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The map label for this gene is ubiB [H]

Identifier: 170749816

GI number: 170749816

Start: 3626681

End: 3628363

Strand: Direct

Name: ubiB [H]

Synonym: Mrad2831_3415

Alternate gene names: 170749816

Gene position: 3626681-3628363 (Clockwise)

Preceding gene: 170749815

Following gene: 170749817

Centisome position: 59.67

GC content: 68.33

Gene sequence:

>1683_bases
ATGCTCGTGCTGTCCGGACGCCCAATCCCGTCCGACCGGATCGCTCCATTCATGCTGAAGACAGCCTTCGTTGCCGCCCG
CGACCGCCAGCGGCTGTCGGAGATCGCGACGATCCTCATCGGCTTCGGCGTCACCCGCGTCGTGGACCGGCTCGGCCTGC
GCTACCTGCCGCTGGTGCCGCGCCGTCAGCCTCGGGTCGACGTCACGCGCCTGTCCGAGCCGGAGCGGCTGCGCCGGGCG
ATCGAGGCGCTCGGGCCGACCTTCATCAAGTTCGGGCAGGTGCTGGCGAGCCGGCCGGACCTCCTGTCGCCGGCCTGGAC
CGAGGAGCTGCAGAAGCTCCACAGCCAGGTCGTGCCGGTGACGTGGGAGCAGATCGGCCCGCAGCTCGAGCTCGATCTCG
GCGCCTCGCCCATGGAGGTGTTCGCCGAGTTCGACACCAACCCGATCGCCTCGGCGTCGATCGCCCAGGTCTACCGGGCG
CGGCTGCACTCGGGCGAGGACGTCATCGTCAAGGTGCTGCGGCCGAACCTGCGCAAGATCATCGAGGCGGATCTGCGCCT
GATGGCGCACGGCGCCCGCATCGTCGAGAACGAGTGGCCCGACATGGCCCGCTACCAGCCGCGGGAGCAGATGCGCCACC
TCGCGGAGGGCCTGAACGGCGAGCTCGACCTGCTCAACGAGGCGCGCAACTGCGAGTTGCTGGCCCAGATCTTCGAGGAC
CGCGACGACATCGTCTTCCCGAAGATCCACTGGGAGTACTGCTCCGAGCGGGTGCTGGTTCAGGACTTCATCCACGGCAT
CCCGCCCAACGACGAGGCGGCCCTGCGCGCGGCGGGCATCGACAAGAAACTGCTTGCCCAGAAGGGCACCGACGCGTTCC
TGCAGATGGCGCTGATCGAGGGCGTGTTCCACGCCGACCCGCATCCCGGCAACATGCTGGCGCTCCCGGGCAACAAGATC
GGCTTCATCGATTTCGGCATCATCGGCCGGCTGTCGCAGCGGCGGCGCTCGCAGCTGCTCGTGCTGATCGGCGCCATGCT
CAAGCAGGACGCGGACGGCCTCATGGCCGTGCTCCTCGACTGGACCGGCACCAGCAACCCGGACCTCACCCGCCTCCAGG
TCTCGGCCCAGTCCTTCGTGGAGAGCCACTCGTCGATCCCGCTGAATCTCGGGCTGGTGCTCACCGACTTCATGAACATG
GCCCGCGAGAACGACCTCGCCATGCCGACCGACCTCGCCATCCTGTTCAAGGGGCTGGTCACCGCCGACGGCGTGATGCG
CCACCTCGACCCGAATTTCGACCTGTTCGCCGCCGCCGGCCCGACGGTCCGGGCGAGCATGCAGACGCAGTTCTCGCTCT
CGGCCCTCAAGCAGAAGGCCGAGGCCCTGGGCGTCGGCCTCTACGGCGCCGCCTCGGAGCTGCCGACCCTGATCCACCTG
ATGCTGGTGCGGTTGAAGCAGGGCCGCGTCACCGTCGAGATCGAGGTGAAGGGCCTCGACAAGGTCACCCGCGGCATCGA
GCGCGCGGCCGCGCGCGTCGCGGTGGCCCTGGTGGTGGCGGCCTTCGCCACCCAGCTCGCGCCCCGCCTCATCGATCTCG
GCACGCCCGTCTTCGTCTCGATCGGATTGATAATTTTCATCCTCGGGATCGGCTGGCTCGTGCTGCTGATGCGAAACAAG
TAA

Upstream 100 bases:

>100_bases
CCGTCCGCGCCGGCCCCGCCGCCGCCGCGCCCCGCCGACCGCGCCGCCTAAGTTGCGGCCCCGGGGCGGAACCGGGGTTC
GCGACCGCAAAAAAGTCCTT

Downstream 100 bases:

>100_bases
CCGTCTTCGCACCGGCCAGAGACATCAACATAAGTTTACACCCGCAATCGAATACGGGACTGAGTTGATAATCCCGCGCG
TCATGGTAGCGTGACACATC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MLVLSGRPIPSDRIAPFMLKTAFVAARDRQRLSEIATILIGFGVTRVVDRLGLRYLPLVPRRQPRVDVTRLSEPERLRRA
IEALGPTFIKFGQVLASRPDLLSPAWTEELQKLHSQVVPVTWEQIGPQLELDLGASPMEVFAEFDTNPIASASIAQVYRA
RLHSGEDVIVKVLRPNLRKIIEADLRLMAHGARIVENEWPDMARYQPREQMRHLAEGLNGELDLLNEARNCELLAQIFED
RDDIVFPKIHWEYCSERVLVQDFIHGIPPNDEAALRAAGIDKKLLAQKGTDAFLQMALIEGVFHADPHPGNMLALPGNKI
GFIDFGIIGRLSQRRRSQLLVLIGAMLKQDADGLMAVLLDWTGTSNPDLTRLQVSAQSFVESHSSIPLNLGLVLTDFMNM
ARENDLAMPTDLAILFKGLVTADGVMRHLDPNFDLFAAAGPTVRASMQTQFSLSALKQKAEALGVGLYGAASELPTLIHL
MLVRLKQGRVTVEIEVKGLDKVTRGIERAAARVAVALVVAAFATQLAPRLIDLGTPVFVSIGLIIFILGIGWLVLLMRNK

Sequences:

>Translated_560_residues
MLVLSGRPIPSDRIAPFMLKTAFVAARDRQRLSEIATILIGFGVTRVVDRLGLRYLPLVPRRQPRVDVTRLSEPERLRRA
IEALGPTFIKFGQVLASRPDLLSPAWTEELQKLHSQVVPVTWEQIGPQLELDLGASPMEVFAEFDTNPIASASIAQVYRA
RLHSGEDVIVKVLRPNLRKIIEADLRLMAHGARIVENEWPDMARYQPREQMRHLAEGLNGELDLLNEARNCELLAQIFED
RDDIVFPKIHWEYCSERVLVQDFIHGIPPNDEAALRAAGIDKKLLAQKGTDAFLQMALIEGVFHADPHPGNMLALPGNKI
GFIDFGIIGRLSQRRRSQLLVLIGAMLKQDADGLMAVLLDWTGTSNPDLTRLQVSAQSFVESHSSIPLNLGLVLTDFMNM
ARENDLAMPTDLAILFKGLVTADGVMRHLDPNFDLFAAAGPTVRASMQTQFSLSALKQKAEALGVGLYGAASELPTLIHL
MLVRLKQGRVTVEIEVKGLDKVTRGIERAAARVAVALVVAAFATQLAPRLIDLGTPVFVSIGLIIFILGIGWLVLLMRNK
>Mature_560_residues
MLVLSGRPIPSDRIAPFMLKTAFVAARDRQRLSEIATILIGFGVTRVVDRLGLRYLPLVPRRQPRVDVTRLSEPERLRRA
IEALGPTFIKFGQVLASRPDLLSPAWTEELQKLHSQVVPVTWEQIGPQLELDLGASPMEVFAEFDTNPIASASIAQVYRA
RLHSGEDVIVKVLRPNLRKIIEADLRLMAHGARIVENEWPDMARYQPREQMRHLAEGLNGELDLLNEARNCELLAQIFED
RDDIVFPKIHWEYCSERVLVQDFIHGIPPNDEAALRAAGIDKKLLAQKGTDAFLQMALIEGVFHADPHPGNMLALPGNKI
GFIDFGIIGRLSQRRRSQLLVLIGAMLKQDADGLMAVLLDWTGTSNPDLTRLQVSAQSFVESHSSIPLNLGLVLTDFMNM
ARENDLAMPTDLAILFKGLVTADGVMRHLDPNFDLFAAAGPTVRASMQTQFSLSALKQKAEALGVGLYGAASELPTLIHL
MLVRLKQGRVTVEIEVKGLDKVTRGIERAAARVAVALVVAAFATQLAPRLIDLGTPVFVSIGLIIFILGIGWLVLLMRNK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=34.4444444444444, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI40254938, Length=286, Percent_Identity=32.1678321678322, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI217035081, Length=230, Percent_Identity=31.304347826087, Blast_Score=116, Evalue=7e-26,
Organism=Escherichia coli, GI2367309, Length=453, Percent_Identity=34.4370860927152, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17559152, Length=271, Percent_Identity=31.3653136531365, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=248, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=26.605504587156, Blast_Score=133, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323282, Length=261, Percent_Identity=27.2030651340996, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24662575, Length=302, Percent_Identity=31.1258278145695, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI22024280, Length=284, Percent_Identity=31.3380281690141, Blast_Score=136, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61954; Mature: 61954

