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The map label for this gene is pepA [H]

Identifier: 170749981

GI number: 170749981

Start: 3806249

End: 3807649

Strand: Direct

Name: pepA [H]

Synonym: Mrad2831_3582

Alternate gene names: 170749981

Gene position: 3806249-3807649 (Clockwise)

Preceding gene: 170749975

Following gene: 170749986

Centisome position: 62.63

GC content: 75.16

Gene sequence:

>1401_bases
ATGACCCAGGCCGAGATTCCGGCGACGACCCGCGGGCTCCTGCCCGGCGACACCCAGGCCGTACCGGTGACGCTGGTCAC
GACGGGGGATTGGGCGGTCGTCGAGTCCGGCCTGGAGCCGGCCCAGCGGAGCTTCGCCCAGGCCATCGGCTTCACGCCGA
AGGCGGGCAGCCTCGCGCTCCTGCCCGGCCCGGACGGCAGCCTCGCGCGGGTCCTGTTCGGCCTCGGCGATCCGGAGGCG
GCCAACTACGACCGTCTCCTCGTCGGCAAGCTGCCGGGGCTGCTGCCGGAGGGGATCTTCCGCCTCGAGAACGCCGCCGA
GCCGCATGAGGCCGCCCTCGCCTGGCTGATGGGGAGCTACCGCTTCGGCCGCTACCGGTCCGGCGGCGGGACCAAGGCCC
GGCTCGCGGCGCCGGCCGGCATCGACGTGGCCGAGGTCGAGCGGATCGCCGCCGCGGTCGCGCTGGGCCGGGATCTCGTC
AACACGCCGGCCAACGATCTCGGACCCGCCGAGATCGAGGCGGCTGCCCGGGCACTCGGCGACCGTCACGGCGCCACCGT
CACGGTGACGGAGGGCGCGGCCCTCGCCGAGGGGTACCCGCTGATCCACGCGGTCGGCGCCGCCTCGCCCCGGGCACCGC
GGCTGATCGACCTGACCTGGGGGCCGGCGGACGCGCCGCGCGTGACCCTGGTCGGCAAGGGCGTCGCCTTCGACACCGGC
GGCCTCGACCTCAAGCCGTCGGCCGCGATGCTGCTGATGAAGAAGGATATGGGCGGCGCCGCCGCGGCGCTGGCCGCCGC
TGACATGGTCATGGGCGCGGGCCTGACCCTGCGCCTGCGCCTGCTGATCCCCGCGGTGGAGAACGCGGTCGCGGGCAACG
CCTTCCGCCCCGGCGACGTGCTGCCCAGCCGGGCCGGGCTCAGCGTCGAGATCGGCAACACCGACGCGGAGGGCCGGCTG
ATCCTCGCCGACGCGCTCGCCCTCGCGGACGCCGACGCGCCCGAGCTGATCCTCGACTTCTCGACCCTGACCGGTGCGGC
CCGGGTGGCCCTCGGGCCGGACCTGCCGGCCTTCTTCACGGAGGACGACGCGCTGGCCGAGGCGGTGGCGCGGGCCGGGC
GGACGGCGATCGATCCGGTCTGGCGCATGCCGCTGCACGCGCCCTACGCGAGCCTGCTCGACTCCAAGGTGGCCGATCTC
AACAACGTCTCCGGCGGGCCGTTCGCGGGGGCGATCACCGCGGCCCTGTTCCTGCGCCGCTTCGCGCCCAACACGAGGGC
GCACGGCCATTTCGACCTCTACGGCTGGAACCCCTCGACCAAGCCCGGCCGGCCGGAGGGCGGCGAGGTCCAGACCGCGC
GGCTGACCTACGCGCTGCTCAAGGCCCGCTACGGCGGCTGA

Upstream 100 bases:

>100_bases
GACGCGATGGCACGCGCTTCACGCTCCCGGCCGGCCGGTGATAGAGCGTTAACCCTAATCACCGGTTAAGCCGCCGCTCC
GGGCGGCACGCGAGAGGCAC

Downstream 100 bases:

>100_bases
TCGCCGCTCTTCGCTGCGCTCGGGACGACGGAGCGGCTCAAGCGAGCCCCGCCTGCCGCAGCAGGATCCCGGCCCCGGCG
CACAGCGCCAGGGTCTGGAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTQAEIPATTRGLLPGDTQAVPVTLVTTGDWAVVESGLEPAQRSFAQAIGFTPKAGSLALLPGPDGSLARVLFGLGDPEA
ANYDRLLVGKLPGLLPEGIFRLENAAEPHEAALAWLMGSYRFGRYRSGGGTKARLAAPAGIDVAEVERIAAAVALGRDLV
NTPANDLGPAEIEAAARALGDRHGATVTVTEGAALAEGYPLIHAVGAASPRAPRLIDLTWGPADAPRVTLVGKGVAFDTG
GLDLKPSAAMLLMKKDMGGAAAALAAADMVMGAGLTLRLRLLIPAVENAVAGNAFRPGDVLPSRAGLSVEIGNTDAEGRL
ILADALALADADAPELILDFSTLTGAARVALGPDLPAFFTEDDALAEAVARAGRTAIDPVWRMPLHAPYASLLDSKVADL
NNVSGGPFAGAITAALFLRRFAPNTRAHGHFDLYGWNPSTKPGRPEGGEVQTARLTYALLKARYGG

Sequences:

>Translated_466_residues
MTQAEIPATTRGLLPGDTQAVPVTLVTTGDWAVVESGLEPAQRSFAQAIGFTPKAGSLALLPGPDGSLARVLFGLGDPEA
ANYDRLLVGKLPGLLPEGIFRLENAAEPHEAALAWLMGSYRFGRYRSGGGTKARLAAPAGIDVAEVERIAAAVALGRDLV
NTPANDLGPAEIEAAARALGDRHGATVTVTEGAALAEGYPLIHAVGAASPRAPRLIDLTWGPADAPRVTLVGKGVAFDTG
GLDLKPSAAMLLMKKDMGGAAAALAAADMVMGAGLTLRLRLLIPAVENAVAGNAFRPGDVLPSRAGLSVEIGNTDAEGRL
ILADALALADADAPELILDFSTLTGAARVALGPDLPAFFTEDDALAEAVARAGRTAIDPVWRMPLHAPYASLLDSKVADL
NNVSGGPFAGAITAALFLRRFAPNTRAHGHFDLYGWNPSTKPGRPEGGEVQTARLTYALLKARYGG
>Mature_465_residues
TQAEIPATTRGLLPGDTQAVPVTLVTTGDWAVVESGLEPAQRSFAQAIGFTPKAGSLALLPGPDGSLARVLFGLGDPEAA
NYDRLLVGKLPGLLPEGIFRLENAAEPHEAALAWLMGSYRFGRYRSGGGTKARLAAPAGIDVAEVERIAAAVALGRDLVN
TPANDLGPAEIEAAARALGDRHGATVTVTEGAALAEGYPLIHAVGAASPRAPRLIDLTWGPADAPRVTLVGKGVAFDTGG
LDLKPSAAMLLMKKDMGGAAAALAAADMVMGAGLTLRLRLLIPAVENAVAGNAFRPGDVLPSRAGLSVEIGNTDAEGRLI
LADALALADADAPELILDFSTLTGAARVALGPDLPAFFTEDDALAEAVARAGRTAIDPVWRMPLHAPYASLLDSKVADLN
NVSGGPFAGAITAALFLRRFAPNTRAHGHFDLYGWNPSTKPGRPEGGEVQTARLTYALLKARYGG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=296, Percent_Identity=37.1621621621622, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI47155554, Length=270, Percent_Identity=35.5555555555556, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082123, Length=350, Percent_Identity=39.4285714285714, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1790710, Length=286, Percent_Identity=37.7622377622378, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=267, Percent_Identity=37.8277153558052, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=222, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355725, Length=341, Percent_Identity=33.7243401759531, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24661038, Length=341, Percent_Identity=33.1378299120235, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357381, Length=275, Percent_Identity=36, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221379063, Length=275, Percent_Identity=36, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221379062, Length=275, Percent_Identity=36, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=324, Percent_Identity=28.7037037037037, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355645, Length=345, Percent_Identity=28.695652173913, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24662223, Length=345, Percent_Identity=28.695652173913, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24662227, Length=304, Percent_Identity=28.2894736842105, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI161077148, Length=294, Percent_Identity=28.9115646258503, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130057, Length=294, Percent_Identity=28.9115646258503, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646701, Length=207, Percent_Identity=33.8164251207729, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24646703, Length=207, Percent_Identity=33.8164251207729, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21358201, Length=207, Percent_Identity=33.8164251207729, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20129963, Length=276, Percent_Identity=27.8985507246377, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922386, Length=322, Percent_Identity=25.776397515528, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 47965; Mature: 47834

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAEIPATTRGLLPGDTQAVPVTLVTTGDWAVVESGLEPAQRSFAQAIGFTPKAGSLAL
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEE
LPGPDGSLARVLFGLGDPEAANYDRLLVGKLPGLLPEGIFRLENAAEPHEAALAWLMGSY
EECCCCHHHHHHHCCCCCCCCCCCEEEEHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCC
RFGRYRSGGGTKARLAAPAGIDVAEVERIAAAVALGRDLVNTPANDLGPAEIEAAARALG
CCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
DRHGATVTVTEGAALAEGYPLIHAVGAASPRAPRLIDLTWGPADAPRVTLVGKGVAFDTG
CCCCCEEEEECCCHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEECCC
GLDLKPSAAMLLMKKDMGGAAAALAAADMVMGAGLTLRLRLLIPAVENAVAGNAFRPGDV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCCCCCC
LPSRAGLSVEIGNTDAEGRLILADALALADADAPELILDFSTLTGAARVALGPDLPAFFT
CCCCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCEEC
EDDALAEAVARAGRTAIDPVWRMPLHAPYASLLDSKVADLNNVSGGPFAGAITAALFLRR
CCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
FAPNTRAHGHFDLYGWNPSTKPGRPEGGEVQTARLTYALLKARYGG
HCCCCCCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQAEIPATTRGLLPGDTQAVPVTLVTTGDWAVVESGLEPAQRSFAQAIGFTPKAGSLAL
CCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEE
LPGPDGSLARVLFGLGDPEAANYDRLLVGKLPGLLPEGIFRLENAAEPHEAALAWLMGSY
EECCCCHHHHHHHCCCCCCCCCCCEEEEHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCC
RFGRYRSGGGTKARLAAPAGIDVAEVERIAAAVALGRDLVNTPANDLGPAEIEAAARALG
CCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
DRHGATVTVTEGAALAEGYPLIHAVGAASPRAPRLIDLTWGPADAPRVTLVGKGVAFDTG
CCCCCEEEEECCCHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCEEECCC
GLDLKPSAAMLLMKKDMGGAAAALAAADMVMGAGLTLRLRLLIPAVENAVAGNAFRPGDV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCCCCCC
LPSRAGLSVEIGNTDAEGRLILADALALADADAPELILDFSTLTGAARVALGPDLPAFFT
CCCCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCEEC
EDDALAEAVARAGRTAIDPVWRMPLHAPYASLLDSKVADLNNVSGGPFAGAITAALFLRR
CCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
FAPNTRAHGHFDLYGWNPSTKPGRPEGGEVQTARLTYALLKARYGG
HCCCCCCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA