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The map label for this gene is hemN [H]

Identifier: 170749675

GI number: 170749675

Start: 3469767

End: 3471113

Strand: Direct

Name: hemN [H]

Synonym: Mrad2831_3273

Alternate gene names: 170749675

Gene position: 3469767-3471113 (Clockwise)

Preceding gene: 170749674

Following gene: 170749676

Centisome position: 57.09

GC content: 72.16

Gene sequence:

>1347_bases
ATGCGCGAGGTCTTGCGGACGCACTACGGCGCGGAGCGGTTGCCTCGCTACACGAGCTACCCGGCGAGTCCCCATTTCAC
CGACGCGGTCGATGCCGGAACTTACGGGGACTGGCTGCGCGGGATCCCCGCGGACGCGACCGCGTCGCTCTACCTGCACG
TCCCCTTCTGCCGGTCGATGTGCTGGTACTGCGGGTGCCACACGACCATCACCCAGCACGACGCGCCCATCGCCGCCTAC
CTCGCCACCCTGCAAGCCGAGACGGTGCTCGTCGCGCGCCACCTCGACCGGGCTCCGCGCGTCCGCCACGTGCATTTCGG
GGGCGGTACGCCTACCATCGTGACGCCGGACGCCTTCCGCGAGCTCGTCGCGCTCCTCCGCGACCATTTCCCCGTCGCCT
CGGACGCCGAGATCGCCGTCGAGATCGATCCGCGCACCCTGACCCCCGCGATGACGCGGGCGCTCGGCGCCGCGGGCGTC
TCGCGGGCCAGCCTCGGTGTCCAGAGCTTCGACCCGGTGGTCCAGGACGCGATCCGGCGCCGCCAGAGCTTCGCGGAGAC
CGCGGCGGCCGTCGCGGGTCTCCGGGCCGCGGGCGTCGACGGGATCAATCTCGATCTGATCTACGGCCTCCCGCATCAGT
CGGTGGCGTCCTGCGTCGAGACGGTCCGGCAATCCCTGCGGTTGCGGCCCGATCGCTTGGCCGTGTTCGGCTACGCCCAC
GTCCCGACGTTCAAGAAGCATCAGCGCCACATCGAGGACGCGACGTTGCCGGATGGCCGCGTCCGGCAGGCCCAAGCCGA
GGCCATCGCCGCCCTGCTCGGTGAGGCCGGCTACGCGCGGATCGGGCTCGACCACTTCGCGCTGCCGGGGGATGCGCTGG
CGCGGGCGGGACGTGCGGTCCGCCGGAATTTCCAGGGCTACACGACGGATCCGAGCGACCTGCTGATCGGTTTCGGGGCA
TCGGCGATCGGGCGGCTACCGCAGGGCTACGTCCAGAACGACCCGGCCCTGCGCGGCTACGCGGACCGGGTCGCCAGAGG
GGCGCTCGCGACGCTGAAGGGCTACGCCCTCACGCCGGACGATCGTCTCCGGGCCGACCTGATCGAGCGGGTCATGTGCG
AGTTCCGAGTCGACGTCGGTGCCGTGTGCCGCGCGCATCGGCGCGATCCGGACGCGCTCCTCGCCGCGCTGCCTCGCCTG
CCGCGGCTCCTGGCCGACGGGCTGGTCCGCCGGGAAGGCGCCACCCTCCACGTCCCCGACGACGCGAGGGCTTTCGTGAG
AAGCGTCGCCGCCGCCTTCGACGCGCATCTCGGCACCTCTGCCGCGATGCACAGCCGCGCGGCCTAG

Upstream 100 bases:

>100_bases
CGATTGCGTCAGATCAAGGTCGCGCAGGCAGCCAGACGATACGGCTGCTTCGACAGCGCGGGCCCGTGCGGGTCCCGGCG
CGGACGATGAGGAAACGCGC

Downstream 100 bases:

>100_bases
CCGGCAGCGCCGCGCGCGGTGATGACGCCGGACCGCGGACATCCCCGCGCGCCGGCTGTTTTCCGATGCAACCGGCGGTG
TAAGACGGGCGCCGACGACC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MREVLRTHYGAERLPRYTSYPASPHFTDAVDAGTYGDWLRGIPADATASLYLHVPFCRSMCWYCGCHTTITQHDAPIAAY
LATLQAETVLVARHLDRAPRVRHVHFGGGTPTIVTPDAFRELVALLRDHFPVASDAEIAVEIDPRTLTPAMTRALGAAGV
SRASLGVQSFDPVVQDAIRRRQSFAETAAAVAGLRAAGVDGINLDLIYGLPHQSVASCVETVRQSLRLRPDRLAVFGYAH
VPTFKKHQRHIEDATLPDGRVRQAQAEAIAALLGEAGYARIGLDHFALPGDALARAGRAVRRNFQGYTTDPSDLLIGFGA
SAIGRLPQGYVQNDPALRGYADRVARGALATLKGYALTPDDRLRADLIERVMCEFRVDVGAVCRAHRRDPDALLAALPRL
PRLLADGLVRREGATLHVPDDARAFVRSVAAAFDAHLGTSAAMHSRAA

