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The map label for this gene is moaB [H]

Identifier: 170750077

GI number: 170750077

Start: 3912199

End: 3912756

Strand: Reverse

Name: moaB [H]

Synonym: Mrad2831_3678

Alternate gene names: 170750077

Gene position: 3912756-3912199 (Counterclockwise)

Preceding gene: 170750082

Following gene: 170750074

Centisome position: 64.38

GC content: 71.86

Gene sequence:

>558_bases
ATGGCCGATCAGACCGACGCCCGCCGCTTCATTCCCCTGAACATCGCGGTCCTGACCGTCTCCGACACGCGCCGTCCGGA
GGACGACCGCTCGGGCGACACCCTGACCCAGCGCCTCACCGAGGCGGGGCACAGTCTGGCGGCCCGGTCCATCGTTCCGG
ACGAGATCCCGGCGATCCGCGAGCGGGTGGAGGCGTGGCTGCGCGATCCCGGCGTCGACGTGGTGATCACCACCGGCGGG
ACCGGCTTCACCGGCCGCGACGTCACCCCCGAGGCGCTGGAGCCGCTGTTCGAGAAGCGCATGGACGGCTTCTCGGCCGT
GTTCCACCGGATCTCGTACGACAAGATCGGCACCTCGACCCTGCAATCCCGCGCCACCGCGGGGGTCGCGCGGGCGACCT
ACGTGTTCGTGCTGCCGGGCTCGCCCGGCGCCTGCCGCGACGCCTGGGACGGGATCCTGGCCCAGCAGCTCGACTACCGG
CACCGGCCCTGCAACTTCGTCGAGATCATGCCGCGCCTCGACGAGCACCTGCGGCGCGGCGCGAGCCTCACCGTGTGA

Upstream 100 bases:

>100_bases
AAGGGGGGCGCGGGGGGGGGGCGCGGGCGCGGCGGCCCCCGGGGGCGACAAGCGGTCCCGCCGGGCCCATATCGGTCTCC
CGCACCGGAGAGCCCGCACG

Downstream 100 bases:

>100_bases
GGCGGCGCTAGGCCAGATTCCCCTCCTTGCGGCGCAGGACAGAGTGCTTGCGGCCGTAGAAGAAGTACACGACGAGGCCG
ATCGCCATCCAGATCACCAG

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MADQTDARRFIPLNIAVLTVSDTRRPEDDRSGDTLTQRLTEAGHSLAARSIVPDEIPAIRERVEAWLRDPGVDVVITTGG
TGFTGRDVTPEALEPLFEKRMDGFSAVFHRISYDKIGTSTLQSRATAGVARATYVFVLPGSPGACRDAWDGILAQQLDYR
HRPCNFVEIMPRLDEHLRRGASLTV

Sequences:

>Translated_185_residues
MADQTDARRFIPLNIAVLTVSDTRRPEDDRSGDTLTQRLTEAGHSLAARSIVPDEIPAIRERVEAWLRDPGVDVVITTGG
TGFTGRDVTPEALEPLFEKRMDGFSAVFHRISYDKIGTSTLQSRATAGVARATYVFVLPGSPGACRDAWDGILAQQLDYR
HRPCNFVEIMPRLDEHLRRGASLTV
>Mature_184_residues
ADQTDARRFIPLNIAVLTVSDTRRPEDDRSGDTLTQRLTEAGHSLAARSIVPDEIPAIRERVEAWLRDPGVDVVITTGGT
GFTGRDVTPEALEPLFEKRMDGFSAVFHRISYDKIGTSTLQSRATAGVARATYVFVLPGSPGACRDAWDGILAQQLDYRH
RPCNFVEIMPRLDEHLRRGASLTV

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=146, Percent_Identity=35.6164383561644, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI66932975, Length=146, Percent_Identity=35.6164383561644, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1787000, Length=157, Percent_Identity=54.140127388535, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136978, Length=145, Percent_Identity=37.2413793103448, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24638841, Length=145, Percent_Identity=37.2413793103448, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 20448; Mature: 20317

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQTDARRFIPLNIAVLTVSDTRRPEDDRSGDTLTQRLTEAGHSLAARSIVPDEIPAIR
CCCCCCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ERVEAWLRDPGVDVVITTGGTGFTGRDVTPEALEPLFEKRMDGFSAVFHRISYDKIGTST
HHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LQSRATAGVARATYVFVLPGSPGACRDAWDGILAQQLDYRHRPCNFVEIMPRLDEHLRRG
HHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
ASLTV
CCCCC
>Mature Secondary Structure 
ADQTDARRFIPLNIAVLTVSDTRRPEDDRSGDTLTQRLTEAGHSLAARSIVPDEIPAIR
CCCCCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ERVEAWLRDPGVDVVITTGGTGFTGRDVTPEALEPLFEKRMDGFSAVFHRISYDKIGTST
HHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LQSRATAGVARATYVFVLPGSPGACRDAWDGILAQQLDYRHRPCNFVEIMPRLDEHLRRG
HHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
ASLTV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]