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The map label for this gene is hemA [H]

Identifier: 170749908

GI number: 170749908

Start: 3722785

End: 3724080

Strand: Reverse

Name: hemA [H]

Synonym: Mrad2831_3508

Alternate gene names: 170749908

Gene position: 3724080-3722785 (Counterclockwise)

Preceding gene: 170749910

Following gene: 170749907

Centisome position: 61.27

GC content: 70.83

Gene sequence:

>1296_bases
ATGACCGTCACCCGGATGCCCAGCACGATGCTCGCCCAAGCGGGATCGACGCGCGCCGGATCCGGCTACGAGCGCTACTT
CCGCGGGGCCCTGGATCAGCTGCACGGCGAGCGGCGCTACCGGGTCTTCGCCGACATCGAGCGGATTTCGGGCCGTTTCC
CGACGGCCAAGTGGCGCCAGCCCGAGGGCAAGACCACCGAGATCACGGTGTGGTGCTCCAACGACTACCTCGGCATGGGC
CAGCACAAGGAGGTCGTGGCGGCCATGACCGAGACCGCCGCCCGCTGCGGCGTCGGCGCCGGCGGCACCCGCAACATCGC
CGGCAACACCTCGCCGCTGGTCGATCTGGAGCGCGAGCTCGCCGACCTGCACGGCAAGGAGGCCGGCCTCGTCTTCACCT
CCGGCTACGTCTCGAACCAGGCCGGCATCTCGACCATCGCCAAGCTGATCCCCGACTGCCTGATCCTGTCGGACGCCTTC
AACCACAACTCGATGATCGAGGGCGTGCGCCATTCCGGCTGCGCGAAGAAGATCTTCCGCCACAACGATCTCCAGCACCT
GGAGGAGCTGCTCCGGGAGGCCGGCGACCGGCCCAAGCTGATCGTGTTCGAGTCGGTCTACTCGATGGACGGCGACGTGG
CGCCGATCGGCGAGATCTGCGACCTCGCCGACCGCTACGGGGCGATGACCTACCTCGACGAGGTCCACGCCGTCGGCCTC
TACGGCCCGCGCGGCGGCGGCATCGCCGAGCGCGACGGCGTCATGCACCGGGTCGACGTGATCGAGGGGACGCTGGCCAA
GGGCTTCGGCTGCGTGGGCGGCTACATCACGGCTTCGGCGGCGATCTGCGACGCGGTGCGCAGCTTCGCGCCGGGCTTCA
TATTCACGACGGCGCTGCCGCCTGCCGTGGCGGCGGCGGCGCGGGCGTCGGTGCGGTATCTCAAGCGCTCGGGCGCGGAG
CGGGAGGCGCACCAGCGCCAGGCGGCGGCCACCAAGGCGGCGCTGCGCGCGGCGGGCCTGCCGGTCCTGGAGACGGAGAC
GCACATCGTGCCGGTGATGGTGGGCGATGCCGAGCTGTGCAAGGCGGCGGCCGACCATCTTCTGGAGCACCACGCGATCT
ACATCCAGCCGATCAACTACCCGACGGTGCCGCGCGGGACCGAGCGCCTGCGGATCACGCCGTCGCCCTTCCACGACGCG
GCGCATATCGAGCGCCTGGCTGCGGCGCTGACGGAGACCTGGGAGGCGCTGGACCTGCCCCGCGCCGGCACGGTGTTCGT
CGAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
CCTCACGCGAAGGACTGGACCGAGGCCGGACCTCGATCGCGGGCCTGAGATGCCGCCTCGGCGGTGTCGCCCGCGCGGCC
GAATACGCGAAGGACGCTCG

Downstream 100 bases:

>100_bases
GATCCGCGCCGCCTCTCCCCGAGAGGCGGTGCTGCGGGCGCCCGCTTCCGCGAAGGGGGCGAAGCAACCCGGGGGGCCCG
TTCACCGACGGCCTGCTGCC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTVTRMPSTMLAQAGSTRAGSGYERYFRGALDQLHGERRYRVFADIERISGRFPTAKWRQPEGKTTEITVWCSNDYLGMG
QHKEVVAAMTETAARCGVGAGGTRNIAGNTSPLVDLERELADLHGKEAGLVFTSGYVSNQAGISTIAKLIPDCLILSDAF
NHNSMIEGVRHSGCAKKIFRHNDLQHLEELLREAGDRPKLIVFESVYSMDGDVAPIGEICDLADRYGAMTYLDEVHAVGL
YGPRGGGIAERDGVMHRVDVIEGTLAKGFGCVGGYITASAAICDAVRSFAPGFIFTTALPPAVAAAARASVRYLKRSGAE
REAHQRQAAATKAALRAAGLPVLETETHIVPVMVGDAELCKAAADHLLEHHAIYIQPINYPTVPRGTERLRITPSPFHDA
AHIERLAAALTETWEALDLPRAGTVFVEAAE

Sequences:

