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The map label for this gene is gor [H]

Identifier: 170749103

GI number: 170749103

Start: 2841284

End: 2842666

Strand: Reverse

Name: gor [H]

Synonym: Mrad2831_2696

Alternate gene names: 170749103

Gene position: 2842666-2841284 (Counterclockwise)

Preceding gene: 170749104

Following gene: 170749102

Centisome position: 46.77

GC content: 71.58

Gene sequence:

>1383_bases
ATGAGCGCGTTCGACGTCGACCTCTTCGTCATCGGCGGCGGGTCCGGTGGTGTCCGCGCGGCGCGGATCGCGGCCGGGTA
CGGCGCGCGGGTGATGCTGGCCGAGGAGTACCGGGTGGGCGGCACCTGCGTGATCCGCGGCTGCGTGCCGAAGAAGCTGA
TGGTCTATGCCGGCCGCTTCGCCGACGAGTTCGAGGACGCCGCGGGCTTCGGCTGGACCGTGGAGAAGCCCCGCTTCGAC
TGGGGCACCCTCAAGACGCGGCGCGACGCGGAGGTGACCCGGCTCGAGGGCATCTACGACGCCAACCTGATCCGCGCCGG
CGTCGAGATCGTGCCCGAGCGGGCGGTGATCGAGGATCCCCACACGGTCCGCCTCGTGGCGTCCGGCCGCACGGTCCGCG
CCGAGCGGATCCTGGTGGCGGTCGGCGCGCATCCCGTGAAGGAGCCGGCGGTGCCGGGGATCGACCTGGCGATCACATCG
AACGAGGTGTTCGAGCTGGAGAGCCTGCCGGAGCGGATCCTGGTGATCGGCGGCGGCTACATCGCGGTGGAATTCGCCGG
CGTCTTCGCGGCGCTCGGCAGCCGCACGACGCTGCTGCACCGGGGCGACAGGCTGCTGCGCGGGTTCGACGACGAGATCC
GCGACGCCCTGGCCGAGGCCTACGGCCAGCGGATGGACCTGCGGCTCGGTCGCACGCTGCGGCGCGTCGAGCGCCGGGAC
GGCGGGCTGTGCGCGCAGCTCGACGACGGCAGCGACATCCTGGTGGATCAGGTGCTCGTCGCGACGGGCCGGCGGCCGAA
CGTCGAGGGCCTCGGCCTCGACCGCGTCGGCATCGCGACCGACGCCGCCGGCGCGATCCCGGTTGACGCCTTCTCGCAGA
CCCGAGTTCCCTCGATCTACGCGGTGGGCGACGTGACCAACCGCGCCAACCTCACGCCGGTGGCGATCCGCGAGGGCCAC
GCCTTCGCCGACACGGTCTACGGCGGCAAGCCCGCCTGCGTCGATCATCGCCTGATCCCGACCGCGGTGTTCTCGACCCC
CGAGATCGGCGTCGTCGGCCACAACGAGGCGGCCGCCCGCGAGATCTACGGCAAGATCGACGTCTACAAGGCGCGCTTCC
GCCCGATGAAGGCGACCCTGTCCGGCCGCGAGGAGCGGATCCTCATGAAGGTGCTGGTCGACTGCGCCAGCGACCGGGTG
GTGGGCGTCCACATCTTCGGCCACGACGCCGGAGAAGTCATCCAGGCGGTGGGAATCGCCGTGACCATGGGCGCCACGAA
GGCGGATTTCGACCGGACCATCGCGGTCCATCCGACCGCCGCCGAGGAGCTCGTGACCATGCGGGTCCCGGAAGTCACCA
AGCACCCGGTCGGCGTCGGCTGA

Upstream 100 bases:

>100_bases
GGGCGGCGTGGTGGACGGCGGGGCTCGGCGCTGCCATCACCTGGATGCGCGCGGCCTCTCCGGCCGGCGCGCGCGAGAGA
TCCGAGCGGGACGGTCCGGC

Downstream 100 bases:

>100_bases
GACCTCCGCGCGGCCGGGGCCTCGACGCGGTGCGCGACCGAGCCATATCAGGGGCATGGGCAAGCAGGGCACCGGCAAGG
GACGACGCGAGGACGACGCG

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSAFDVDLFVIGGGSGGVRAARIAAGYGARVMLAEEYRVGGTCVIRGCVPKKLMVYAGRFADEFEDAAGFGWTVEKPRFD
WGTLKTRRDAEVTRLEGIYDANLIRAGVEIVPERAVIEDPHTVRLVASGRTVRAERILVAVGAHPVKEPAVPGIDLAITS
NEVFELESLPERILVIGGGYIAVEFAGVFAALGSRTTLLHRGDRLLRGFDDEIRDALAEAYGQRMDLRLGRTLRRVERRD
GGLCAQLDDGSDILVDQVLVATGRRPNVEGLGLDRVGIATDAAGAIPVDAFSQTRVPSIYAVGDVTNRANLTPVAIREGH
AFADTVYGGKPACVDHRLIPTAVFSTPEIGVVGHNEAAAREIYGKIDVYKARFRPMKATLSGREERILMKVLVDCASDRV
VGVHIFGHDAGEVIQAVGIAVTMGATKADFDRTIAVHPTAAEELVTMRVPEVTKHPVGVG

Sequences:

>Translated_460_residues
MSAFDVDLFVIGGGSGGVRAARIAAGYGARVMLAEEYRVGGTCVIRGCVPKKLMVYAGRFADEFEDAAGFGWTVEKPRFD
WGTLKTRRDAEVTRLEGIYDANLIRAGVEIVPERAVIEDPHTVRLVASGRTVRAERILVAVGAHPVKEPAVPGIDLAITS
NEVFELESLPERILVIGGGYIAVEFAGVFAALGSRTTLLHRGDRLLRGFDDEIRDALAEAYGQRMDLRLGRTLRRVERRD
GGLCAQLDDGSDILVDQVLVATGRRPNVEGLGLDRVGIATDAAGAIPVDAFSQTRVPSIYAVGDVTNRANLTPVAIREGH
AFADTVYGGKPACVDHRLIPTAVFSTPEIGVVGHNEAAAREIYGKIDVYKARFRPMKATLSGREERILMKVLVDCASDRV
VGVHIFGHDAGEVIQAVGIAVTMGATKADFDRTIAVHPTAAEELVTMRVPEVTKHPVGVG
>Mature_459_residues
SAFDVDLFVIGGGSGGVRAARIAAGYGARVMLAEEYRVGGTCVIRGCVPKKLMVYAGRFADEFEDAAGFGWTVEKPRFDW
GTLKTRRDAEVTRLEGIYDANLIRAGVEIVPERAVIEDPHTVRLVASGRTVRAERILVAVGAHPVKEPAVPGIDLAITSN
EVFELESLPERILVIGGGYIAVEFAGVFAALGSRTTLLHRGDRLLRGFDDEIRDALAEAYGQRMDLRLGRTLRRVERRDG
GLCAQLDDGSDILVDQVLVATGRRPNVEGLGLDRVGIATDAAGAIPVDAFSQTRVPSIYAVGDVTNRANLTPVAIREGHA
FADTVYGGKPACVDHRLIPTAVFSTPEIGVVGHNEAAAREIYGKIDVYKARFRPMKATLSGREERILMKVLVDCASDRVV
GVHIFGHDAGEVIQAVGIAVTMGATKADFDRTIAVHPTAAEELVTMRVPEVTKHPVGVG

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=40.4814004376368, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=33.4029227557411, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=33.4029227557411, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=33.4029227557411, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI148277065, Length=482, Percent_Identity=33.6099585062241, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI148277071, Length=482, Percent_Identity=33.6099585062241, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI291045266, Length=486, Percent_Identity=32.9218106995885, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI22035672, Length=433, Percent_Identity=34.4110854503464, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI291045268, Length=484, Percent_Identity=30.7851239669421, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=28.6334056399132, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=38.568129330254, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=28.6343612334802, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=29.5154185022026, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87081717, Length=445, Percent_Identity=28.0898876404494, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789065, Length=212, Percent_Identity=28.7735849056604, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=437, Percent_Identity=41.6475972540046, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71983419, Length=437, Percent_Identity=41.6475972540046, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=30.8176100628931, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71982272, Length=442, Percent_Identity=29.8642533936652, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=30.3687635574837, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=38.2608695652174, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=26.9565217391304, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=27.6595744680851, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=35.5789473684211, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=33.8266384778013, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=33.8266384778013, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=33.8266384778013, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=29.5116772823779, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49384; Mature: 49253

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFDVDLFVIGGGSGGVRAARIAAGYGARVMLAEEYRVGGTCVIRGCVPKKLMVYAGRF
CCCEEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHCHH
ADEFEDAAGFGWTVEKPRFDWGTLKTRRDAEVTRLEGIYDANLIRAGVEIVPERAVIEDP
HHHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCHHCCCCCCEECCC
HTVRLVASGRTVRAERILVAVGAHPVKEPAVPGIDLAITSNEVFELESLPERILVIGGGY
CEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCEEEEEECCCEEEHHCCCCEEEEEECCE
IAVEFAGVFAALGSRTTLLHRGDRLLRGFDDEIRDALAEAYGQRMDLRLGRTLRRVERRD
EEEEHHHHHHHHCCCEEEECCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
GGLCAQLDDGSDILVDQVLVATGRRPNVEGLGLDRVGIATDAAGAIPVDAFSQTRVPSIY
CCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
AVGDVTNRANLTPVAIREGHAFADTVYGGKPACVDHRLIPTAVFSTPEIGVVGHNEAAAR
EECCCCCCCCCCEEEEECCCCEEHHCCCCCCCCCCCCCCCHHEECCCCEEEEECCHHHHH
EIYGKIDVYKARFRPMKATLSGREERILMKVLVDCASDRVVGVHIFGHDAGEVIQAVGIA
HHHCCCEEEEHHCCCEEHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCEE
VTMGATKADFDRTIAVHPTAAEELVTMRVPEVTKHPVGVG
EEECCCCCCCCCEEEECCCCHHHHEEEECCCHHCCCCCCC
>Mature Secondary Structure 
SAFDVDLFVIGGGSGGVRAARIAAGYGARVMLAEEYRVGGTCVIRGCVPKKLMVYAGRF
CCEEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHCHH
ADEFEDAAGFGWTVEKPRFDWGTLKTRRDAEVTRLEGIYDANLIRAGVEIVPERAVIEDP
HHHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCHHCCCCCCEECCC
HTVRLVASGRTVRAERILVAVGAHPVKEPAVPGIDLAITSNEVFELESLPERILVIGGGY
CEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCEEEEEECCCEEEHHCCCCEEEEEECCE
IAVEFAGVFAALGSRTTLLHRGDRLLRGFDDEIRDALAEAYGQRMDLRLGRTLRRVERRD
EEEEHHHHHHHHCCCEEEECCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
GGLCAQLDDGSDILVDQVLVATGRRPNVEGLGLDRVGIATDAAGAIPVDAFSQTRVPSIY
CCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
AVGDVTNRANLTPVAIREGHAFADTVYGGKPACVDHRLIPTAVFSTPEIGVVGHNEAAAR
EECCCCCCCCCCEEEEECCCCEEHHCCCCCCCCCCCCCCCHHEECCCCEEEEECCHHHHH
EIYGKIDVYKARFRPMKATLSGREERILMKVLVDCASDRVVGVHIFGHDAGEVIQAVGIA
HHHCCCEEEEHHCCCEEHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCEE
VTMGATKADFDRTIAVHPTAAEELVTMRVPEVTKHPVGVG
EEECCCCCCCCCEEEECCCCHHHHEEEECCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]