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The map label for this gene is rkpK [H]

Identifier: 170750995

GI number: 170750995

Start: 4899303

End: 4900673

Strand: Direct

Name: rkpK [H]

Synonym: Mrad2831_4606

Alternate gene names: 170750995

Gene position: 4899303-4900673 (Clockwise)

Preceding gene: 170750990

Following gene: 170750996

Centisome position: 80.61

GC content: 71.92

Gene sequence:

>1371_bases
ATGAACATCACGATGGTCGGGTCGGGCTACGTCGGTCTGGTCTCCGGCGCGTGCTTTGCGGATTTCGGCCACACGGTCGT
GTGCGTCGACAGCAATCGCGGCCGGATCGACGCGCTGAATGCCGGCCGGATGCCGATCTACGAGCCGGGCCTCGAGGCCC
TCGTCGCCGAGAACGTCCGTCAGGATCGCCTGTCCTTCATCACCGACCTGGAGGCGGCGGTCGGGCAGGCGGACGCGGTG
TTCATCGCGGTGGGCACGCCCTCCCGCCGCGGCGACGGTTTCGCCGACCTGAGCTTCGTCTACGCGGCTGCCCGGAGCAT
CGCGCGCGCGCTGCGCGGCTTCACCGTGGTGGTGACCAAGTCGACCGTGCCGGTGGGCACCGGCGACGAGGTCGAGCGCA
TCATCCGCGAGACCAACCCCGGGGCGCAGTTCGCGGTCGTGTCGAACCCCGAGTTCCTGCGCGAGGGCGCGGCCATCGCC
GACTTCAAGCGCCCCGACCGCATCGTCGTCGGCACCGATGAGCCGCGGGCCGTTGCGGTCATGGAGCAGATCTACCGCCC
GCTCTACCTCAACGCCGCCCCGATCGTGGCGATGAGCCGCCGGACCGCCGAGCTGACCAAGTACGCGGCGAACGCGTTCC
TGGCGGCGAAGATCACGTTCATCAACGAGGTCGCGGACCTGTGCGAGGCGGTGGGCGCGGACGTGCAGGCGGTCGCGCGC
GGCATCGGCCTGGACAACCGGATCGGGTCGAAGTTCCTGCACGCCGGGCCGGGCTACGGCGGCTCGTGCTTCCCCAAGGA
CACGCTGGCGCTGGTCAAGACGGCGCAGGACGCCGGCACGCCGCTGCGGCTGGTCGAGACGGTGGTGGCGGTCAACGACC
AGCGCAAGCGCGCGATGGCGCGCAAGGTGATCAGGGCCTGCGGCGGGTCGGTGCGGGGCAAGACGGTGGCGCTGCTCGGC
CTGACCTTCAAGCCGAACACCGACGACATGCGCGACGCGCCCTCGCTGGCGATCGTGGCCGGCCTGCAGGATGCCGGCGC
CGTGGTCCGCGCCTACGATCCCGAGGGCATGGAGCAGGCGCGCCCGCTCCTGCCCGGCGTCGCCTTCGCGGAGGATGCCT
ATCACTGCGCCGAGGGCGCGGACGTGCTGGTCCTCGTCACCGAATGGGACGCGTTCCGGGCGCTGGACCTCGACCGGCTG
CGGGCGGTGATGCAGCGACCGGTCCTCGTGGATCTCCGCAACGTCTACCGGGCCGACGACGTCCGGGCTCACGGCTTCGC
CTACAGCAGCGTGGGCCGCCCCGCCGCGCCCGGGGACGAGGCCGAGATCCCGCCGGCTCCCCATCGCGCGGACGCCGCCG
CGACGGCGTGA

Upstream 100 bases:

>100_bases
ACGCCGGATCGGCAGAGTCGCGTACGCCTAAGATATGATGTTGGTCGCCCCGTCGGGCCGCCGTAGACCCGAGCGTCGGT
GCGCTCGCGGCGAGGACTCC

Downstream 100 bases:

>100_bases
GGCGGGGCCGACATCGGCGGATGGAAGCCCCGCAGATCCTCGGGATCGCCGACCCGGCGCGCGACCTTTCCGGCACGCGG
GATCTCCGCCCGGCCGGCGG

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MNITMVGSGYVGLVSGACFADFGHTVVCVDSNRGRIDALNAGRMPIYEPGLEALVAENVRQDRLSFITDLEAAVGQADAV
FIAVGTPSRRGDGFADLSFVYAAARSIARALRGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVVSNPEFLREGAAIA
DFKRPDRIVVGTDEPRAVAVMEQIYRPLYLNAAPIVAMSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARPLLPGVAFAEDAYHCAEGADVLVLVTEWDAFRALDLDRL
RAVMQRPVLVDLRNVYRADDVRAHGFAYSSVGRPAAPGDEAEIPPAPHRADAAATA

Sequences:

>Translated_456_residues
MNITMVGSGYVGLVSGACFADFGHTVVCVDSNRGRIDALNAGRMPIYEPGLEALVAENVRQDRLSFITDLEAAVGQADAV
FIAVGTPSRRGDGFADLSFVYAAARSIARALRGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVVSNPEFLREGAAIA
DFKRPDRIVVGTDEPRAVAVMEQIYRPLYLNAAPIVAMSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARPLLPGVAFAEDAYHCAEGADVLVLVTEWDAFRALDLDRL
RAVMQRPVLVDLRNVYRADDVRAHGFAYSSVGRPAAPGDEAEIPPAPHRADAAATA
>Mature_456_residues
MNITMVGSGYVGLVSGACFADFGHTVVCVDSNRGRIDALNAGRMPIYEPGLEALVAENVRQDRLSFITDLEAAVGQADAV
FIAVGTPSRRGDGFADLSFVYAAARSIARALRGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVVSNPEFLREGAAIA
DFKRPDRIVVGTDEPRAVAVMEQIYRPLYLNAAPIVAMSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARPLLPGVAFAEDAYHCAEGADVLVLVTEWDAFRALDLDRL
RAVMQRPVLVDLRNVYRADDVRAHGFAYSSVGRPAAPGDEAEIPPAPHRADAAATA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=474, Percent_Identity=37.9746835443038, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI296040438, Length=376, Percent_Identity=37.5, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI296040443, Length=470, Percent_Identity=32.9787234042553, Blast_Score=234, Evalue=2e-61,
Organism=Escherichia coli, GI48994968, Length=437, Percent_Identity=29.5194508009153, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=28.9325842696629, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=36.4425162689805, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=36.4425162689805, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48426; Mature: 48426

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITMVGSGYVGLVSGACFADFGHTVVCVDSNRGRIDALNAGRMPIYEPGLEALVAENVR
CEEEEEECCCHHHHCCHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHH
QDRLSFITDLEAAVGQADAVFIAVGTPSRRGDGFADLSFVYAAARSIARALRGFTVVVTK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPGAQFAVVSNPEFLREGAAIADFKRPDRIVVGTDEPRAVAV
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHH
MEQIYRPLYLNAAPIVAMSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMA
HCCCCCHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
RKVIRACGGSVRGKTVALLGLTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
RPLLPGVAFAEDAYHCAEGADVLVLVTEWDAFRALDLDRLRAVMQRPVLVDLRNVYRADD
HHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHCCHHHHHHHHHCCHHEEHHHHHHCCC
VRAHGFAYSSVGRPAAPGDEAEIPPAPHRADAAATA
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNITMVGSGYVGLVSGACFADFGHTVVCVDSNRGRIDALNAGRMPIYEPGLEALVAENVR
CEEEEEECCCHHHHCCHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHH
QDRLSFITDLEAAVGQADAVFIAVGTPSRRGDGFADLSFVYAAARSIARALRGFTVVVTK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPGAQFAVVSNPEFLREGAAIADFKRPDRIVVGTDEPRAVAV
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHH
MEQIYRPLYLNAAPIVAMSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMA
HCCCCCHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
RKVIRACGGSVRGKTVALLGLTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
RPLLPGVAFAEDAYHCAEGADVLVLVTEWDAFRALDLDRLRAVMQRPVLVDLRNVYRADD
HHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHCCHHHHHHHHHCCHHEEHHHHHHCCC
VRAHGFAYSSVGRPAAPGDEAEIPPAPHRADAAATA
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]