Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 170750062

GI number: 170750062

Start: 3892193

End: 3893164

Strand: Reverse

Name: mcl1 [H]

Synonym: Mrad2831_3663

Alternate gene names: 170750062

Gene position: 3893164-3892193 (Counterclockwise)

Preceding gene: 170750063

Following gene: 170750057

Centisome position: 64.06

GC content: 67.18

Gene sequence:

>972_bases
ATGAGCTTCACCCTGATCCAGCAGGCCAAGCCGCGCCTGCACCGCTCCGAACTCGCCGTGCCCGGCTCGAACCCGACCTT
CATGGAGAAGTCGGCTTCCTCGGCGGCGGACGTGATCTTCCTCGACCTCGAGGACGCGGTCGCCCCCGACGACAAGGAGA
AGGCCCGCACCAACATCATCCAGGCGCTGAACGACCTGGATTGGGGCAACAAGACCATGATGATCCGCATCAACGGTCTC
GACACCCACTACATGTACCGCGACGTGGTCGACATCGTCGAAGCCTGCCCGCGGCTCGACATGGTGCTGATCCCCAAGGT
CGGCGTGCCGGCCGACGTCTACGCCATCGACGTGCTGGTCACGCAGATCGAGCAGGCCAAGAAGCGCGAGAAGCAGATCG
GCTTCGAGGTGCTGATCGAGACGGCGCTCGGCATGGCCAACGTCGAGGCGATTGCCCAGTCCTCCAAGCGCCTGGAGGCG
ATGTCCTTCGGCGTCGCCGACTACGCCGCCTCGACCCGCGCCCGCTCAACCGTGATCGGCGGCGTGAACCCCGACTTCTC
GGTGCTCACCGACAAGGACGAGTCCGGCAGCCGCCAGACCCACTGGCAGGACCCGTGGCTGTTCGCCCAGAACCGCATGC
TGGTGGCCTGTCGCGCCTATGGTCTGCGTCCGATCGACGGACCGTTCGGCGACTTCTCGGATCCGGACGGCTACCGCTCG
GCCGCCCGCCGCTGCGCCGCCCTCGGCTTCGAGGGCAAATGGGCGATCCACCCGAGCCAGATCGAGCTCGCCAACGAGGT
GTTCACCCCCTCGGAGGCCGAGGTCACCAAGGCCCGCCGCATCCTCGAGGCCATGGAAGAGGCCGCCAAGGCCGGCCGCG
GCGCCGTGTCCCTGGACGGTCGCCTCATCGACATCGCCTCGATCCGCATGGCCGAGGCGCTGATCGAGAAGGCGAACGCC
ATGAAGGGCTGA

Upstream 100 bases:

>100_bases
CGCGCTCTGTCAGAGCGTCCGGCGCGCGCCATTTGCCGCCGGTGAACGGGATCGCATCCCGCAACGGCACCAGAACCGTC
ACCAGGAGAGAGAACCCAAG

Downstream 100 bases:

>100_bases
GGCCGCCCGCGGGCGCGCCGAGCTTCGACGCGCCCGAGGCCGGGGCTCTCTGGGAGGCGGACCGCGGTCACGTCCGCGAT
CCGCCCGACACGTTCGGTTG

Product: Citryl-CoA lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSFTLIQQAKPRLHRSELAVPGSNPTFMEKSASSAADVIFLDLEDAVAPDDKEKARTNIIQALNDLDWGNKTMMIRINGL
DTHYMYRDVVDIVEACPRLDMVLIPKVGVPADVYAIDVLVTQIEQAKKREKQIGFEVLIETALGMANVEAIAQSSKRLEA
MSFGVADYAASTRARSTVIGGVNPDFSVLTDKDESGSRQTHWQDPWLFAQNRMLVACRAYGLRPIDGPFGDFSDPDGYRS
AARRCAALGFEGKWAIHPSQIELANEVFTPSEAEVTKARRILEAMEEAAKAGRGAVSLDGRLIDIASIRMAEALIEKANA
MKG

Sequences:

>Translated_323_residues
MSFTLIQQAKPRLHRSELAVPGSNPTFMEKSASSAADVIFLDLEDAVAPDDKEKARTNIIQALNDLDWGNKTMMIRINGL
DTHYMYRDVVDIVEACPRLDMVLIPKVGVPADVYAIDVLVTQIEQAKKREKQIGFEVLIETALGMANVEAIAQSSKRLEA
MSFGVADYAASTRARSTVIGGVNPDFSVLTDKDESGSRQTHWQDPWLFAQNRMLVACRAYGLRPIDGPFGDFSDPDGYRS
AARRCAALGFEGKWAIHPSQIELANEVFTPSEAEVTKARRILEAMEEAAKAGRGAVSLDGRLIDIASIRMAEALIEKANA
MKG
>Mature_322_residues
SFTLIQQAKPRLHRSELAVPGSNPTFMEKSASSAADVIFLDLEDAVAPDDKEKARTNIIQALNDLDWGNKTMMIRINGLD
THYMYRDVVDIVEACPRLDMVLIPKVGVPADVYAIDVLVTQIEQAKKREKQIGFEVLIETALGMANVEAIAQSSKRLEAM
SFGVADYAASTRARSTVIGGVNPDFSVLTDKDESGSRQTHWQDPWLFAQNRMLVACRAYGLRPIDGPFGDFSDPDGYRSA
ARRCAALGFEGKWAIHPSQIELANEVFTPSEAEVTKARRILEAMEEAAKAGRGAVSLDGRLIDIASIRMAEALIEKANAM
KG

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=320, Percent_Identity=28.125, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87081764, Length=314, Percent_Identity=32.1656050955414, Blast_Score=134, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17557458, Length=307, Percent_Identity=26.7100977198697, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 35433; Mature: 35302

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTLIQQAKPRLHRSELAVPGSNPTFMEKSASSAADVIFLDLEDAVAPDDKEKARTNII
CCCCHHHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECHHCCCCCCHHHHHHHHH
QALNDLDWGNKTMMIRINGLDTHYMYRDVVDIVEACPRLDMVLIPKVGVPADVYAIDVLV
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
TQIEQAKKREKQIGFEVLIETALGMANVEAIAQSSKRLEAMSFGVADYAASTRARSTVIG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEC
GVNPDFSVLTDKDESGSRQTHWQDPWLFAQNRMLVACRAYGLRPIDGPFGDFSDPDGYRS
CCCCCCEEEECCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
AARRCAALGFEGKWAIHPSQIELANEVFTPSEAEVTKARRILEAMEEAAKAGRGAVSLDG
HHHHHHHCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECC
RLIDIASIRMAEALIEKANAMKG
EEEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFTLIQQAKPRLHRSELAVPGSNPTFMEKSASSAADVIFLDLEDAVAPDDKEKARTNII
CCCHHHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECHHCCCCCCHHHHHHHHH
QALNDLDWGNKTMMIRINGLDTHYMYRDVVDIVEACPRLDMVLIPKVGVPADVYAIDVLV
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHH
TQIEQAKKREKQIGFEVLIETALGMANVEAIAQSSKRLEAMSFGVADYAASTRARSTVIG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEC
GVNPDFSVLTDKDESGSRQTHWQDPWLFAQNRMLVACRAYGLRPIDGPFGDFSDPDGYRS
CCCCCCEEEECCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
AARRCAALGFEGKWAIHPSQIELANEVFTPSEAEVTKARRILEAMEEAAKAGRGAVSLDG
HHHHHHHCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECC
RLIDIASIRMAEALIEKANAMKG
EEEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA