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The map label for this gene is phr [H]

Identifier: 170750160

GI number: 170750160

Start: 4002689

End: 4004077

Strand: Reverse

Name: phr [H]

Synonym: Mrad2831_3762

Alternate gene names: 170750160

Gene position: 4004077-4002689 (Counterclockwise)

Preceding gene: 170750161

Following gene: 170750159

Centisome position: 65.88

GC content: 68.68

Gene sequence:

>1389_bases
ATGGCGATCCAGGGTGAGCGGGTCCGGATCCTCAACGATGTCGAGCCGGGCGGAGACGGTGCCTACGTCCTGTATCTCCT
GCAGCAGGCCAATCGGGCGACGTTCAACCCGGCCCTTGAACTCGCCATCGAGGAGGCGAACCGCCTCGATCTGCCGGTCG
TCGCCTGCTTCGGCCTGCTCGACGGCGCCAGCGGCTTTCCCGAAGCCAATGCCCGCCACTACGCCTTCCTGCTCCAGGGT
CTCGCGGATGCGAAGGCGGGCCTGGAGAAGCGCGGGGTCGGCTTCGTCATGCGCAAGTGCTCGCCCGCCGAGATCGCCAT
CGCCCTCGCCGAGGACGCCGCGCTCCTCGTGCTCGACCGCGGCTACCTCGCGATCCAGAAGGGCTGGTACCGGGAGATCG
CCGCGGCGGTGAAGACGCGGATCGTCCAGGTCGAGGGCGACGTCGTCGTGCCGGTCGAGACGGCCTCGCCGAAGCACGAG
TACGCCGCCCGGACGCTGCGGCCGAAGCTGAACCGGCTGTGGGACCCGTTCCTCGCGCCGCTGAAGCCCCGCAGGGTGAA
GCACTCCGCCGATCGGCTGACGCTGAAGAGCGCGATCGACGTCTCCGATCCGGAGGCGGTACTCGCCGGGATGACCCTCG
ACCGGGAGGTCGGCCCGGTGAGGCGCTTCACCGGCGGCGAGACGCAGGCCCGCAAGCGCCTGAAGGCGTTCCTGAAAGAC
GGGTTCTCGGGCTACGGCGCGGGGCGCAACATGCCGGAGGCGGCCGCCGCCTCGCACATGAGCCCGTACCTGCATTTCGG
GCAGATCTCGCCGGTGGAGATCGCCCTGGCGGTGCGGGAAGCCAAGGTCGGCGATTCCGACGACCGCGGCGCCTACCTGG
AGGAGCTGATCGTCCGGCGCGAGCTCGCCATGAACCACGTCTACTACACGGAGGGCTACGACGATTACGACAGGGCGGTG
CCGGACTGGGCGCGCAAGACCCTGGCGGAGCACGCGAGGGACGAGCGCCCCCACGCCTACTCGGAAGCGCAGCTCGCCGC
CGGCGAGACCCACGACCGCTACTGGAACGCCGCGATGCGCGAGATGCGCGAGACCGGCTACATGCACAACCAGCTGCGGA
TGTACTGGGGCAAGAAGATCCTCGAATGGTCCCCATCCCCCCGGGAGGGCTTCGCCCGGACGCTCCGGCTGAACAACCGC
TACTTCCTCGACGGGCGCGATCCGAATTCCTTCACCAACGTCGCCTGGGTGTACGGTCTGCACGACCGGCCCTGGCAGAA
GCGCAAGATCTTCGGCACGGTCCGCTATCAGAGCGAGAACTCGCTCAAGAAGTTCGACGCCAAGGCGTACGTGCGGGCGG
TTGAGAGGCTCTGCGCCGCGGAGGTCTGA

Upstream 100 bases:

>100_bases
CGGCTTTTCATCCGCCCCGTCCGGACGGACGAAATTCCCGCCCGCTCTACCTTCTCCAGCCAAGGTTCGGCGCGACGCGC
CAAGCAAGGGGCAGGTGAGT

Downstream 100 bases:

>100_bases
GGCGGGACCGACGCGTCCGTGCGCTGCCGCACGGGCGCCGCGACGCGCGCGAAATCGTTACGGGATGACCGAAGCCGTCG
GCAAGGTATCGCGACGCTCG

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAIQGERVRILNDVEPGGDGAYVLYLLQQANRATFNPALELAIEEANRLDLPVVACFGLLDGASGFPEANARHYAFLLQG
LADAKAGLEKRGVGFVMRKCSPAEIAIALAEDAALLVLDRGYLAIQKGWYREIAAAVKTRIVQVEGDVVVPVETASPKHE
YAARTLRPKLNRLWDPFLAPLKPRRVKHSADRLTLKSAIDVSDPEAVLAGMTLDREVGPVRRFTGGETQARKRLKAFLKD
GFSGYGAGRNMPEAAAASHMSPYLHFGQISPVEIALAVREAKVGDSDDRGAYLEELIVRRELAMNHVYYTEGYDDYDRAV
PDWARKTLAEHARDERPHAYSEAQLAAGETHDRYWNAAMREMRETGYMHNQLRMYWGKKILEWSPSPREGFARTLRLNNR
YFLDGRDPNSFTNVAWVYGLHDRPWQKRKIFGTVRYQSENSLKKFDAKAYVRAVERLCAAEV

Sequences:

>Translated_462_residues
MAIQGERVRILNDVEPGGDGAYVLYLLQQANRATFNPALELAIEEANRLDLPVVACFGLLDGASGFPEANARHYAFLLQG
LADAKAGLEKRGVGFVMRKCSPAEIAIALAEDAALLVLDRGYLAIQKGWYREIAAAVKTRIVQVEGDVVVPVETASPKHE
YAARTLRPKLNRLWDPFLAPLKPRRVKHSADRLTLKSAIDVSDPEAVLAGMTLDREVGPVRRFTGGETQARKRLKAFLKD
GFSGYGAGRNMPEAAAASHMSPYLHFGQISPVEIALAVREAKVGDSDDRGAYLEELIVRRELAMNHVYYTEGYDDYDRAV
PDWARKTLAEHARDERPHAYSEAQLAAGETHDRYWNAAMREMRETGYMHNQLRMYWGKKILEWSPSPREGFARTLRLNNR
YFLDGRDPNSFTNVAWVYGLHDRPWQKRKIFGTVRYQSENSLKKFDAKAYVRAVERLCAAEV
>Mature_461_residues
AIQGERVRILNDVEPGGDGAYVLYLLQQANRATFNPALELAIEEANRLDLPVVACFGLLDGASGFPEANARHYAFLLQGL
ADAKAGLEKRGVGFVMRKCSPAEIAIALAEDAALLVLDRGYLAIQKGWYREIAAAVKTRIVQVEGDVVVPVETASPKHEY
AARTLRPKLNRLWDPFLAPLKPRRVKHSADRLTLKSAIDVSDPEAVLAGMTLDREVGPVRRFTGGETQARKRLKAFLKDG
FSGYGAGRNMPEAAAASHMSPYLHFGQISPVEIALAVREAKVGDSDDRGAYLEELIVRRELAMNHVYYTEGYDDYDRAVP
DWARKTLAEHARDERPHAYSEAQLAAGETHDRYWNAAMREMRETGYMHNQLRMYWGKKILEWSPSPREGFARTLRLNNRY
FLDGRDPNSFTNVAWVYGLHDRPWQKRKIFGTVRYQSENSLKKFDAKAYVRAVERLCAAEV

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=459, Percent_Identity=34.4226579520697, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586398, Length=459, Percent_Identity=34.4226579520697, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586404, Length=151, Percent_Identity=41.7218543046358, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51983; Mature: 51852

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQGERVRILNDVEPGGDGAYVLYLLQQANRATFNPALELAIEEANRLDLPVVACFGLL
CCCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
DGASGFPEANARHYAFLLQGLADAKAGLEKRGVGFVMRKCSPAEIAIALAEDAALLVLDR
CCCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHCCCCCCEEEEEECCCEEEEEEC
GYLAIQKGWYREIAAAVKTRIVQVEGDVVVPVETASPKHEYAARTLRPKLNRLWDPFLAP
CEEEEHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
LKPRRVKHSADRLTLKSAIDVSDPEAVLAGMTLDREVGPVRRFTGGETQARKRLKAFLKD
CCCHHHHCCHHHEEHHHHCCCCCCHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GFSGYGAGRNMPEAAAASHMSPYLHFGQISPVEIALAVREAKVGDSDDRGAYLEELIVRR
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHH
ELAMNHVYYTEGYDDYDRAVPDWARKTLAEHARDERPHAYSEAQLAAGETHDRYWNAAMR
HHHHCCEEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHH
EMRETGYMHNQLRMYWGKKILEWSPSPREGFARTLRLNNRYFLDGRDPNSFTNVAWVYGL
HHHHHCHHHHHHHHHHCCHHCCCCCCCHHHHHHHEEECCEEEECCCCCCCCCCEEEEEEC
HDRPWQKRKIFGTVRYQSENSLKKFDAKAYVRAVERLCAAEV
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIQGERVRILNDVEPGGDGAYVLYLLQQANRATFNPALELAIEEANRLDLPVVACFGLL
CCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
DGASGFPEANARHYAFLLQGLADAKAGLEKRGVGFVMRKCSPAEIAIALAEDAALLVLDR
CCCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHCCCCCCEEEEEECCCEEEEEEC
GYLAIQKGWYREIAAAVKTRIVQVEGDVVVPVETASPKHEYAARTLRPKLNRLWDPFLAP
CEEEEHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
LKPRRVKHSADRLTLKSAIDVSDPEAVLAGMTLDREVGPVRRFTGGETQARKRLKAFLKD
CCCHHHHCCHHHEEHHHHCCCCCCHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GFSGYGAGRNMPEAAAASHMSPYLHFGQISPVEIALAVREAKVGDSDDRGAYLEELIVRR
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHH
ELAMNHVYYTEGYDDYDRAVPDWARKTLAEHARDERPHAYSEAQLAAGETHDRYWNAAMR
HHHHCCEEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHH
EMRETGYMHNQLRMYWGKKILEWSPSPREGFARTLRLNNRYFLDGRDPNSFTNVAWVYGL
HHHHHCHHHHHHHHHHCCHHCCCCCCCHHHHHHHEEECCEEEECCCCCCCCCCEEEEEEC
HDRPWQKRKIFGTVRYQSENSLKKFDAKAYVRAVERLCAAEV
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]