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The map label for this gene is typA [H]

Identifier: 170749770

GI number: 170749770

Start: 3573327

End: 3575150

Strand: Reverse

Name: typA [H]

Synonym: Mrad2831_3369

Alternate gene names: 170749770

Gene position: 3575150-3573327 (Counterclockwise)

Preceding gene: 170749773

Following gene: 170749769

Centisome position: 58.82

GC content: 67.6

Gene sequence:

>1824_bases
ATGAATCTGCGCAACATCGCCATCATCGCTCACGTCGACCACGGCAAGACGACCCTCGTCGACAAGCTGCTGGCCCAGTC
CGGCACCTTCCGCGAGAATCAGCGGGTCGAGGAGCGGGCGATGGACTCGAACGACCTCGAGAAGGAGCGCGGCATCACGA
TCCTCGCCAAGGCGACCTCGGTCGTCTGGAAGGACACCCGCGTCAACATCGTCGACACTCCCGGCCACGCCGATTTCGGC
GGCGAGGTCGAGCGCATCCTGTCGATGGTCGACGGCGTGATCGTGCTGGTGGACGCCGCCGAGGGGCCGATGCCCCAGAC
CAAGTTCGTGGTCGGCAAGGCGCTCAAGATCGGCCTGCGCCCGATCGTGGCGATCAACAAGGTCGACCGTCCGGACGCCC
GCATCAACGAGGTCGTGAACGAGGTCTTCGACCTGTTCGCCGCCCTCGACGCCACCGACGAGCAGCTCGACTTCCCGATC
CTCTACGGGTCGGGCCGCAACGGCTGGATGGCCGACAGCCCGGACGCGGACCCGTCGGTCGGCCTCACCCCGCTGTTCGA
CCTCGTGCTCAAGCACGTGCCGCCGGCCCGCACCGAGGAGGGGCCGTTCCGGATGCTCGGCACCCTGCTGGAGGCCAACC
CGTTCCTCGGCCGCATCATCACCGGCCGCATCGCCGCGGGCTCGGTGAAGCCCAACCAGTCGATCAAGGTCCTCGACCGT
CACGGCAAGGTCGTCGAGACCGGCCGCGTGTCGAAGATCCTCGCCTTCCGCGGCCTCGAGCGCGCCCCGATCGATGTGGG
CGAGGCGGGCGACATCGTGTCGATCGCCGGCCTGATGAAGGGCACCGTGGCCGACACGTTCTGCGACCCGCAGGTCGAGA
CCCCGATCCAGGCGCAGCCGATCGACCCGCCGACCGTGACGATGTCGTTCATCGTCAACGACAGCCCGCTCGCCGGCACC
GAGGGCGACAAGGTCACGAGCCGCATGATCCGCGACCGCCTGTTCAAGGAGGCCGAGGGCAACGTCACGCTCAAGATCGA
GGAGGCCGCCGACAAGGACAGCTTCTACGTCTCGGGCCGCGGCGAGCTGCAGCTCTCGATCCTAATCGAGACCATGCGCC
GCGAGGGTTTCGAGATCGCCGTGTCGCGGCCCCGCGTCGTGTACGAGCGCGACGAGAACGGCGGACTTCTGGAGCCGATC
GAGGAGGTCGTCATCGACGTCGACGAGGAGCATTCCGGCGTCGTCGTGCAGAAGATGTCCGAGCGGAAGGCCGAGATGCT
GGAGATGCGGCCCTCGGGCGGTAACCGCCTGCGCCTCGTGTTCCACGCCCCGACCCGCGGCCTGATCGGCTACCAGGGCG
AGCTGCTGACCGACACCCGCGGCACCGCGATCATGAACCGGCTGTTCAAGGCCTACGAGCCCTACAAGGGCGAGATGCCG
GGCCGGCGCAACGGCGTGCTGATCTCCAACGACCAGGGCGAGGCCGTGGCCTACGCCATGTGGAACCTGGAGGACCGCGG
CCCGATGATGATCGAGCCCGGCTGGAAGGTGTACCAGGGCATGATCGTCGGCGAGCACAACCGCGAGAACGATCTCGAGG
TGAACGTGCTCAAGGGCAAGAAGCTCACCAACATCCGCACCACGTCGAAGGACGAGGCGGTGCGCCTCACGCCGCCGATC
CGGATGACCCTGGAGCGCTCGCTGGCCTGGATCCAGGACGACGAGCTCGTCGAGGTGACGCCGAAGTCGATCCGCCTGCG
CAAGGCGATCCTCGACCCGAACGACCGCAAGCGGGCCGAGCGGTCGAAGGAGAACGCCGCCTGA