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLSGRPIPSDRIAPFMLKTAFVAARDRQRLSEIATILIGFGVTRVVDRLGLRYLPLVP
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECCCCC
RRQPRVDVTRLSEPERLRRAIEALGPTFIKFGQVLASRPDLLSPAWTEELQKLHSQVVPV
CCCCCCCHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
TWEQIGPQLELDLGASPMEVFAEFDTNPIASASIAQVYRARLHSGEDVIVKVLRPNLRKI
CHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IEADLRLMAHGARIVENEWPDMARYQPREQMRHLAEGLNGELDLLNEARNCELLAQIFED
HHHHHHHHHCCCHHHHCCCCCHHCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCC
RDDIVFPKIHWEYCSERVLVQDFIHGIPPNDEAALRAAGIDKKLLAQKGTDAFLQMALIE
CCCEEECEEEHHHHCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHH
GVFHADPHPGNMLALPGNKIGFIDFGIIGRLSQRRRSQLLVLIGAMLKQDADGLMAVLLD
HHHCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
WTGTSNPDLTRLQVSAQSFVESHSSIPLNLGLVLTDFMNMARENDLAMPTDLAILFKGLV
CCCCCCCCCEEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TADGVMRHLDPNFDLFAAAGPTVRASMQTQFSLSALKQKAEALGVGLYGAASELPTLIHL
HHHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MLVRLKQGRVTVEIEVKGLDKVTRGIERAAARVAVALVVAAFATQLAPRLIDLGTPVFVS
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IGLIIFILGIGWLVLLMRNK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVLSGRPIPSDRIAPFMLKTAFVAARDRQRLSEIATILIGFGVTRVVDRLGLRYLPLVP
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECCCCC
RRQPRVDVTRLSEPERLRRAIEALGPTFIKFGQVLASRPDLLSPAWTEELQKLHSQVVPV
CCCCCCCHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
TWEQIGPQLELDLGASPMEVFAEFDTNPIASASIAQVYRARLHSGEDVIVKVLRPNLRKI
CHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IEADLRLMAHGARIVENEWPDMARYQPREQMRHLAEGLNGELDLLNEARNCELLAQIFED
HHHHHHHHHCCCHHHHCCCCCHHCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCC
RDDIVFPKIHWEYCSERVLVQDFIHGIPPNDEAALRAAGIDKKLLAQKGTDAFLQMALIE
CCCEEECEEEHHHHCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHH
GVFHADPHPGNMLALPGNKIGFIDFGIIGRLSQRRRSQLLVLIGAMLKQDADGLMAVLLD
HHHCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
WTGTSNPDLTRLQVSAQSFVESHSSIPLNLGLVLTDFMNMARENDLAMPTDLAILFKGLV
CCCCCCCCCEEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TADGVMRHLDPNFDLFAAAGPTVRASMQTQFSLSALKQKAEALGVGLYGAASELPTLIHL
HHHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MLVRLKQGRVTVEIEVKGLDKVTRGIERAAARVAVALVVAAFATQLAPRLIDLGTPVFVS
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IGLIIFILGIGWLVLLMRNK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]