Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 170749824

GI number: 170749824

Start: 3636225

End: 3637625

Strand: Direct

Name: zraR [H]

Synonym: Mrad2831_3424

Alternate gene names: 170749824

Gene position: 3636225-3637625 (Clockwise)

Preceding gene: 170749823

Following gene: 170749825

Centisome position: 59.83

GC content: 75.45

Gene sequence:

>1401_bases
ATGGCAACCATCCTGATCGTCGACGACGACAGAGCCCTGCGCGACGGGCTCGCCGAGACGGTGACCGATCTCGGGCACAC
CGCGCTCCCGGTCGCCTCCGGCTCGGAGGCCCTGGCGCGGCTGGCCGAGGGTCCGGTGGCGGCGGTGCTCCTCGACCTGC
GCATGCCCGGCGCCCTCGACGGCATGGCCACGCTCGAGCGGATCCGCGCCCTGCCGGAGCCGCCCCCCGTGACGGTGCTG
ACGGCCTTCGCGAGCCCGGCCAACACCATCGAGGCGATGCGCCTGGGGGCGCACGACCACCTGACCAAGCCGATCGGCCG
GGCCGATCTCGCCGCCGCCCTCGACGCGATGCTGCGCGACGCCCGCTGCGATCCCGGCAGCGCCGCCCCGCCGCCGGGCC
ACCCGGTCCTGATCGGGTCGAGCGCGGGCATGCGGAAGGTCCAGAAGACCATCGGCCTCGTCGCCGACAGCGCCTCCACG
ATCCTGATCCAGGGCGAGACCGGCACCGGCAAGGAGGAGGTCGCCCGGGCCCTCCACGCCTTCTCGCGGCGCCGCGCGCG
GCCGTTCATCCCGGTGAACTGCGCGGCGATCCCCGCCGACGCGCTGGAGAGCGAGCTCTTCGGCCATGTCCGGGGCGCCT
TCGCCGGGGCGGCCTCGGACCGCGCCGGCGCCTTCCACGAGGCCGAGGGCGGCACCCTGTTCCTGGACGAGATCGGCGAC
ATGCCGGCGGCGATGCAGGCCAAGATCCTGCGGGTGATCCAGGACTGCGTCGTCACCCCGCTGGGTGGCCGGTCCGCCCG
GGTCGATGTCCGGCTCGTGGCGGCGACGCATCGCGACCTGCCGGCGCTGGTCGCCGAGGGCACGTTCCGCGCCGACCTGT
ACTACCGGCTGAACGTCGTGCCGATCGCCCTGCCGCCCCTGCGCGAGCGGCTGGCCGACATCGTGCCGCTCGCCGAGCAC
TTCCTGGCCCCCTCCGGCAAGCGCCTGAGCGGCGGTGCCGCCTCGCGCCTGCTCGCCTACGAGTGGCCCGGCAACGTCCG
CGAGCTGCGCAACGTCGTGGAGCGGGCCGCCGTGCTGGTGCGCGGCGGCGTGATCGCGGCCGAGGCCATCGATCTGCCGG
CCGCGCGGCCCGAGCGGCGCGGCGACGACGCGGTGACGGACGGGCTCGCCGGCGACCTGCCGGGCGCCGTGGCCCACCTG
GAGCGGACCCTGATCGCCGCCGCGCTCCGCGAGGCCGACGGCAACCGCGCCCGGGCCGCCCGCCGGCTCGGCATCCAGCG
GCAGCTCCTCTACGCCAAGATCGAGCGCTACGGCCTCGCCGCGCCGGGGATCGATCTGTCGGAAGAGACGACAGATGCTG
TCGGAAATCCCGACGCTTCGGCGGGCACCGACCCGGCCTGA

Upstream 100 bases:

>100_bases
GCCTCGGGCTCGCGATCGTGCGCGAGATCGCCCTGGCCCATCGGGGCGAGGCGAGGCTGGTCGAGGGCGCTCCGGAGACC
ACCTTTGTCCTGGACCTGCC

Downstream 100 bases:

>100_bases
GGCCCATCGGGCCGGAGAATCGTTCACATCCCGCGTGAGGTCCCGGCGGCGCGGGAACCGATGGCGCGCGCGGGCGTCGA
GCCCCGCGTGCGACGGCGCG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MATILIVDDDRALRDGLAETVTDLGHTALPVASGSEALARLAEGPVAAVLLDLRMPGALDGMATLERIRALPEPPPVTVL
TAFASPANTIEAMRLGAHDHLTKPIGRADLAAALDAMLRDARCDPGSAAPPPGHPVLIGSSAGMRKVQKTIGLVADSAST
ILIQGETGTGKEEVARALHAFSRRRARPFIPVNCAAIPADALESELFGHVRGAFAGAASDRAGAFHEAEGGTLFLDEIGD
MPAAMQAKILRVIQDCVVTPLGGRSARVDVRLVAATHRDLPALVAEGTFRADLYYRLNVVPIALPPLRERLADIVPLAEH
FLAPSGKRLSGGAASRLLAYEWPGNVRELRNVVERAAVLVRGGVIAAEAIDLPAARPERRGDDAVTDGLAGDLPGAVAHL
ERTLIAAALREADGNRARAARRLGIQRQLLYAKIERYGLAAPGIDLSEETTDAVGNPDASAGTDPA

