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The map label for this gene is actR [H]

Identifier: 170750752

GI number: 170750752

Start: 4625791

End: 4626390

Strand: Reverse

Name: actR [H]

Synonym: Mrad2831_4363

Alternate gene names: 170750752

Gene position: 4626390-4625791 (Counterclockwise)

Preceding gene: 170750753

Following gene: 170750751

Centisome position: 76.12

GC content: 72.67

Gene sequence:

>600_bases
ATGCTCACGCAGCCCGGGACCTCGGCGGCGACAGACCCCGCCGTGATCAACGATGCCGATCCACTGGCCGCCTTCTCCGA
CCGCAGCCTGCTGATCGTCGACGACGACAAGCCCTTCCAGACCCGCCTCGCCCGCGCCATGGAGAGCCGCGGCTATCACG
TGCAGGTGGCCGACAGCGTCGCGGACGGCGTCTCCGCCGTCGAGGCGCGCGCGCCCGCGTTCGCGGTGATCGACATGCGC
CTCGGCGACGGCAACGGCCTCGACGTGATCGCCCGCCTCAAGGAGCGCCGCCCCGAGGCCCGGGGCGTGATCCTCACCGG
CTACGGCAACATCGCCACGGCGGTGACCGCGGTGAAGCTCGGCGCCTTCGACTACCTCGCCAAGCCGGCCGACGCCGACG
AGATCCACGGCACGCTGATGGCGCAGCCGGGCGAGCGGGCCGACCCGCCCGAGAACCCGATGTCGGCCGACCGGGTCCGC
TGGGAGCACATCCAGCGCGTCTACGAGCTGTGCAGCCGCAACGTCAGCGAGACCGCCCGGCGCCTCAACATGCACCGGCG
GACCCTGCAGCGGATCCTGGCCAAGCGCGCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CCGGAACTCAGTATCCGCGCCCCCCTGCCACCGCGCGACGCCGTACCTATATGAAGGACAGACCAAGAACCCGACGACGT
AAACCCGAAAGGAGTGCCGG

Downstream 100 bases:

>100_bases
GGCCGGACCGCTCCGGCGCCGCCCGGTCGGTTGCATCGCCCCGCCTCTGTGGGCTAGCTGCGCGGGTCCCGGACGGTTCG
TCCGGGGCCCGAAATCTTTT

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLTQPGTSAATDPAVINDADPLAAFSDRSLLIVDDDKPFQTRLARAMESRGYHVQVADSVADGVSAVEARAPAFAVIDMR
LGDGNGLDVIARLKERRPEARGVILTGYGNIATAVTAVKLGAFDYLAKPADADEIHGTLMAQPGERADPPENPMSADRVR
WEHIQRVYELCSRNVSETARRLNMHRRTLQRILAKRAPR

Sequences:

>Translated_199_residues
MLTQPGTSAATDPAVINDADPLAAFSDRSLLIVDDDKPFQTRLARAMESRGYHVQVADSVADGVSAVEARAPAFAVIDMR
LGDGNGLDVIARLKERRPEARGVILTGYGNIATAVTAVKLGAFDYLAKPADADEIHGTLMAQPGERADPPENPMSADRVR
WEHIQRVYELCSRNVSETARRLNMHRRTLQRILAKRAPR
>Mature_199_residues
MLTQPGTSAATDPAVINDADPLAAFSDRSLLIVDDDKPFQTRLARAMESRGYHVQVADSVADGVSAVEARAPAFAVIDMR
LGDGNGLDVIARLKERRPEARGVILTGYGNIATAVTAVKLGAFDYLAKPADADEIHGTLMAQPGERADPPENPMSADRVR
WEHIQRVYELCSRNVSETARRLNMHRRTLQRILAKRAPR

Specific function: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response [H]

COG id: COG4567

COG function: function code TK; Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=33.6363636363636, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790299, Length=105, Percent_Identity=32.3809523809524, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788905, Length=107, Percent_Identity=32.7102803738318, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=27.1028037383178, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21756; Mature: 21756

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQPGTSAATDPAVINDADPLAAFSDRSLLIVDDDKPFQTRLARAMESRGYHVQVADSV
CCCCCCCCCCCCCCEECCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHH
ADGVSAVEARAPAFAVIDMRLGDGNGLDVIARLKERRPEARGVILTGYGNIATAVTAVKL
HHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
GAFDYLAKPADADEIHGTLMAQPGERADPPENPMSADRVRWEHIQRVYELCSRNVSETAR
HHHHHHCCCCCHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RLNMHRRTLQRILAKRAPR
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTQPGTSAATDPAVINDADPLAAFSDRSLLIVDDDKPFQTRLARAMESRGYHVQVADSV
CCCCCCCCCCCCCCEECCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHH
ADGVSAVEARAPAFAVIDMRLGDGNGLDVIARLKERRPEARGVILTGYGNIATAVTAVKL
HHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
GAFDYLAKPADADEIHGTLMAQPGERADPPENPMSADRVRWEHIQRVYELCSRNVSETAR
HHHHHHCCCCCHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RLNMHRRTLQRILAKRAPR
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]