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The map label for this gene is chaA [C]

Identifier: 170749798

GI number: 170749798

Start: 3607307

End: 3608404

Strand: Direct

Name: chaA [C]

Synonym: Mrad2831_3397

Alternate gene names: 170749798

Gene position: 3607307-3608404 (Clockwise)

Preceding gene: 170749796

Following gene: 170749801

Centisome position: 59.35

GC content: 69.03

Gene sequence:

>1098_bases
ATGATGGCAGCTCTGCGGGTGGCGGTAGCCTGGGCGACGGTTCTCGCCTTCGCGTGGTTCGGCAAGGGCTGGCTCGGAGA
CCTGTCGGACCCCCTGTTCGCGGGGAGCCTGTTCGCGTGGCTGCTCGGCGTGATCGTCTGGGCGGCCTTCGGCGTGGTGC
ACGAGGCCGAGGAGCTGGCGCACCGCCTCGGCGAGCCCCTGGGCACCCTGGTCCTGACCCTGGCCATCGTCATCATCGAG
GTGGCGCTGATCTCCGCCGTGATGCTGTCGGCCAAGGACGCGCCGACGCTCGGCCGCGACACGATGTTCGCGGTGCTGAT
GATCGTGCTGAACGGCGTGGTCGGGCTGGGCCTCCTCGTCGGCGGCCTGCGCCACCACCAGCAGCGCTACAACCTCCAGG
GTGCCTCGGCCTTCCTGTCGGTGATCATCCCGCTCACCACCATCGCGCTGATCATCCCGAACTTCACGAGCTCTACCAGC
GACGGGACCCTCACGACCCTGCAGGCGGTGACGTTCTCGGTGTTCACCCTCGCCCTCTACGGCGTGTTCCTGCTGATCCA
GACCGGGCGCCACAGCGAGTTCTTCATCGACGCGGAAGTCCCCGAGGCGACGGAGCCGTCGCACGGCGCGGATCCGGTCT
CGGGCGGCAGCGTCGCCAAGCATATCGGCCTGCTGCTCGCCAACGTCGTGCCGATCGTGATCCTGGCCAAGAGCCTCGCG
GTGATCCTCGACCACGGCATCGCCGCCCTCGGCGCGCCGACGGCGCTGGGCGGCGTGCTGATCGCCGCCATCGTGTTCAC
GCCGGAAGGGATCTCGGCGCTCAAGGCGGTGGCCCGCAACGAGCTCCAGCGGGCGATCAACCTGTGCCTGGGGGCGGCCA
CCTCGACGGTCGGCCTCACCGTGCCGGCGATCCTGACTATCGGGCTGCTCACCGGCCAGACCGTGGTGCTGGGCCTCAAG
CCCACCGAGATGACCCTGCTCGCCGTGACGCTGATCCTCAGCGCGCAGACCTTCTCGGGCTCGCGCACCACCGTGCTCGA
GGGCGCGGTGCACCTCGTGCTGTTCTTCGTCTACCTCGTGCTGATCTTCAGCCCCTGA

Upstream 100 bases:

>100_bases
GCCGACACCGAGGCCGACACCGGTGCTGCGACCTGCTAAGGCACGGTCGAGTCTCGTACATCGCAGCCCCGACGCGATCC
GGCCGGAGTAGACGTTCATC

Downstream 100 bases:

>100_bases
CAGGCTGTTCGTTTGTACCCTCGGTGGACGCGCCCCTCTCCGTCATCGCGAGCGCAGCGAAGCGATCCAGGGCAGCGCGG
CCTCGACGGGGGTGGCACCG

Product: sodium/calcium exchanger membrane region

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MMAALRVAVAWATVLAFAWFGKGWLGDLSDPLFAGSLFAWLLGVIVWAAFGVVHEAEELAHRLGEPLGTLVLTLAIVIIE
VALISAVMLSAKDAPTLGRDTMFAVLMIVLNGVVGLGLLVGGLRHHQQRYNLQGASAFLSVIIPLTTIALIIPNFTSSTS
DGTLTTLQAVTFSVFTLALYGVFLLIQTGRHSEFFIDAEVPEATEPSHGADPVSGGSVAKHIGLLLANVVPIVILAKSLA
VILDHGIAALGAPTALGGVLIAAIVFTPEGISALKAVARNELQRAINLCLGAATSTVGLTVPAILTIGLLTGQTVVLGLK
PTEMTLLAVTLILSAQTFSGSRTTVLEGAVHLVLFFVYLVLIFSP

Sequences:

>Translated_365_residues
MMAALRVAVAWATVLAFAWFGKGWLGDLSDPLFAGSLFAWLLGVIVWAAFGVVHEAEELAHRLGEPLGTLVLTLAIVIIE
VALISAVMLSAKDAPTLGRDTMFAVLMIVLNGVVGLGLLVGGLRHHQQRYNLQGASAFLSVIIPLTTIALIIPNFTSSTS
DGTLTTLQAVTFSVFTLALYGVFLLIQTGRHSEFFIDAEVPEATEPSHGADPVSGGSVAKHIGLLLANVVPIVILAKSLA
VILDHGIAALGAPTALGGVLIAAIVFTPEGISALKAVARNELQRAINLCLGAATSTVGLTVPAILTIGLLTGQTVVLGLK
PTEMTLLAVTLILSAQTFSGSRTTVLEGAVHLVLFFVYLVLIFSP
>Mature_365_residues
MMAALRVAVAWATVLAFAWFGKGWLGDLSDPLFAGSLFAWLLGVIVWAAFGVVHEAEELAHRLGEPLGTLVLTLAIVIIE
VALISAVMLSAKDAPTLGRDTMFAVLMIVLNGVVGLGLLVGGLRHHQQRYNLQGASAFLSVIIPLTTIALIIPNFTSSTS
DGTLTTLQAVTFSVFTLALYGVFLLIQTGRHSEFFIDAEVPEATEPSHGADPVSGGSVAKHIGLLLANVVPIVILAKSLA
VILDHGIAALGAPTALGGVLIAAIVFTPEGISALKAVARNELQRAINLCLGAATSTVGLTVPAILTIGLLTGQTVVLGLK
PTEMTLLAVTLILSAQTFSGSRTTVLEGAVHLVLFFVYLVLIFSP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=321, Percent_Identity=39.8753894080997, Blast_Score=221, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 38009; Mature: 38009

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAALRVAVAWATVLAFAWFGKGWLGDLSDPLFAGSLFAWLLGVIVWAAFGVVHEAEELA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLGEPLGTLVLTLAIVIIEVALISAVMLSAKDAPTLGRDTMFAVLMIVLNGVVGLGLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGLRHHQQRYNLQGASAFLSVIIPLTTIALIIPNFTSSTSDGTLTTLQAVTFSVFTLALY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GVFLLIQTGRHSEFFIDAEVPEATEPSHGADPVSGGSVAKHIGLLLANVVPIVILAKSLA
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VILDHGIAALGAPTALGGVLIAAIVFTPEGISALKAVARNELQRAINLCLGAATSTVGLT
HHHHCCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPAILTIGLLTGQTVVLGLKPTEMTLLAVTLILSAQTFSGSRTTVLEGAVHLVLFFVYLV
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LIFSP
HHCCC
>Mature Secondary Structure
MMAALRVAVAWATVLAFAWFGKGWLGDLSDPLFAGSLFAWLLGVIVWAAFGVVHEAEELA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLGEPLGTLVLTLAIVIIEVALISAVMLSAKDAPTLGRDTMFAVLMIVLNGVVGLGLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGLRHHQQRYNLQGASAFLSVIIPLTTIALIIPNFTSSTSDGTLTTLQAVTFSVFTLALY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GVFLLIQTGRHSEFFIDAEVPEATEPSHGADPVSGGSVAKHIGLLLANVVPIVILAKSLA
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VILDHGIAALGAPTALGGVLIAAIVFTPEGISALKAVARNELQRAINLCLGAATSTVGLT
HHHHCCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPAILTIGLLTGQTVVLGLKPTEMTLLAVTLILSAQTFSGSRTTVLEGAVHLVLFFVYLV
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LIFSP
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]