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The map label for this gene is msrA [H]

Identifier: 170750901

GI number: 170750901

Start: 4791900

End: 4792556

Strand: Direct

Name: msrA [H]

Synonym: Mrad2831_4512

Alternate gene names: 170750901

Gene position: 4791900-4792556 (Clockwise)

Preceding gene: 170750899

Following gene: 170750904

Centisome position: 78.84

GC content: 71.84

Gene sequence:

>657_bases
ATGTTCCTGTTTCGCAAGCGTCCCGCGATGCCGGCCCCGGCCGACGCCCTGCCCGGACGCCCGACCCCGATCCCGACCGC
CGAGACGCATGTCGTCAACGGCAACCCGCTCAAGGGTCCCTATCCGCCGGGCACCGGGACGATCGTGCTCGGGCTCGGCT
GCTTCTGGGGCGCCGAGCGTCGGTTCTGGCAGCTGCCCGAGGGGGTGTTCGTGACGGCCGTCGGCTACGCCGGCGGCTAC
ACCCCGAACCCGACCTACGAGGAGGTCTGCACCGGCCGGACCGGCCACAACGAGGTGGTGCTGGTCGCCTTCGATCCGGC
GGTTCTGCCCCTGGAGGCGGTGGTGCGGACCTTCTTCGAGAGTCACGACCCGACGCAGGGGATGCGCCAGGGCAACGATG
TCGGCACGCAGTACCGCTCGGGCATCTACACCGTCGGCCCCGACCAGGACGCCGCGGCCCGGTCCGTGCGCGCCGCCTAC
GCGGAGGCGCTCAAGGCGCGCGGCTTTCCCGACGTCACCACGGAGATCCGGCCGCTGGAGCAGTTCTACTTCGCGGAGGC
CTACCACCAGCAGTACCTGGCGAAGAACCCGGCCGGCTATTGCGGCCTGGGCGGCACCGGCGTCAGCTGCCCGGTGGGAG
CCGGCGTCGCCGCCTGA

Upstream 100 bases:

>100_bases
AGTCTCGCGGCTCGATTTAGGGCGGCCGGAGCGCCGAACGCTTTCCCGGCGGTCCCGGCCGTTCCATATCGGGCGGAGCC
CGAGACCGGAAGGCGAGCCG

Downstream 100 bases:

>100_bases
GCCTCACGGGTTCCGGCTGTCGGGCCGCGTCTGCGGGCCCGGCACCGGGGCGCCGGCGGCGCTGCCCCGCAGGGGCGGGG
TGCTGTTCGGGCTGCGCAGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFLFRKRPAMPAPADALPGRPTPIPTAETHVVNGNPLKGPYPPGTGTIVLGLGCFWGAERRFWQLPEGVFVTAVGYAGGY
TPNPTYEEVCTGRTGHNEVVLVAFDPAVLPLEAVVRTFFESHDPTQGMRQGNDVGTQYRSGIYTVGPDQDAAARSVRAAY
AEALKARGFPDVTTEIRPLEQFYFAEAYHQQYLAKNPAGYCGLGGTGVSCPVGAGVAA

Sequences:

>Translated_218_residues
MFLFRKRPAMPAPADALPGRPTPIPTAETHVVNGNPLKGPYPPGTGTIVLGLGCFWGAERRFWQLPEGVFVTAVGYAGGY
TPNPTYEEVCTGRTGHNEVVLVAFDPAVLPLEAVVRTFFESHDPTQGMRQGNDVGTQYRSGIYTVGPDQDAAARSVRAAY
AEALKARGFPDVTTEIRPLEQFYFAEAYHQQYLAKNPAGYCGLGGTGVSCPVGAGVAA
>Mature_218_residues
MFLFRKRPAMPAPADALPGRPTPIPTAETHVVNGNPLKGPYPPGTGTIVLGLGCFWGAERRFWQLPEGVFVTAVGYAGGY
TPNPTYEEVCTGRTGHNEVVLVAFDPAVLPLEAVVRTFFESHDPTQGMRQGNDVGTQYRSGIYTVGPDQDAAARSVRAAY
AEALKARGFPDVTTEIRPLEQFYFAEAYHQQYLAKNPAGYCGLGGTGVSCPVGAGVAA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=202, Percent_Identity=58.4158415841584, Blast_Score=250, Evalue=8e-67,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=59.7826086956522, Blast_Score=233, Evalue=7e-62,
Organism=Homo sapiens, GI208609993, Length=202, Percent_Identity=44.0594059405941, Blast_Score=165, Evalue=2e-41,
Organism=Escherichia coli, GI1790665, Length=198, Percent_Identity=55.5555555555556, Blast_Score=216, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=37.9310344827586, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=37.9518072289157, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=36.0544217687075, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=36.1702127659575, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=35.3741496598639, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23265; Mature: 23265

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLFRKRPAMPAPADALPGRPTPIPTAETHVVNGNPLKGPYPPGTGTIVLGLGCFWGAER
CCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECHHHHCCCC
RFWQLPEGVFVTAVGYAGGYTPNPTYEEVCTGRTGHNEVVLVAFDPAVLPLEAVVRTFFE
CEEECCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
SHDPTQGMRQGNDVGTQYRSGIYTVGPDQDAAARSVRAAYAEALKARGFPDVTTEIRPLE
CCCCHHHHHCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QFYFAEAYHQQYLAKNPAGYCGLGGTGVSCPVGAGVAA
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFLFRKRPAMPAPADALPGRPTPIPTAETHVVNGNPLKGPYPPGTGTIVLGLGCFWGAER
CCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECHHHHCCCC
RFWQLPEGVFVTAVGYAGGYTPNPTYEEVCTGRTGHNEVVLVAFDPAVLPLEAVVRTFFE
CEEECCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
SHDPTQGMRQGNDVGTQYRSGIYTVGPDQDAAARSVRAAYAEALKARGFPDVTTEIRPLE
CCCCHHHHHCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QFYFAEAYHQQYLAKNPAGYCGLGGTGVSCPVGAGVAA
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA