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The map label for this gene is lig [H]

Identifier: 170750090

GI number: 170750090

Start: 3929425

End: 3931143

Strand: Reverse

Name: lig [H]

Synonym: Mrad2831_3691

Alternate gene names: 170750090

Gene position: 3931143-3929425 (Counterclockwise)

Preceding gene: 170750091

Following gene: 170750089

Centisome position: 64.68

GC content: 72.37

Gene sequence:

>1719_bases
GTGAACGAGTTCGCCCATCTCCTCGACCGCCTCGCCTACGAGCCGCGCCGCAACGCGAAGCTGCGCATGCTCCAGGACTA
CTTCGCGCGCACGCCCGACCCCGAGCGCGGCTACGCGCTGGGCGCCATGACCGGCACGCTGAGCTTCCGCGAGGCCAAGC
CGGCCCTGATCCGCGGGCTGGTGGAGGAGCGGATCGACCCGGTGCTGTTCCGGCTCTCGCACAACTACGTGGGCGACCTC
GCGGAGACGACGGCGCTGATCTGGCCGGGACCGACGGAGGCGCCGCGGGAGCCGGGCCCCGGCCACAACAATCCGCCGCC
CCACGTCCCGACCCTGGCCGAGGTCGTGGAGACCCTCGCGACCATCCCCAAGCGCGAGCTGCCCCGCCATCTCGCGGACT
GGCTCGACGCCCTCGACGAGACCGGGCGCTGGGCGCTCCTGAAGCTCGTCACCGGCAACCTGCGGGTCGGCGTGTCGGCG
CGACTCGCCAAGACGGCGGTCGGCGCGCTGGGCGGCCACGACGCCGACGCCGTCGAGGAGGTCTGGCACGGCCTGACCCC
GCCCTTCGAGACTCTGTTCGCCTGGGTCGAGGGCCGGGCCGAGCGGCCCGAGACCCTGAACCCCGCGCCGTTCCGGCCGC
CGATGCTGTCGCACCCGATCGAGGAGGAGGCCGACCTCGAGAAGCTGGAGGCCGAGGCCTTCTCGGCCGAGTGGAAGTGG
GACGGCATCCGTGTCCAGCTCGTCGGCGGTCTCGACCGGGCCGGCCAGCAGGTCGGGAAGGTCTATTCCCGCACCGGCGA
GGACATCACCGGGGCGTTCCCGGACCTCGCCGAGGCCATCACCTTCGCGGGCGCCCTCGACGGCGAGCTGCTGATCCTCC
GCGAGCGGCGGGTGCAGAGCTTCAACGTGCTGCAGCAGCGCCTGAACCGGAAGGCCGTGACGGGCAAGCTCCTGGAGGAA
TTCCCGGCCCACGTGCGGGCCTACGACCTCCTCACCCTGGAGGGCGACGATCTGCGCGGGGAGCCGTTCGCAACACGGCG
GCAGAAGCTGGAGGCGCTGGTCACGCGCCTCGACCACGCGCGGATCGACATCTCGCCGCTCGTGCCCTTCGCGGATTGGG
AGGCCCTGGCGGCCGCCCGGGCGGATCCGGCCTCGGTGGGCGCCGGCGCGGATGCCGACGCCATCGAGGGCGTGATGCTC
AAGCGCCTCAACAGCCCCTACCTGCCGGGACGCCCCAAGGGGCCGTGGTGGAAGTGGAAGCGCGAGCCGCACATCGTCGA
CGCCGTGATGATGTATGCCCAGCGCGGGCACGGGAAGCGCTCGTCCTTCTACTCGGACTACACGTTCGGGGTCTGGCGGG
AGGCGCCCGAGGGCGGCGACGAGCTGGTGCCGGTGGGCAAGGCCTATCACGGCTTCACCGACGCCGAGCTCGCCAAGCTC
GACCGCTACGTCCGCAACAACACCACCAAGCGCTTCGGCCCGGTGCGCGAGGTCGCCCACGGCCGCGAGGCCGGGCTCGT
CCTCGAGATCGCCTTCGAGGGCGTGCAGCGCTCGACCCGGCACAAGTCGGGCGTGGCCATGCGCTTCCCCCGGGTCAGCC
GCATCCGCTGGGACAAGCCGCCCGCGGAGGCCGACCGGATCGACGTGCTCGAACGGATCCTCGCCCGGGGCGAGCGCGAG
ATCGCGCCGGGCGCGACGCTGATGGAGAAGACCGCATGA

