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The map label for this gene is zwf [H]

Identifier: 170750302

GI number: 170750302

Start: 4153102

End: 4154574

Strand: Reverse

Name: zwf [H]

Synonym: Mrad2831_3905

Alternate gene names: 170750302

Gene position: 4154574-4153102 (Counterclockwise)

Preceding gene: 170750303

Following gene: 170750301

Centisome position: 68.36

GC content: 69.52

Gene sequence:

>1473_bases
TTGGCCACGATCATCCCCGTCGCTTCCTTCGACTGCGTCGTGTTCGGCGCGACCGGCGATCTGACCGCGCGGAAGCTGCT
GCCGGCGCTGTTCTACCGTTTCCGCGACGGCCAGATCCCCGAGACCAGCCGGATCATCGGCGCCTCGCGGTCGGAGCTGT
CCCTCGACGCCTTCCGCGAGCACGCCCGCGACGCCCTCAAGCGATTCGTGCCGGCCGCCGACCTGACCGACGACGTGCTC
GGGCGCTTCCTCGACCACGTCGACTACGTCGCCGTGGACGGGGCCGGCGACAGCGGCTGGACCGACCTCGTCGCCAAGCT
CGACGAGCGGCCCGACCAGGTCCGGCCCTACTATCTCGCTACCTCGCCCGACCTCTACGGCTCGATCTGCCGCAACCTCG
CCGCCCACGGGCTCGTCGGCGAGAAGTCCCGCGTCGTGCTGGAGAAGCCGATCGGCAAGGACCTGAAATCGGCCCGGGCG
ATCAACGACGCGGTCGGCGAGGTCTTCCCCGAATCGCAGATCTTCCGCATCGACCACTATCTCGGCAAGGAGACGGTCCA
GAACCTGCTCTCGCTCCGCTTCGCCAACACGATCTTCGAGCGGCTCTGGACCTCGGACGTGATCGACCACGTCCAGATCA
CCGTCGCCGAGACGGTGGGGGTCGAGGGCCGGGCCGGCTACTACGACACGTCGGGCGCGATGCGCGACATGCTGCAGAAC
CACATCCTGCAGCTCCTCTGCCTGACCGCCATGGAGAGCCCGCTCAATCTCGAGGCGAACTCGGTCCGCGACGAGAAGCT
GAAGGTGCTGCGCGCCCTCAAGCCGATCACCACGCACGACATCCAGAGCGTCACGGTGCGCGGCCAGTACGTGGCGGGCG
CCGTCGACGGCAAGCCGGTCGAGGGCTACCTCGCCGAGCTCGGCCACGAGAGCCGGACCGAGACCTTCGTGGCCATGAAG
GTCGAGATCCAGTCGGGGCGCTGGGCCGGGGTGCCGTTCTACCTGCGCACCGGCAAGCGCCTGCCCCAGAAGCTCTCCGA
GATCGTGGTGCAGTTCCGCGCCTCGCCCTTCTCGATCTTCCCCGAGGAGGCCTTCGGTCGCGAGCCGAACCGACTCGTGA
TCCGCCTGCAGCCGCAGGAGGGCATGAAGCTCGAGGTGATGACCAAGGATCCCGGTCCCGGCGGCCTGCGCCTGCGCCCG
ACCGACCTCGACATCTCCTTCGAGGAGACCTTCAAGCAGCGCTACCCCGACGCCTACGAGCGCCTGCTGATGGACGTGGT
CCGCGGCAACGCGACGCTGTTCATGCGCCGCGACGAGGTCGAGGCCGCCTGGGCCTGGGCGGACGGCGTGCTCAAGGCCT
GGGCCGACCGGCCCGAGGCGCCCCGGCCCTACCCGGCCGGCAGCTGGGGGCCGACCGCCGCCATCGCGCTGATCGAGCGC
GACGGCCGGACCTGGCACGAGGAGCTGCGGTAA

Upstream 100 bases:

>100_bases
CTGGCCTGCGCCCCTCGTCTGGCGAAGCCCTTGCACACGGGCTAGGTCAGTGCGACGCAGCCGCCGCACGAGATCAGCGC
ACGACATCCGGGAGCCGCCC

Downstream 100 bases:

>100_bases
CGACGAATCGCGGCTCACGGCCAAGCTGCCTTGATACGGTCAAGCCAGATGTGAAATCTGTCTGCGCTGCCGGATACTGC
CCCGTCAGAGGGTGGAGACG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MATIIPVASFDCVVFGATGDLTARKLLPALFYRFRDGQIPETSRIIGASRSELSLDAFREHARDALKRFVPAADLTDDVL
GRFLDHVDYVAVDGAGDSGWTDLVAKLDERPDQVRPYYLATSPDLYGSICRNLAAHGLVGEKSRVVLEKPIGKDLKSARA
INDAVGEVFPESQIFRIDHYLGKETVQNLLSLRFANTIFERLWTSDVIDHVQITVAETVGVEGRAGYYDTSGAMRDMLQN
HILQLLCLTAMESPLNLEANSVRDEKLKVLRALKPITTHDIQSVTVRGQYVAGAVDGKPVEGYLAELGHESRTETFVAMK
VEIQSGRWAGVPFYLRTGKRLPQKLSEIVVQFRASPFSIFPEEAFGREPNRLVIRLQPQEGMKLEVMTKDPGPGGLRLRP
TDLDISFEETFKQRYPDAYERLLMDVVRGNATLFMRRDEVEAAWAWADGVLKAWADRPEAPRPYPAGSWGPTAAIALIER
DGRTWHEELR