Upstream 100 bases:

>100_bases
TTATATTGCGACGCAACCACCACGACTCCGTACCTGAACCGGCGCGGACGGCCGCGCCGCGCGGCCGCCAGGGAGCCGGC
ACAACCCGTTTCGGGCCGCC

Downstream 100 bases:

>100_bases
GGCGGTCGACCGTCGCCGATCGTGAACGACAGGCAACCGGGCGCTCAGGCCCGGTTGCTGATGCGGCCCTTATTCCGGGC
CGCTCTCGGGCCCATCGAAC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MNLRNIAIIAHVDHGKTTLVDKLLAQSGTFRENQRVEERAMDSNDLEKERGITILAKATSVVWKDTRVNIVDTPGHADFG
GEVERILSMVDGVIVLVDAAEGPMPQTKFVVGKALKIGLRPIVAINKVDRPDARINEVVNEVFDLFAALDATDEQLDFPI
LYGSGRNGWMADSPDADPSVGLTPLFDLVLKHVPPARTEEGPFRMLGTLLEANPFLGRIITGRIAAGSVKPNQSIKVLDR
HGKVVETGRVSKILAFRGLERAPIDVGEAGDIVSIAGLMKGTVADTFCDPQVETPIQAQPIDPPTVTMSFIVNDSPLAGT
EGDKVTSRMIRDRLFKEAEGNVTLKIEEAADKDSFYVSGRGELQLSILIETMRREGFEIAVSRPRVVYERDENGGLLEPI
EEVVIDVDEEHSGVVVQKMSERKAEMLEMRPSGGNRLRLVFHAPTRGLIGYQGELLTDTRGTAIMNRLFKAYEPYKGEMP
GRRNGVLISNDQGEAVAYAMWNLEDRGPMMIEPGWKVYQGMIVGEHNRENDLEVNVLKGKKLTNIRTTSKDEAVRLTPPI
RMTLERSLAWIQDDELVEVTPKSIRLRKAILDPNDRKRAERSKENAA

Sequences:

>Translated_607_residues
MNLRNIAIIAHVDHGKTTLVDKLLAQSGTFRENQRVEERAMDSNDLEKERGITILAKATSVVWKDTRVNIVDTPGHADFG
GEVERILSMVDGVIVLVDAAEGPMPQTKFVVGKALKIGLRPIVAINKVDRPDARINEVVNEVFDLFAALDATDEQLDFPI
LYGSGRNGWMADSPDADPSVGLTPLFDLVLKHVPPARTEEGPFRMLGTLLEANPFLGRIITGRIAAGSVKPNQSIKVLDR
HGKVVETGRVSKILAFRGLERAPIDVGEAGDIVSIAGLMKGTVADTFCDPQVETPIQAQPIDPPTVTMSFIVNDSPLAGT
EGDKVTSRMIRDRLFKEAEGNVTLKIEEAADKDSFYVSGRGELQLSILIETMRREGFEIAVSRPRVVYERDENGGLLEPI
EEVVIDVDEEHSGVVVQKMSERKAEMLEMRPSGGNRLRLVFHAPTRGLIGYQGELLTDTRGTAIMNRLFKAYEPYKGEMP
GRRNGVLISNDQGEAVAYAMWNLEDRGPMMIEPGWKVYQGMIVGEHNRENDLEVNVLKGKKLTNIRTTSKDEAVRLTPPI
RMTLERSLAWIQDDELVEVTPKSIRLRKAILDPNDRKRAERSKENAA
>Mature_607_residues
MNLRNIAIIAHVDHGKTTLVDKLLAQSGTFRENQRVEERAMDSNDLEKERGITILAKATSVVWKDTRVNIVDTPGHADFG
GEVERILSMVDGVIVLVDAAEGPMPQTKFVVGKALKIGLRPIVAINKVDRPDARINEVVNEVFDLFAALDATDEQLDFPI
LYGSGRNGWMADSPDADPSVGLTPLFDLVLKHVPPARTEEGPFRMLGTLLEANPFLGRIITGRIAAGSVKPNQSIKVLDR
HGKVVETGRVSKILAFRGLERAPIDVGEAGDIVSIAGLMKGTVADTFCDPQVETPIQAQPIDPPTVTMSFIVNDSPLAGT
EGDKVTSRMIRDRLFKEAEGNVTLKIEEAADKDSFYVSGRGELQLSILIETMRREGFEIAVSRPRVVYERDENGGLLEPI
EEVVIDVDEEHSGVVVQKMSERKAEMLEMRPSGGNRLRLVFHAPTRGLIGYQGELLTDTRGTAIMNRLFKAYEPYKGEMP
GRRNGVLISNDQGEAVAYAMWNLEDRGPMMIEPGWKVYQGMIVGEHNRENDLEVNVLKGKKLTNIRTTSKDEAVRLTPPI
RMTLERSLAWIQDDELVEVTPKSIRLRKAILDPNDRKRAERSKENAA

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=42.8571428571429, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI157426893, Length=313, Percent_Identity=28.4345047923323, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI18390331, Length=133, Percent_Identity=42.1052631578947, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4503483, Length=205, Percent_Identity=31.7073170731707, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19923640, Length=142, Percent_Identity=40.1408450704225, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI25306283, Length=142, Percent_Identity=40.1408450704225, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI25306287, Length=142, Percent_Identity=40.1408450704225, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI34147630, Length=287, Percent_Identity=32.0557491289199, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=40.5405405405405, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=40.5405405405405, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=40.5405405405405, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI217272894, Length=181, Percent_Identity=35.3591160220994, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI217272892, Length=181, Percent_Identity=35.3591160220994, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI5729864, Length=330, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI223555963, Length=330, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=30.2325581395349, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4503471, Length=273, Percent_Identity=26.3736263736264, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=56.8106312292359, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=546, Percent_Identity=25.6410256410256, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789738, Length=149, Percent_Identity=39.5973154362416, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790835, Length=150, Percent_Identity=34, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790412, Length=287, Percent_Identity=30.3135888501742, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789737, Length=287, Percent_Identity=30.3135888501742, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=235, Percent_Identity=32.3404255319149, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=41.5492957746479, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988819, Length=129, Percent_Identity=36.4341085271318, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=129, Percent_Identity=36.4341085271318, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=137, Percent_Identity=41.6058394160584, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=38.0597014925373, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=292, Percent_Identity=28.4246575342466, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17552884, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569207, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=503, Percent_Identity=25.4473161033797, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324707, Length=202, Percent_Identity=36.1386138613861, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=202, Percent_Identity=36.1386138613861, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=166, Percent_Identity=36.7469879518072, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=39.8648648648649, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=34.4444444444444, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=282, Percent_Identity=30.1418439716312, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24582462, Length=134, Percent_Identity=45.5223880597015, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI78706572, Length=401, Percent_Identity=27.6807980049875, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585711, Length=165, Percent_Identity=34.5454545454545, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585713, Length=165, Percent_Identity=34.5454545454545, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=165, Percent_Identity=34.5454545454545, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574573, Length=215, Percent_Identity=32.093023255814, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=40, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357743, Length=173, Percent_Identity=35.8381502890173, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281363316, Length=306, Percent_Identity=29.0849673202614, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864358, Length=306, Percent_Identity=29.0849673202614, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19921738, Length=260, Percent_Identity=29.2307692307692, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28572034, Length=146, Percent_Identity=34.2465753424658, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67207; Mature: 67207

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRNIAIIAHVDHGKTTLVDKLLAQSGTFRENQRVEERAMDSNDLEKERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHCCEEEEEEEEE
VVWKDTRVNIVDTPGHADFGGEVERILSMVDGVIVLVDAAEGPMPQTKFVVGKALKIGLR
EEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVAINKVDRPDARINEVVNEVFDLFAALDATDEQLDFPILYGSGRNGWMADSPDADPSV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
GLTPLFDLVLKHVPPARTEEGPFRMLGTLLEANPFLGRIITGRIAAGSVKPNQSIKVLDR
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHEEECEEEECCCCCCCCEEEEEC
HGKVVETGRVSKILAFRGLERAPIDVGEAGDIVSIAGLMKGTVADTFCDPQVETPIQAQP
CCCEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
IDPPTVTMSFIVNDSPLAGTEGDKVTSRMIRDRLFKEAEGNVTLKIEEAADKDSFYVSGR
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECC
GELQLSILIETMRREGFEIAVSRPRVVYERDENGGLLEPIEEVVIDVDEEHSGVVVQKMS
CCEEEEHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCHHHHHH
ERKAEMLEMRPSGGNRLRLVFHAPTRGLIGYQGELLTDTRGTAIMNRLFKAYEPYKGEMP
HHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
GRRNGVLISNDQGEAVAYAMWNLEDRGPMMIEPGWKVYQGMIVGEHNRENDLEVNVLKGK
CCCCCEEEECCCCCEEEEEEECCCCCCCEEECCCHHEEEEEEEECCCCCCCCEEEEECCC
KLTNIRTTSKDEAVRLTPPIRMTLERSLAWIQDDELVEVTPKSIRLRKAILDPNDRKRAE
EECEEECCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHH
RSKENAA
HHHCCCC
>Mature Secondary Structure
MNLRNIAIIAHVDHGKTTLVDKLLAQSGTFRENQRVEERAMDSNDLEKERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHCCEEEEEEEEE
VVWKDTRVNIVDTPGHADFGGEVERILSMVDGVIVLVDAAEGPMPQTKFVVGKALKIGLR
EEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVAINKVDRPDARINEVVNEVFDLFAALDATDEQLDFPILYGSGRNGWMADSPDADPSV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
GLTPLFDLVLKHVPPARTEEGPFRMLGTLLEANPFLGRIITGRIAAGSVKPNQSIKVLDR
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHEEECEEEECCCCCCCCEEEEEC
HGKVVETGRVSKILAFRGLERAPIDVGEAGDIVSIAGLMKGTVADTFCDPQVETPIQAQP
CCCEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
IDPPTVTMSFIVNDSPLAGTEGDKVTSRMIRDRLFKEAEGNVTLKIEEAADKDSFYVSGR
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECC
GELQLSILIETMRREGFEIAVSRPRVVYERDENGGLLEPIEEVVIDVDEEHSGVVVQKMS
CCEEEEHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCHHHHHH
ERKAEMLEMRPSGGNRLRLVFHAPTRGLIGYQGELLTDTRGTAIMNRLFKAYEPYKGEMP
HHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
GRRNGVLISNDQGEAVAYAMWNLEDRGPMMIEPGWKVYQGMIVGEHNRENDLEVNVLKGK
CCCCCEEEECCCCCEEEEEEECCCCCCCEEECCCHHEEEEEEEECCCCCCCCEEEEECCC
KLTNIRTTSKDEAVRLTPPIRMTLERSLAWIQDDELVEVTPKSIRLRKAILDPNDRKRAE
EECEEECCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHH
RSKENAA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]