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The map label for this gene is zwf [H]

Identifier: 170750704

GI number: 170750704

Start: 4563925

End: 4565451

Strand: Reverse

Name: zwf [H]

Synonym: Mrad2831_4314

Alternate gene names: 170750704

Gene position: 4565451-4563925 (Counterclockwise)

Preceding gene: 170750705

Following gene: 170750700

Centisome position: 75.12

GC content: 68.43

Gene sequence:

>1527_bases
ATGGCCGAGCCGACGACAGCCCTCAAGGACACGGCAGCTTGCGGCACGCAGCCGGCGCCGCCCTGCACGCTGGTGATCTT
CGGGGCCGGCGGCGACCTGACCAAGCGCCTGCTGATGCCCTCGCTCTACAACCTCGCGGGGGCGGGCCTCCTGTCCGAGG
GCTTCTCGATCCTCGGCATCGATCACAATGACGGTACCGACGAGTCGCTCCGCGAGAATCTCACCCAGACCCTGGAGGCG
TTCAGCAAGGACCCGACCTCGGAGTTCCACGCCGACCACATCGACCCGAAGAGCTGGGATTTCATCCGGGACCGGCTCCA
CTACCTGAAGGGCGATTTCGAGAAGCCCGAGACCTACGCGGCCGTGAAGCAGCGGGTCACCGGCAGCGCGGTGTTCTACT
GCGCGGTGGCGGCGCGCTTCTTCGGGACGATCGTGGACGGGCTCGGGCAGGCCGGCCTGCTGAAGCAGGAGGGCGGAACG
TTCCGCCGCGTCGTCATCGAGAAGCCGTTCGGCTCCGATCTGGCCTCGGCCCGGGAGCTGAACGCCCGCATCCTCCGCCA
GGGCGACGAGAGCCAGTTCTACCGGATCGACCACTTCCTGGGTAAGGAGACCGTTCAGTCGATCATGGCGTTCCGCTTCG
CCAACGGCCTGCTGGAGCCGGTCTGGCGGCGGGAATACATCGACAGCATCCAGATCACGGCGGCCGAGACCGTCGGCGTC
GAGGAGCGGGGCGGCTTCTACGAGCCGACCGGGGCGCTGCGCGACATGGTGCCGAACCACATGTTCCAGCTGCTCTGCAT
GGTCGCCATGGAGCCGCCGAACTCCTTCGACGCGGAGGCCGTGCGCACCGAGAAGGCCAAGCTCGCCGAGGCCGTGAAGC
CGATCCCGCCGGAGGACGCGGTGCGCGGCCAGTACACGGCCGGCACCTCGGAGGGGCGCGACGTGCCCGCCTACCGGGAC
GAGCCGCACGTCGCGAAGGATTCGGTCACCGAGACCTACATCGCCCTGAAGCTCAACATCGAGAACTGGCGCTGGGCCGG
GGTGCCGTTCTACGTCCGCACCGGCAAGCGCATGACCGGGCGACGCACCGAGATCGCCGTGCTGTTCAAGCCGGCGCCGT
TCAAGATGTTCGAGGACACGCCCACGGCCGACCTCGGGCCCACCGTGATGCGGATCCAGATCGATCCCGATCACGGGGTC
GGCACCGAGTTCAACGTCAAGGTGCCGGGGCCGCAGATGAAGATCGGCCGGGTGCGCTCCGGCTTCCGCTACAAGGACTT
CTTCGCCGACCGGCCGAATGTCGGCTACGAGACGCTGCTCTACGATTGCATGACCGGCGACGCGACGCTGTTCCAGCGCG
CCGACAACATCGAGGCCGGCTGGGCGGCGGTCGATCCCCTGCTCAAGGGCTGGCCGCAGGCGGAGGTGACATTCTATCCC
GCGGGCAGCGCCGGCCCGACGGAGGCCGACGCTCTGCTCGCCCGCGACGGCCGCCACTGGCTAGGACTGGACGGCGAGAC
CGACTGA

Upstream 100 bases:

>100_bases
CTAGACTCGGCGCGGCATAGCCCGAGGGGCACCGGAACGGGCCCCGCCGCGGCGGGTTGTCAGGCCGGTTTGCTGCACCG
CAGTCACACGGGAGTCAGGG

Downstream 100 bases:

>100_bases
GCGGGTCCGATCCGGAGCGCGCGAACGCCGCTCAGGGCCGCCGCCAGGATCTCCGCGCGGTTGCCGGTGGTGCGGGCTTC
GCCCCCTGAGAGCGCCACGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MAEPTTALKDTAACGTQPAPPCTLVIFGAGGDLTKRLLMPSLYNLAGAGLLSEGFSILGIDHNDGTDESLRENLTQTLEA
FSKDPTSEFHADHIDPKSWDFIRDRLHYLKGDFEKPETYAAVKQRVTGSAVFYCAVAARFFGTIVDGLGQAGLLKQEGGT
FRRVVIEKPFGSDLASARELNARILRQGDESQFYRIDHFLGKETVQSIMAFRFANGLLEPVWRREYIDSIQITAAETVGV
EERGGFYEPTGALRDMVPNHMFQLLCMVAMEPPNSFDAEAVRTEKAKLAEAVKPIPPEDAVRGQYTAGTSEGRDVPAYRD
EPHVAKDSVTETYIALKLNIENWRWAGVPFYVRTGKRMTGRRTEIAVLFKPAPFKMFEDTPTADLGPTVMRIQIDPDHGV
GTEFNVKVPGPQMKIGRVRSGFRYKDFFADRPNVGYETLLYDCMTGDATLFQRADNIEAGWAAVDPLLKGWPQAEVTFYP
AGSAGPTEADALLARDGRHWLGLDGETD

