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The map label for this gene is pleC [H]

Identifier: 170749689

GI number: 170749689

Start: 3487433

End: 3489187

Strand: Direct

Name: pleC [H]

Synonym: Mrad2831_3287

Alternate gene names: 170749689

Gene position: 3487433-3489187 (Clockwise)

Preceding gene: 170749684

Following gene: 170749690

Centisome position: 57.38

GC content: 70.48

Gene sequence:

>1755_bases
ATGGACGATGATACCCTCACGTTGATCCCCGACGATCCCGATGAGGCGCAACCGACCGCGGGAGCCTGGGTGATCGCCGT
GATCGACGACGATCCGGCGGTCCATGACGGCACGCGTTACGCGCTGGCGAGCTACACCCTCGACGGGCGGGGCCTGGAGA
TCCTCACCGCCCGGTCGGCCGCGGAGGCGCGGGTGCTGCTCGCCGAGCGCCGCGACGTGGCGGTGGTGCTGCTCGACGTG
GTGATGGAGACCGACAATGCCGGGCTGGAGCTGGTGGACTACATCCGGCGCGAACTCCGGCAGGAGACCGTGCGCATCAT
CCTGCGGACCGGCCAGCCCGGCCAGGCACCGGAGCGGCGGATCATCGTCGATTACGACATCAACGACTACAAGGCGAAGA
CCGAACTGACCGCCGACAAGCTGTTCACCAGCCTCACCGCGGCCCTGCGCGCCCACCAGCAGCTGAAGCGCCTCGACGAG
ACCCGGCGTGGGCTCGAGATCATCATCGACGCGGCGCCGATGCTCCTCGACCACAAATCGATGCAGCGCCTGGCCGAGGG
TGTCCTCACCCAGGTCGCCTCGCTCCTGAACGTCGCCTGCGCGGGGATCCTGGTCCTGCGCGAGACCGCCGCCCCGCAGG
AGCGCTTCTGCGTCCTGGCCGGGTCCGGCTGCTATGGCCACTATGCCGGGCGCGAGCCGGCCTGGCCGCTGGAGGAGCGG
GTGCAACCCCTCGTTGAGCGGGCCTTCGCCGAGCGCCGCCACAGCTTCGGCGAGCATTGGTCGACCCTGTACCTGCACAC
GGCGAGCGGCAGCGAGATCGTCGCGCTGATCGAGGCCGACCGCCAGCTCTCCGAGACGGACCGGTCGCTCATCGCCCTGT
TCACGAGCCGGCTGTCGATCGCGTTCGACAACGTCATCCTCTACGAGCGGCTGCAGCAAACCAACGCCGACCTGGAGCGG
CGGGTCGTCGAGCGGACCGCGGAGCTGATCCGGGCGAACCGCCGGCTGGACCTGCAGCGCTCGGACCTGCGGCGCGCCAA
CAGCCTCAAGACCGAGATCCTCGGCACGATCGCGCACGATCTGAAGAATCCGCTGGCGGTGATCCTCGGCCGCGCCGAGA
TGCTGTCCGACCTGATCGACATGCAAGGGGACCGGGAGCAGATGCGGGCGCAGGTGCAGCACGTGCGCACCAGCGCGAAG
GGGCTGACGACCATGATCGACAGCCTCATGGCGGACGCGATGAACGACGCCCTCGACATCAGCCTGCGCCGGGAACCGGT
GGACCTCGCGGGCCTCGCCCAGGAGGTCTGCGAGGCCGACCGGCCGCTGGCCGACGCCAAGGGCCAGACCCTGGTCTGCG
AGGGCCCGGACGAGCTGTTCCTCTGCGGCGACGCCGAGCGCCTCCGCGAGGCGCTCGACAACCTCGTCTCCAACGCCATC
AAGTACAGCCCGGCCGGCGGCGCGATCACGGTGCGGGTCAGCCGCGAGCCGGGCCCGAGGGGCGCGGAGCTGGTCTGCGC
CGTCGCCGATCACGGGCCCGGCCTGTCGCCGGAGGATTCGTCCCGCGTGTTCGGCCGGTTCCAGCGCCTGTCGGCCAAGC
CCACCGGCGGCGAGAACTCGACCGGTCTCGGGCTCTCGATCGTCCGTCGGATCGCCGAGCTGCACGGCGGCCGCGCCACG
GCCGAGAGCGCCGGGCCGGGCTTAGGCGCGGTCTTCGCGATCCGCTTCCCGGAAGAATCCGTCGGCCTGTTCTGA

Upstream 100 bases:

>100_bases
ACGAATGCAGGAATCGTATCGGCTCACGTTACCGTGACAAGTTTTCAACACGATTTCTAGCGTAGTCGTCCGGTTGCGAG
CAGCATTTCGGGTCATAGCC

Downstream 100 bases:

>100_bases
GGGGAGGCTCCCGGAGCTCTGCCGGACCGACGTCGGCTTGCCGCCGTCGCGAAGGACGGCCGCAGACTGCCGGTTCCGGC
GATCCCGCGCGGGCCGGGAT

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MDDDTLTLIPDDPDEAQPTAGAWVIAVIDDDPAVHDGTRYALASYTLDGRGLEILTARSAAEARVLLAERRDVAVVLLDV
VMETDNAGLELVDYIRRELRQETVRIILRTGQPGQAPERRIIVDYDINDYKAKTELTADKLFTSLTAALRAHQQLKRLDE
TRRGLEIIIDAAPMLLDHKSMQRLAEGVLTQVASLLNVACAGILVLRETAAPQERFCVLAGSGCYGHYAGREPAWPLEER
VQPLVERAFAERRHSFGEHWSTLYLHTASGSEIVALIEADRQLSETDRSLIALFTSRLSIAFDNVILYERLQQTNADLER
RVVERTAELIRANRRLDLQRSDLRRANSLKTEILGTIAHDLKNPLAVILGRAEMLSDLIDMQGDREQMRAQVQHVRTSAK
GLTTMIDSLMADAMNDALDISLRREPVDLAGLAQEVCEADRPLADAKGQTLVCEGPDELFLCGDAERLREALDNLVSNAI
KYSPAGGAITVRVSREPGPRGAELVCAVADHGPGLSPEDSSRVFGRFQRLSAKPTGGENSTGLGLSIVRRIAELHGGRAT
AESAGPGLGAVFAIRFPEESVGLF

Sequences:

>Translated_584_residues
MDDDTLTLIPDDPDEAQPTAGAWVIAVIDDDPAVHDGTRYALASYTLDGRGLEILTARSAAEARVLLAERRDVAVVLLDV
VMETDNAGLELVDYIRRELRQETVRIILRTGQPGQAPERRIIVDYDINDYKAKTELTADKLFTSLTAALRAHQQLKRLDE
TRRGLEIIIDAAPMLLDHKSMQRLAEGVLTQVASLLNVACAGILVLRETAAPQERFCVLAGSGCYGHYAGREPAWPLEER
VQPLVERAFAERRHSFGEHWSTLYLHTASGSEIVALIEADRQLSETDRSLIALFTSRLSIAFDNVILYERLQQTNADLER
RVVERTAELIRANRRLDLQRSDLRRANSLKTEILGTIAHDLKNPLAVILGRAEMLSDLIDMQGDREQMRAQVQHVRTSAK
GLTTMIDSLMADAMNDALDISLRREPVDLAGLAQEVCEADRPLADAKGQTLVCEGPDELFLCGDAERLREALDNLVSNAI
KYSPAGGAITVRVSREPGPRGAELVCAVADHGPGLSPEDSSRVFGRFQRLSAKPTGGENSTGLGLSIVRRIAELHGGRAT
AESAGPGLGAVFAIRFPEESVGLF
>Mature_584_residues
MDDDTLTLIPDDPDEAQPTAGAWVIAVIDDDPAVHDGTRYALASYTLDGRGLEILTARSAAEARVLLAERRDVAVVLLDV
VMETDNAGLELVDYIRRELRQETVRIILRTGQPGQAPERRIIVDYDINDYKAKTELTADKLFTSLTAALRAHQQLKRLDE
TRRGLEIIIDAAPMLLDHKSMQRLAEGVLTQVASLLNVACAGILVLRETAAPQERFCVLAGSGCYGHYAGREPAWPLEER
VQPLVERAFAERRHSFGEHWSTLYLHTASGSEIVALIEADRQLSETDRSLIALFTSRLSIAFDNVILYERLQQTNADLER
RVVERTAELIRANRRLDLQRSDLRRANSLKTEILGTIAHDLKNPLAVILGRAEMLSDLIDMQGDREQMRAQVQHVRTSAK
GLTTMIDSLMADAMNDALDISLRREPVDLAGLAQEVCEADRPLADAKGQTLVCEGPDELFLCGDAERLREALDNLVSNAI
KYSPAGGAITVRVSREPGPRGAELVCAVADHGPGLSPEDSSRVFGRFQRLSAKPTGGENSTGLGLSIVRRIAELHGGRAT
AESAGPGLGAVFAIRFPEESVGLF

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG3437

COG function: function code KT; Response regulator containing a CheY-like receiver domain and an HD-GYP domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=28.4518828451883, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=32.7731092436975, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=26.7924528301887, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081816, Length=270, Percent_Identity=28.8888888888889, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=28.3261802575107, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=28.4552845528455, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789149, Length=272, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=27.6422764227642, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790861, Length=255, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790346, Length=251, Percent_Identity=26.6932270916335, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=117, Percent_Identity=37.6068376068376, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=27.0386266094421, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=306, Percent_Identity=26.4705882352941, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64026; Mature: 64026

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00681 CHAPERONINS_CPN10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDDTLTLIPDDPDEAQPTAGAWVIAVIDDDPAVHDGTRYALASYTLDGRGLEILTARSA
CCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEEECCH
AEARVLLAERRDVAVVLLDVVMETDNAGLELVDYIRRELRQETVRIILRTGQPGQAPERR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCE
IIVDYDINDYKAKTELTADKLFTSLTAALRAHQQLKRLDETRRGLEIIIDAAPMLLDHKS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHH
MQRLAEGVLTQVASLLNVACAGILVLRETAAPQERFCVLAGSGCYGHYAGREPAWPLEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHH
VQPLVERAFAERRHSFGEHWSTLYLHTASGSEIVALIEADRQLSETDRSLIALFTSRLSI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
AFDNVILYERLQQTNADLERRVVERTAELIRANRRLDLQRSDLRRANSLKTEILGTIAHD
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKNPLAVILGRAEMLSDLIDMQGDREQMRAQVQHVRTSAKGLTTMIDSLMADAMNDALDI
HCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEE
SLRREPVDLAGLAQEVCEADRPLADAKGQTLVCEGPDELFLCGDAERLREALDNLVSNAI
EECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHH
KYSPAGGAITVRVSREPGPRGAELVCAVADHGPGLSPEDSSRVFGRFQRLSAKPTGGENS
EECCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
TGLGLSIVRRIAELHGGRATAESAGPGLGAVFAIRFPEESVGLF
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHCCCC
>Mature Secondary Structure
MDDDTLTLIPDDPDEAQPTAGAWVIAVIDDDPAVHDGTRYALASYTLDGRGLEILTARSA
CCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEEECCH
AEARVLLAERRDVAVVLLDVVMETDNAGLELVDYIRRELRQETVRIILRTGQPGQAPERR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCE
IIVDYDINDYKAKTELTADKLFTSLTAALRAHQQLKRLDETRRGLEIIIDAAPMLLDHKS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHH
MQRLAEGVLTQVASLLNVACAGILVLRETAAPQERFCVLAGSGCYGHYAGREPAWPLEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHH
VQPLVERAFAERRHSFGEHWSTLYLHTASGSEIVALIEADRQLSETDRSLIALFTSRLSI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
AFDNVILYERLQQTNADLERRVVERTAELIRANRRLDLQRSDLRRANSLKTEILGTIAHD
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKNPLAVILGRAEMLSDLIDMQGDREQMRAQVQHVRTSAKGLTTMIDSLMADAMNDALDI
HCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEE
SLRREPVDLAGLAQEVCEADRPLADAKGQTLVCEGPDELFLCGDAERLREALDNLVSNAI
EECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHH
KYSPAGGAITVRVSREPGPRGAELVCAVADHGPGLSPEDSSRVFGRFQRLSAKPTGGENS
EECCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
TGLGLSIVRRIAELHGGRATAESAGPGLGAVFAIRFPEESVGLF
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]