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The map label for this gene is upp [H]

Identifier: 170749378

GI number: 170749378

Start: 3128658

End: 3129293

Strand: Reverse

Name: upp [H]

Synonym: Mrad2831_2971

Alternate gene names: 170749378

Gene position: 3129293-3128658 (Counterclockwise)

Preceding gene: 170749380

Following gene: 170749373

Centisome position: 51.49

GC content: 68.55

Gene sequence:

>636_bases
ATGTCGACGGGTCGGGTCACCGTGGTCGATCACCCGCTGGTGCAGCACAAGCTCACCTATCTGCGGGACAAGAACCGCTC
GACCAAGGGTTTCCGGCAGATCCTCAACGAGATCGGGATGCTCCTCGCCTACGAGGTGACCCGGGATCTGCCGCTGGAAC
CGGTGACGATCGAGACGCCGCTCCAGCCGATGCAGGGGCAGCAGATCCAGGGCAAGAAGCTGGTCCTGGCGCCGATCCTC
CGCGCCGGGGTCGGCTTCCTCGACGGCATGCTGTCGCTGGTCCCGTCGGCCCGCGTGGCGCATATCGGGCTCTACCGGGA
TCCCGAGACGCTGGAGGCCGTGGAGTACTACTTCAAGGCGCCCTCCGATCTGGCTGATCGGACGGTGCTGGTGCTGGATC
CGATGCTCGCGACCGCCAACTCGGCCATCGCGGCCCTGGACCGCCTCAAGGCCAGGGGCGCCTCGGACCTCCGCTTCGTC
TGCCTGCTGGCGGCGCCGGAGGGCCTCGCCAAGTTCCAGGCCGCCCATCCCGACGTGCCGGTCTGGACCGCGGCGATCGA
CAGCCACCTGAACGACCACGGCTACATCGTCCCCGGCCTCGGCGATGCCGGGGACCGGATGTACGGCACCCGCTAG

Upstream 100 bases:

>100_bases
GGCCGCGTCGGCCCCGTCTCCCCGCGCTGTCCGAGAGGACGAGTTGCGCCCCGGCTCCCGCTCCGGCATTGGTCCTCAAC
CGCGAGGAGAGGTGTTGGGC

Downstream 100 bases:

>100_bases
GAGTCCGCCTCAGCGCCGGCCGCGCCTGGCTCCGGCACGGCCCTTGCCGACGACGTTGCGGAGGGTCTGCGACAGCTGAT
CCACCGAGTAGGGCTTCTGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSTGRVTVVDHPLVQHKLTYLRDKNRSTKGFRQILNEIGMLLAYEVTRDLPLEPVTIETPLQPMQGQQIQGKKLVLAPIL
RAGVGFLDGMLSLVPSARVAHIGLYRDPETLEAVEYYFKAPSDLADRTVLVLDPMLATANSAIAALDRLKARGASDLRFV
CLLAAPEGLAKFQAAHPDVPVWTAAIDSHLNDHGYIVPGLGDAGDRMYGTR

Sequences:

>Translated_211_residues
MSTGRVTVVDHPLVQHKLTYLRDKNRSTKGFRQILNEIGMLLAYEVTRDLPLEPVTIETPLQPMQGQQIQGKKLVLAPIL
RAGVGFLDGMLSLVPSARVAHIGLYRDPETLEAVEYYFKAPSDLADRTVLVLDPMLATANSAIAALDRLKARGASDLRFV
CLLAAPEGLAKFQAAHPDVPVWTAAIDSHLNDHGYIVPGLGDAGDRMYGTR
>Mature_210_residues
STGRVTVVDHPLVQHKLTYLRDKNRSTKGFRQILNEIGMLLAYEVTRDLPLEPVTIETPLQPMQGQQIQGKKLVLAPILR
AGVGFLDGMLSLVPSARVAHIGLYRDPETLEAVEYYFKAPSDLADRTVLVLDPMLATANSAIAALDRLKARGASDLRFVC
LLAAPEGLAKFQAAHPDVPVWTAAIDSHLNDHGYIVPGLGDAGDRMYGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.7128712871287, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.7128712871287, Blast_Score=80, Evalue=9e-16,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=52.1739130434783, Blast_Score=233, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=25.3658536585366, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=25.3658536585366, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=37.8238341968912, Blast_Score=118, Evalue=9e-28,
Organism=Drosophila melanogaster, GI45550449, Length=205, Percent_Identity=28.2926829268293, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573516, Length=205, Percent_Identity=28.2926829268293, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573514, Length=205, Percent_Identity=28.2926829268293, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573512, Length=205, Percent_Identity=28.2926829268293, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23051; Mature: 22920

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGRVTVVDHPLVQHKLTYLRDKNRSTKGFRQILNEIGMLLAYEVTRDLPLEPVTIETP
CCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LQPMQGQQIQGKKLVLAPILRAGVGFLDGMLSLVPSARVAHIGLYRDPETLEAVEYYFKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHCC
PSDLADRTVLVLDPMLATANSAIAALDRLKARGASDLRFVCLLAAPEGLAKFQAAHPDVP
CCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCC
VWTAAIDSHLNDHGYIVPGLGDAGDRMYGTR
CHHHHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
STGRVTVVDHPLVQHKLTYLRDKNRSTKGFRQILNEIGMLLAYEVTRDLPLEPVTIETP
CCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
LQPMQGQQIQGKKLVLAPILRAGVGFLDGMLSLVPSARVAHIGLYRDPETLEAVEYYFKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHCC
PSDLADRTVLVLDPMLATANSAIAALDRLKARGASDLRFVCLLAAPEGLAKFQAAHPDVP
CCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCC
VWTAAIDSHLNDHGYIVPGLGDAGDRMYGTR
CHHHHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA