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The map label for this gene is rnr [H]

Identifier: 170749971

GI number: 170749971

Start: 3793021

End: 3795342

Strand: Direct

Name: rnr [H]

Synonym: Mrad2831_3572

Alternate gene names: 170749971

Gene position: 3793021-3795342 (Clockwise)

Preceding gene: 170749970

Following gene: 170749972

Centisome position: 62.41

GC content: 74.03

Gene sequence:

>2322_bases
TTGGCACGACGCACCACCGCCCCGGCGGCCGAGCCCGCCGCTCCGCAGCCCTTCCCCACCCGTGAGCAGATCCTCGCCTT
CGTGGCCGAGTCGAAGGAGCGCGTCGGCAAGCGGGAGATCGCCAAGGCCTTCGGCATCAAGGGGGCCGCCAAGATCGACC
TGAAGCGCGTCCTGAAGGAGATCGAAGAGGACGGCGCCCTCGACCGCGGCCGCGGCGGCCTCGCCCCGGCGGGCCACCTA
CCGCCGGTCGTGCTGGCCGACATCCGCTCCCGCGACCGCCACGGCGACTTCCTGGCGATCCCGGTGGAGTGGACCGGGAC
CGGCAAGCCGCCCGCCATCGTTCTGGTGCAGCCGCGCGGCCCCCGGAAGGGCAACCGTCCGGCCCCGGGCATCGGCGACC
GCGCCCTGATCCGGGTCGAGCGCGACGCGGAAGGCGGCTACGCCGGCCGGGTCGTCAAGGTCATCGGGAAGAACAAGGCC
GAGATCATCGGCGTCTACCGGGCCGGCGCGCAGGGCGGCCGGATCGTGCCCGTCGAGAAGCGCGCGCAGGGCCGCGAGAT
CCTGATCCCGCCCGGCGAGGAGGGGCAGGCCCGCGACGGCGACCTCGTCAGCGTCTCGCTGGAGCGCGAGACGCGGTTCG
GCCTGCCGAAGGGGCGTGTGCGCGAGCGATTGGGCTCGCTCGGTTCCGAGAAGGCGGTGAGCCTGATCGCGCTGCACCTC
CACAACATCCCGCACGTCTTCGCCGACGCGACCCTGGCGGAGGCCGACGCCGCCAGGCCCGCCACGCTGAAGGGCCGCGA
GGACTGGCGCGACCGGCCCCTCCTGACCATCGACCCGCCGGACGCCAAGGACCACGACGATGCCGTCATGGCCGAGGCCG
ATCCCGACCCGGCCAATCCCGGCGGCTTCATCCTCACCGTCGCCATCGCGGACGTGGCCGCCTATGTCCGGCCGGGCTCC
AGCCTCGACCGCGAGGCCCTGGAACGGGGCAACTCGGTCTACTTCCCCGACCGGGTCGTGCCGATGCTGCCCGAGCGGAT
CTCGAACGACCTCTGCTCCCTCCGCGAGGGCGAGGACCGGCCGGCGCTGGCGGTGCGGATGGTCATCGCCGCCGACGGCG
AGAAGCGCCGCCACGGCTTCCACCGGGTGATGATACGCTCCCGCGCGAAGCTCGCCTACGCGCAGGCGCAGGCCGCCATC
GACGGGCGCCCGGACGATGCGACCGGGCCGCTTCTGGAGACGGCCCTTCGCCCCCTCTGGGCGGCCTACGCGGCCCTGCG
CGCGGCCCGCGACCGCCGGGGGCCGCTGGCCCTCGACCTGCCCGAGCGCAAGGTCCTGCTCTCGCCCGAGGGCGCGGTCG
ACCGGGTGATCGTGCCGGAGCGCCTCGACGCCCACCGGCTGATCGAGGAGTTCATGATCCAGGCGAACGTCGCCGCCGCC
GAGACGCTGGAGCAGGCCCGACAGCCCCTGATCTACCGCGTCCACGACGAGCCCGCCCTGGAGAAGATGCGGGCGCTCGG
CGAGGTCCTGGCCTCGGTGGGCATCAAGCTGCCCAAGGAAGGGGCGCTGCGCCCCGCCCTGTTCAACCGGATCCTCGCCA
CGGCGGCCGAGACCGAGCACGGCGTCTTCCTCAACGAGGTGATCCTGCGCAGCCAGGCCCAGGCCGTCTACGCCCCCGAG
AATCTCGGGCATTTCGGCCTGAACCTGCGCCGCTACGCGCACTTCACCTCGCCGATCCGGCGCTACGCCGACCTGATCGT
GCACCGGGCGCTGATCACCGCCTGCCGGCTCGGATCGGACGGGCTCGCGAGCGACGTCTCCCTCGGCGAGCTGGCGCAGA
TCGGCGAGCAGATCTCGGCGGCCGAGCGCCGCGCCATGGCGGCCGAGCGCGAGACGATCGACCGGCTCATCGCCCACCAC
CTCGCCGACCAGGTCGGCGCGACCTTCGCGGGTCAGATCGCCGGCGTCACCCGGGCCGGCCTGTTCATCAAGCTCGACGA
GACCGGCGCGGACGGCTTCGTGCCGGTCTCGCAGCTCGGCGCCGACTATTTCCGCCACGAGGAGGGCCGCCACGCCCTGG
TGGGCGAGCGCACCGGGGAGACGTTCCGCCTCGGCGACCGGGTCGAAGTGCGGCTCGTGGAGGCCGCACCGGTGGCCGGG
GCGTTGCGCTTCGAGCTGCTCAGCGAGGGCCGGACCCGCTCCGGTGGCCGGACTGCCGGGCCCGGCAAGAAGGCCGGCGG
CCGGGCCTTCAAGGCCGCGCCGCCCGGCCGCCCCCCCGGCATCCGCAACACCGGGTCGCGCCACCGCGGCTCGCGCCACT
GA