Sequences:

>Translated_448_residues
MREVLRTHYGAERLPRYTSYPASPHFTDAVDAGTYGDWLRGIPADATASLYLHVPFCRSMCWYCGCHTTITQHDAPIAAY
LATLQAETVLVARHLDRAPRVRHVHFGGGTPTIVTPDAFRELVALLRDHFPVASDAEIAVEIDPRTLTPAMTRALGAAGV
SRASLGVQSFDPVVQDAIRRRQSFAETAAAVAGLRAAGVDGINLDLIYGLPHQSVASCVETVRQSLRLRPDRLAVFGYAH
VPTFKKHQRHIEDATLPDGRVRQAQAEAIAALLGEAGYARIGLDHFALPGDALARAGRAVRRNFQGYTTDPSDLLIGFGA
SAIGRLPQGYVQNDPALRGYADRVARGALATLKGYALTPDDRLRADLIERVMCEFRVDVGAVCRAHRRDPDALLAALPRL
PRLLADGLVRREGATLHVPDDARAFVRSVAAAFDAHLGTSAAMHSRAA
>Mature_448_residues
MREVLRTHYGAERLPRYTSYPASPHFTDAVDAGTYGDWLRGIPADATASLYLHVPFCRSMCWYCGCHTTITQHDAPIAAY
LATLQAETVLVARHLDRAPRVRHVHFGGGTPTIVTPDAFRELVALLRDHFPVASDAEIAVEIDPRTLTPAMTRALGAAGV
SRASLGVQSFDPVVQDAIRRRQSFAETAAAVAGLRAAGVDGINLDLIYGLPHQSVASCVETVRQSLRLRPDRLAVFGYAH
VPTFKKHQRHIEDATLPDGRVRQAQAEAIAALLGEAGYARIGLDHFALPGDALARAGRAVRRNFQGYTTDPSDLLIGFGA
SAIGRLPQGYVQNDPALRGYADRVARGALATLKGYALTPDDRLRADLIERVMCEFRVDVGAVCRAHRRDPDALLAALPRL
PRLLADGLVRREGATLHVPDDARAFVRSVAAAFDAHLGTSAAMHSRAA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=293, Percent_Identity=28.3276450511945, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082341, Length=439, Percent_Identity=36.9020501138952, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789325, Length=242, Percent_Identity=29.7520661157025, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 48488; Mature: 48488

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVLRTHYGAERLPRYTSYPASPHFTDAVDAGTYGDWLRGIPADATASLYLHVPFCRSM
CHHHHHHHCCHHHCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCCCEEEEEECHHHHHH
CWYCGCHTTITQHDAPIAAYLATLQAETVLVARHLDRAPRVRHVHFGGGTPTIVTPDAFR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECHHHHH
ELVALLRDHFPVASDAEIAVEIDPRTLTPAMTRALGAAGVSRASLGVQSFDPVVQDAIRR
HHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHCCCHHCCHHHHHHHHH
RQSFAETAAAVAGLRAAGVDGINLDLIYGLPHQSVASCVETVRQSLRLRPDRLAVFGYAH
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPTFKKHQRHIEDATLPDGRVRQAQAEAIAALLGEAGYARIGLDHFALPGDALARAGRAV
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHCCCHHHHHHHHHHH
RRNFQGYTTDPSDLLIGFGASAIGRLPQGYVQNDPALRGYADRVARGALATLKGYALTPD
HHCCCCCCCCHHHHEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCC
DRLRADLIERVMCEFRVDVGAVCRAHRRDPDALLAALPRLPRLLADGLVRREGATLHVPD
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
DARAFVRSVAAAFDAHLGTSAAMHSRAA
HHHHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MREVLRTHYGAERLPRYTSYPASPHFTDAVDAGTYGDWLRGIPADATASLYLHVPFCRSM
CHHHHHHHCCHHHCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCCCEEEEEECHHHHHH
CWYCGCHTTITQHDAPIAAYLATLQAETVLVARHLDRAPRVRHVHFGGGTPTIVTPDAFR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECHHHHH
ELVALLRDHFPVASDAEIAVEIDPRTLTPAMTRALGAAGVSRASLGVQSFDPVVQDAIRR
HHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHCCCHHCCHHHHHHHHH
RQSFAETAAAVAGLRAAGVDGINLDLIYGLPHQSVASCVETVRQSLRLRPDRLAVFGYAH
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPTFKKHQRHIEDATLPDGRVRQAQAEAIAALLGEAGYARIGLDHFALPGDALARAGRAV
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHCCCHHHHHHHHHHH
RRNFQGYTTDPSDLLIGFGASAIGRLPQGYVQNDPALRGYADRVARGALATLKGYALTPD
HHCCCCCCCCHHHHEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCC
DRLRADLIERVMCEFRVDVGAVCRAHRRDPDALLAALPRLPRLLADGLVRREGATLHVPD
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
DARAFVRSVAAAFDAHLGTSAAMHSRAA
HHHHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]