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The map label for this gene is purC1 [H]

Identifier: 170749887

GI number: 170749887

Start: 3704686

End: 3705480

Strand: Direct

Name: purC1 [H]

Synonym: Mrad2831_3487

Alternate gene names: 170749887

Gene position: 3704686-3705480 (Clockwise)

Preceding gene: 170749886

Following gene: 170749892

Centisome position: 60.95

GC content: 63.9

Gene sequence:

>795_bases
ATGGACTTCCTCAAACCACGGTACACGCCTATGAATCGCCGCCGTCGCATCTACGAGGGCAAGGCGAAGGTCCTCTACGA
GGGGCCGGAGCCCGGCACGCTCATCCAGCACTTCAAGGATGACGCGACGGCCTTCAACGCGAAGAAGCACGAGGTCATCG
ACGGCAAGGGTGTGCTGAACAACCGGATCTCGGAGTTCGTCTTCCAGCACCTCAACGACATCGGCGTGCCGACGCACTTC
ATCCGCCGGCTGAACATGCGCGAGCAGCTGATCCGCGAGGTCGAGATCATCCCCCTCGAGGTCGTGGTGCGCAACGTCGC
GGCCGGCTCGCTGGCGACGCGGCTCGGTCTTGAGGAAGGCACCCAGCTGCCGCGCTCGATCATCGAGTTCTACTACAAGA
ACGACGCGCTGAACGACCCGATGGTCTCGGAGGAGCACATCACGGCTTTCGGCTGGGCGACGCCCCAGGAGATCGACGAC
ATCATGGCGCTGGCGATCCGCGTCAACGACTTCCTGTCCGGCCTCTTCCTCGGCGTCGGCATCCGGCTCGTCGACTTCAA
GATGGAGACCGGCCGCCTGTGGGAAGGCGACATGATGCGCATCGTGGTGGCGGACGAGATCTCCCCGGATTCCTGTCGGC
TCTGGGACATCAAGTCCTCCGACAAGCTCGACAAGGACCGGTTCCGCAAGGATCTCGGCGGCCTGATCGAGGCCTATACC
GAGGTCGCCAAGCGGCTCGGCATCATGTCGGAGAACGAGAAGGTCCAGGGCGGCGGCCCGCGCCTCGTGCAGTAG

Upstream 100 bases:

>100_bases
GCCGGGGCCCTCGGGCAGAGGCCGTCCGGCGGCCCGACCTCGCGTCCGGTCGCCGCGCCGCGGATTCCTCCCAATCGTCG
CGCATCAGGAGCCTCGGCCC

Downstream 100 bases:

>100_bases
GCCCGGTCAGGCTGTCGGCCGGCGCAGGGGCGCCGGTCCGGCCTCGGGAAAACCTGCGCGCAGTCGCGCGTGGGTCGAGA
GCGCCGGGTCGAAACCCGGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase A [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDFLKPRYTPMNRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHEVIDGKGVLNNRISEFVFQHLNDIGVPTHF
IRRLNMREQLIREVEIIPLEVVVRNVAAGSLATRLGLEEGTQLPRSIIEFYYKNDALNDPMVSEEHITAFGWATPQEIDD
IMALAIRVNDFLSGLFLGVGIRLVDFKMETGRLWEGDMMRIVVADEISPDSCRLWDIKSSDKLDKDRFRKDLGGLIEAYT
EVAKRLGIMSENEKVQGGGPRLVQ

Sequences:

>Translated_264_residues
MDFLKPRYTPMNRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHEVIDGKGVLNNRISEFVFQHLNDIGVPTHF
IRRLNMREQLIREVEIIPLEVVVRNVAAGSLATRLGLEEGTQLPRSIIEFYYKNDALNDPMVSEEHITAFGWATPQEIDD
IMALAIRVNDFLSGLFLGVGIRLVDFKMETGRLWEGDMMRIVVADEISPDSCRLWDIKSSDKLDKDRFRKDLGGLIEAYT
EVAKRLGIMSENEKVQGGGPRLVQ
>Mature_264_residues
MDFLKPRYTPMNRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHEVIDGKGVLNNRISEFVFQHLNDIGVPTHF
IRRLNMREQLIREVEIIPLEVVVRNVAAGSLATRLGLEEGTQLPRSIIEFYYKNDALNDPMVSEEHITAFGWATPQEIDD
IMALAIRVNDFLSGLFLGVGIRLVDFKMETGRLWEGDMMRIVVADEISPDSCRLWDIKSSDKLDKDRFRKDLGGLIEAYT
EVAKRLGIMSENEKVQGGGPRLVQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=228, Percent_Identity=34.6491228070175, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI5453539, Length=228, Percent_Identity=34.6491228070175, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI119220559, Length=235, Percent_Identity=33.1914893617021, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=43.2773109243698, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=255, Percent_Identity=29.8039215686275, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18860083, Length=240, Percent_Identity=32.5, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583917, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 30133; Mature: 30133

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLKPRYTPMNRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHEVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEECCCCCHHH
NRISEFVFQHLNDIGVPTHFIRRLNMREQLIREVEIIPLEVVVRNVAAGSLATRLGLEEG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
TQLPRSIIEFYYKNDALNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDFLSGLFLGVG
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMETGRLWEGDMMRIVVADEISPDSCRLWDIKSSDKLDKDRFRKDLGGLIEAYT
EEEEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVAKRLGIMSENEKVQGGGPRLVQ
HHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFLKPRYTPMNRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHEVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEECCCCCHHH
NRISEFVFQHLNDIGVPTHFIRRLNMREQLIREVEIIPLEVVVRNVAAGSLATRLGLEEG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
TQLPRSIIEFYYKNDALNDPMVSEEHITAFGWATPQEIDDIMALAIRVNDFLSGLFLGVG
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMETGRLWEGDMMRIVVADEISPDSCRLWDIKSSDKLDKDRFRKDLGGLIEAYT
EEEEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVAKRLGIMSENEKVQGGGPRLVQ
HHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]