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The map label for this gene is sppA [C]

Identifier: 170748863

GI number: 170748863

Start: 2610099

End: 2611061

Strand: Reverse

Name: sppA [C]

Synonym: Mrad2831_2445

Alternate gene names: 170748863

Gene position: 2611061-2610099 (Counterclockwise)

Preceding gene: 170748864

Following gene: 170748862

Centisome position: 42.96

GC content: 72.79

Gene sequence:

>963_bases
ATGGCAGCCGATGCCGAACTGCTGATTGACCGGCGGCGCCTGCGCCGCAGGTTGTCCCTCTGGCGCGTGCTCGGCGTCGG
CGGCCTCATCGTGGCGGTCGGGGCTCTCGGGTACCGGGTGCGGACGGGCGCGGACGGCGCCTTCGCGGTCCAGCCGCAGA
TCGCGCGCATCTCCGTCTCGGGCTTCATCGCCGGGAGCGAGGCCACCGCGAAGCTGATGAAGCGGGTCGGCGATTCGGAC
GCCGTGAAGGGCGTGATCGTCTCGATCAACTCGCCCGGCGGCACCACGACGGGCTCGGAGGAGATCTTCCGCAACCTCCG
GGCGCTCGCCGCCAAGAAGCCGATCGTGGCCTTCGTGGACGGCACCGCCGCCTCGGGCGCCTACATCACCGCCATCGCGG
CCGATCACATCGTCGCGCGCGAGACCAGTCTGGTCGGCTCGATCGGCGTGCTGTTCCAGTACCCGGACTTCTCGGGTCTC
CTGGACAAGGTCGGCGTCAAGGTCGAGTCGGTGAAGTCGTCGCCGCTCAAGGCCGAGCCCTCGGGCTTCACCCCGACCTC
GCCGGAGGCGCGCGCCGCGCTCGCCTCCGTGGTCGGCGACACCTACGCGTGGTTCAAGGGCCTCGTCGCGGAGCGCCGCG
GCATGGATCCGGCGCAGCTCAGCACCGTCTCGGACGGCCGGGTGTTCAGCGGGCGCCAGAGCGTGCCGCTGAAGCTGGTC
GACGAACTCGGGGGCGAGCGGCAGGCGGTGGCGTGGCTGGAGAGCGCCCGCGGCGTCCAGGCGAACCTGCCGATCAAGGA
CTGGAAGCCCGCCTCGGAGAGCCGGTTCTCCCTCTGGTCCGCCGCCGGGATCGGCGCCGACCTCCTCGGCCTGGAAGGCC
TCGCGGCGCGGCTGCGGGCCGTCGGCGCCGAGGCCGAGGCCGCCCGGGGCGGGATGCTCGCCCTCTGGCGCCCGGAACCC
TGA

Upstream 100 bases:

>100_bases
CCGAGCGAGCCGAAGGAAACCAAGGACTTGCCCGGCGCGGGGGTACGCCTCCCGCACCCCGTCGAGGGGCCGGTCGGGGT
GCTTTAGGGGAAGCGACAGC

Downstream 100 bases:

>100_bases
ACGACCGCCGCCGCGCAGCCCGCCCCGATCCCGCGAGAAGATCCCACGCCATGATCAAGTCGGAGCTCGTCCTCAAGATC
GCCGAGCAGAACCCGCATCT

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MAADAELLIDRRRLRRRLSLWRVLGVGGLIVAVGALGYRVRTGADGAFAVQPQIARISVSGFIAGSEATAKLMKRVGDSD
AVKGVIVSINSPGGTTTGSEEIFRNLRALAAKKPIVAFVDGTAASGAYITAIAADHIVARETSLVGSIGVLFQYPDFSGL
LDKVGVKVESVKSSPLKAEPSGFTPTSPEARAALASVVGDTYAWFKGLVAERRGMDPAQLSTVSDGRVFSGRQSVPLKLV
DELGGERQAVAWLESARGVQANLPIKDWKPASESRFSLWSAAGIGADLLGLEGLAARLRAVGAEAEAARGGMLALWRPEP

Sequences:

>Translated_320_residues
MAADAELLIDRRRLRRRLSLWRVLGVGGLIVAVGALGYRVRTGADGAFAVQPQIARISVSGFIAGSEATAKLMKRVGDSD
AVKGVIVSINSPGGTTTGSEEIFRNLRALAAKKPIVAFVDGTAASGAYITAIAADHIVARETSLVGSIGVLFQYPDFSGL
LDKVGVKVESVKSSPLKAEPSGFTPTSPEARAALASVVGDTYAWFKGLVAERRGMDPAQLSTVSDGRVFSGRQSVPLKLV
DELGGERQAVAWLESARGVQANLPIKDWKPASESRFSLWSAAGIGADLLGLEGLAARLRAVGAEAEAARGGMLALWRPEP
>Mature_319_residues
AADAELLIDRRRLRRRLSLWRVLGVGGLIVAVGALGYRVRTGADGAFAVQPQIARISVSGFIAGSEATAKLMKRVGDSDA
VKGVIVSINSPGGTTTGSEEIFRNLRALAAKKPIVAFVDGTAASGAYITAIAADHIVARETSLVGSIGVLFQYPDFSGLL
DKVGVKVESVKSSPLKAEPSGFTPTSPEARAALASVVGDTYAWFKGLVAERRGMDPAQLSTVSDGRVFSGRQSVPLKLVD
ELGGERQAVAWLESARGVQANLPIKDWKPASESRFSLWSAAGIGADLLGLEGLAARLRAVGAEAEAARGGMLALWRPEP

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=188, Percent_Identity=35.6382978723404, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787527, Length=177, Percent_Identity=31.0734463276836, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 33492; Mature: 33361

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADAELLIDRRRLRRRLSLWRVLGVGGLIVAVGALGYRVRTGADGAFAVQPQIARISVS
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCEEEECCCEEEEEEE
GFIAGSEATAKLMKRVGDSDAVKGVIVSINSPGGTTTGSEEIFRNLRALAAKKPIVAFVD
EEEECCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GTAASGAYITAIAADHIVARETSLVGSIGVLFQYPDFSGLLDKVGVKVESVKSSPLKAEP
CCCCCCCEEEEEHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHCCEEEECCCCCCCCCC
SGFTPTSPEARAALASVVGDTYAWFKGLVAERRGMDPAQLSTVSDGRVFSGRQSVPLKLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCEECCCCCCCHHHH
DELGGERQAVAWLESARGVQANLPIKDWKPASESRFSLWSAAGIGADLLGLEGLAARLRA
HHCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGAEAEAARGGMLALWRPEP
HCCCHHHCCCCEEEEECCCC
>Mature Secondary Structure 
AADAELLIDRRRLRRRLSLWRVLGVGGLIVAVGALGYRVRTGADGAFAVQPQIARISVS
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCEEEECCCEEEEEEE
GFIAGSEATAKLMKRVGDSDAVKGVIVSINSPGGTTTGSEEIFRNLRALAAKKPIVAFVD
EEEECCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GTAASGAYITAIAADHIVARETSLVGSIGVLFQYPDFSGLLDKVGVKVESVKSSPLKAEP
CCCCCCCEEEEEHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHCCEEEECCCCCCCCCC
SGFTPTSPEARAALASVVGDTYAWFKGLVAERRGMDPAQLSTVSDGRVFSGRQSVPLKLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCEECCCCCCCHHHH
DELGGERQAVAWLESARGVQANLPIKDWKPASESRFSLWSAAGIGADLLGLEGLAARLRA
HHCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGAEAEAARGGMLALWRPEP
HCCCHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]