Upstream 100 bases:

>100_bases
GCGCGGGCCGGACACCCATGTTAGCCTCACAGGACCGACGCCTCGGTCCCGCGCCCGCACGCGGGTCCCGTCTATCGCAG
AACTGTCCGGCACCCCCCTT

Downstream 100 bases:

>100_bases
CCCGGGCGGTGTAGACCCTGGACATGGCCGCCGACGCGATACCCGAGCGCACCCGCCTGATCCCCGCGATGGCCCGGGGC
TTCATCGGCCGCTGCCCGCA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 773; Mature: 772

Protein sequence:

>773_residues
MARRTTAPAAEPAAPQPFPTREQILAFVAESKERVGKREIAKAFGIKGAAKIDLKRVLKEIEEDGALDRGRGGLAPAGHL
PPVVLADIRSRDRHGDFLAIPVEWTGTGKPPAIVLVQPRGPRKGNRPAPGIGDRALIRVERDAEGGYAGRVVKVIGKNKA
EIIGVYRAGAQGGRIVPVEKRAQGREILIPPGEEGQARDGDLVSVSLERETRFGLPKGRVRERLGSLGSEKAVSLIALHL
HNIPHVFADATLAEADAARPATLKGREDWRDRPLLTIDPPDAKDHDDAVMAEADPDPANPGGFILTVAIADVAAYVRPGS
SLDREALERGNSVYFPDRVVPMLPERISNDLCSLREGEDRPALAVRMVIAADGEKRRHGFHRVMIRSRAKLAYAQAQAAI
DGRPDDATGPLLETALRPLWAAYAALRAARDRRGPLALDLPERKVLLSPEGAVDRVIVPERLDAHRLIEEFMIQANVAAA
ETLEQARQPLIYRVHDEPALEKMRALGEVLASVGIKLPKEGALRPALFNRILATAAETEHGVFLNEVILRSQAQAVYAPE
NLGHFGLNLRRYAHFTSPIRRYADLIVHRALITACRLGSDGLASDVSLGELAQIGEQISAAERRAMAAERETIDRLIAHH
LADQVGATFAGQIAGVTRAGLFIKLDETGADGFVPVSQLGADYFRHEEGRHALVGERTGETFRLGDRVEVRLVEAAPVAG
ALRFELLSEGRTRSGGRTAGPGKKAGGRAFKAAPPGRPPGIRNTGSRHRGSRH

Sequences:

