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The map label for this gene is ybiC [H]

Identifier: 170749466

GI number: 170749466

Start: 3234228

End: 3235298

Strand: Reverse

Name: ybiC [H]

Synonym: Mrad2831_3061

Alternate gene names: 170749466

Gene position: 3235298-3234228 (Counterclockwise)

Preceding gene: 170749467

Following gene: 170749465

Centisome position: 53.23

GC content: 74.32

Gene sequence:

>1071_bases
ATGCGGATTCCGGCCGACAGGCTGACCGCCTACGTGCGGGACATTTTCGTGCGCGAGGGCTGCGCCGAGCCGGAGGCCGA
GCGGATCGGCCGCTTCCTGGTGGCGGCGAACCTCACCGGCCACGACAGTCACGGCGTCGTCCGTGTCACCCGCTACGTCG
AGTGGCTGCGCGCGGGCGAGGTCGAGGCCGGCCGCACGCCCGAGATCGTCACCGACGCGCCGAACTTCGCCCTCGTGGAC
GCGCATTACGGGTTCGGGCAGACGGCCGGCCCCTTCGCCACCGATCTCGGGATCGCCAAGGCGCGGGAGAACGGCGTCGC
GATCATCGCCCTGCGGCACGCCGGGCATATCGGCCGGATCGGCGAGTGGGCCGAGCGGGCGGCGGCGGCGGGGCTCGTCT
CGGTGCACTTCGTCAACGTGGCGGGGAGCCTCCTCGTGGCACCCTTCGGATCCGTGGAGCGCCGATTCTCGACGGCCCCC
TTCGCGGCCGGCTTCCCGGTCCCGGGGGGCGACCCGATCATCCTCGATTTCGCCACGTCGCTGGTCGCCGAGGGCAAGGT
GCTCGTCGCCTCCCGGGGCGGCAAGCCGCTGCCCGAGGGCGCGCTGATCGAGCCGGACGGCCGCCTCAGCGCCGACCCTG
CGACCCTGTTCGGCCCGCTGGAGGGCGTCGAGCGCGACAACCAGCGCGGCGCCGGGGCGATCCGGGCCTTCGGCGAGCAC
AAGGGCTCCGGCCTCGCGCTGATGTGCGAGCTCCTCGCCGGCGCGCTCACCGGCTCCGGCACGGCCGGCCCCGGGCAGCG
GCGGATCTGCAACGGCATGCTGTCGATCTACGTCACGCCGACCGCCCTCGGCACCGAGGACGCCCTCGCGGTCGAGACGC
GGGCCTATCTCGACTTCTTCAAGAGCGCCAAGCCGATGCCGGGCGCCGAGGTCCTGCTGCCCGGCGAGCCGGAGCGGCGC
ATGCGCGCCGAGCGCCTCGCCGAGGGTGTGCCGCTGCCGGAGCCCGTCTGGGAGACCCTGCTCGCCGCCGGCCGGCCGCA
CGGCCTCGACGGCAACGCCTACCGCACCTGA

Upstream 100 bases:

>100_bases
GGTGGCGGCCGCCGTCACCCGCCGGTGCTCGCCCTGCACGTGCGAGGACGCTAGGTTCATCCCGCACGCGCTCGGTGAAG
CGCGGCGAGGGAGAGACGGG

Downstream 100 bases:

>100_bases
GCCGGACGAGGGCCGGCACGACACCACGCTCGGCGGCGACCCTCGGCCCCAACGGGGGCGCCGCACGGACCGGGGACGCC
ATCCCCGGAAGACGGGAGGA

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRIPADRLTAYVRDIFVREGCAEPEAERIGRFLVAANLTGHDSHGVVRVTRYVEWLRAGEVEAGRTPEIVTDAPNFALVD
AHYGFGQTAGPFATDLGIAKARENGVAIIALRHAGHIGRIGEWAERAAAAGLVSVHFVNVAGSLLVAPFGSVERRFSTAP
FAAGFPVPGGDPIILDFATSLVAEGKVLVASRGGKPLPEGALIEPDGRLSADPATLFGPLEGVERDNQRGAGAIRAFGEH
KGSGLALMCELLAGALTGSGTAGPGQRRICNGMLSIYVTPTALGTEDALAVETRAYLDFFKSAKPMPGAEVLLPGEPERR
MRAERLAEGVPLPEPVWETLLAAGRPHGLDGNAYRT

Sequences:

>Translated_356_residues
MRIPADRLTAYVRDIFVREGCAEPEAERIGRFLVAANLTGHDSHGVVRVTRYVEWLRAGEVEAGRTPEIVTDAPNFALVD
AHYGFGQTAGPFATDLGIAKARENGVAIIALRHAGHIGRIGEWAERAAAAGLVSVHFVNVAGSLLVAPFGSVERRFSTAP
FAAGFPVPGGDPIILDFATSLVAEGKVLVASRGGKPLPEGALIEPDGRLSADPATLFGPLEGVERDNQRGAGAIRAFGEH
KGSGLALMCELLAGALTGSGTAGPGQRRICNGMLSIYVTPTALGTEDALAVETRAYLDFFKSAKPMPGAEVLLPGEPERR
MRAERLAEGVPLPEPVWETLLAAGRPHGLDGNAYRT
>Mature_356_residues
MRIPADRLTAYVRDIFVREGCAEPEAERIGRFLVAANLTGHDSHGVVRVTRYVEWLRAGEVEAGRTPEIVTDAPNFALVD
AHYGFGQTAGPFATDLGIAKARENGVAIIALRHAGHIGRIGEWAERAAAAGLVSVHFVNVAGSLLVAPFGSVERRFSTAP
FAAGFPVPGGDPIILDFATSLVAEGKVLVASRGGKPLPEGALIEPDGRLSADPATLFGPLEGVERDNQRGAGAIRAFGEH
KGSGLALMCELLAGALTGSGTAGPGQRRICNGMLSIYVTPTALGTEDALAVETRAYLDFFKSAKPMPGAEVLLPGEPERR
MRAERLAEGVPLPEPVWETLLAAGRPHGLDGNAYRT

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=353, Percent_Identity=37.9603399433428, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786727, Length=356, Percent_Identity=25.561797752809, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790000, Length=351, Percent_Identity=24.7863247863248, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17507179, Length=263, Percent_Identity=29.6577946768061, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17536633, Length=344, Percent_Identity=26.453488372093, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45553211, Length=336, Percent_Identity=30.6547619047619, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24667912, Length=336, Percent_Identity=30.6547619047619, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24667908, Length=336, Percent_Identity=30.6547619047619, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24667904, Length=336, Percent_Identity=30.6547619047619, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24658010, Length=326, Percent_Identity=25.4601226993865, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648360, Length=278, Percent_Identity=28.4172661870504, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 37468; Mature: 37468

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPADRLTAYVRDIFVREGCAEPEAERIGRFLVAANLTGHDSHGVVRVTRYVEWLRAGE
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VEAGRTPEIVTDAPNFALVDAHYGFGQTAGPFATDLGIAKARENGVAIIALRHAGHIGRI
CCCCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCH
GEWAERAAAAGLVSVHFVNVAGSLLVAPFGSVERRFSTAPFAAGFPVPGGDPIILDFATS
HHHHHHHHHHHHHEEEEEHHCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHH
LVAEGKVLVASRGGKPLPEGALIEPDGRLSADPATLFGPLEGVERDNQRGAGAIRAFGEH
HHHCCEEEEEECCCCCCCCCCEECCCCCCCCCCHHHHCCHHCCCCCCCCCCHHHHHHHCC
KGSGLALMCELLAGALTGSGTAGPGQRRICNGMLSIYVTPTALGTEDALAVETRAYLDFF
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
KSAKPMPGAEVLLPGEPERRMRAERLAEGVPLPEPVWETLLAAGRPHGLDGNAYRT
HHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIPADRLTAYVRDIFVREGCAEPEAERIGRFLVAANLTGHDSHGVVRVTRYVEWLRAGE
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VEAGRTPEIVTDAPNFALVDAHYGFGQTAGPFATDLGIAKARENGVAIIALRHAGHIGRI
CCCCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCH
GEWAERAAAAGLVSVHFVNVAGSLLVAPFGSVERRFSTAPFAAGFPVPGGDPIILDFATS
HHHHHHHHHHHHHEEEEEHHCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHH
LVAEGKVLVASRGGKPLPEGALIEPDGRLSADPATLFGPLEGVERDNQRGAGAIRAFGEH
HHHCCEEEEEECCCCCCCCCCEECCCCCCCCCCHHHHCCHHCCCCCCCCCCHHHHHHHCC
KGSGLALMCELLAGALTGSGTAGPGQRRICNGMLSIYVTPTALGTEDALAVETRAYLDFF
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
KSAKPMPGAEVLLPGEPERRMRAERLAEGVPLPEPVWETLLAAGRPHGLDGNAYRT
HHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]