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The map label for this gene is apt

Identifier: 170749906

GI number: 170749906

Start: 3721092

End: 3721637

Strand: Reverse

Name: apt

Synonym: Mrad2831_3506

Alternate gene names: 170749906

Gene position: 3721637-3721092 (Counterclockwise)

Preceding gene: 170749907

Following gene: 170749905

Centisome position: 61.23

GC content: 69.05

Gene sequence:

>546_bases
ATGGAAGCCCGCCGCCACGTCGCGCTGAAGGAATCGGTCCGCTCGATTCCCGATTACCCGAAGCCGGGGATCATCTTCCG
CGACATCACCACGCTGCTGAGCGACCCGCGCGCCTTCCGGCGGGCGGTCGACGCCCTGGTGCACCCCTACGCCGGCGGAC
AGATCCACCAAGTGGCCGGCATCGAGGCGCGGGGCTTCATCCTGGGCGGGGCCATCGCCCACCAGCTCTCCTGCGGCTTC
GTGCCGATCCGCAAGAAGGGCAAGCTGCCCCACAAGACCGTGTCGATGGCCTACGCCCTCGAGTACGGGACCGACGAGAT
CGAGATCCACGTCGACGCCGTCCGGCCGGGCGACAAGGTGCTGCTGGTCGACGACCTGATCGCCACCGGCGGCACGGCGA
TCGCGGCCGTGAACCTGCTCCAGAAGATCGGCGCCGAGATCGTGGCCGCCTGCTTCGTCATCGACCTGCCCGAGATCGGC
GGCGCGCAGCGCCTGCGCGACCTGGGCGTCGAGGTGCGCACCCTCATGCAGTTCGAGGGTCATTAG

Upstream 100 bases:

>100_bases
GCCATCCTCAAGAAGGTCCAGGCGGCCTGAGCCGCCGCGAACTGGTCAGGGCGCCGAGCTTCTGCTTTAAGCCCGCGGTT
CTCCACGGAAGGCCGAACGC

Downstream 100 bases:

>100_bases
GGCCCGCGAAACGTTGACTTCGCGGGGCCCATCCGCCATAAGCCCGCCACTCGCGACGTGGCGCCCCGCATGGGCGCCCT
TCGTGTTTGCAGACAACCAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MEARRHVALKESVRSIPDYPKPGIIFRDITTLLSDPRAFRRAVDALVHPYAGGQIHQVAGIEARGFILGGAIAHQLSCGF
VPIRKKGKLPHKTVSMAYALEYGTDEIEIHVDAVRPGDKVLLVDDLIATGGTAIAAVNLLQKIGAEIVAACFVIDLPEIG
GAQRLRDLGVEVRTLMQFEGH

Sequences:

>Translated_181_residues
MEARRHVALKESVRSIPDYPKPGIIFRDITTLLSDPRAFRRAVDALVHPYAGGQIHQVAGIEARGFILGGAIAHQLSCGF
VPIRKKGKLPHKTVSMAYALEYGTDEIEIHVDAVRPGDKVLLVDDLIATGGTAIAAVNLLQKIGAEIVAACFVIDLPEIG
GAQRLRDLGVEVRTLMQFEGH
>Mature_181_residues
MEARRHVALKESVRSIPDYPKPGIIFRDITTLLSDPRAFRRAVDALVHPYAGGQIHQVAGIEARGFILGGAIAHQLSCGF
VPIRKKGKLPHKTVSMAYALEYGTDEIEIHVDAVRPGDKVLLVDDLIATGGTAIAAVNLLQKIGAEIVAACFVIDLPEIG
GAQRLRDLGVEVRTLMQFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=42.5287356321839, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=47.2, Blast_Score=127, Evalue=8e-30,
Organism=Escherichia coli, GI1786675, Length=179, Percent_Identity=53.6312849162011, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=41.7142857142857, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=37.037037037037, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=35.4037267080745, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=41.5094339622642, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_METRJ (B1LUP7)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756166.1
- ProteinModelPortal:   B1LUP7
- SMR:   B1LUP7
- GeneID:   6139559
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_3506
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19580; Mature: 19580

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEARRHVALKESVRSIPDYPKPGIIFRDITTLLSDPRAFRRAVDALVHPYAGGQIHQVAG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECC
IEARGFILGGAIAHQLSCGFVPIRKKGKLPHKTVSMAYALEYGTDEIEIHVDAVRPGDKV
CCCCCEEEHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHEECCCCEEEEEEEEECCCCEE
LLVDDLIATGGTAIAAVNLLQKIGAEIVAACFVIDLPEIGGAQRLRDLGVEVRTLMQFEG
EEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHHCC
H
C
>Mature Secondary Structure
MEARRHVALKESVRSIPDYPKPGIIFRDITTLLSDPRAFRRAVDALVHPYAGGQIHQVAG
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECC
IEARGFILGGAIAHQLSCGFVPIRKKGKLPHKTVSMAYALEYGTDEIEIHVDAVRPGDKV
CCCCCEEEHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHEECCCCEEEEEEEEECCCCEE
LLVDDLIATGGTAIAAVNLLQKIGAEIVAACFVIDLPEIGGAQRLRDLGVEVRTLMQFEG
EEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA