Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 170749810

GI number: 170749810

Start: 3619601

End: 3620689

Strand: Reverse

Name: cytR [H]

Synonym: Mrad2831_3409

Alternate gene names: 170749810

Gene position: 3620689-3619601 (Counterclockwise)

Preceding gene: 170749818

Following gene: 170749809

Centisome position: 59.57

GC content: 73.37

Gene sequence:

>1089_bases
ATGCCCGTCGGGCCGCTCGGGGGTGGGGGATCGATCTCAGTGCTGGACCTGCCGGAAGAGATCCTCGAGCCGCCGACGCG
CGGCCCGGTTGCCCGGGACGTCGCCCGCCGCGCCGGCGTCTCGACCGCGACGGTCTCCCGGGTTCTCAACGGCTCCGCCG
GGGTCCGGGCCGACAAGCGCGAGGCGGTGATGCGGGCCGCGCAGGATCTCGGCTTCGTCGCCAACGGCGCGGCCCGGGCG
CTCTCCACGCGACGGTTCATGGCGGTCGGCGCGGTCGTGCCGAACATCGAGAACGAGGCCTTCGTGCGCGTCCTGTCGAG
CTTCCAGGACCGGCTGCGGCAGGCGGGTTACACCCTGGTCGCGGCCAATGCCGGCTACGACCTGGAGGACGAGCTCCGCG
AGGCGACGTTCCTGCTGGAGCGGGGCGTCGACGGGCTGATGCTGGTCGGCGACATCCACCACCCGGATCTCCACGCCCGG
ATCGCCCGCGCCGGCATCCCGATGGTCCAGACCTTCAGCCTGTCCCGCGAGCGGCCCTGCGTGGGCTTCGACAACGCCGC
CTCGGCGGCCCGGGCGGCCAACTACCTGATGGACCTCGGTCACCGCCGGATCGGGGTGATCTCGGGTCTGCGCAAGGACA
ACGATCGCGGCGGCGCCCGGGTCACGGGCATCGCGGCGGCGCTCGCGGCCCGGGGCCTGCGGCTCGCCCCGGAGCACGAC
ATCGAGATCTCCTACGGGATCGGCGGCGGCCGCGACGGGTTTCGCCAGATGCTGGCGGGCGGACCGCCGCCGACCGCGAT
CATCTGCGGCACCGATCAGATCGCCTTCGGGGCGATGATCGAGGCGCGGGCCCGCGGGCTCTCCGTCCCCGGGGACCTGT
CGGTGATCGGCCACAACGATTCCGACTTCGCGCCCTTCCTGGACCCGGCGCTGACGACGATCCGCATCCACTCCGCCGAG
ATCGGCCACGCCGCCGGCGACCACCTGATCGCCCGGATCCAGGGGCGGCCGATGGTCCGCCTCACCGAGATCGACGCCGA
ACTGATCCTGCGCGCCAGCACGGCCCCGCCGAGGCGTACCGGCGCCTGA

Upstream 100 bases:

>100_bases
AGCGCTTTCAGATAGCCAGCGGCCGAGCGAGGTGTCAATATTCTGCCGGTCCGGCTCAGTTGGCCGGGCATCGCCGCGTC
GCGTATCCGGTACCGGCGCG

Downstream 100 bases:

>100_bases
CCTGCGCTATCTTGCCACCGCTTTGAAATCGCTTACAACATGCGGACCGGCGCGGCCGGGTCCGCGCCCTCTCCGGAACA
CAGCATGGCTCCCCGCATCG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MPVGPLGGGGSISVLDLPEEILEPPTRGPVARDVARRAGVSTATVSRVLNGSAGVRADKREAVMRAAQDLGFVANGAARA
LSTRRFMAVGAVVPNIENEAFVRVLSSFQDRLRQAGYTLVAANAGYDLEDELREATFLLERGVDGLMLVGDIHHPDLHAR
IARAGIPMVQTFSLSRERPCVGFDNAASAARAANYLMDLGHRRIGVISGLRKDNDRGGARVTGIAAALAARGLRLAPEHD
IEISYGIGGGRDGFRQMLAGGPPPTAIICGTDQIAFGAMIEARARGLSVPGDLSVIGHNDSDFAPFLDPALTTIRIHSAE
IGHAAGDHLIARIQGRPMVRLTEIDAELILRASTAPPRRTGA

Sequences:

>Translated_362_residues
MPVGPLGGGGSISVLDLPEEILEPPTRGPVARDVARRAGVSTATVSRVLNGSAGVRADKREAVMRAAQDLGFVANGAARA
LSTRRFMAVGAVVPNIENEAFVRVLSSFQDRLRQAGYTLVAANAGYDLEDELREATFLLERGVDGLMLVGDIHHPDLHAR
IARAGIPMVQTFSLSRERPCVGFDNAASAARAANYLMDLGHRRIGVISGLRKDNDRGGARVTGIAAALAARGLRLAPEHD
IEISYGIGGGRDGFRQMLAGGPPPTAIICGTDQIAFGAMIEARARGLSVPGDLSVIGHNDSDFAPFLDPALTTIRIHSAE
IGHAAGDHLIARIQGRPMVRLTEIDAELILRASTAPPRRTGA
>Mature_361_residues
PVGPLGGGGSISVLDLPEEILEPPTRGPVARDVARRAGVSTATVSRVLNGSAGVRADKREAVMRAAQDLGFVANGAARAL
STRRFMAVGAVVPNIENEAFVRVLSSFQDRLRQAGYTLVAANAGYDLEDELREATFLLERGVDGLMLVGDIHHPDLHARI
ARAGIPMVQTFSLSRERPCVGFDNAASAARAANYLMDLGHRRIGVISGLRKDNDRGGARVTGIAAALAARGLRLAPEHDI
EISYGIGGGRDGFRQMLAGGPPPTAIICGTDQIAFGAMIEARARGLSVPGDLSVIGHNDSDFAPFLDPALTTIRIHSAEI
GHAAGDHLIARIQGRPMVRLTEIDAELILRASTAPPRRTGA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=32.3170731707317, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=29.7058823529412, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=30.8681672025724, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790194, Length=305, Percent_Identity=30.1639344262295, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788474, Length=291, Percent_Identity=31.6151202749141, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789068, Length=332, Percent_Identity=28.9156626506024, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=30.03003003003, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=309, Percent_Identity=25.8899676375405, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787580, Length=319, Percent_Identity=25.0783699059561, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=27.1641791044776, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789456, Length=342, Percent_Identity=29.5321637426901, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787906, Length=251, Percent_Identity=28.2868525896414, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786268, Length=298, Percent_Identity=26.1744966442953, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790689, Length=314, Percent_Identity=26.4331210191083, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38143; Mature: 38012

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVGPLGGGGSISVLDLPEEILEPPTRGPVARDVARRAGVSTATVSRVLNGSAGVRADKR
CCCCCCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHH
EAVMRAAQDLGFVANGAARALSTRRFMAVGAVVPNIENEAFVRVLSSFQDRLRQAGYTLV
HHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEE
AANAGYDLEDELREATFLLERGVDGLMLVGDIHHPDLHARIARAGIPMVQTFSLSRERPC
EECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCC
VGFDNAASAARAANYLMDLGHRRIGVISGLRKDNDRGGARVTGIAAALAARGLRLAPEHD
CCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
IEISYGIGGGRDGFRQMLAGGPPPTAIICGTDQIAFGAMIEARARGLSVPGDLSVIGHND
CEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
SDFAPFLDPALTTIRIHSAEIGHAAGDHLIARIQGRPMVRLTEIDAELILRASTAPPRRT
CCCCCHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCHHHEEEECCCCCCCC
GA
CC
>Mature Secondary Structure 
PVGPLGGGGSISVLDLPEEILEPPTRGPVARDVARRAGVSTATVSRVLNGSAGVRADKR
CCCCCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHH
EAVMRAAQDLGFVANGAARALSTRRFMAVGAVVPNIENEAFVRVLSSFQDRLRQAGYTLV
HHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEE
AANAGYDLEDELREATFLLERGVDGLMLVGDIHHPDLHARIARAGIPMVQTFSLSRERPC
EECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCC
VGFDNAASAARAANYLMDLGHRRIGVISGLRKDNDRGGARVTGIAAALAARGLRLAPEHD
CCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
IEISYGIGGGRDGFRQMLAGGPPPTAIICGTDQIAFGAMIEARARGLSVPGDLSVIGHND
CEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
SDFAPFLDPALTTIRIHSAEIGHAAGDHLIARIQGRPMVRLTEIDAELILRASTAPPRRT
CCCCCHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCHHHEEEECCCCCCCC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]