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The map label for this gene is rbsK [C]

Identifier: 170749932

GI number: 170749932

Start: 3747368

End: 3748381

Strand: Direct

Name: rbsK [C]

Synonym: Mrad2831_3532

Alternate gene names: 170749932

Gene position: 3747368-3748381 (Clockwise)

Preceding gene: 170749931

Following gene: 170749942

Centisome position: 61.66

GC content: 73.18

Gene sequence:

>1014_bases
ATGACTGCACCCCTCGATCTCCTCGTGCTCGGCAACGCGATCGTCGACGTGATCGCCCGCACGGACGACGCCTTCCTGGC
GGCGCAGGGCGTCACCAAGGGCGCGATGCAGCTCATCGACGAGCCGCGGGCCGAGGCGCTGTTCCAGGCGATGGGACCGG
CGACGATCGTGTCGGGCGGCTCGGGCGCCAACACCGCGGTCGGCGCGGCGCTCCTCGGGGCCAGGACCGGCTTCGTCGGC
AAGGTCCGGAACGACGAGCTCGGCGGCCTGTTCAGCCACGACCTCAAGGCGACCGGCGTCGACTTCACCGTCCCGGCCGC
CGCCGAGGGTCCGGCCACCGCCCGGTGCTTCGTGCTCGTGACGCCGGACGGCGAGCGCACGATGAGCACCTATCTCGGCG
CCTGCCAGGGCCTGTCGCCCGACGATGTCGACAAGACGCTCGTGAGCTCGGCCCGCGTCGTCTATCTCGAGGGCTATCTC
TGGGATCCGCCGGCCGCCAAGGACGCGTTCCGCAAGGCCGCGCAGCTCGCCCATCAGGCGGGCAACGCCGTCGCGCTGAC
CCTCTCGGACGCGTTCTGCGTGGGCCGCTACCGCGACGAGTTCCTCGGCCTCGTGCGGGACGGCAGCATCGACATCCTGT
TCGCCAACATGGCCGAGCTGCAGAGCCTCTACGAGACCGAGGATCCCGAGGCCGCCGTCGCGGCCCTGCGCGACGAGCGC
AACGCCCGCGGTCGCCACCTGCTCGGCTTGGTCACGCGCTCGGCCGACGGCGCCCTGGTGGTGCAGGGTGGCGAGGTCCG
GGCCGTCGAGGCGAGCCCGGTCCAGACGGTGGTCGACACGACCGGCGCGGGCGACCTGTTCGCCGCCGGCTTCCTGGCCG
GCCACGCCCGCGGGCTGGACAACGTCGCCAGCGCCCGCCTGGGCACGCTCGCGGCCGCCGAGGTCATCCAGCACATCGGC
GCCCGCCCGCAGGCGGATCTGATCGGCCTGGCCAAGGCGCGCGGGCTCCTCTGA

Upstream 100 bases:

>100_bases
GTGCCCGAGCTGTTCGCCGACCTCGCGCCCGCCGACGACGGCGCTTGATCCGATCCGAGGCGGATGCCACAGCGGCGCGA
ACGCGAATCAGGACGCCCGG

Downstream 100 bases:

>100_bases
GCCGGCGCGCCGGGCGCGCGGTCGGGCGCGCGTCCGCTCCGATCCCGCGCGCTCAGGCCGCGCGGACGGTCGCGAGGAAG
CGCGTCACCTCGTCCCTGAG

Product: ribokinase-like domain-containing protein

Products: ADP; H+; alpha-D-Ribose 5-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTAPLDLLVLGNAIVDVIARTDDAFLAAQGVTKGAMQLIDEPRAEALFQAMGPATIVSGGSGANTAVGAALLGARTGFVG
KVRNDELGGLFSHDLKATGVDFTVPAAAEGPATARCFVLVTPDGERTMSTYLGACQGLSPDDVDKTLVSSARVVYLEGYL
WDPPAAKDAFRKAAQLAHQAGNAVALTLSDAFCVGRYRDEFLGLVRDGSIDILFANMAELQSLYETEDPEAAVAALRDER
NARGRHLLGLVTRSADGALVVQGGEVRAVEASPVQTVVDTTGAGDLFAAGFLAGHARGLDNVASARLGTLAAAEVIQHIG
ARPQADLIGLAKARGLL

Sequences:

>Translated_337_residues
MTAPLDLLVLGNAIVDVIARTDDAFLAAQGVTKGAMQLIDEPRAEALFQAMGPATIVSGGSGANTAVGAALLGARTGFVG
KVRNDELGGLFSHDLKATGVDFTVPAAAEGPATARCFVLVTPDGERTMSTYLGACQGLSPDDVDKTLVSSARVVYLEGYL
WDPPAAKDAFRKAAQLAHQAGNAVALTLSDAFCVGRYRDEFLGLVRDGSIDILFANMAELQSLYETEDPEAAVAALRDER
NARGRHLLGLVTRSADGALVVQGGEVRAVEASPVQTVVDTTGAGDLFAAGFLAGHARGLDNVASARLGTLAAAEVIQHIG
ARPQADLIGLAKARGLL
>Mature_336_residues
TAPLDLLVLGNAIVDVIARTDDAFLAAQGVTKGAMQLIDEPRAEALFQAMGPATIVSGGSGANTAVGAALLGARTGFVGK
VRNDELGGLFSHDLKATGVDFTVPAAAEGPATARCFVLVTPDGERTMSTYLGACQGLSPDDVDKTLVSSARVVYLEGYLW
DPPAAKDAFRKAAQLAHQAGNAVALTLSDAFCVGRYRDEFLGLVRDGSIDILFANMAELQSLYETEDPEAAVAALRDERN
ARGRHLLGLVTRSADGALVVQGGEVRAVEASPVQTVVDTTGAGDLFAAGFLAGHARGLDNVASARLGTLAAAEVIQHIGA
RPQADLIGLAKARGLL

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484975, Length=335, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32484973, Length=335, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790193, Length=242, Percent_Identity=29.3388429752066, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786684, Length=231, Percent_Identity=26.4069264069264, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789775, Length=265, Percent_Identity=29.0566037735849, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541820, Length=335, Percent_Identity=24.7761194029851, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322565, Length=349, Percent_Identity=28.080229226361, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24663633, Length=260, Percent_Identity=25.7692307692308, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356339, Length=260, Percent_Identity=25.7692307692308, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.15 [C]

Molecular weight: Translated: 34780; Mature: 34649

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLDLLVLGNAIVDVIARTDDAFLAAQGVTKGAMQLIDEPRAEALFQAMGPATIVSGG
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCCEEEEECC
SGANTAVGAALLGARTGFVGKVRNDELGGLFSHDLKATGVDFTVPAAAEGPATARCFVLV
CCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHCCCCCCCCCEECCCCCCCCCCEEEEEEE
TPDGERTMSTYLGACQGLSPDDVDKTLVSSARVVYLEGYLWDPPAAKDAFRKAAQLAHQA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHC
GNAVALTLSDAFCVGRYRDEFLGLVRDGSIDILFANMAELQSLYETEDPEAAVAALRDER
CCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHC
NARGRHLLGLVTRSADGALVVQGGEVRAVEASPVQTVVDTTGAGDLFAAGFLAGHARGLD
CCCCCEEEEEEEECCCCEEEEECCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHCCHH
NVASARLGTLAAAEVIQHIGARPQADLIGLAKARGLL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TAPLDLLVLGNAIVDVIARTDDAFLAAQGVTKGAMQLIDEPRAEALFQAMGPATIVSGG
CCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCCEEEEECC
SGANTAVGAALLGARTGFVGKVRNDELGGLFSHDLKATGVDFTVPAAAEGPATARCFVLV
CCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHCCCCCCCCCEECCCCCCCCCCEEEEEEE
TPDGERTMSTYLGACQGLSPDDVDKTLVSSARVVYLEGYLWDPPAAKDAFRKAAQLAHQA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHC
GNAVALTLSDAFCVGRYRDEFLGLVRDGSIDILFANMAELQSLYETEDPEAAVAALRDER
CCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHHC
NARGRHLLGLVTRSADGALVVQGGEVRAVEASPVQTVVDTTGAGDLFAAGFLAGHARGLD
CCCCCEEEEEEEECCCCEEEEECCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHCCHH
NVASARLGTLAAAEVIQHIGARPQADLIGLAKARGLL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-Ribose [C]

Specific reaction: ATP + D-Ribose --> ADP + H+ + alpha-D-Ribose 5-phosphate [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]