Sequences:

>Translated_466_residues
MATILIVDDDRALRDGLAETVTDLGHTALPVASGSEALARLAEGPVAAVLLDLRMPGALDGMATLERIRALPEPPPVTVL
TAFASPANTIEAMRLGAHDHLTKPIGRADLAAALDAMLRDARCDPGSAAPPPGHPVLIGSSAGMRKVQKTIGLVADSAST
ILIQGETGTGKEEVARALHAFSRRRARPFIPVNCAAIPADALESELFGHVRGAFAGAASDRAGAFHEAEGGTLFLDEIGD
MPAAMQAKILRVIQDCVVTPLGGRSARVDVRLVAATHRDLPALVAEGTFRADLYYRLNVVPIALPPLRERLADIVPLAEH
FLAPSGKRLSGGAASRLLAYEWPGNVRELRNVVERAAVLVRGGVIAAEAIDLPAARPERRGDDAVTDGLAGDLPGAVAHL
ERTLIAAALREADGNRARAARRLGIQRQLLYAKIERYGLAAPGIDLSEETTDAVGNPDASAGTDPA
>Mature_465_residues
ATILIVDDDRALRDGLAETVTDLGHTALPVASGSEALARLAEGPVAAVLLDLRMPGALDGMATLERIRALPEPPPVTVLT
AFASPANTIEAMRLGAHDHLTKPIGRADLAAALDAMLRDARCDPGSAAPPPGHPVLIGSSAGMRKVQKTIGLVADSASTI
LIQGETGTGKEEVARALHAFSRRRARPFIPVNCAAIPADALESELFGHVRGAFAGAASDRAGAFHEAEGGTLFLDEIGDM
PAAMQAKILRVIQDCVVTPLGGRSARVDVRLVAATHRDLPALVAEGTFRADLYYRLNVVPIALPPLRERLADIVPLAEHF
LAPSGKRLSGGAASRLLAYEWPGNVRELRNVVERAAVLVRGGVIAAEAIDLPAARPERRGDDAVTDGLAGDLPGAVAHLE
RTLIAAALREADGNRARAARRLGIQRQLLYAKIERYGLAAPGIDLSEETTDAVGNPDASAGTDPA

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=43.6651583710407, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=41.2663755458515, Blast_Score=316, Evalue=3e-87,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=40.5286343612335, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=38.6752136752137, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=44.8598130841121, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=47.1337579617834, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=42.2619047619048, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI87082152, Length=334, Percent_Identity=43.1137724550898, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1786524, Length=245, Percent_Identity=49.3877551020408, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.6875, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=37.5394321766561, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789828, Length=243, Percent_Identity=37.8600823045267, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=33.8983050847458, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789402, Length=208, Percent_Identity=29.3269230769231, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=32.4786324786325, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48717; Mature: 48586

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILIVDDDRALRDGLAETVTDLGHTALPVASGSEALARLAEGPVAAVLLDLRMPGALD
CEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCCCH
GMATLERIRALPEPPPVTVLTAFASPANTIEAMRLGAHDHLTKPIGRADLAAALDAMLRD
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
ARCDPGSAAPPPGHPVLIGSSAGMRKVQKTIGLVADSASTILIQGETGTGKEEVARALHA
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
FSRRRARPFIPVNCAAIPADALESELFGHVRGAFAGAASDRAGAFHEAEGGTLFLDEIGD
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEHHHHCC
MPAAMQAKILRVIQDCVVTPLGGRSARVDVRLVAATHRDLPALVAEGTFRADLYYRLNVV
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHCCCEEEEEEEEEEEE
PIALPPLRERLADIVPLAEHFLAPSGKRLSGGAASRLLAYEWPGNVRELRNVVERAAVLV
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEEEECCCCHHHHHHHHHHHHHHH
RGGVIAAEAIDLPAARPERRGDDAVTDGLAGDLPGAVAHLERTLIAAALREADGNRARAA
HCCEEEEHHHCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RRLGIQRQLLYAKIERYGLAAPGIDLSEETTDAVGNPDASAGTDPA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATILIVDDDRALRDGLAETVTDLGHTALPVASGSEALARLAEGPVAAVLLDLRMPGALD
EEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCCCH
GMATLERIRALPEPPPVTVLTAFASPANTIEAMRLGAHDHLTKPIGRADLAAALDAMLRD
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
ARCDPGSAAPPPGHPVLIGSSAGMRKVQKTIGLVADSASTILIQGETGTGKEEVARALHA
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
FSRRRARPFIPVNCAAIPADALESELFGHVRGAFAGAASDRAGAFHEAEGGTLFLDEIGD
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEHHHHCC
MPAAMQAKILRVIQDCVVTPLGGRSARVDVRLVAATHRDLPALVAEGTFRADLYYRLNVV
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHCCCEEEEEEEEEEEE
PIALPPLRERLADIVPLAEHFLAPSGKRLSGGAASRLLAYEWPGNVRELRNVVERAAVLV
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEEEECCCCHHHHHHHHHHHHHHH
RGGVIAAEAIDLPAARPERRGDDAVTDGLAGDLPGAVAHLERTLIAAALREADGNRARAA
HCCEEEEHHHCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RRLGIQRQLLYAKIERYGLAAPGIDLSEETTDAVGNPDASAGTDPA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]