>Translated_773_residues
MARRTTAPAAEPAAPQPFPTREQILAFVAESKERVGKREIAKAFGIKGAAKIDLKRVLKEIEEDGALDRGRGGLAPAGHL
PPVVLADIRSRDRHGDFLAIPVEWTGTGKPPAIVLVQPRGPRKGNRPAPGIGDRALIRVERDAEGGYAGRVVKVIGKNKA
EIIGVYRAGAQGGRIVPVEKRAQGREILIPPGEEGQARDGDLVSVSLERETRFGLPKGRVRERLGSLGSEKAVSLIALHL
HNIPHVFADATLAEADAARPATLKGREDWRDRPLLTIDPPDAKDHDDAVMAEADPDPANPGGFILTVAIADVAAYVRPGS
SLDREALERGNSVYFPDRVVPMLPERISNDLCSLREGEDRPALAVRMVIAADGEKRRHGFHRVMIRSRAKLAYAQAQAAI
DGRPDDATGPLLETALRPLWAAYAALRAARDRRGPLALDLPERKVLLSPEGAVDRVIVPERLDAHRLIEEFMIQANVAAA
ETLEQARQPLIYRVHDEPALEKMRALGEVLASVGIKLPKEGALRPALFNRILATAAETEHGVFLNEVILRSQAQAVYAPE
NLGHFGLNLRRYAHFTSPIRRYADLIVHRALITACRLGSDGLASDVSLGELAQIGEQISAAERRAMAAERETIDRLIAHH
LADQVGATFAGQIAGVTRAGLFIKLDETGADGFVPVSQLGADYFRHEEGRHALVGERTGETFRLGDRVEVRLVEAAPVAG
ALRFELLSEGRTRSGGRTAGPGKKAGGRAFKAAPPGRPPGIRNTGSRHRGSRH
>Mature_772_residues
ARRTTAPAAEPAAPQPFPTREQILAFVAESKERVGKREIAKAFGIKGAAKIDLKRVLKEIEEDGALDRGRGGLAPAGHLP
PVVLADIRSRDRHGDFLAIPVEWTGTGKPPAIVLVQPRGPRKGNRPAPGIGDRALIRVERDAEGGYAGRVVKVIGKNKAE
IIGVYRAGAQGGRIVPVEKRAQGREILIPPGEEGQARDGDLVSVSLERETRFGLPKGRVRERLGSLGSEKAVSLIALHLH
NIPHVFADATLAEADAARPATLKGREDWRDRPLLTIDPPDAKDHDDAVMAEADPDPANPGGFILTVAIADVAAYVRPGSS
LDREALERGNSVYFPDRVVPMLPERISNDLCSLREGEDRPALAVRMVIAADGEKRRHGFHRVMIRSRAKLAYAQAQAAID
GRPDDATGPLLETALRPLWAAYAALRAARDRRGPLALDLPERKVLLSPEGAVDRVIVPERLDAHRLIEEFMIQANVAAAE
TLEQARQPLIYRVHDEPALEKMRALGEVLASVGIKLPKEGALRPALFNRILATAAETEHGVFLNEVILRSQAQAVYAPEN
LGHFGLNLRRYAHFTSPIRRYADLIVHRALITACRLGSDGLASDVSLGELAQIGEQISAAERRAMAAERETIDRLIAHHL
ADQVGATFAGQIAGVTRAGLFIKLDETGADGFVPVSQLGADYFRHEEGRHALVGERTGETFRLGDRVEVRLVEAAPVAGA
LRFELLSEGRTRSGGRTAGPGKKAGGRAFKAAPPGRPPGIRNTGSRHRGSRH

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=582, Percent_Identity=27.4914089347079, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI190014623, Length=582, Percent_Identity=27.4914089347079, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI134288890, Length=362, Percent_Identity=32.3204419889503, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI219521928, Length=732, Percent_Identity=27.1857923497268, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI19115966, Length=732, Percent_Identity=27.1857923497268, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI156105693, Length=693, Percent_Identity=24.0981240981241, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI156105695, Length=693, Percent_Identity=24.0981240981241, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI87082383, Length=751, Percent_Identity=37.8162450066578, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1787542, Length=473, Percent_Identity=33.1923890063425, Blast_Score=172, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI212645896, Length=558, Percent_Identity=29.3906810035842, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=410, Percent_Identity=32.6829268292683, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=491, Percent_Identity=29.7352342158859, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24649634, Length=481, Percent_Identity=28.2744282744283, Blast_Score=154, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922976, Length=364, Percent_Identity=30.4945054945055, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24654597, Length=364, Percent_Identity=30.4945054945055, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24654592, Length=364, Percent_Identity=30.4945054945055, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 83546; Mature: 83414

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRTTAPAAEPAAPQPFPTREQILAFVAESKERVGKREIAKAFGIKGAAKIDLKRVLKE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IEEDGALDRGRGGLAPAGHLPPVVLADIRSRDRHGDFLAIPVEWTGTGKPPAIVLVQPRG
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCC
PRKGNRPAPGIGDRALIRVERDAEGGYAGRVVKVIGKNKAEIIGVYRAGAQGGRIVPVEK
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCCCCEEEEEHH
RAQGREILIPPGEEGQARDGDLVSVSLERETRFGLPKGRVRERLGSLGSEKAVSLIALHL
CCCCCEEEECCCCCCCCCCCCEEEEEECCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
HNIPHVFADATLAEADAARPATLKGREDWRDRPLLTIDPPDAKDHDDAVMAEADPDPANP
HCCCHHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCC
GGFILTVAIADVAAYVRPGSSLDREALERGNSVYFPDRVVPMLPERISNDLCSLREGEDR
CCEEEEHHHHHHHHHHCCCCCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCC
PALAVRMVIAADGEKRRHGFHRVMIRSRAKLAYAQAQAAIDGRPDDATGPLLETALRPLW
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AAYAALRAARDRRGPLALDLPERKVLLSPEGAVDRVIVPERLDAHRLIEEFMIQANVAAA
HHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHH
ETLEQARQPLIYRVHDEPALEKMRALGEVLASVGIKLPKEGALRPALFNRILATAAETEH
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GVFLNEVILRSQAQAVYAPENLGHFGLNLRRYAHFTSPIRRYADLIVHRALITACRLGSD
CHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLASDVSLGELAQIGEQISAAERRAMAAERETIDRLIAHHLADQVGATFAGQIAGVTRAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEECC
LFIKLDETGADGFVPVSQLGADYFRHEEGRHALVGERTGETFRLGDRVEVRLVEAAPVAG
EEEEEECCCCCCCCCHHHHCHHHHHCCCCCEEECCCCCCCEEECCCCEEEEEEECCCCHH
ALRFELLSEGRTRSGGRTAGPGKKAGGRAFKAAPPGRPPGIRNTGSRHRGSRH
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARRTTAPAAEPAAPQPFPTREQILAFVAESKERVGKREIAKAFGIKGAAKIDLKRVLKE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IEEDGALDRGRGGLAPAGHLPPVVLADIRSRDRHGDFLAIPVEWTGTGKPPAIVLVQPRG
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCC
PRKGNRPAPGIGDRALIRVERDAEGGYAGRVVKVIGKNKAEIIGVYRAGAQGGRIVPVEK
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCCCCEEEEEHH
RAQGREILIPPGEEGQARDGDLVSVSLERETRFGLPKGRVRERLGSLGSEKAVSLIALHL
CCCCCEEEECCCCCCCCCCCCEEEEEECCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
HNIPHVFADATLAEADAARPATLKGREDWRDRPLLTIDPPDAKDHDDAVMAEADPDPANP
HCCCHHHHCCHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCCC
GGFILTVAIADVAAYVRPGSSLDREALERGNSVYFPDRVVPMLPERISNDLCSLREGEDR
CCEEEEHHHHHHHHHHCCCCCCCHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCC
PALAVRMVIAADGEKRRHGFHRVMIRSRAKLAYAQAQAAIDGRPDDATGPLLETALRPLW
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AAYAALRAARDRRGPLALDLPERKVLLSPEGAVDRVIVPERLDAHRLIEEFMIQANVAAA
HHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHH
ETLEQARQPLIYRVHDEPALEKMRALGEVLASVGIKLPKEGALRPALFNRILATAAETEH
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GVFLNEVILRSQAQAVYAPENLGHFGLNLRRYAHFTSPIRRYADLIVHRALITACRLGSD
CHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLASDVSLGELAQIGEQISAAERRAMAAERETIDRLIAHHLADQVGATFAGQIAGVTRAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEECC
LFIKLDETGADGFVPVSQLGADYFRHEEGRHALVGERTGETFRLGDRVEVRLVEAAPVAG
EEEEEECCCCCCCCCHHHHCHHHHHCCCCCEEECCCCCCCEEECCCCEEEEEEECCCCHH
ALRFELLSEGRTRSGGRTAGPGKKAGGRAFKAAPPGRPPGIRNTGSRHRGSRH
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]