Sequences:

>Translated_490_residues
MATIIPVASFDCVVFGATGDLTARKLLPALFYRFRDGQIPETSRIIGASRSELSLDAFREHARDALKRFVPAADLTDDVL
GRFLDHVDYVAVDGAGDSGWTDLVAKLDERPDQVRPYYLATSPDLYGSICRNLAAHGLVGEKSRVVLEKPIGKDLKSARA
INDAVGEVFPESQIFRIDHYLGKETVQNLLSLRFANTIFERLWTSDVIDHVQITVAETVGVEGRAGYYDTSGAMRDMLQN
HILQLLCLTAMESPLNLEANSVRDEKLKVLRALKPITTHDIQSVTVRGQYVAGAVDGKPVEGYLAELGHESRTETFVAMK
VEIQSGRWAGVPFYLRTGKRLPQKLSEIVVQFRASPFSIFPEEAFGREPNRLVIRLQPQEGMKLEVMTKDPGPGGLRLRP
TDLDISFEETFKQRYPDAYERLLMDVVRGNATLFMRRDEVEAAWAWADGVLKAWADRPEAPRPYPAGSWGPTAAIALIER
DGRTWHEELR
>Mature_489_residues
ATIIPVASFDCVVFGATGDLTARKLLPALFYRFRDGQIPETSRIIGASRSELSLDAFREHARDALKRFVPAADLTDDVLG
RFLDHVDYVAVDGAGDSGWTDLVAKLDERPDQVRPYYLATSPDLYGSICRNLAAHGLVGEKSRVVLEKPIGKDLKSARAI
NDAVGEVFPESQIFRIDHYLGKETVQNLLSLRFANTIFERLWTSDVIDHVQITVAETVGVEGRAGYYDTSGAMRDMLQNH
ILQLLCLTAMESPLNLEANSVRDEKLKVLRALKPITTHDIQSVTVRGQYVAGAVDGKPVEGYLAELGHESRTETFVAMKV
EIQSGRWAGVPFYLRTGKRLPQKLSEIVVQFRASPFSIFPEEAFGREPNRLVIRLQPQEGMKLEVMTKDPGPGGLRLRPT
DLDISFEETFKQRYPDAYERLLMDVVRGNATLFMRRDEVEAAWAWADGVLKAWADRPEAPRPYPAGSWGPTAAIALIERD
GRTWHEELR

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=37.8378378378378, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=37.8378378378378, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI52145310, Length=494, Percent_Identity=29.5546558704453, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=48.2688391038697, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=38.5567010309278, Blast_Score=317, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=35.8921161825726, Blast_Score=294, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=35.6687898089172, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=35.6687898089172, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI221513548, Length=507, Percent_Identity=29.7830374753452, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54814; Mature: 54683

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIIPVASFDCVVFGATGDLTARKLLPALFYRFRDGQIPETSRIIGASRSELSLDAFRE
CCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHH
HARDALKRFVPAADLTDDVLGRFLDHVDYVAVDGAGDSGWTDLVAKLDERPDQVRPYYLA
HHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
TSPDLYGSICRNLAAHGLVGEKSRVVLEKPIGKDLKSARAINDAVGEVFPESQIFRIDHY
CCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHH
LGKETVQNLLSLRFANTIFERLWTSDVIDHVQITVAETVGVEGRAGYYDTSGAMRDMLQN
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCCCCCHHHHHHHHHH
HILQLLCLTAMESPLNLEANSVRDEKLKVLRALKPITTHDIQSVTVRGQYVAGAVDGKPV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECEEEEECCCCCCH
EGYLAELGHESRTETFVAMKVEIQSGRWAGVPFYLRTGKRLPQKLSEIVVQFRASPFSIF
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCC
PEEAFGREPNRLVIRLQPQEGMKLEVMTKDPGPGGLRLRPTDLDISFEETFKQRYPDAYE
CHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEECCCCCCCHHHHHHHHCCHHHH
RLLMDVVRGNATLFMRRDEVEAAWAWADGVLKAWADRPEAPRPYPAGSWGPTAAIALIER
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEC
DGRTWHEELR
CCCCHHHHCC
>Mature Secondary Structure 
ATIIPVASFDCVVFGATGDLTARKLLPALFYRFRDGQIPETSRIIGASRSELSLDAFRE
CEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHH
HARDALKRFVPAADLTDDVLGRFLDHVDYVAVDGAGDSGWTDLVAKLDERPDQVRPYYLA
HHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
TSPDLYGSICRNLAAHGLVGEKSRVVLEKPIGKDLKSARAINDAVGEVFPESQIFRIDHY
CCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHH
LGKETVQNLLSLRFANTIFERLWTSDVIDHVQITVAETVGVEGRAGYYDTSGAMRDMLQN
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCCCCCHHHHHHHHHH
HILQLLCLTAMESPLNLEANSVRDEKLKVLRALKPITTHDIQSVTVRGQYVAGAVDGKPV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECEEEEECCCCCCH
EGYLAELGHESRTETFVAMKVEIQSGRWAGVPFYLRTGKRLPQKLSEIVVQFRASPFSIF
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCC
PEEAFGREPNRLVIRLQPQEGMKLEVMTKDPGPGGLRLRPTDLDISFEETFKQRYPDAYE
CHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEECCCCCCCHHHHHHHHCCHHHH
RLLMDVVRGNATLFMRRDEVEAAWAWADGVLKAWADRPEAPRPYPAGSWGPTAAIALIER
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEC
DGRTWHEELR
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]