>Translated_431_residues
MTVTRMPSTMLAQAGSTRAGSGYERYFRGALDQLHGERRYRVFADIERISGRFPTAKWRQPEGKTTEITVWCSNDYLGMG
QHKEVVAAMTETAARCGVGAGGTRNIAGNTSPLVDLERELADLHGKEAGLVFTSGYVSNQAGISTIAKLIPDCLILSDAF
NHNSMIEGVRHSGCAKKIFRHNDLQHLEELLREAGDRPKLIVFESVYSMDGDVAPIGEICDLADRYGAMTYLDEVHAVGL
YGPRGGGIAERDGVMHRVDVIEGTLAKGFGCVGGYITASAAICDAVRSFAPGFIFTTALPPAVAAAARASVRYLKRSGAE
REAHQRQAAATKAALRAAGLPVLETETHIVPVMVGDAELCKAAADHLLEHHAIYIQPINYPTVPRGTERLRITPSPFHDA
AHIERLAAALTETWEALDLPRAGTVFVEAAE
>Mature_430_residues
TVTRMPSTMLAQAGSTRAGSGYERYFRGALDQLHGERRYRVFADIERISGRFPTAKWRQPEGKTTEITVWCSNDYLGMGQ
HKEVVAAMTETAARCGVGAGGTRNIAGNTSPLVDLERELADLHGKEAGLVFTSGYVSNQAGISTIAKLIPDCLILSDAFN
HNSMIEGVRHSGCAKKIFRHNDLQHLEELLREAGDRPKLIVFESVYSMDGDVAPIGEICDLADRYGAMTYLDEVHAVGLY
GPRGGGIAERDGVMHRVDVIEGTLAKGFGCVGGYITASAAICDAVRSFAPGFIFTTALPPAVAAAARASVRYLKRSGAER
EAHQRQAAATKAALRAAGLPVLETETHIVPVMVGDAELCKAAADHLLEHHAIYIQPINYPTVPRGTERLRITPSPFHDAA
HIERLAAALTETWEALDLPRAGTVFVEAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=402, Percent_Identity=49.2537313432836, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI83977440, Length=402, Percent_Identity=49.2537313432836, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI83977444, Length=402, Percent_Identity=49.2537313432836, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4502025, Length=401, Percent_Identity=49.8753117206983, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI40316939, Length=401, Percent_Identity=49.8753117206983, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI284448556, Length=351, Percent_Identity=36.4672364672365, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI7657118, Length=354, Percent_Identity=36.1581920903955, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI119220554, Length=397, Percent_Identity=28.9672544080605, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=31.7073170731707, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=26.8774703557312, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790046, Length=359, Percent_Identity=34.8189415041783, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=418, Percent_Identity=33.4928229665072, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=391, Percent_Identity=30.1790281329923, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=28.2608695652174, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=28.2608695652174, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=251, Percent_Identity=27.4900398406374, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=251, Percent_Identity=27.4900398406374, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=429, Percent_Identity=48.4848484848485, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=30.327868852459, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=285, Percent_Identity=24.5614035087719, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=47.0149253731343, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24662918, Length=361, Percent_Identity=35.1800554016621, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17136286, Length=377, Percent_Identity=28.1167108753316, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24653280, Length=290, Percent_Identity=27.2413793103448, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653276, Length=290, Percent_Identity=27.2413793103448, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653278, Length=290, Percent_Identity=27.2413793103448, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46493; Mature: 46362

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRMPSTMLAQAGSTRAGSGYERYFRGALDQLHGERRYRVFADIERISGRFPTAKWRQ
CCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
PEGKTTEITVWCSNDYLGMGQHKEVVAAMTETAARCGVGAGGTRNIAGNTSPLVDLEREL
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
ADLHGKEAGLVFTSGYVSNQAGISTIAKLIPDCLILSDAFNHNSMIEGVRHSGCAKKIFR
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
HNDLQHLEELLREAGDRPKLIVFESVYSMDGDVAPIGEICDLADRYGAMTYLDEVHAVGL
CCCHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
YGPRGGGIAERDGVMHRVDVIEGTLAKGFGCVGGYITASAAICDAVRSFAPGFIFTTALP
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
PAVAAAARASVRYLKRSGAEREAHQRQAAATKAALRAAGLPVLETETHIVPVMVGDAELC
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCHHHH
KAAADHLLEHHAIYIQPINYPTVPRGTERLRITPSPFHDAAHIERLAAALTETWEALDLP
HHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
RAGTVFVEAAE
CCCEEEEEECC
>Mature Secondary Structure 
TVTRMPSTMLAQAGSTRAGSGYERYFRGALDQLHGERRYRVFADIERISGRFPTAKWRQ
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
PEGKTTEITVWCSNDYLGMGQHKEVVAAMTETAARCGVGAGGTRNIAGNTSPLVDLEREL
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
ADLHGKEAGLVFTSGYVSNQAGISTIAKLIPDCLILSDAFNHNSMIEGVRHSGCAKKIFR
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
HNDLQHLEELLREAGDRPKLIVFESVYSMDGDVAPIGEICDLADRYGAMTYLDEVHAVGL
CCCHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
YGPRGGGIAERDGVMHRVDVIEGTLAKGFGCVGGYITASAAICDAVRSFAPGFIFTTALP
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
PAVAAAARASVRYLKRSGAEREAHQRQAAATKAALRAAGLPVLETETHIVPVMVGDAELC
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCHHHH
KAAADHLLEHHAIYIQPINYPTVPRGTERLRITPSPFHDAAHIERLAAALTETWEALDLP
HHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
RAGTVFVEAAE
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]