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The map label for this gene is cynR [H]

Identifier: 170750445

GI number: 170750445

Start: 4295869

End: 4296795

Strand: Direct

Name: cynR [H]

Synonym: Mrad2831_4050

Alternate gene names: 170750445

Gene position: 4295869-4296795 (Clockwise)

Preceding gene: 170750440

Following gene: 170750447

Centisome position: 70.68

GC content: 74.33

Gene sequence:

>927_bases
ATGGATCTCAACCTGCGGCAGGTGCGGGCCTTCGTGTCGGTCGTCCAGGCCGGCAGCTTCACCCGGGCCGCCGCCCTGCT
GAACCTGTCGCAGCCCGCCCTGACGGTTCAGATCCGGCGCCTGGAGGAGACGCTCGACGCGCGGCTCCTCGACCGGACCA
GCCGCACCGTCGCGCCGACGCGGCTCGGCCGCGACCTGCTGCCCGTGTTCCAGCGCGTGCTGCGCGACCTCGACGCGGTG
GTGGTCGACACCCGCGACCTCGCGGCAAGGCGCCACGGGGTCGTGCGCGTCGCGACGCTGCCGTCCTTCGCGGCGAGCGT
GCTGTCCGACGCGATCGTCCGCTTCCGCGCCGAGCACCCCGCCGTGACCTTCCGGATCAAGGACGTCATCGCGCAGCGGG
TGCTCGACCTCGTGCGCGGCGAGGAGGCGGATCTCGGCATCGTCGGCGGCGACGTCCGCGATCCGGAGATCGGCGTCCTG
CACCGGACGCGCGACGCCCTGCACGTGATCTATCCCGCCGATCACCCGATCGGCGCGCTGCCCCGGGTCACGATCGCGGC
GCTCGCCGAGCACCCCCTGATCCTGATGGATCCGGCCACGAGCGTGCGGGCGGTCGTCGACCGCGCCTTCATCGGCTCGG
GCCGGCTGCCCCGCGTGGCCTGCGAGGCCACCTACATGATGACCGCGGTCAGCATGGTCCGGGCCGGCCTCGGCCTGACG
ATCCTCCCGGGCGCGGCGCGGGAGATCCGGGCCGAGCCCCTGCTCCGCTCGCGGGCGATCGACGACCCGCTGTTCGAGCG
TCCGGTCTGCCTGATCAAGAAGGCGGGGCGGACGATGCCGCCGGCCGCCGAGGCGTTCTGCCGGATGGTGGCGGACCGGC
TCGCGGATCCGGGCGGGACAGACGCCGGCGCCGCGCCGAGCCCCTGA

Upstream 100 bases:

>100_bases
CGCCGGCGCGGTTCGAATCCGCGCCTGTATCGGGTCAGGAGACGGCGGAACACTTCATGACACAATTGAAAAGATCGGAT
CGCAGCGATAGCCTGAGTTT

Downstream 100 bases:

>100_bases
GCGGCGGTCGGATCCTCAGGCCCGGTGCCGCACGACGCCGTCCATCATGGTCAGGACGACCGCGGTCCGGTGGATCTCGT
GCGGATCGATCGCGAGGATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDLNLRQVRAFVSVVQAGSFTRAAALLNLSQPALTVQIRRLEETLDARLLDRTSRTVAPTRLGRDLLPVFQRVLRDLDAV
VVDTRDLAARRHGVVRVATLPSFAASVLSDAIVRFRAEHPAVTFRIKDVIAQRVLDLVRGEEADLGIVGGDVRDPEIGVL
HRTRDALHVIYPADHPIGALPRVTIAALAEHPLILMDPATSVRAVVDRAFIGSGRLPRVACEATYMMTAVSMVRAGLGLT
ILPGAAREIRAEPLLRSRAIDDPLFERPVCLIKKAGRTMPPAAEAFCRMVADRLADPGGTDAGAAPSP

Sequences:

>Translated_308_residues
MDLNLRQVRAFVSVVQAGSFTRAAALLNLSQPALTVQIRRLEETLDARLLDRTSRTVAPTRLGRDLLPVFQRVLRDLDAV
VVDTRDLAARRHGVVRVATLPSFAASVLSDAIVRFRAEHPAVTFRIKDVIAQRVLDLVRGEEADLGIVGGDVRDPEIGVL
HRTRDALHVIYPADHPIGALPRVTIAALAEHPLILMDPATSVRAVVDRAFIGSGRLPRVACEATYMMTAVSMVRAGLGLT
ILPGAAREIRAEPLLRSRAIDDPLFERPVCLIKKAGRTMPPAAEAFCRMVADRLADPGGTDAGAAPSP
>Mature_308_residues
MDLNLRQVRAFVSVVQAGSFTRAAALLNLSQPALTVQIRRLEETLDARLLDRTSRTVAPTRLGRDLLPVFQRVLRDLDAV
VVDTRDLAARRHGVVRVATLPSFAASVLSDAIVRFRAEHPAVTFRIKDVIAQRVLDLVRGEEADLGIVGGDVRDPEIGVL
HRTRDALHVIYPADHPIGALPRVTIAALAEHPLILMDPATSVRAVVDRAFIGSGRLPRVACEATYMMTAVSMVRAGLGLT
ILPGAAREIRAEPLLRSRAIDDPLFERPVCLIKKAGRTMPPAAEAFCRMVADRLADPGGTDAGAAPSP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=297, Percent_Identity=29.2929292929293, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI145693105, Length=302, Percent_Identity=27.4834437086093, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788748, Length=296, Percent_Identity=30.4054054054054, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787879, Length=298, Percent_Identity=29.8657718120805, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788887, Length=303, Percent_Identity=29.3729372937294, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787589, Length=254, Percent_Identity=31.496062992126, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789204, Length=246, Percent_Identity=27.2357723577236, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=26.7206477732794, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788481, Length=244, Percent_Identity=28.6885245901639, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87081904, Length=211, Percent_Identity=31.2796208530806, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI2367136, Length=240, Percent_Identity=26.25, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787601, Length=257, Percent_Identity=26.8482490272374, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787530, Length=266, Percent_Identity=26.6917293233083, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=27.2357723577236, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788296, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082132, Length=315, Percent_Identity=24.1269841269841, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=304, Percent_Identity=27.9605263157895, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786448, Length=151, Percent_Identity=33.112582781457, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33304; Mature: 33304

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNLRQVRAFVSVVQAGSFTRAAALLNLSQPALTVQIRRLEETLDARLLDRTSRTVAPT
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLGRDLLPVFQRVLRDLDAVVVDTRDLAARRHGVVRVATLPSFAASVLSDAIVRFRAEHP
HHCHHHHHHHHHHHHHHHHHEECHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCC
AVTFRIKDVIAQRVLDLVRGEEADLGIVGGDVRDPEIGVLHRTRDALHVIYPADHPIGAL
EEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEECCCCEEEEECCCCCCCCC
PRVTIAALAEHPLILMDPATSVRAVVDRAFIGSGRLPRVACEATYMMTAVSMVRAGLGLT
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
ILPGAAREIRAEPLLRSRAIDDPLFERPVCLIKKAGRTMPPAAEAFCRMVADRLADPGGT
ECCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
DAGAAPSP
CCCCCCCC
>Mature Secondary Structure
MDLNLRQVRAFVSVVQAGSFTRAAALLNLSQPALTVQIRRLEETLDARLLDRTSRTVAPT
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLGRDLLPVFQRVLRDLDAVVVDTRDLAARRHGVVRVATLPSFAASVLSDAIVRFRAEHP
HHCHHHHHHHHHHHHHHHHHEECHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCC
AVTFRIKDVIAQRVLDLVRGEEADLGIVGGDVRDPEIGVLHRTRDALHVIYPADHPIGAL
EEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEECCCCEEEEECCCCCCCCC
PRVTIAALAEHPLILMDPATSVRAVVDRAFIGSGRLPRVACEATYMMTAVSMVRAGLGLT
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
ILPGAAREIRAEPLLRSRAIDDPLFERPVCLIKKAGRTMPPAAEAFCRMVADRLADPGGT
ECCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
DAGAAPSP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]