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The map label for this gene is mltA [H]

Identifier: 170750112

GI number: 170750112

Start: 3952220

End: 3953416

Strand: Direct

Name: mltA [H]

Synonym: Mrad2831_3714

Alternate gene names: 170750112

Gene position: 3952220-3953416 (Clockwise)

Preceding gene: 170750111

Following gene: 170750113

Centisome position: 65.03

GC content: 79.03

Gene sequence:

>1197_bases
GTGCCGATCCCCCGCGCCCGGTCCGGAGCAGTCCCGGCCGCCCTCCTCGCGTCCCTCCTGAGCCAGGCCGTGTCCGCCGC
GCCGGCGGCGGTCGGCGACGCGGTGCTGATCCCCGTCGCCGCGGCCGACCTGCCGGGCTTCCCCGGCGCGCGGGCGGACG
CGGCGCTCGCCGCCTTCCGCCGGGTCTGCGCGGCTCCGCCGCCCGCCCTGCCCCAGCCCGACGGCGTCGCGGGGGATCTG
GCGGCCCTCGCCGAGGCCTGCGCGGCCGCCGCCGACCCCGTGCCGGACGCGGCCGCCTTCTTCCGGGACCGGTTCGCGGC
GTTCCGCGTCGCGCGGCCCGGCGCGGACCGACCCGGCTTCCTGACCGGCTATTTCGAGCCGGAACTCACGGGCTCCCTCG
AGCCGGGCCCGGACTTCCCGACGCCGGTGCTCGCCCGCCCCGACGACCTGATCTCCCTCGGCCCCGGCGAGACCCGCCCG
GGGCTCGATCCCGGCCTGCGCGCCGCCCGGGCCACGGCGGATGGGTTCGCCCCCTACCCCGACCGCGCCGCGATCGAGGA
CGGTGCCCTCGGCGCGCGCGCGAAGCCGATCCTGTGGCTGCGCGACCCGGTCGACCTGCTGGTCCTGCAGGTCCAGGGTT
CCGGGCGCGTCCGGCTGCCGGACGGGCGCGCGGTCCGGGTGCTCTACGACGGCCGCAACGGCCGCCCGTACACGGCGGTG
GCCAAGCTGATCGTCCAGGAGGGCCACCTGCCCCTGGAAGGACTGACGCTCGCCCGCTGGACCGGCTGGCTGCGCGCCCA
TCCCGAGACCGCCAAGCGCCTGATCCGCGCCAACGCCTCCTACATCTTCTTCCGCCTCGCCCCGGTCGCCGACCCGGCCC
TCGGGCCGCCGGGCGCCGCGAACGCCCCGCTCAGTCCGGGCCGCAGCCTGGCGGTGGATTCGACCCTCTGGCGCTACGGC
CTGCCGTTCTGGCTCGCGGGCCCGCTCCCCGCGGAGGCGGGGGCCGGCGCGCCGGACGCGGCCGGGCGCCTCGTCGTCGC
CGCCGATACCGGCTCGGCGATCGTCGGCCCCGCCCGCGGCGACCTCTTCGTCGGCACCGGTCCGGAGGCCGGGGCGGTCG
CCGGAAACCTCCGCGACGCCGTGGGTTTCGTGGTCCTGCTGCCGCGTCGCGGCGGTGCATCCGGAGCCGCGCCGTGA

Upstream 100 bases:

>100_bases
CCTTCGCCCGCACGCTCGGCTCGCGGGATCCGAACTGGCAGCTCGTGGCCACCGAGGCCGGCGCCTGAGCCCGTGACCGG
CGTGCCGTGACGATCTCGCC

Downstream 100 bases:

>100_bases
GGGCCTCGCGCCGCGGGCGCCGCCTCACCGCGGGCGAGGCCCGGCTCTGGGACGCGATCGCCAAGCTGGTGACCCCGTTG
CCGGGCCGCGCAGCCCCGAT

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MPIPRARSGAVPAALLASLLSQAVSAAPAAVGDAVLIPVAAADLPGFPGARADAALAAFRRVCAAPPPALPQPDGVAGDL
AALAEACAAAADPVPDAAAFFRDRFAAFRVARPGADRPGFLTGYFEPELTGSLEPGPDFPTPVLARPDDLISLGPGETRP
GLDPGLRAARATADGFAPYPDRAAIEDGALGARAKPILWLRDPVDLLVLQVQGSGRVRLPDGRAVRVLYDGRNGRPYTAV
AKLIVQEGHLPLEGLTLARWTGWLRAHPETAKRLIRANASYIFFRLAPVADPALGPPGAANAPLSPGRSLAVDSTLWRYG
LPFWLAGPLPAEAGAGAPDAAGRLVVAADTGSAIVGPARGDLFVGTGPEAGAVAGNLRDAVGFVVLLPRRGGASGAAP

