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The map label for this gene is dcp [H]

Identifier: 170749341

GI number: 170749341

Start: 3092064

End: 3094133

Strand: Reverse

Name: dcp [H]

Synonym: Mrad2831_2934

Alternate gene names: 170749341

Gene position: 3094133-3092064 (Counterclockwise)

Preceding gene: 170749345

Following gene: 170749340

Centisome position: 50.91

GC content: 71.64

Gene sequence:

>2070_bases
ATGTCGGACGCAGCTGATGCCGGGCTCCCGAGCCTGCCGCAGGACAATCCCTTCCGCGAAGCGCAGTGGAGCACCCCGCA
CGGCCTGCCGCCGTTCGAGCGGATCCGGCCGGAGCACTACGGACCCGCGTTCGAGGCCGCGCTCGCCGCGCACGATTCCG
AGATCCGCGCCATCGCCGGCCAGACCGCGCCGGCCACCTTCGCCAACACCGTCGCGGCGATGGAGCGGGCCGGCCTCGCC
CTCGAGCGCGTCGCCGGCGTGTTCTACAATCTGACCGGCAGCCACACCAACCCGGAGTTGCAGGCCATCGAGCGGGAGAT
CGGGCCCAAACTCGCCCGGCACGGGAGCGCCATCTACCTCAACCCCGAGCTCTGGGCCCGGATCTCGGCGATCGACGCCG
GGGGGCTCGGTGCGGAGGAGCGGCGGGTCCTCGACCGGTACCGGATCCGCTTCCGCCGGTCGGGGGCGGATCTCGGGCTC
GAGGACAAGGCCCGCATCGCCGAGATCGCGGCGCGCATGTCGGAGCTCGGGACGACGTTCAGTCAGAACCTCCTGGCCGA
CGAGAGCAGCTTCATCCTGCCGCTGCAGGGCGAGGAGGACCTGGCCGGCCTGCCGCCGTTCCTGCGGGCCGCGACCGAGA
GCGCCGCGAGGGAGCGCGGCCTCGACGGGCACGTCGTCACCCTGTCCCGCTCGCTGATCGAGCCGTTCCTGGTCTGCTCG
ACGCGGCGCGACCTGCGCGAGCGCGCCTACGCGGCCTGGACCAGGCGCGGCGAGAACGGCGGCGCGACCGATAACCGCGC
GATCATCGCGGAGATCATCCGGCTGCGCGCCGAGCGCGCGCGGCTCCTCGGCTTCGAGAGCTTCGCGCATTTCGCCCTCG
ACGACACGATGGCGGCGAGCCCGGACGCGGCGACCGGGCTGCTGCGGGACGTGTGGACGCCGGCCCGCGCGCGGGCGGCG
GAGGAGCGCGATCGCCTCCAGGCCACGATCCAGGCGGAGGGCCACAACTTCGCCCTGCAGGCGCACGATTGGCGGCACTA
CGCCGAGAAGGTGCGGCGCGCCGAGCACGACCTCGACGAGAGCGAGATCAAGGCGTACCTGCCCCTCGAGCGGATGATCC
AGGCGGCGTTCGACACGGCCGCCCGGCTGTTCGGCCTGACCTTCACGGAACTCTCCGACGTGCCGCGCTACCATCCCGAT
GTCCGGGTCTGGCGGGTCGGCAATCCCGACGGGTCCGAGGTCGGCCTGTTCCTGGGGGACTATTTCGCCCGCGCCTCGAA
GCGGTCCGGCGCCTGGATGAGCGCCTTCCGCTCGCAGGAGCGCCTCAACGGGCCGATCACGCCGATCATCGTCAACGTCA
TGAACTTCGCCAAGGCGCCCGACGGCGAGGCGACGCTGCTGTCGTTCGACGACGCCCGCACCCTGTTCCACGAGTTCGGC
CACGCCCTGCACGGGCTGCTCTCGGACGTGACCTACCCGCTCCTGTCCGGGACGGCGGTGTCGCGCGACTTCGTCGAGCT
GCCCTCGCAGCTCTACGAGCACTGGCTCGAGCAACCGGAGGTCCTGCGCGCCCACGCGCGCCACCATCGCACGGGCGAGC
CCATGCCCGACGCCCTGCTCAGGAAGCTGCTCGCCGCGCGGACCTTCAATCAGGGCTTCGCCACGGTGGAGTACACCGCC
TCGGCGATCGTCGACATGACGCTGCACCTCTCGGCGGAGGGCGAGGGCGGTCTCGACGTGCCCGCCTTCGAGGCCGAGGC
CCTGCGGCGGATCAGCATGCCGGCCGAGATCAGCATGCGGCACCGCACGCCGCACTTCGCCCACATCTTCTCGGGGGACG
GCTACGCCGCCGGATACTACAGCTACCTCTGGTCGGAAGTGCTGGACGCGGACGCCTTCGACGCGTTCCGCGAGGCCGGC
GACATCTTCGATCCGGAGACGGCGAAGCGGCTGCGTACCTTCGTGTACGGGGCCGGCAACCTGCGCGATCCGCGCGAGGC
CTACACGGCCTTCCGCGGGCGGATGCCGAGCATCGAGCCGCTGCTGAAGAAGCGCGGGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
ATCGGACCACTGTCTTCCAGATCGCGCCGGCACACCCCATGTCGGCGCACCGGCGGCGCAGACGAACGCGCTGTCGCGTG
GACGTAGATTTGAGGACTGC

Downstream 100 bases:

>100_bases
GCCGTCAGACCGCGGTAAGGGTTTCGTAAACAAACGTCCTTAACGAACGCTTGCAGCGCGAGGCCGCGTGCGGAGTTCGG
GGCGATGACGAAGATCGAAG

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MSDAADAGLPSLPQDNPFREAQWSTPHGLPPFERIRPEHYGPAFEAALAAHDSEIRAIAGQTAPATFANTVAAMERAGLA
LERVAGVFYNLTGSHTNPELQAIEREIGPKLARHGSAIYLNPELWARISAIDAGGLGAEERRVLDRYRIRFRRSGADLGL
EDKARIAEIAARMSELGTTFSQNLLADESSFILPLQGEEDLAGLPPFLRAATESAARERGLDGHVVTLSRSLIEPFLVCS
TRRDLRERAYAAWTRRGENGGATDNRAIIAEIIRLRAERARLLGFESFAHFALDDTMAASPDAATGLLRDVWTPARARAA
EERDRLQATIQAEGHNFALQAHDWRHYAEKVRRAEHDLDESEIKAYLPLERMIQAAFDTAARLFGLTFTELSDVPRYHPD
VRVWRVGNPDGSEVGLFLGDYFARASKRSGAWMSAFRSQERLNGPITPIIVNVMNFAKAPDGEATLLSFDDARTLFHEFG
HALHGLLSDVTYPLLSGTAVSRDFVELPSQLYEHWLEQPEVLRAHARHHRTGEPMPDALLRKLLAARTFNQGFATVEYTA
SAIVDMTLHLSAEGEGGLDVPAFEAEALRRISMPAEISMRHRTPHFAHIFSGDGYAAGYYSYLWSEVLDADAFDAFREAG
DIFDPETAKRLRTFVYGAGNLRDPREAYTAFRGRMPSIEPLLKKRGLAA

Sequences:

>Translated_689_residues
MSDAADAGLPSLPQDNPFREAQWSTPHGLPPFERIRPEHYGPAFEAALAAHDSEIRAIAGQTAPATFANTVAAMERAGLA
LERVAGVFYNLTGSHTNPELQAIEREIGPKLARHGSAIYLNPELWARISAIDAGGLGAEERRVLDRYRIRFRRSGADLGL
EDKARIAEIAARMSELGTTFSQNLLADESSFILPLQGEEDLAGLPPFLRAATESAARERGLDGHVVTLSRSLIEPFLVCS
TRRDLRERAYAAWTRRGENGGATDNRAIIAEIIRLRAERARLLGFESFAHFALDDTMAASPDAATGLLRDVWTPARARAA
EERDRLQATIQAEGHNFALQAHDWRHYAEKVRRAEHDLDESEIKAYLPLERMIQAAFDTAARLFGLTFTELSDVPRYHPD
VRVWRVGNPDGSEVGLFLGDYFARASKRSGAWMSAFRSQERLNGPITPIIVNVMNFAKAPDGEATLLSFDDARTLFHEFG
HALHGLLSDVTYPLLSGTAVSRDFVELPSQLYEHWLEQPEVLRAHARHHRTGEPMPDALLRKLLAARTFNQGFATVEYTA
SAIVDMTLHLSAEGEGGLDVPAFEAEALRRISMPAEISMRHRTPHFAHIFSGDGYAAGYYSYLWSEVLDADAFDAFREAG
DIFDPETAKRLRTFVYGAGNLRDPREAYTAFRGRMPSIEPLLKKRGLAA
>Mature_688_residues
SDAADAGLPSLPQDNPFREAQWSTPHGLPPFERIRPEHYGPAFEAALAAHDSEIRAIAGQTAPATFANTVAAMERAGLAL
ERVAGVFYNLTGSHTNPELQAIEREIGPKLARHGSAIYLNPELWARISAIDAGGLGAEERRVLDRYRIRFRRSGADLGLE
DKARIAEIAARMSELGTTFSQNLLADESSFILPLQGEEDLAGLPPFLRAATESAARERGLDGHVVTLSRSLIEPFLVCST
RRDLRERAYAAWTRRGENGGATDNRAIIAEIIRLRAERARLLGFESFAHFALDDTMAASPDAATGLLRDVWTPARARAAE
ERDRLQATIQAEGHNFALQAHDWRHYAEKVRRAEHDLDESEIKAYLPLERMIQAAFDTAARLFGLTFTELSDVPRYHPDV
RVWRVGNPDGSEVGLFLGDYFARASKRSGAWMSAFRSQERLNGPITPIIVNVMNFAKAPDGEATLLSFDDARTLFHEFGH
ALHGLLSDVTYPLLSGTAVSRDFVELPSQLYEHWLEQPEVLRAHARHHRTGEPMPDALLRKLLAARTFNQGFATVEYTAS
AIVDMTLHLSAEGEGGLDVPAFEAEALRRISMPAEISMRHRTPHFAHIFSGDGYAAGYYSYLWSEVLDADAFDAFREAGD
IFDPETAKRLRTFVYGAGNLRDPREAYTAFRGRMPSIEPLLKKRGLAA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=614, Percent_Identity=28.9902280130293, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI14149738, Length=610, Percent_Identity=27.0491803278689, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI156105687, Length=660, Percent_Identity=22.8787878787879, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=41.0294117647059, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1789913, Length=675, Percent_Identity=33.037037037037, Blast_Score=346, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI71999758, Length=575, Percent_Identity=22.6086956521739, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32565901, Length=592, Percent_Identity=21.7905405405405, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319793, Length=585, Percent_Identity=26.1538461538462, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322715, Length=337, Percent_Identity=26.7062314540059, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=24.3937232524964, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129717, Length=409, Percent_Identity=24.6943765281174, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 76421; Mature: 76290

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAADAGLPSLPQDNPFREAQWSTPHGLPPFERIRPEHYGPAFEAALAAHDSEIRAIAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHC
QTAPATFANTVAAMERAGLALERVAGVFYNLTGSHTNPELQAIEREIGPKLARHGSAIYL
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEE
NPELWARISAIDAGGLGAEERRVLDRYRIRFRRSGADLGLEDKARIAEIAARMSELGTTF
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
SQNLLADESSFILPLQGEEDLAGLPPFLRAATESAARERGLDGHVVTLSRSLIEPFLVCS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
TRRDLRERAYAAWTRRGENGGATDNRAIIAEIIRLRAERARLLGFESFAHFALDDTMAAS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
PDAATGLLRDVWTPARARAAEERDRLQATIQAEGHNFALQAHDWRHYAEKVRRAEHDLDE
CCHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHCCCCH
SEIKAYLPLERMIQAAFDTAARLFGLTFTELSDVPRYHPDVRVWRVGNPDGSEVGLFLGD
HHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHH
YFARASKRSGAWMSAFRSQERLNGPITPIIVNVMNFAKAPDGEATLLSFDDARTLFHEFG
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHH
HALHGLLSDVTYPLLSGTAVSRDFVELPSQLYEHWLEQPEVLRAHARHHRTGEPMPDALL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHH
RKLLAARTFNQGFATVEYTASAIVDMTLHLSAEGEGGLDVPAFEAEALRRISMPAEISMR
HHHHHHHHHCCCCEEHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHH
HRTPHFAHIFSGDGYAAGYYSYLWSEVLDADAFDAFREAGDIFDPETAKRLRTFVYGAGN
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
LRDPREAYTAFRGRMPSIEPLLKKRGLAA
CCCHHHHHHHHHCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SDAADAGLPSLPQDNPFREAQWSTPHGLPPFERIRPEHYGPAFEAALAAHDSEIRAIAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHC
QTAPATFANTVAAMERAGLALERVAGVFYNLTGSHTNPELQAIEREIGPKLARHGSAIYL
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEE
NPELWARISAIDAGGLGAEERRVLDRYRIRFRRSGADLGLEDKARIAEIAARMSELGTTF
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
SQNLLADESSFILPLQGEEDLAGLPPFLRAATESAARERGLDGHVVTLSRSLIEPFLVCS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
TRRDLRERAYAAWTRRGENGGATDNRAIIAEIIRLRAERARLLGFESFAHFALDDTMAAS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
PDAATGLLRDVWTPARARAAEERDRLQATIQAEGHNFALQAHDWRHYAEKVRRAEHDLDE
CCHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHCCCCH
SEIKAYLPLERMIQAAFDTAARLFGLTFTELSDVPRYHPDVRVWRVGNPDGSEVGLFLGD
HHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHH
YFARASKRSGAWMSAFRSQERLNGPITPIIVNVMNFAKAPDGEATLLSFDDARTLFHEFG
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHH
HALHGLLSDVTYPLLSGTAVSRDFVELPSQLYEHWLEQPEVLRAHARHHRTGEPMPDALL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHH
RKLLAARTFNQGFATVEYTASAIVDMTLHLSAEGEGGLDVPAFEAEALRRISMPAEISMR
HHHHHHHHHCCCCEEHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHH
HRTPHFAHIFSGDGYAAGYYSYLWSEVLDADAFDAFREAGDIFDPETAKRLRTFVYGAGN
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
LRDPREAYTAFRGRMPSIEPLLKKRGLAA
CCCHHHHHHHHHCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]