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The map label for this gene is fumC [H]

Identifier: 170750910

GI number: 170750910

Start: 4797829

End: 4799238

Strand: Reverse

Name: fumC [H]

Synonym: Mrad2831_4521

Alternate gene names: 170750910

Gene position: 4799238-4797829 (Counterclockwise)

Preceding gene: 170750912

Following gene: 170750909

Centisome position: 78.96

GC content: 70.0

Gene sequence:

>1410_bases
ATGTCGCCCACCGAGACCGCCACCCGCACCGAGTCCGACACCTTCGGTCCGATCGAGGTCCCGGCGCATCGCTACTGGGG
CGCGCAGACGCAGCGCTCGATCCAGAACTTCAAGATCGGCACCGACCGGATGCCGGCGCCGCTCGTCCACGCCCTCGGTG
TGGTGAAGCAGGCCGCCGCCCTGGTGAACAAGGATCTCGGCGCCCTCGACCCGAAGCTCGCCGACGCCATCGCGGCCTCG
GCCGCCGAGGTCGTGGAGGGCCGCTACGACGACGAGTTCCCGCTCGTCATCTATCAGACCGGCTCGGGCACCCAGTCGAA
CATGAACGCCAACGAGGTGATCGCGAGCCTCGCCAACGAGCGGCTCGGCGGCCAGCGCGGCGGCAAGTCGCCGGTCCACC
CGAACGACCATTGCAACCGCGGCCAGTCCTCGAACGACACCTTCCCCACCGCCATGCACATCGCGGTGGCCCGCGAGATC
CAGGGGCGCCTGCTGCCGGCGCTCTCCCACCTGCACGGGGCGCTCGACGCCAAGGCCAAGGAATTCGAGTCGATCGTCAA
GATCGGCCGCACCCATCTGCAGGATGCGACCCCGGTCTCCCTCGGCCAGGAATTCTCCGGCTACGTCGCGCAGGTCGCGC
TCGGCGGCTCGCGGGTCGCCGCGACCCTGCCGGGCGTGCTGGCCCTCGCCCAAGGCGGGACCGCGGTCGGCACCGGCCTC
AACGCCCACCCGGAATTCGCCGAGCGCTTCGCCGCCAAGGTCGCCGAGCTGACCGGCCTGCCCTTCACCTCGGCCGAGAA
CAAGTTCGAGGCGCTCGCCACCCACGACGCCCTCGTCTTCACGCAGGGCGCCCTGTCGGCGCTCGCCGCCGGCCTGTTCA
AGATCGCCCAGGACATCCGCTTCCTCGGCTCGGGGCCGCGCTCCGGCCTCGGCGAGCTGTCGCTGCCCGAGAACGAGCCC
GGCTCCTCGATCATGCCCGGCAAGGTCAACCCGACCCAGTGCGAGGCCCTGACGATGGTCTGCGCCCAGGTGATCGGCAA
CGGCACCACGGTGAGCTTCGCCGGCTCCCAGGGCAATTTCGAGCTCAACGTGTTCAAGCCGGTGATCGCCAACGCGGTGC
TGCAGTCGGTGCGGCTGCTCGCCGACGCGGCGGTGAGCTTCACCGACAATTGCGTCGTCGGCATCAAGGCCAACGAGGAC
AAGATCGCCGACCTGATGAGCCGCTCGCTCATGCTGGTGACCGCCCTCGCGCCCTCGATCGGCTACGACAAGGCCGCCGA
GATCGCCAAGACCGCGCACAAGAACGGCACCACCCTCAAGGAGGAGGCCCTGCGCCTCGGCTACGTCACCGAGGAGGAGT
TCGCGCGCGTGGTCCGGCCGGAGACCATGCTGGCGCCGAGCGCCGACTGA

Upstream 100 bases:

>100_bases
CAGAGCCCCGCCCTTGTCGGCGCGCCGGGAAAACCGGCATCGCGATTCACCCGCACCTCATTTAAGTAGGCACCGCACTG
CACCAGACGTAGAGGCCACG

Downstream 100 bases:

>100_bases
TTCTTCCGAGACTCGCCGGCGCGGTCCGCCCGCGCCGGCCGCGGGACACCGGGAGGCGATCCATGGCCGAGATCATCAAC
CTGCGTCAGGTCCGCAAGGC

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSPTETATRTESDTFGPIEVPAHRYWGAQTQRSIQNFKIGTDRMPAPLVHALGVVKQAAALVNKDLGALDPKLADAIAAS
AAEVVEGRYDDEFPLVIYQTGSGTQSNMNANEVIASLANERLGGQRGGKSPVHPNDHCNRGQSSNDTFPTAMHIAVAREI
QGRLLPALSHLHGALDAKAKEFESIVKIGRTHLQDATPVSLGQEFSGYVAQVALGGSRVAATLPGVLALAQGGTAVGTGL
NAHPEFAERFAAKVAELTGLPFTSAENKFEALATHDALVFTQGALSALAAGLFKIAQDIRFLGSGPRSGLGELSLPENEP
GSSIMPGKVNPTQCEALTMVCAQVIGNGTTVSFAGSQGNFELNVFKPVIANAVLQSVRLLADAAVSFTDNCVVGIKANED
KIADLMSRSLMLVTALAPSIGYDKAAEIAKTAHKNGTTLKEEALRLGYVTEEEFARVVRPETMLAPSAD