Sequences:

>Translated_398_residues
MPIPRARSGAVPAALLASLLSQAVSAAPAAVGDAVLIPVAAADLPGFPGARADAALAAFRRVCAAPPPALPQPDGVAGDL
AALAEACAAAADPVPDAAAFFRDRFAAFRVARPGADRPGFLTGYFEPELTGSLEPGPDFPTPVLARPDDLISLGPGETRP
GLDPGLRAARATADGFAPYPDRAAIEDGALGARAKPILWLRDPVDLLVLQVQGSGRVRLPDGRAVRVLYDGRNGRPYTAV
AKLIVQEGHLPLEGLTLARWTGWLRAHPETAKRLIRANASYIFFRLAPVADPALGPPGAANAPLSPGRSLAVDSTLWRYG
LPFWLAGPLPAEAGAGAPDAAGRLVVAADTGSAIVGPARGDLFVGTGPEAGAVAGNLRDAVGFVVLLPRRGGASGAAP
>Mature_397_residues
PIPRARSGAVPAALLASLLSQAVSAAPAAVGDAVLIPVAAADLPGFPGARADAALAAFRRVCAAPPPALPQPDGVAGDLA
ALAEACAAAADPVPDAAAFFRDRFAAFRVARPGADRPGFLTGYFEPELTGSLEPGPDFPTPVLARPDDLISLGPGETRPG
LDPGLRAARATADGFAPYPDRAAIEDGALGARAKPILWLRDPVDLLVLQVQGSGRVRLPDGRAVRVLYDGRNGRPYTAVA
KLIVQEGHLPLEGLTLARWTGWLRAHPETAKRLIRANASYIFFRLAPVADPALGPPGAANAPLSPGRSLAVDSTLWRYGL
PFWLAGPLPAEAGAGAPDAAGRLVVAADTGSAIVGPARGDLFVGTGPEAGAVAGNLRDAVGFVVLLPRRGGASGAAP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=202, Percent_Identity=32.6732673267327, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40485; Mature: 40353

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPRARSGAVPAALLASLLSQAVSAAPAAVGDAVLIPVAAADLPGFPGARADAALAAFR
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
RVCAAPPPALPQPDGVAGDLAALAEACAAAADPVPDAAAFFRDRFAAFRVARPGADRPGF
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCCCCCCE
LTGYFEPELTGSLEPGPDFPTPVLARPDDLISLGPGETRPGLDPGLRAARATADGFAPYP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCC
DRAAIEDGALGARAKPILWLRDPVDLLVLQVQGSGRVRLPDGRAVRVLYDGRNGRPYTAV
CCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEECCCCCEEEEEEECCCCCCHHHH
AKLIVQEGHLPLEGLTLARWTGWLRAHPETAKRLIRANASYIFFRLAPVADPALGPPGAA
HHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
NAPLSPGRSLAVDSTLWRYGLPFWLAGPLPAEAGAGAPDAAGRLVVAADTGSAIVGPARG
CCCCCCCCCEEECHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCC
DLFVGTGPEAGAVAGNLRDAVGFVVLLPRRGGASGAAP
CEEEECCCCCCCHHCCHHHCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
PIPRARSGAVPAALLASLLSQAVSAAPAAVGDAVLIPVAAADLPGFPGARADAALAAFR
CCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
RVCAAPPPALPQPDGVAGDLAALAEACAAAADPVPDAAAFFRDRFAAFRVARPGADRPGF
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCCCCCCE
LTGYFEPELTGSLEPGPDFPTPVLARPDDLISLGPGETRPGLDPGLRAARATADGFAPYP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCC
DRAAIEDGALGARAKPILWLRDPVDLLVLQVQGSGRVRLPDGRAVRVLYDGRNGRPYTAV
CCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCEEECCCCCEEEEEEECCCCCCHHHH
AKLIVQEGHLPLEGLTLARWTGWLRAHPETAKRLIRANASYIFFRLAPVADPALGPPGAA
HHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
NAPLSPGRSLAVDSTLWRYGLPFWLAGPLPAEAGAGAPDAAGRLVVAADTGSAIVGPARG
CCCCCCCCCEEECHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCC
DLFVGTGPEAGAVAGNLRDAVGFVVLLPRRGGASGAAP
CEEEECCCCCCCHHCCHHHCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]