Sequences:

>Translated_508_residues
MAEPTTALKDTAACGTQPAPPCTLVIFGAGGDLTKRLLMPSLYNLAGAGLLSEGFSILGIDHNDGTDESLRENLTQTLEA
FSKDPTSEFHADHIDPKSWDFIRDRLHYLKGDFEKPETYAAVKQRVTGSAVFYCAVAARFFGTIVDGLGQAGLLKQEGGT
FRRVVIEKPFGSDLASARELNARILRQGDESQFYRIDHFLGKETVQSIMAFRFANGLLEPVWRREYIDSIQITAAETVGV
EERGGFYEPTGALRDMVPNHMFQLLCMVAMEPPNSFDAEAVRTEKAKLAEAVKPIPPEDAVRGQYTAGTSEGRDVPAYRD
EPHVAKDSVTETYIALKLNIENWRWAGVPFYVRTGKRMTGRRTEIAVLFKPAPFKMFEDTPTADLGPTVMRIQIDPDHGV
GTEFNVKVPGPQMKIGRVRSGFRYKDFFADRPNVGYETLLYDCMTGDATLFQRADNIEAGWAAVDPLLKGWPQAEVTFYP
AGSAGPTEADALLARDGRHWLGLDGETD
>Mature_507_residues
AEPTTALKDTAACGTQPAPPCTLVIFGAGGDLTKRLLMPSLYNLAGAGLLSEGFSILGIDHNDGTDESLRENLTQTLEAF
SKDPTSEFHADHIDPKSWDFIRDRLHYLKGDFEKPETYAAVKQRVTGSAVFYCAVAARFFGTIVDGLGQAGLLKQEGGTF
RRVVIEKPFGSDLASARELNARILRQGDESQFYRIDHFLGKETVQSIMAFRFANGLLEPVWRREYIDSIQITAAETVGVE
ERGGFYEPTGALRDMVPNHMFQLLCMVAMEPPNSFDAEAVRTEKAKLAEAVKPIPPEDAVRGQYTAGTSEGRDVPAYRDE
PHVAKDSVTETYIALKLNIENWRWAGVPFYVRTGKRMTGRRTEIAVLFKPAPFKMFEDTPTADLGPTVMRIQIDPDHGVG
TEFNVKVPGPQMKIGRVRSGFRYKDFFADRPNVGYETLLYDCMTGDATLFQRADNIEAGWAAVDPLLKGWPQAEVTFYPA
GSAGPTEADALLARDGRHWLGLDGETD

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=530, Percent_Identity=32.0754716981132, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI108773793, Length=530, Percent_Identity=32.0754716981132, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI52145310, Length=493, Percent_Identity=28.1947261663286, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1788158, Length=500, Percent_Identity=38.6, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17538218, Length=508, Percent_Identity=31.2992125984252, Blast_Score=261, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=35.1239669421488, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=32.1649484536082, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=32.1649484536082, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=26.0330578512397, Blast_Score=178, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56152; Mature: 56021

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPTTALKDTAACGTQPAPPCTLVIFGAGGDLTKRLLMPSLYNLAGAGLLSEGFSILGI
CCCCCCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEEE
DHNDGTDESLRENLTQTLEAFSKDPTSEFHADHIDPKSWDFIRDRLHYLKGDFEKPETYA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AVKQRVTGSAVFYCAVAARFFGTIVDGLGQAGLLKQEGGTFRRVVIEKPFGSDLASAREL
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHH
NARILRQGDESQFYRIDHFLGKETVQSIMAFRFANGLLEPVWRREYIDSIQITAAETVGV
HHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCC
EERGGFYEPTGALRDMVPNHMFQLLCMVAMEPPNSFDAEAVRTEKAKLAEAVKPIPPEDA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
VRGQYTAGTSEGRDVPAYRDEPHVAKDSVTETYIALKLNIENWRWAGVPFYVRTGKRMTG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEECCCCEEEECCCCCCC
RRTEIAVLFKPAPFKMFEDTPTADLGPTVMRIQIDPDHGVGTEFNVKVPGPQMKIGRVRS
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHC
GFRYKDFFADRPNVGYETLLYDCMTGDATLFQRADNIEAGWAAVDPLLKGWPQAEVTFYP
CCCHHHHCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEE
AGSAGPTEADALLARDGRHWLGLDGETD
CCCCCCCHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
AEPTTALKDTAACGTQPAPPCTLVIFGAGGDLTKRLLMPSLYNLAGAGLLSEGFSILGI
CCCCCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEEE
DHNDGTDESLRENLTQTLEAFSKDPTSEFHADHIDPKSWDFIRDRLHYLKGDFEKPETYA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AVKQRVTGSAVFYCAVAARFFGTIVDGLGQAGLLKQEGGTFRRVVIEKPFGSDLASAREL
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHH
NARILRQGDESQFYRIDHFLGKETVQSIMAFRFANGLLEPVWRREYIDSIQITAAETVGV
HHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCC
EERGGFYEPTGALRDMVPNHMFQLLCMVAMEPPNSFDAEAVRTEKAKLAEAVKPIPPEDA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
VRGQYTAGTSEGRDVPAYRDEPHVAKDSVTETYIALKLNIENWRWAGVPFYVRTGKRMTG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEECCCCEEEECCCCCCC
RRTEIAVLFKPAPFKMFEDTPTADLGPTVMRIQIDPDHGVGTEFNVKVPGPQMKIGRVRS
CCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHC
GFRYKDFFADRPNVGYETLLYDCMTGDATLFQRADNIEAGWAAVDPLLKGWPQAEVTFYP
CCCHHHHCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEE
AGSAGPTEADALLARDGRHWLGLDGETD
CCCCCCCHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]