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The map label for this gene is lhgO [H]

Identifier: 170749788

GI number: 170749788

Start: 3597483

End: 3598580

Strand: Direct

Name: lhgO [H]

Synonym: Mrad2831_3387

Alternate gene names: 170749788

Gene position: 3597483-3598580 (Clockwise)

Preceding gene: 170749786

Following gene: 170749796

Centisome position: 59.19

GC content: 74.5

Gene sequence:

>1098_bases
ATGGAGGTCCTGGTCGTCGGAGCCGGCGTCGTCGGGCTCGCCACCGGGCGGGCGCTCGCTCTGCGCGGGCACGCCGTCAT
CGTGGCGGAAGCCGAGGACGCCTTCGGCACGGGAGTCTCGTCCCGGAGCTCCGAGGTGATCCACGCCGGCATGTACTACC
CGGGCGGATCCGAGCGCGCGCACCACTGCGTCGAGGGCGCCCGGCAGCTATACAACTTTTGCGCGAGTCACGGCGTTCCG
CATCGCGCGTGCGGCAAGCTGATCGTCGCGTCCGACGACGGGGAGGCCGAGAAGATCGCGGCGATCCGCCGCCAGGGCGA
GGCCAACGGCGTCCCGGGCCTCGAACTCCTCGACGGGAGCGCCGCCCGCCGGCTGGAGCCGAATCTCGCCTGCACCGTGG
CGCTGCACTCGCCGCGCACCGGCGTCGTGGATAGCCACGCGCTGATGCTCGCCCTGCTCGGTGAGATCGAGGATCACGGC
GGCGCGCTCGCCCTGCGCACGCCCGTCGAGGACCTGAGCCGGCGGGACGGTCAGTGGCAGGCCGCGTTCGGCGGAGCCGA
GCCCGGCACGATGGCCTTCGACGCCGTGGTCAACGCCGCGAGCTTCGGCGCGCCGGCCCTGGCCGCCCGCACGGAGGGCT
ACCCGGCCGAGCGCGTGCCGACGCTGCGCCTCGCTCGCGGCAACTACTTCGGCTGCACCGGCAAGCCGGCCTTCTCGCGC
CTGATCTACCCGGCGCCCCGGATCGACGGCGGCCTCGGCATCCACCTGACCCTGGACCTCGCCGGCCGCACCCGCTTCGG
GCCCGACGTGGAGTGGGTCGACGGGTTCGACTACCGGGTCGATCCCGGGCGCGCGGAGGCCTTCTACGGCGCGATCCGGC
GCTACTGGCCCGGCCTGCCCGACGGCGCGCTGTATCCGGACTACGCGGGCCTGCGGCCGAAGCTGACCGGCCCGGGCGAG
GCGGCGGCCGATTTCCGGATCGACGGGCCGGCCGAGCACGGCCTGCCGGGGCTCGTGCACCTGTTCGGGATCGAGAGCCC
GGGCCTGACCTCCAGCCTGTCGCTCGCCGAGGCGGTGGCCGACCGGCTGGACGCCTGA

Upstream 100 bases:

>100_bases
TTAGGGTCAACGACGAATCAACGGGCGCGTCGTTGTTCCGACTCAAGTGCGGTATTGAGGACTCACCTGCCCGTCCGGGC
GCGCTGGAGAACGCGAACAC

Downstream 100 bases:

>100_bases
GCCTCAGAACAGCAGGTGCAGCGCCAGGGGCGCGAGGACCGCCGTCAGGAAGGCGTTGAGCCCCATGGCGATGCCCGCGA
AGGTGCCGGCGACCTCGCTG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MEVLVVGAGVVGLATGRALALRGHAVIVAEAEDAFGTGVSSRSSEVIHAGMYYPGGSERAHHCVEGARQLYNFCASHGVP
HRACGKLIVASDDGEAEKIAAIRRQGEANGVPGLELLDGSAARRLEPNLACTVALHSPRTGVVDSHALMLALLGEIEDHG
GALALRTPVEDLSRRDGQWQAAFGGAEPGTMAFDAVVNAASFGAPALAARTEGYPAERVPTLRLARGNYFGCTGKPAFSR
LIYPAPRIDGGLGIHLTLDLAGRTRFGPDVEWVDGFDYRVDPGRAEAFYGAIRRYWPGLPDGALYPDYAGLRPKLTGPGE
AAADFRIDGPAEHGLPGLVHLFGIESPGLTSSLSLAEAVADRLDA

Sequences:

>Translated_365_residues
MEVLVVGAGVVGLATGRALALRGHAVIVAEAEDAFGTGVSSRSSEVIHAGMYYPGGSERAHHCVEGARQLYNFCASHGVP
HRACGKLIVASDDGEAEKIAAIRRQGEANGVPGLELLDGSAARRLEPNLACTVALHSPRTGVVDSHALMLALLGEIEDHG
GALALRTPVEDLSRRDGQWQAAFGGAEPGTMAFDAVVNAASFGAPALAARTEGYPAERVPTLRLARGNYFGCTGKPAFSR
LIYPAPRIDGGLGIHLTLDLAGRTRFGPDVEWVDGFDYRVDPGRAEAFYGAIRRYWPGLPDGALYPDYAGLRPKLTGPGE
AAADFRIDGPAEHGLPGLVHLFGIESPGLTSSLSLAEAVADRLDA
>Mature_365_residues
MEVLVVGAGVVGLATGRALALRGHAVIVAEAEDAFGTGVSSRSSEVIHAGMYYPGGSERAHHCVEGARQLYNFCASHGVP
HRACGKLIVASDDGEAEKIAAIRRQGEANGVPGLELLDGSAARRLEPNLACTVALHSPRTGVVDSHALMLALLGEIEDHG
GALALRTPVEDLSRRDGQWQAAFGGAEPGTMAFDAVVNAASFGAPALAARTEGYPAERVPTLRLARGNYFGCTGKPAFSR
LIYPAPRIDGGLGIHLTLDLAGRTRFGPDVEWVDGFDYRVDPGRAEAFYGAIRRYWPGLPDGALYPDYAGLRPKLTGPGE
AAADFRIDGPAEHGLPGLVHLFGIESPGLTSSLSLAEAVADRLDA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=403, Percent_Identity=26.7990074441687, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI87082148, Length=390, Percent_Identity=24.3589743589744, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17565764, Length=404, Percent_Identity=28.2178217821782, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585081, Length=397, Percent_Identity=28.9672544080605, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38205; Mature: 38205

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLVVGAGVVGLATGRALALRGHAVIVAEAEDAFGTGVSSRSSEVIHAGMYYPGGSERA
CEEEEEECCCEECCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHH
HHCVEGARQLYNFCASHGVPHRACGKLIVASDDGEAEKIAAIRRQGEANGVPGLELLDGS
HHHHHHHHHHHHHHHHCCCCCHHHCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECCC
AARRLEPNLACTVALHSPRTGVVDSHALMLALLGEIEDHGGALALRTPVEDLSRRDGQWQ
CHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEE
AAFGGAEPGTMAFDAVVNAASFGAPALAARTEGYPAERVPTLRLARGNYFGCTGKPAFSR
EECCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHCCCEEEEECCCEECCCCCHHHHH
LIYPAPRIDGGLGIHLTLDLAGRTRFGPDVEWVDGFDYRVDPGRAEAFYGAIRRYWPGLP
HCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEECCCCEEECCCHHHHHHHHHHHHCCCCC
DGALYPDYAGLRPKLTGPGEAAADFRIDGPAEHGLPGLVHLFGIESPGLTSSLSLAEAVA
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
DRLDA
HHHCC
>Mature Secondary Structure
MEVLVVGAGVVGLATGRALALRGHAVIVAEAEDAFGTGVSSRSSEVIHAGMYYPGGSERA
CEEEEEECCCEECCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHH
HHCVEGARQLYNFCASHGVPHRACGKLIVASDDGEAEKIAAIRRQGEANGVPGLELLDGS
HHHHHHHHHHHHHHHHCCCCCHHHCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECCC
AARRLEPNLACTVALHSPRTGVVDSHALMLALLGEIEDHGGALALRTPVEDLSRRDGQWQ
CHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEE
AAFGGAEPGTMAFDAVVNAASFGAPALAARTEGYPAERVPTLRLARGNYFGCTGKPAFSR
EECCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHCCCEEEEECCCEECCCCCHHHHH
LIYPAPRIDGGLGIHLTLDLAGRTRFGPDVEWVDGFDYRVDPGRAEAFYGAIRRYWPGLP
HCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEECCCCEEECCCHHHHHHHHHHHHCCCCC
DGALYPDYAGLRPKLTGPGEAAADFRIDGPAEHGLPGLVHLFGIESPGLTSSLSLAEAVA
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
DRLDA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]