Upstream 100 bases:

>100_bases
CGCAGGGCATCCGGGCGAAGCCGCTCCACCTGCTCGGCTACGGCGATGACGGCGAGGTCGAGGGGACCTCGGAGGCGAGC
TCTGAGGCGGAGGCGGCCGC

Downstream 100 bases:

>100_bases
GGCAGGGACACGGCCGGGAGGGCAGGATCGGGCCGGTCGAGGCGCTGGCCTCCGGCCCGGTGGCGCGCCACGCCAGCGGC
CGCCTCACCGTCGCGACCCC

Product: ATP dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MNEFAHLLDRLAYEPRRNAKLRMLQDYFARTPDPERGYALGAMTGTLSFREAKPALIRGLVEERIDPVLFRLSHNYVGDL
AETTALIWPGPTEAPREPGPGHNNPPPHVPTLAEVVETLATIPKRELPRHLADWLDALDETGRWALLKLVTGNLRVGVSA
RLAKTAVGALGGHDADAVEEVWHGLTPPFETLFAWVEGRAERPETLNPAPFRPPMLSHPIEEEADLEKLEAEAFSAEWKW
DGIRVQLVGGLDRAGQQVGKVYSRTGEDITGAFPDLAEAITFAGALDGELLILRERRVQSFNVLQQRLNRKAVTGKLLEE
FPAHVRAYDLLTLEGDDLRGEPFATRRQKLEALVTRLDHARIDISPLVPFADWEALAAARADPASVGAGADADAIEGVML
KRLNSPYLPGRPKGPWWKWKREPHIVDAVMMYAQRGHGKRSSFYSDYTFGVWREAPEGGDELVPVGKAYHGFTDAELAKL
DRYVRNNTTKRFGPVREVAHGREAGLVLEIAFEGVQRSTRHKSGVAMRFPRVSRIRWDKPPAEADRIDVLERILARGERE
IAPGATLMEKTA

Sequences:

>Translated_572_residues
MNEFAHLLDRLAYEPRRNAKLRMLQDYFARTPDPERGYALGAMTGTLSFREAKPALIRGLVEERIDPVLFRLSHNYVGDL
AETTALIWPGPTEAPREPGPGHNNPPPHVPTLAEVVETLATIPKRELPRHLADWLDALDETGRWALLKLVTGNLRVGVSA
RLAKTAVGALGGHDADAVEEVWHGLTPPFETLFAWVEGRAERPETLNPAPFRPPMLSHPIEEEADLEKLEAEAFSAEWKW
DGIRVQLVGGLDRAGQQVGKVYSRTGEDITGAFPDLAEAITFAGALDGELLILRERRVQSFNVLQQRLNRKAVTGKLLEE
FPAHVRAYDLLTLEGDDLRGEPFATRRQKLEALVTRLDHARIDISPLVPFADWEALAAARADPASVGAGADADAIEGVML
KRLNSPYLPGRPKGPWWKWKREPHIVDAVMMYAQRGHGKRSSFYSDYTFGVWREAPEGGDELVPVGKAYHGFTDAELAKL
DRYVRNNTTKRFGPVREVAHGREAGLVLEIAFEGVQRSTRHKSGVAMRFPRVSRIRWDKPPAEADRIDVLERILARGERE
IAPGATLMEKTA
>Mature_572_residues
MNEFAHLLDRLAYEPRRNAKLRMLQDYFARTPDPERGYALGAMTGTLSFREAKPALIRGLVEERIDPVLFRLSHNYVGDL
AETTALIWPGPTEAPREPGPGHNNPPPHVPTLAEVVETLATIPKRELPRHLADWLDALDETGRWALLKLVTGNLRVGVSA
RLAKTAVGALGGHDADAVEEVWHGLTPPFETLFAWVEGRAERPETLNPAPFRPPMLSHPIEEEADLEKLEAEAFSAEWKW
DGIRVQLVGGLDRAGQQVGKVYSRTGEDITGAFPDLAEAITFAGALDGELLILRERRVQSFNVLQQRLNRKAVTGKLLEE
FPAHVRAYDLLTLEGDDLRGEPFATRRQKLEALVTRLDHARIDISPLVPFADWEALAAARADPASVGAGADADAIEGVML
KRLNSPYLPGRPKGPWWKWKREPHIVDAVMMYAQRGHGKRSSFYSDYTFGVWREAPEGGDELVPVGKAYHGFTDAELAKL
DRYVRNNTTKRFGPVREVAHGREAGLVLEIAFEGVQRSTRHKSGVAMRFPRVSRIRWDKPPAEADRIDVLERILARGERE
IAPGATLMEKTA

