CVPEMAADVLEHAHRQGLEAYGISFHVGSQQGNTEAWDGALGSAAAVFRECAERGIGLSMVNLGGGFPTKYLKAVPGVES
YGEAIFRGLTKHFGNQIPETIIEPGRGMVGNAGLIEAEVVLVSRKSADADEVRWVYLDIGKFGGLAETMDEAIRYPIRTA
RDGDATEPCVIAGPTCDSVDVLYERQLYPLPVSLSIGDKVLIEGAGAYTTTYAAVAFNGFPPLQQIVI

Sequences:

>Translated_388_residues
MTDRIRDYLRVRRDLGQDEGPVMVLDLDVVRDNYTAFARSLPDTRVFYAVKANPAPEVLRLLAEMGSCFDTASVAEMEMV
LAAGATADRISFGNTIKKERCIGRALKLGIRLFAVDCQAEVEKIARAAEAVDVPAGEIRVFCRILCDGVGADWPLSRKFG
CVPEMAADVLEHAHRQGLEAYGISFHVGSQQGNTEAWDGALGSAAAVFRECAERGIGLSMVNLGGGFPTKYLKAVPGVES
YGEAIFRGLTKHFGNQIPETIIEPGRGMVGNAGLIEAEVVLVSRKSADADEVRWVYLDIGKFGGLAETMDEAIRYPIRTA
RDGDATEPCVIAGPTCDSVDVLYERQLYPLPVSLSIGDKVLIEGAGAYTTTYAAVAFNGFPPLQQIVI
>Mature_387_residues
TDRIRDYLRVRRDLGQDEGPVMVLDLDVVRDNYTAFARSLPDTRVFYAVKANPAPEVLRLLAEMGSCFDTASVAEMEMVL
AAGATADRISFGNTIKKERCIGRALKLGIRLFAVDCQAEVEKIARAAEAVDVPAGEIRVFCRILCDGVGADWPLSRKFGC
VPEMAADVLEHAHRQGLEAYGISFHVGSQQGNTEAWDGALGSAAAVFRECAERGIGLSMVNLGGGFPTKYLKAVPGVESY
GEAIFRGLTKHFGNQIPETIIEPGRGMVGNAGLIEAEVVLVSRKSADADEVRWVYLDIGKFGGLAETMDEAIRYPIRTAR
DGDATEPCVIAGPTCDSVDVLYERQLYPLPVSLSIGDKVLIEGAGAYTTTYAAVAFNGFPPLQQIVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=377, Percent_Identity=30.5039787798408, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI16506287, Length=366, Percent_Identity=28.9617486338798, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI22538418, Length=375, Percent_Identity=26.4, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21361583, Length=375, Percent_Identity=26.4, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562780, Length=382, Percent_Identity=31.6753926701571, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322664, Length=402, Percent_Identity=28.8557213930348, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24586472, Length=385, Percent_Identity=29.6103896103896, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24586474, Length=401, Percent_Identity=28.1795511221945, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41888; Mature: 41757

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRIRDYLRVRRDLGQDEGPVMVLDLDVVRDNYTAFARSLPDTRVFYAVKANPAPEVLR
CCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCHHHHHHCCCCCEEEEEEECCCHHHHHH
LLAEMGSCFDTASVAEMEMVLAAGATADRISFGNTIKKERCIGRALKLGIRLFAVDCQAE
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCEEEEEECHHHH
VEKIARAAEAVDVPAGEIRVFCRILCDGVGADWPLSRKFGCVPEMAADVLEHAHRQGLEA
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
YGISFHVGSQQGNTEAWDGALGSAAAVFRECAERGIGLSMVNLGGGFPTKYLKAVPGVES
CCEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCHHH
YGEAIFRGLTKHFGNQIPETIIEPGRGMVGNAGLIEAEVVLVSRKSADADEVRWVYLDIG
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECC
KFGGLAETMDEAIRYPIRTARDGDATEPCVIAGPTCDSVDVLYERQLYPLPVSLSIGDKV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEECCCCEE
LIEGAGAYTTTYAAVAFNGFPPLQQIVI
EEECCCCHHHHEEEEEECCCCCHHHHCC
>Mature Secondary Structure 
TDRIRDYLRVRRDLGQDEGPVMVLDLDVVRDNYTAFARSLPDTRVFYAVKANPAPEVLR
CHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCHHHHHHCCCCCEEEEEEECCCHHHHHH
LLAEMGSCFDTASVAEMEMVLAAGATADRISFGNTIKKERCIGRALKLGIRLFAVDCQAE
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHCEEEEEECHHHH
VEKIARAAEAVDVPAGEIRVFCRILCDGVGADWPLSRKFGCVPEMAADVLEHAHRQGLEA
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
YGISFHVGSQQGNTEAWDGALGSAAAVFRECAERGIGLSMVNLGGGFPTKYLKAVPGVES
CCEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCHHH
YGEAIFRGLTKHFGNQIPETIIEPGRGMVGNAGLIEAEVVLVSRKSADADEVRWVYLDIG
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECC
KFGGLAETMDEAIRYPIRTARDGDATEPCVIAGPTCDSVDVLYERQLYPLPVSLSIGDKV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEECCCCEE
LIEGAGAYTTTYAAVAFNGFPPLQQIVI
EEECCCCHHHHEEEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]