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The map label for this gene is cusR [H]

Identifier: 170749884

GI number: 170749884

Start: 3696173

End: 3696922

Strand: Reverse

Name: cusR [H]

Synonym: Mrad2831_3484

Alternate gene names: 170749884

Gene position: 3696922-3696173 (Counterclockwise)

Preceding gene: 170749885

Following gene: 170749883

Centisome position: 60.83

GC content: 70.13

Gene sequence:

>750_bases
ATGTTGATGGAGATACGTTCCCCCGACCCGCGCGGCGCGCTATGGAACGGGGCCATGCGACTGCTCATCATCGAGGACGA
CCGGGAGGCGGCGGCCTATCTCGTCAAGGCGTTCCGCGAGACCGGACACGTCGCCGACAGCGCGCATGATGGTCTCGACG
GGTACGCGCTCGCCCGCGAGGGCGACTACGACGTGCTGATCGTCGACAGGATGCTGCCGAAGCTCGACGGCCTGTCGCTG
ATCCGGTCGCTGCGCGAGCAGAACGTCGCGACGCCGACCCTGATCCTGTCCGCGCTGGGGCAGGTCGACGACCGGGTGAA
GGGGCTGCGCGCCGGCGGCGACGACTACCTGCCGAAGCCCTACGCGTTCTCCGAGCTCCTGGCACGGACCGAGGCGCTGG
CCCGGCGACAGGCCGGATCCGGCGCCGCGGAGGAGACGCGCTACCGGATCGGCGACCTGGAGCTCGACCGCCTGTCGCAT
CGGGTGACCCGGGCCGGCCGCGAGATCCCGCTGCAGCCGCGCGAGTTCCGCCTCCTCGAGTACCTGATGCGTCACGCCGG
ACAGGTCGTGACGCGCACCATGCTGCTCGAGCACGTGTGGGACTACCACTTCGACCCGCAGACCAACGTCATCGACGTCC
ACGTCTCGCGCCTGCGCAGCAAGCTCGACAAGGGCTTCCCGTCGCCGATCATCCACACGGTCCGGGGGGCCGGCTACGTG
CTGCGCTTCGACGACGGCGCGGCCGGGTGA

Upstream 100 bases:

>100_bases
GATCTCGCGCCCTCCGAGTCGTCCGCGCCCCGCTTCGGGACGGGTCGAGGTCCGCGGCCTCGGCCCGTTCGTCCCGTGAG
GGGAGGGGAGCGGCTTGACC

Downstream 100 bases:

>100_bases
GCGACGTCGGGACCGAGGCGCCGGTCGCCCGCGAGACCGCGGGGGCGCGGTTCCAGAAGCTGTTCCGCACCACCGCGTTC
AAGCTGTCGCTGGCCTACCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLMEIRSPDPRGALWNGAMRLLIIEDDREAAAYLVKAFRETGHVADSAHDGLDGYALAREGDYDVLIVDRMLPKLDGLSL
IRSLREQNVATPTLILSALGQVDDRVKGLRAGGDDYLPKPYAFSELLARTEALARRQAGSGAAEETRYRIGDLELDRLSH
RVTRAGREIPLQPREFRLLEYLMRHAGQVVTRTMLLEHVWDYHFDPQTNVIDVHVSRLRSKLDKGFPSPIIHTVRGAGYV
LRFDDGAAG

Sequences:

>Translated_249_residues
MLMEIRSPDPRGALWNGAMRLLIIEDDREAAAYLVKAFRETGHVADSAHDGLDGYALAREGDYDVLIVDRMLPKLDGLSL
IRSLREQNVATPTLILSALGQVDDRVKGLRAGGDDYLPKPYAFSELLARTEALARRQAGSGAAEETRYRIGDLELDRLSH
RVTRAGREIPLQPREFRLLEYLMRHAGQVVTRTMLLEHVWDYHFDPQTNVIDVHVSRLRSKLDKGFPSPIIHTVRGAGYV
LRFDDGAAG
>Mature_249_residues
MLMEIRSPDPRGALWNGAMRLLIIEDDREAAAYLVKAFRETGHVADSAHDGLDGYALAREGDYDVLIVDRMLPKLDGLSL
IRSLREQNVATPTLILSALGQVDDRVKGLRAGGDDYLPKPYAFSELLARTEALARRQAGSGAAEETRYRIGDLELDRLSH
RVTRAGREIPLQPREFRLLEYLMRHAGQVVTRTMLLEHVWDYHFDPQTNVIDVHVSRLRSKLDKGFPSPIIHTVRGAGYV
LRFDDGAAG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=48.6842105263158, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=41.1764705882353, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.4618834080717, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=36.322869955157, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.375, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=34.2222222222222, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=32.9059829059829, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.4035087719298, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.2869955156951, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.2775330396476, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=27.5109170305677, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=31.6455696202532, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=29.7297297297297, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27926; Mature: 27926

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMEIRSPDPRGALWNGAMRLLIIEDDREAAAYLVKAFRETGHVADSAHDGLDGYALARE
CCCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
GDYDVLIVDRMLPKLDGLSLIRSLREQNVATPTLILSALGQVDDRVKGLRAGGDDYLPKP
CCCCEEEHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YAFSELLARTEALARRQAGSGAAEETRYRIGDLELDRLSHRVTRAGREIPLQPREFRLLE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
YLMRHAGQVVTRTMLLEHVWDYHFDPQTNVIDVHVSRLRSKLDKGFPSPIIHTVRGAGYV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCEE
LRFDDGAAG
EEECCCCCC
>Mature Secondary Structure
MLMEIRSPDPRGALWNGAMRLLIIEDDREAAAYLVKAFRETGHVADSAHDGLDGYALARE
CCCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
GDYDVLIVDRMLPKLDGLSLIRSLREQNVATPTLILSALGQVDDRVKGLRAGGDDYLPKP
CCCCEEEHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YAFSELLARTEALARRQAGSGAAEETRYRIGDLELDRLSHRVTRAGREIPLQPREFRLLE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
YLMRHAGQVVTRTMLLEHVWDYHFDPQTNVIDVHVSRLRSKLDKGFPSPIIHTVRGAGYV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCEE
LRFDDGAAG
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]