Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 170749764

GI number: 170749764

Start: 3570359

End: 3571333

Strand: Direct

Name: cysK [H]

Synonym: Mrad2831_3363

Alternate gene names: 170749764

Gene position: 3570359-3571333 (Clockwise)

Preceding gene: 170749762

Following gene: 170749765

Centisome position: 58.74

GC content: 68.62

Gene sequence:

>975_bases
ATGGCCGATACCCTCAACGCACCGGCGAAGGTCGGCCACGGCCGTGTCTACGGCTCGATCACCGAGACCATCGGCAACAC
CCCTCTGGTGCGCCTGAACCGGCTGCCCAAGGAGCACGGCGTCGACGCCGAGATTCTGCTGAAGCTCGAGTTCTTCAACC
CGATCGCCAGCGTGAAGGACCGCATCGGCGTCAACATGATCGATTCTTTGGAGGCCTCCGGCAAGCTCCAGCCCGGCGGC
ACGCTGGTCGAGCCGACCTCGGGCAACACCGGCATCGCCCTCGCCTTCACGGCGGCAGCCCGCGGCTACCGGCTCATCCT
GGTGATGCCCGAGACGATGTCGCTGGAGCGGCGCAAGATGCTCGCCTTCCTGGGCGCGGAGCTGGCGCTCACGCCGGGCG
CGCAGGGCATGAAGGGCGCGATCGCAAAGGCCGAGGAGCTGCTGAAGGAGATCCCGGGCTCGGTCATGCCGCAGCAATTC
TCGAACCCGGCCAACCCGGAGATCCACCGCAAGACCACTGCCGAGGAGATCTGGAGCGACACGGGCGGCCAGCTCGACGC
GTTCGTGGCCGGCGTCGGCACCGGCGGCACGGTGACGGGCGTCGGCGAGGTGCTGAAGCCGCGCCTGCCGAACCTCAAGG
TCTTCGCGGTGGAGCCCGAGGATTCCCCGGTGATCTCCGGCGGCCAGCCCGGCCCGCACAAGATCCAGGGCATCGGCGCC
GGGTTCATCCCCGACAACCTGCACACCAACATCCTCGACGGCGTCCTGAAGGTCACCAACCAGGCGGCGTTCGAGACATC
CCGGGCGCTCGCCCGTCTGGAGGGCATCCCGGGCGGCATCTCCACCGGTGGCAACGTCGCGGCGGCGCTGGAGCTGGCCA
AGCGTCCCGAGTTCCAGGGCAAGCGGATCGTGACCGTCGCCTGCTCGTTCGCCGAGCGCTACATCTCGTCCGCCCTCTTC
GACGGGATCGGCTAA

Upstream 100 bases:

>100_bases
TCCGGGCCGGTCAAGCCTCCCACGCGAGGGCGATCCCTTGGCGGGGCCGCCCCCGGGCACGACATCTGTCCGATCCGTCA
CCACGAGCAGGAGTTCCGCG

Downstream 100 bases:

>100_bases
GGCCGGCAGCGGAGCGGCCTTCGGGCCGCTCCCCTACCGTCGGCCACCCGGTCCGCGCGAACACGGATCCGCGCGGCCCT
CGCCCGAGTGGCCACCAATA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MADTLNAPAKVGHGRVYGSITETIGNTPLVRLNRLPKEHGVDAEILLKLEFFNPIASVKDRIGVNMIDSLEASGKLQPGG
TLVEPTSGNTGIALAFTAAARGYRLILVMPETMSLERRKMLAFLGAELALTPGAQGMKGAIAKAEELLKEIPGSVMPQQF
SNPANPEIHRKTTAEEIWSDTGGQLDAFVAGVGTGGTVTGVGEVLKPRLPNLKVFAVEPEDSPVISGGQPGPHKIQGIGA
GFIPDNLHTNILDGVLKVTNQAAFETSRALARLEGIPGGISTGGNVAAALELAKRPEFQGKRIVTVACSFAERYISSALF
DGIG

Sequences:

>Translated_324_residues
MADTLNAPAKVGHGRVYGSITETIGNTPLVRLNRLPKEHGVDAEILLKLEFFNPIASVKDRIGVNMIDSLEASGKLQPGG
TLVEPTSGNTGIALAFTAAARGYRLILVMPETMSLERRKMLAFLGAELALTPGAQGMKGAIAKAEELLKEIPGSVMPQQF
SNPANPEIHRKTTAEEIWSDTGGQLDAFVAGVGTGGTVTGVGEVLKPRLPNLKVFAVEPEDSPVISGGQPGPHKIQGIGA
GFIPDNLHTNILDGVLKVTNQAAFETSRALARLEGIPGGISTGGNVAAALELAKRPEFQGKRIVTVACSFAERYISSALF
DGIG
>Mature_323_residues
ADTLNAPAKVGHGRVYGSITETIGNTPLVRLNRLPKEHGVDAEILLKLEFFNPIASVKDRIGVNMIDSLEASGKLQPGGT
LVEPTSGNTGIALAFTAAARGYRLILVMPETMSLERRKMLAFLGAELALTPGAQGMKGAIAKAEELLKEIPGSVMPQQFS
NPANPEIHRKTTAEEIWSDTGGQLDAFVAGVGTGGTVTGVGEVLKPRLPNLKVFAVEPEDSPVISGGQPGPHKIQGIGAG
FIPDNLHTNILDGVLKVTNQAAFETSRALARLEGIPGGISTGGNVAAALELAKRPEFQGKRIVTVACSFAERYISSALFD
GIG

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=324, Percent_Identity=40.4320987654321, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI295821200, Length=324, Percent_Identity=40.4320987654321, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI4557415, Length=324, Percent_Identity=40.4320987654321, Blast_Score=228, Evalue=4e-60,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=56.8253968253968, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=41.2541254125413, Blast_Score=217, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=53, Blast_Score=305, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=51.1551155115512, Blast_Score=297, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=52.2033898305085, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=53.8205980066445, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17561720, Length=300, Percent_Identity=51.3333333333333, Blast_Score=263, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=49.3023255813954, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17534315, Length=292, Percent_Identity=41.7808219178082, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=289, Percent_Identity=40.4844290657439, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=49.5798319327731, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321594, Length=301, Percent_Identity=36.8770764119601, Blast_Score=188, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=35.9756097560976, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=7e-49,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33935; Mature: 33804

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLNAPAKVGHGRVYGSITETIGNTPLVRLNRLPKEHGVDAEILLKLEFFNPIASVKD
CCCCCCCCCCCCCCEEEEHHHHHHCCCCEEEECCCCHHHCCCCEEEEEEHHCCHHHHHHH
RIGVNMIDSLEASGKLQPGGTLVEPTSGNTGIALAFTAAARGYRLILVMPETMSLERRKM
HCCCCHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
LAFLGAELALTPGAQGMKGAIAKAEELLKEIPGSVMPQQFSNPANPEIHRKTTAEEIWSD
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHCC
TGGQLDAFVAGVGTGGTVTGVGEVLKPRLPNLKVFAVEPEDSPVISGGQPGPHKIQGIGA
CCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCEEEECCC
GFIPDNLHTNILDGVLKVTNQAAFETSRALARLEGIPGGISTGGNVAAALELAKRPEFQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
KRIVTVACSFAERYISSALFDGIG
CEEEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADTLNAPAKVGHGRVYGSITETIGNTPLVRLNRLPKEHGVDAEILLKLEFFNPIASVKD
CCCCCCCCCCCCCEEEEHHHHHHCCCCEEEECCCCHHHCCCCEEEEEEHHCCHHHHHHH
RIGVNMIDSLEASGKLQPGGTLVEPTSGNTGIALAFTAAARGYRLILVMPETMSLERRKM
HCCCCHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
LAFLGAELALTPGAQGMKGAIAKAEELLKEIPGSVMPQQFSNPANPEIHRKTTAEEIWSD
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHCC
TGGQLDAFVAGVGTGGTVTGVGEVLKPRLPNLKVFAVEPEDSPVISGGQPGPHKIQGIGA
CCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCEEEECCC
GFIPDNLHTNILDGVLKVTNQAAFETSRALARLEGIPGGISTGGNVAAALELAKRPEFQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
KRIVTVACSFAERYISSALFDGIG
CEEEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]