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=386, Percent_Identity=26.9430051813472, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71985269, Length=455, Percent_Identity=24.8351648351648, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 63761; Mature: 63761

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFAHLLDRLAYEPRRNAKLRMLQDYFARTPDPERGYALGAMTGTLSFREAKPALIRGL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCHHHCCHHHHHHH
VEERIDPVLFRLSHNYVGDLAETTALIWPGPTEAPREPGPGHNNPPPHVPTLAEVVETLA
HHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TIPKRELPRHLADWLDALDETGRWALLKLVTGNLRVGVSARLAKTAVGALGGHDADAVEE
HCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECHHHHHHHHHHHHCCCCCHHHHHH
VWHGLTPPFETLFAWVEGRAERPETLNPAPFRPPMLSHPIEEEADLEKLEAEAFSAEWKW
HHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
DGIRVQLVGGLDRAGQQVGKVYSRTGEDITGAFPDLAEAITFAGALDGELLILRERRVQS
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHH
FNVLQQRLNRKAVTGKLLEEFPAHVRAYDLLTLEGDDLRGEPFATRRQKLEALVTRLDHA
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
RIDISPLVPFADWEALAAARADPASVGAGADADAIEGVMLKRLNSPYLPGRPKGPWWKWK
CCCCCCCCCCCCHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
REPHIVDAVMMYAQRGHGKRSSFYSDYTFGVWREAPEGGDELVPVGKAYHGFTDAELAKL
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCEEECCHHHCCCCHHHHHHH
DRYVRNNTTKRFGPVREVAHGREAGLVLEIAFEGVQRSTRHKSGVAMRFPRVSRIRWDKP
HHHHHCCCHHHHCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCEEECCCHHCCCCCCC
PAEADRIDVLERILARGEREIAPGATLMEKTA
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MNEFAHLLDRLAYEPRRNAKLRMLQDYFARTPDPERGYALGAMTGTLSFREAKPALIRGL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHCCCCHHHCCHHHHHHH
VEERIDPVLFRLSHNYVGDLAETTALIWPGPTEAPREPGPGHNNPPPHVPTLAEVVETLA
HHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TIPKRELPRHLADWLDALDETGRWALLKLVTGNLRVGVSARLAKTAVGALGGHDADAVEE
HCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECHHHHHHHHHHHHCCCCCHHHHHH
VWHGLTPPFETLFAWVEGRAERPETLNPAPFRPPMLSHPIEEEADLEKLEAEAFSAEWKW
HHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
DGIRVQLVGGLDRAGQQVGKVYSRTGEDITGAFPDLAEAITFAGALDGELLILRERRVQS
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHH
FNVLQQRLNRKAVTGKLLEEFPAHVRAYDLLTLEGDDLRGEPFATRRQKLEALVTRLDHA
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
RIDISPLVPFADWEALAAARADPASVGAGADADAIEGVMLKRLNSPYLPGRPKGPWWKWK
CCCCCCCCCCCCHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
REPHIVDAVMMYAQRGHGKRSSFYSDYTFGVWREAPEGGDELVPVGKAYHGFTDAELAKL
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCEEECCHHHCCCCHHHHHHH
DRYVRNNTTKRFGPVREVAHGREAGLVLEIAFEGVQRSTRHKSGVAMRFPRVSRIRWDKP
HHHHHCCCHHHHCHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCEEECCCHHCCCCCCC
PAEADRIDVLERILARGEREIAPGATLMEKTA
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA