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The map label for this gene is ubiB [C]

Identifier: 170749209

GI number: 170749209

Start: 2941893

End: 2943254

Strand: Reverse

Name: ubiB [C]

Synonym: Mrad2831_2802

Alternate gene names: 170749209

Gene position: 2943254-2941893 (Counterclockwise)

Preceding gene: 170749210

Following gene: 170749208

Centisome position: 48.43

GC content: 68.43

Gene sequence:

>1362_bases
ATGGCCGAGACCGACCGCGAAGCCAACCGCTTCTCCGCCCGCGCCGGGCGCTACGCCAGCGTGGGCGCCAATGTCGGCGG
CGTCGCCGCCCGGATGGCCATGGCGCGGCTGTTCGGAAAGGAGGGCACCACCAACGCCGCCGCCCTGGCGCAGGCGCTGG
GCGGCCTGAAGGGGCCGATCATGAAGGTGGCCCAGCTGCTGGCCACCGTCCCGGACCTGCTCCCGCCGGAGTACGCCACC
GAGTTGCAGAAGCTCCAGGCCGACGCGCCGCCGATGGGCGCGGCCTTCGTCCGACGCCGGATGCAGTCGGAATTGGGCGC
CGGCTGGCAGGCGCGATTCGGGAGCTTCGACCTCAAGCCCGCGGCCGCGGCCTCGCTGGGGCAGGTCCACCGCGCGACTA
CCGAGGACGGCGAGCGGCTCGCCTGCAAGCTGCAATATCCGGACATGCAATCGGCCGTGGAGGCCGACCTCAAGCAGCTG
GAGGTCGCATTCGCGCTGCACCGCCGGATGAACACGTGGCTCGATACGCGCGAGATCGCGAAGGAGATCGGCGCCCGGGT
GCGCGAGGAACTCGACTACGAGCGCGAGGCCAAGCACGCGGCGCTCTACGGGGCCGTGCTGAAGGACATCGCCGCAGTGC
GCGTGCCGCGCGTCTTCCCTGAGCTCTCGACGAAGCGCCTGCTCACGCTCGGCTGGCTCGACGGAGACAAGATCCTGGGC
TTCGCCGACGAGCCCGTCGAGGTGCGTAACCGGATCGCTCAGGCGATGTTCAAGGCGTGGTGGCACCCGTTCAGCCGGGC
GGCGGTGATCCACGGCGACCCGCATCTCGGCAATTACACGGTCTTCTCTGACGCCGGAGAGGCCGCCGGGATCAACCTGC
TGGATTACGGCTGCGTCCGGATCTTCCATCCGCGATTCGTCGGCGGCGTCGTGGACCTCTATCGCGGCCTGCTGGAGAAC
GACGACGCCCGCATCGTCCACGCCTACGAGGTCTGGGGTTTCAAGGATCTCGACAAGGAGAAGATCGAGATCCTGAACAT
CTGGGCCCGCTTCATCTACGGGCCGCTGCTCGAGGACCGCACCCGCACCGTCGCGGACGGGGTGAAGCCAGGGGAGTACG
GTCGGCGGCAGGCCTTCCAGGTCCATCAGGCCCTGAAGGAGCGGGGACCCGTGACGGTGCCGCAGGAATTCGTCTTCATG
GATCGTGCCGCCGTGGGTCTGGGCGCCGTGTTCCTCCACCTCAGGTCGGAACTCAACTACCACCGGTTGTTCGAAGCCGA
GATCGAGCATTTCTCGCTGGACGAACTCACGAAGCGTCAGGGTCGGGTGCTCGCCGAGGCGGACCTGCCGAAACCGGCCT
GA

Upstream 100 bases:

>100_bases
CGCGGGCTCGGCCGATGCCCGCGGCGCAGGGACCCACGCCCCTGGTTCGCGGCCGGGGGCGGCTTATCTGCGGATCATCG
TCAGACGAGCAGATCGAGTG

Downstream 100 bases:

>100_bases
GTCGGCGCGAAGATCCACCGAGAGAGCGATCAACTTGCGTGCGTCCGATTGCGGCAGGTAAACGCTTGAGCTACATCCGA
CCGCGACCGCAAGAAGTCGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAETDREANRFSARAGRYASVGANVGGVAARMAMARLFGKEGTTNAAALAQALGGLKGPIMKVAQLLATVPDLLPPEYAT
ELQKLQADAPPMGAAFVRRRMQSELGAGWQARFGSFDLKPAAAASLGQVHRATTEDGERLACKLQYPDMQSAVEADLKQL
EVAFALHRRMNTWLDTREIAKEIGARVREELDYEREAKHAALYGAVLKDIAAVRVPRVFPELSTKRLLTLGWLDGDKILG
FADEPVEVRNRIAQAMFKAWWHPFSRAAVIHGDPHLGNYTVFSDAGEAAGINLLDYGCVRIFHPRFVGGVVDLYRGLLEN
DDARIVHAYEVWGFKDLDKEKIEILNIWARFIYGPLLEDRTRTVADGVKPGEYGRRQAFQVHQALKERGPVTVPQEFVFM
DRAAVGLGAVFLHLRSELNYHRLFEAEIEHFSLDELTKRQGRVLAEADLPKPA

Sequences:

>Translated_453_residues
MAETDREANRFSARAGRYASVGANVGGVAARMAMARLFGKEGTTNAAALAQALGGLKGPIMKVAQLLATVPDLLPPEYAT
ELQKLQADAPPMGAAFVRRRMQSELGAGWQARFGSFDLKPAAAASLGQVHRATTEDGERLACKLQYPDMQSAVEADLKQL
EVAFALHRRMNTWLDTREIAKEIGARVREELDYEREAKHAALYGAVLKDIAAVRVPRVFPELSTKRLLTLGWLDGDKILG
FADEPVEVRNRIAQAMFKAWWHPFSRAAVIHGDPHLGNYTVFSDAGEAAGINLLDYGCVRIFHPRFVGGVVDLYRGLLEN
DDARIVHAYEVWGFKDLDKEKIEILNIWARFIYGPLLEDRTRTVADGVKPGEYGRRQAFQVHQALKERGPVTVPQEFVFM
DRAAVGLGAVFLHLRSELNYHRLFEAEIEHFSLDELTKRQGRVLAEADLPKPA
>Mature_452_residues
AETDREANRFSARAGRYASVGANVGGVAARMAMARLFGKEGTTNAAALAQALGGLKGPIMKVAQLLATVPDLLPPEYATE
LQKLQADAPPMGAAFVRRRMQSELGAGWQARFGSFDLKPAAAASLGQVHRATTEDGERLACKLQYPDMQSAVEADLKQLE
VAFALHRRMNTWLDTREIAKEIGARVREELDYEREAKHAALYGAVLKDIAAVRVPRVFPELSTKRLLTLGWLDGDKILGF
ADEPVEVRNRIAQAMFKAWWHPFSRAAVIHGDPHLGNYTVFSDAGEAAGINLLDYGCVRIFHPRFVGGVVDLYRGLLEND
DARIVHAYEVWGFKDLDKEKIEILNIWARFIYGPLLEDRTRTVADGVKPGEYGRRQAFQVHQALKERGPVTVPQEFVFMD
RAAVGLGAVFLHLRSELNYHRLFEAEIEHFSLDELTKRQGRVLAEADLPKPA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=308, Percent_Identity=27.9220779220779, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI41393593, Length=285, Percent_Identity=30.1754385964912, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI27363457, Length=394, Percent_Identity=24.3654822335025, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI34147522, Length=314, Percent_Identity=24.5222929936306, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI217416386, Length=339, Percent_Identity=24.7787610619469, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=28.1385281385281, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI2367309, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32565180, Length=350, Percent_Identity=26.5714285714286, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17559152, Length=251, Percent_Identity=28.2868525896414, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=316, Percent_Identity=28.7974683544304, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323282, Length=316, Percent_Identity=25, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI18859849, Length=315, Percent_Identity=26.3492063492064, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI22024280, Length=301, Percent_Identity=27.5747508305648, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24662575, Length=288, Percent_Identity=28.8194444444444, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50341; Mature: 50210

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETDREANRFSARAGRYASVGANVGGVAARMAMARLFGKEGTTNAAALAQALGGLKGPI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHH
MKVAQLLATVPDLLPPEYATELQKLQADAPPMGAAFVRRRMQSELGAGWQARFGSFDLKP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCH
AAAASLGQVHRATTEDGERLACKLQYPDMQSAVEADLKQLEVAFALHRRMNTWLDTREIA
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGARVREELDYEREAKHAALYGAVLKDIAAVRVPRVFPELSTKRLLTLGWLDGDKILG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEC
FADEPVEVRNRIAQAMFKAWWHPFSRAAVIHGDPHLGNYTVFSDAGEAAGINLLDYGCVR
CCCCCHHHHHHHHHHHHHHHCCHHHCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHH
IFHPRFVGGVVDLYRGLLENDDARIVHAYEVWGFKDLDKEKIEILNIWARFIYGPLLEDR
HHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TRTVADGVKPGEYGRRQAFQVHQALKERGPVTVPQEFVFMDRAAVGLGAVFLHLRSELNY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
HRLFEAEIEHFSLDELTKRQGRVLAEADLPKPA
HHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCC
>Mature Secondary Structure 
AETDREANRFSARAGRYASVGANVGGVAARMAMARLFGKEGTTNAAALAQALGGLKGPI
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHH
MKVAQLLATVPDLLPPEYATELQKLQADAPPMGAAFVRRRMQSELGAGWQARFGSFDLKP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCH
AAAASLGQVHRATTEDGERLACKLQYPDMQSAVEADLKQLEVAFALHRRMNTWLDTREIA
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGARVREELDYEREAKHAALYGAVLKDIAAVRVPRVFPELSTKRLLTLGWLDGDKILG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEC
FADEPVEVRNRIAQAMFKAWWHPFSRAAVIHGDPHLGNYTVFSDAGEAAGINLLDYGCVR
CCCCCHHHHHHHHHHHHHHHCCHHHCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHH
IFHPRFVGGVVDLYRGLLENDDARIVHAYEVWGFKDLDKEKIEILNIWARFIYGPLLEDR
HHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TRTVADGVKPGEYGRRQAFQVHQALKERGPVTVPQEFVFMDRAAVGLGAVFLHLRSELNY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
HRLFEAEIEHFSLDELTKRQGRVLAEADLPKPA
HHHHHHHHHHCCHHHHHHHHCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]