Sequences:

>Translated_469_residues
MSPTETATRTESDTFGPIEVPAHRYWGAQTQRSIQNFKIGTDRMPAPLVHALGVVKQAAALVNKDLGALDPKLADAIAAS
AAEVVEGRYDDEFPLVIYQTGSGTQSNMNANEVIASLANERLGGQRGGKSPVHPNDHCNRGQSSNDTFPTAMHIAVAREI
QGRLLPALSHLHGALDAKAKEFESIVKIGRTHLQDATPVSLGQEFSGYVAQVALGGSRVAATLPGVLALAQGGTAVGTGL
NAHPEFAERFAAKVAELTGLPFTSAENKFEALATHDALVFTQGALSALAAGLFKIAQDIRFLGSGPRSGLGELSLPENEP
GSSIMPGKVNPTQCEALTMVCAQVIGNGTTVSFAGSQGNFELNVFKPVIANAVLQSVRLLADAAVSFTDNCVVGIKANED
KIADLMSRSLMLVTALAPSIGYDKAAEIAKTAHKNGTTLKEEALRLGYVTEEEFARVVRPETMLAPSAD
>Mature_468_residues
SPTETATRTESDTFGPIEVPAHRYWGAQTQRSIQNFKIGTDRMPAPLVHALGVVKQAAALVNKDLGALDPKLADAIAASA
AEVVEGRYDDEFPLVIYQTGSGTQSNMNANEVIASLANERLGGQRGGKSPVHPNDHCNRGQSSNDTFPTAMHIAVAREIQ
GRLLPALSHLHGALDAKAKEFESIVKIGRTHLQDATPVSLGQEFSGYVAQVALGGSRVAATLPGVLALAQGGTAVGTGLN
AHPEFAERFAAKVAELTGLPFTSAENKFEALATHDALVFTQGALSALAAGLFKIAQDIRFLGSGPRSGLGELSLPENEPG
SSIMPGKVNPTQCEALTMVCAQVIGNGTTVSFAGSQGNFELNVFKPVIANAVLQSVRLLADAAVSFTDNCVVGIKANEDK
IADLMSRSLMLVTALAPSIGYDKAAEIAKTAHKNGTTLKEEALRLGYVTEEEFARVVRPETMLAPSAD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=465, Percent_Identity=65.3763440860215, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=54.2372881355932, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=59.8684210526316, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=39.8268398268398, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=67.6086956521739, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=69.5384615384615, Blast_Score=456, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=64.7948164146868, Blast_Score=611, Evalue=1e-176,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=64.8590021691974, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=64.8590021691974, Blast_Score=611, Evalue=1e-175,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=60.1731601731602, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24662684, Length=470, Percent_Identity=60.4255319148936, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=51.8358531317495, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49218; Mature: 49087

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTETATRTESDTFGPIEVPAHRYWGAQTQRSIQNFKIGTDRMPAPLVHALGVVKQAAA
CCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVNKDLGALDPKLADAIAASAAEVVEGRYDDEFPLVIYQTGSGTQSNMNANEVIASLANE
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
RLGGQRGGKSPVHPNDHCNRGQSSNDTFPTAMHIAVAREIQGRLLPALSHLHGALDAKAK
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFESIVKIGRTHLQDATPVSLGQEFSGYVAQVALGGSRVAATLPGVLALAQGGTAVGTGL
HHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
NAHPEFAERFAAKVAELTGLPFTSAENKFEALATHDALVFTQGALSALAAGLFKIAQDIR
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHH
FLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTMVCAQVIGNGTTVSFAGSQGNF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCE
ELNVFKPVIANAVLQSVRLLADAAVSFTDNCVVGIKANEDKIADLMSRSLMLVTALAPSI
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
GYDKAAEIAKTAHKNGTTLKEEALRLGYVTEEEFARVVRPETMLAPSAD
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SPTETATRTESDTFGPIEVPAHRYWGAQTQRSIQNFKIGTDRMPAPLVHALGVVKQAAA
CCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVNKDLGALDPKLADAIAASAAEVVEGRYDDEFPLVIYQTGSGTQSNMNANEVIASLANE
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
RLGGQRGGKSPVHPNDHCNRGQSSNDTFPTAMHIAVAREIQGRLLPALSHLHGALDAKAK
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFESIVKIGRTHLQDATPVSLGQEFSGYVAQVALGGSRVAATLPGVLALAQGGTAVGTGL
HHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
NAHPEFAERFAAKVAELTGLPFTSAENKFEALATHDALVFTQGALSALAAGLFKIAQDIR
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHH
FLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTMVCAQVIGNGTTVSFAGSQGNF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCE
ELNVFKPVIANAVLQSVRLLADAAVSFTDNCVVGIKANEDKIADLMSRSLMLVTALAPSI
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
GYDKAAEIAKTAHKNGTTLKEEALRLGYVTEEEFARVVRPETMLAPSAD
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA