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The map label for this gene is glsA

Identifier: 170749929

GI number: 170749929

Start: 3744249

End: 3745178

Strand: Direct

Name: glsA

Synonym: Mrad2831_3529

Alternate gene names: 170749929

Gene position: 3744249-3745178 (Clockwise)

Preceding gene: 170749928

Following gene: 170749930

Centisome position: 61.6

GC content: 69.68

Gene sequence:

>930_bases
GTGCCCGACCTTGCCCACGTCATCCGGGAGATCTCCGAGGAGATGGCCCAGCGCTCCGACCGGGGCGCGGTCGCGGACTA
CATCCCCGAGCTCGCCCGGGTCGATCCCGACCAGTTCGGCATGGCGGTGATCGACGCCGAGGGACAGGTCTTCACCGGCG
GCGACAGCGAGACGCCGTTCTCGATCCAGAGCGTGTCGAAGGTGTTCACGCTCACCCTCGCCCTCGGCATGGTCGGCGAC
CGGCTCTGGAAGCGCGTCGGCCGCGAGCCCTCGGGCAACCCGTTCAATTCCATCGTCCAGCTGGAGCGGGAGCGCGGCGT
GCCGCGCAACCCGTTCATCAACGCGGGCGCGATCGCGGTCACCGACGTGATCCTCTCGGGTCACGAGCCCCGCGAGGCGC
TGGGCGAGATCCTGCGCTTCATGCAGTTCCTGGCCCAGGATTCCGGCATCATCATCGACGAGACGGTGGCGGCCTCGGAG
AAGCGCACGGGCTTCCGCAACACCGCGCTCGCCAACTACATGAAGTCGTTCGGGGTCATCGACAATCCGGTCGACTACAC
GCTCGGCGTCTACTTCCATCACTGCGCCATCGCGATGAACTGCCGCCAGCTCGCGCGGGCCGGCCGGTTCCTGGCGCATA
ACGGCGTCAACCCGTCGACCGGCCACTCGGTGGTCTCGGCGGAGCGCGCGCGCCGCATCAACGCGATCATGCTGACCTGC
GGCCACTACGACGGGTCGGGCGAGTTCGCCTACCGCGTGGGCCTGCCGGGCAAGAGCGGGGTCGGCGGCAGCATCCTGGC
GATCGCGCCCGGCAAGGCGTCCATCGCCGTCTGGTCGCCCGGCCTCGACGCGGCGGGCAATTCCCACCTCGGCCGCATCG
CCCTGGAGCGGCTCACGCAGCGCATGGGCTGGTCCGTCTTCGGCGCGTGA

Upstream 100 bases:

>100_bases
CGGCGCTGCTAGATCACCGCCGGGCCGGACCGGACCTTGCATCGCCTGAGACGTCGCGAACCGGCCCGGTTCCGACGCAA
CGCGACGCCCGAGCCCGACC

Downstream 100 bases:

>100_bases
GGGTCGCCTCCCGGCCGGCGTCGCGCCCCCTTGCGCGGCGCGCGCTTCCGCGGCACTGCGCCGGCGGGGCGCCGCGGCGC
CGAGACGAGGCTCATCGGCA

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPDLAHVIREISEEMAQRSDRGAVADYIPELARVDPDQFGMAVIDAEGQVFTGGDSETPFSIQSVSKVFTLTLALGMVGD
RLWKRVGREPSGNPFNSIVQLERERGVPRNPFINAGAIAVTDVILSGHEPREALGEILRFMQFLAQDSGIIIDETVAASE
KRTGFRNTALANYMKSFGVIDNPVDYTLGVYFHHCAIAMNCRQLARAGRFLAHNGVNPSTGHSVVSAERARRINAIMLTC
GHYDGSGEFAYRVGLPGKSGVGGSILAIAPGKASIAVWSPGLDAAGNSHLGRIALERLTQRMGWSVFGA

Sequences:

>Translated_309_residues
MPDLAHVIREISEEMAQRSDRGAVADYIPELARVDPDQFGMAVIDAEGQVFTGGDSETPFSIQSVSKVFTLTLALGMVGD
RLWKRVGREPSGNPFNSIVQLERERGVPRNPFINAGAIAVTDVILSGHEPREALGEILRFMQFLAQDSGIIIDETVAASE
KRTGFRNTALANYMKSFGVIDNPVDYTLGVYFHHCAIAMNCRQLARAGRFLAHNGVNPSTGHSVVSAERARRINAIMLTC
GHYDGSGEFAYRVGLPGKSGVGGSILAIAPGKASIAVWSPGLDAAGNSHLGRIALERLTQRMGWSVFGA
>Mature_308_residues
PDLAHVIREISEEMAQRSDRGAVADYIPELARVDPDQFGMAVIDAEGQVFTGGDSETPFSIQSVSKVFTLTLALGMVGDR
LWKRVGREPSGNPFNSIVQLERERGVPRNPFINAGAIAVTDVILSGHEPREALGEILRFMQFLAQDSGIIIDETVAASEK
RTGFRNTALANYMKSFGVIDNPVDYTLGVYFHHCAIAMNCRQLARAGRFLAHNGVNPSTGHSVVSAERARRINAIMLTCG
HYDGSGEFAYRVGLPGKSGVGGSILAIAPGKASIAVWSPGLDAAGNSHLGRIALERLTQRMGWSVFGA

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=293, Percent_Identity=37.2013651877133, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI20336214, Length=280, Percent_Identity=37.1428571428571, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1787804, Length=307, Percent_Identity=48.5342019543974, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1786693, Length=287, Percent_Identity=41.4634146341463, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17507019, Length=318, Percent_Identity=38.0503144654088, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI193204073, Length=304, Percent_Identity=36.1842105263158, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI193204075, Length=306, Percent_Identity=35.6209150326797, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17532727, Length=287, Percent_Identity=34.4947735191638, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281363241, Length=314, Percent_Identity=35.3503184713376, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24653164, Length=314, Percent_Identity=35.3503184713376, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653162, Length=314, Percent_Identity=35.3503184713376, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653156, Length=308, Percent_Identity=36.038961038961, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281363239, Length=314, Percent_Identity=35.3503184713376, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653166, Length=308, Percent_Identity=36.038961038961, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24653158, Length=308, Percent_Identity=36.038961038961, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI116008307, Length=308, Percent_Identity=36.038961038961, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_METRJ (B1LUS0)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756189.1
- ProteinModelPortal:   B1LUS0
- SMR:   B1LUS0
- GeneID:   6139582
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_3529
- HOGENOM:   HBG512335
- OMA:   NALMLTC
- ProtClustDB:   PRK00971
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33255; Mature: 33124

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLAHVIREISEEMAQRSDRGAVADYIPELARVDPDQFGMAVIDAEGQVFTGGDSETPF
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHCEEEEECCCCEEECCCCCCCC
SIQSVSKVFTLTLALGMVGDRLWKRVGREPSGNPFNSIVQLERERGVPRNPFINAGAIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
TDVILSGHEPREALGEILRFMQFLAQDSGIIIDETVAASEKRTGFRNTALANYMKSFGVI
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCHHHHHHHHHHHCCCC
DNPVDYTLGVYFHHCAIAMNCRQLARAGRFLAHNGVNPSTGHSVVSAERARRINAIMLTC
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHCEEEEEEE
GHYDGSGEFAYRVGLPGKSGVGGSILAIAPGKASIAVWSPGLDAAGNSHLGRIALERLTQ
CCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
RMGWSVFGA
HHCCHHCCC
>Mature Secondary Structure 
PDLAHVIREISEEMAQRSDRGAVADYIPELARVDPDQFGMAVIDAEGQVFTGGDSETPF
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHCEEEEECCCCEEECCCCCCCC
SIQSVSKVFTLTLALGMVGDRLWKRVGREPSGNPFNSIVQLERERGVPRNPFINAGAIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
TDVILSGHEPREALGEILRFMQFLAQDSGIIIDETVAASEKRTGFRNTALANYMKSFGVI
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCHHHHHHHHHHHCCCC
DNPVDYTLGVYFHHCAIAMNCRQLARAGRFLAHNGVNPSTGHSVVSAERARRINAIMLTC
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHCEEEEEEE
GHYDGSGEFAYRVGLPGKSGVGGSILAIAPGKASIAVWSPGLDAAGNSHLGRIALERLTQ
CCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
RMGWSVFGA
HHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA